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HIV- Human Immunodeficiency
Virus
Presented by:
1. Aditi Tekade PD325
2. Ganesh There PD326
3. Aanya Verma PD327
4. Varsha Wadnere PD328
HIV- Human
Immunodeficiency Virus
Presented by:
Varsha Wadnere PD328
• What Is HIV?
HIV (human immunodeficiency virus) is a virus that attacks
cells that help the body fight infection, making a person more
vulnerable to other infections and diseases.
• Causes:
Stages of HIV Infection:
■ Stages of Infection – (assuming no treatment) ...
■ Stage 1: Infection. ...
■ Stage 2: Asymptomatic. ...
■ Stage 3: Symptomatic. ...Over time the immune system
becomes damaged and weakened by HIV and symptoms
develop. Initially they can be mild but they do worsen,
symptoms include fatigue, weight loss, mouth ulcers, thrush
and severe diarrhea
■ 4: AIDS/Progression of HIV to AIDS.
PATHOPHISIOLOGY OF HIV
SOAP Analysis
• Patient Details:
■ AGE :14
■ SEX:Female
■ Weight:35kg
■ Height:142cm
■ BMI:17.9
Subjective Data:
■ Cough: Insidious onset
■ productive-yellow colored sputum.
■ Blood stained
■ more in recumbent posture
■ Fever : intermittent high grade no chills or rigors
■ Oral lesions- white in color not associated with pain with gradually
increasing in nature.
Objective Data:
■ Hb:8.1g%
■ TC : 240ocells cells / cum D
■ C : N68 L28 E3
■ PLATELETS : 3-3 lakhs
■ Mantoux: Negative
■ HIV ( Elisa ):Positive
■ Thro for fungus : negative
■ Sputum for AFB : negative
■ CXR : B / L basal bronchiectasis
CT thorax : B / L bronchiectasis and features of infective bronchiolitis .
B / L hilar and mediastinal lymphadenopathy
Assessment:
■ Final diagnosis- HIV Stage III
Past History:
■ Scaly skin lesions over both legs :3 years
■ Recurrent respiratory infections:1 12 years
■ Similar oral lesions: 1Year
■ Loose mucoid stools , on & off : 1 year
■ P/H/ O febrile seizures was on regular AED'S till 3
years of age .
Goals of Treatment:
■ People living with HIV should be active participant in their
health management and requires an understanding of the
HIV infection, management and treatment.
■ Attention to growth , nutrition and immunization of child .
■ Treatment and prevention of opportunistic infections
Antiretroviral therapy .
Tab. Cotrimoxazole (sulfamethoxazole and trimethoprim):
• INDICATION: treatment for pneumocystis jirovecii pneumonia
• ADR: Nausea, vomiting, anorexia, seizures.
• CONTRAINDICATION: hypersensitivity
• INTERACTION: ACE inhibitors ,amiodarone, anti-diabetic drugs.
• DOSE: 15TMP/kg/day in 2 divided doses for 3 times.
Tab. ISONIAZID (10-15mg)
• INDICATION : treatment for TB (highly recommended for all children living
with HIV)
• ADVERSE DRUG REACTION: increased serum transaminase level, anorexia,
dizziness and Hepatotoxicity.
• CONTRAINDICATION: acute liver disease, fatal hepatitis.
• INTERACTION: Antacids, corticosteroids.
Tab. Zidovudine (300mg)
• INDICATION : treatment for HIV.
• ADVERSE DRUG REACTION: anorexia, weakness, fever, headache,
nausea, vomiting.
• CONTRAINDICATIONS: fatty liver disease, bone marrow
suppression.
• INTERACTIONS: Probenecid, fluconazole and ganciclovir.
Tab. Stavudine (30mg)
• INDICATION :treatment for HIV.
• ADVERSE DRUG REACTION: abdominal pain, vomiting, anxiety, fever.
• CONTRAINDICATIONS: pancreatitis, immune reconstitution syndrom.
• INTERACTIONS: zidovudine, metronidazole, isoniazid.
Tab. Tenofovir (100mg)
• INDICATION: treatment for HIV.
• ADVERSE DRUG REACTIONS: abdominal pain, increase creatinine kinase,
insomnia, depression, dizziness.
• CONTRAINDICATIONS: nephrotoxicity, immune reconstitution syndrome,
decrease bone mineral density.
• INTERACTIONS: Atazanavir, adefovir.
• PLANNING:
1. Monitoring parameters :serum potassium level, creatinine level and
CBC.
2. Discharge medication : patient not yet discharged.
3. Therapeutic monitoring : Blood glucose level , PH , Bicarbonate
• Point To Physician:
■ Tab. Stavudine is having interaction with Zidovudine and
Isoniazid.
ALTERNATE THERAPY- Tab. Didanosine(200mg)
Tab. Didanosine (200mg)
• INDICATION: treatment for HIV
• ADVERSE DRUG REACTIONS: GI disturbances, peripheral neuropathy, abnormal
LFT.
• CONTRAINDICATIONS: Pancreatitis, severe hepatomegaly, immune
reconstitution syndrome.
• INTERACTIONS: Allopurinol, Indinavir, Ribavirin.
• Point to Patient:
1.Guide her about post discharge medication.
2.Guide her about the diet.
3.Guide her about the lifestyle.
Reference:
■ http://www.slideshare.net/9751111158/hiv-
casepresentation1?from_m_app=android
■ www.indiadrugindex/in
Thank You 

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HIV-Human Immunodeficiency Virus Presentation

  • 1. HIV- Human Immunodeficiency Virus Presented by: 1. Aditi Tekade PD325 2. Ganesh There PD326 3. Aanya Verma PD327 4. Varsha Wadnere PD328 HIV- Human Immunodeficiency Virus Presented by: Varsha Wadnere PD328
  • 2. • What Is HIV? HIV (human immunodeficiency virus) is a virus that attacks cells that help the body fight infection, making a person more vulnerable to other infections and diseases.
  • 4. Stages of HIV Infection: ■ Stages of Infection – (assuming no treatment) ... ■ Stage 1: Infection. ... ■ Stage 2: Asymptomatic. ... ■ Stage 3: Symptomatic. ...Over time the immune system becomes damaged and weakened by HIV and symptoms develop. Initially they can be mild but they do worsen, symptoms include fatigue, weight loss, mouth ulcers, thrush and severe diarrhea ■ 4: AIDS/Progression of HIV to AIDS.
  • 7. • Patient Details: ■ AGE :14 ■ SEX:Female ■ Weight:35kg ■ Height:142cm ■ BMI:17.9
  • 8. Subjective Data: ■ Cough: Insidious onset ■ productive-yellow colored sputum. ■ Blood stained ■ more in recumbent posture ■ Fever : intermittent high grade no chills or rigors ■ Oral lesions- white in color not associated with pain with gradually increasing in nature.
  • 9. Objective Data: ■ Hb:8.1g% ■ TC : 240ocells cells / cum D ■ C : N68 L28 E3 ■ PLATELETS : 3-3 lakhs ■ Mantoux: Negative ■ HIV ( Elisa ):Positive ■ Thro for fungus : negative ■ Sputum for AFB : negative ■ CXR : B / L basal bronchiectasis CT thorax : B / L bronchiectasis and features of infective bronchiolitis . B / L hilar and mediastinal lymphadenopathy
  • 11. Past History: ■ Scaly skin lesions over both legs :3 years ■ Recurrent respiratory infections:1 12 years ■ Similar oral lesions: 1Year ■ Loose mucoid stools , on & off : 1 year ■ P/H/ O febrile seizures was on regular AED'S till 3 years of age .
  • 12. Goals of Treatment: ■ People living with HIV should be active participant in their health management and requires an understanding of the HIV infection, management and treatment. ■ Attention to growth , nutrition and immunization of child . ■ Treatment and prevention of opportunistic infections Antiretroviral therapy .
  • 13. Tab. Cotrimoxazole (sulfamethoxazole and trimethoprim): • INDICATION: treatment for pneumocystis jirovecii pneumonia • ADR: Nausea, vomiting, anorexia, seizures. • CONTRAINDICATION: hypersensitivity • INTERACTION: ACE inhibitors ,amiodarone, anti-diabetic drugs. • DOSE: 15TMP/kg/day in 2 divided doses for 3 times.
  • 14. Tab. ISONIAZID (10-15mg) • INDICATION : treatment for TB (highly recommended for all children living with HIV) • ADVERSE DRUG REACTION: increased serum transaminase level, anorexia, dizziness and Hepatotoxicity. • CONTRAINDICATION: acute liver disease, fatal hepatitis. • INTERACTION: Antacids, corticosteroids.
  • 15. Tab. Zidovudine (300mg) • INDICATION : treatment for HIV. • ADVERSE DRUG REACTION: anorexia, weakness, fever, headache, nausea, vomiting. • CONTRAINDICATIONS: fatty liver disease, bone marrow suppression. • INTERACTIONS: Probenecid, fluconazole and ganciclovir.
  • 16. Tab. Stavudine (30mg) • INDICATION :treatment for HIV. • ADVERSE DRUG REACTION: abdominal pain, vomiting, anxiety, fever. • CONTRAINDICATIONS: pancreatitis, immune reconstitution syndrom. • INTERACTIONS: zidovudine, metronidazole, isoniazid.
  • 17. Tab. Tenofovir (100mg) • INDICATION: treatment for HIV. • ADVERSE DRUG REACTIONS: abdominal pain, increase creatinine kinase, insomnia, depression, dizziness. • CONTRAINDICATIONS: nephrotoxicity, immune reconstitution syndrome, decrease bone mineral density. • INTERACTIONS: Atazanavir, adefovir.
  • 18. • PLANNING: 1. Monitoring parameters :serum potassium level, creatinine level and CBC. 2. Discharge medication : patient not yet discharged. 3. Therapeutic monitoring : Blood glucose level , PH , Bicarbonate
  • 19. • Point To Physician: ■ Tab. Stavudine is having interaction with Zidovudine and Isoniazid. ALTERNATE THERAPY- Tab. Didanosine(200mg)
  • 20. Tab. Didanosine (200mg) • INDICATION: treatment for HIV • ADVERSE DRUG REACTIONS: GI disturbances, peripheral neuropathy, abnormal LFT. • CONTRAINDICATIONS: Pancreatitis, severe hepatomegaly, immune reconstitution syndrome. • INTERACTIONS: Allopurinol, Indinavir, Ribavirin.
  • 21. • Point to Patient: 1.Guide her about post discharge medication. 2.Guide her about the diet. 3.Guide her about the lifestyle.