Zinc,PSM,Community Medicine,DR NARENDRA KUMAR YADAV
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Zinc is a mineral that acts as an antioxidant in the body. It is found in animal foods like meat and fish and plays important roles in growth, wound healing, immune function, and insulin production. Zinc deficiency can result in loss of taste and appetite, skin issues, impaired immunity, growth problems, delayed sexual maturation, and poor wound healing. Supplementing zinc along with oral rehydration solution can reduce the duration and severity of diarrhea in children.
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Influenza.PSM,COMMUNITY MEDICINE,MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
Influenza.PSM,COMMUNITY MEDICINE,MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
Rubella (German measles),PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
Rubella (German measles),PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
Mumps.PSM,COMMUNITY MEDICINE, MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
Mumps.PSM,COMMUNITY MEDICINE, MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
Diphtheria.PSM,COMMUNITY MEDICINE,MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
Diphtheria.PSM,COMMUNITY MEDICINE,MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
LF, Lymphatic Filariasis, PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
LF, Lymphatic Filariasis, PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
MEASLES,PSM,COMMUNITY MEDICINE,MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
MEASLES,PSM,COMMUNITY MEDICINE,MBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
Tuberculosis,TB,COMMUNITY MEDICINE,MBBS,MD,BPH,MPH,DR NARENDRA KUMAR YADAV
Tuberculosis,TB,COMMUNITY MEDICINE,MBBS,MD,BPH,MPH,DR NARENDRA KUMAR YADAV
HIV:AIDS.PSM, COMMUNITY MEDINE,MBBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
HIV:AIDS.PSM, COMMUNITY MEDINE,MBBBS,BPH,MD,MPH,DR NARENDRA KUMAR YADAV
Chickenpox and Smallpox.PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV,DR NAR...
Chickenpox and Smallpox.PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV,DR NAR...
Salt Fortification.BPH,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV,DR NARENDRA...
Salt Fortification.BPH,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV,DR NARENDRA...
Fluorine,PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
Fluorine,PSM,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
Iodine Deficiency Disorder (IDD),BPH,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
Iodine Deficiency Disorder (IDD),BPH,COMMUNITY MEDICINE,DR NARENDRA KUMAR YADAV
ARI (Community Medicine), PSM, Community Medicine,DR NARENDRA KUMAR YADAV
ARI (Community Medicine), PSM, Community Medicine,DR NARENDRA KUMAR YADAV
Dengue, PSM, Community Medicine,DR NARENDRA KUMAR YADAV
Dengue, PSM, Community Medicine,DR NARENDRA KUMAR YADAV
Recently uploaded
SENSORY NEEDS B.SC. NURSING SEMESTER II.
Sensation is the neurological process by which we become aware of surrounding environment.
Cervical Disc Arthroplasty ORSI 2024.pptx
Indication and installation of a mobile cervical disc prosthesis. Benefits of the PRODISC C VIVO mobile disc prosthesis (Centinel Spine)
Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Pollen and Fungal allergy: aeroallergy.pdf
Pollen and Fungal allergy: aeroallergy.pdfChulalongkorn Allergy and Clinical Immunology Research Group
Pollen and Fungal allergy
Presented by Chaloemchai Chumsaengchotsakul, MD.
June 14, 2024Nano-gold for Cancer Therapy chemistry investigatory project
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Acute Gout Care & Urate Lowering Therapy .pdf
In this document , the management of acute gout attacks and a description of urate lowering therapy is mentioned.
Patellar Instability: Diagnosis Management
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdf
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
5 Effective Homeopathic Medicines for Irregular Periods
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
biomechanics of running. Dr.dhwani.pptx
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
PGx Analysis in VarSeq: A User’s Perspective
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Ageing, the Elderly, Gerontology and Public Health
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“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
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“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montrealWhat are the different types of Dental implants.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort. Recently uploaded (20)
Nano-gold for Cancer Therapy chemistry investigatory project
Nano-gold for Cancer Therapy chemistry investigatory project
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdf
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdf
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
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5 Effective Homeopathic Medicines for Irregular Periods
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Ageing, the Elderly, Gerontology and Public Health
Ageing, the Elderly, Gerontology and Public Health
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Zinc,PSM,Community Medicine,DR NARENDRA KUMAR YADAV
- 1. Zinc Deficiency DR NARENDRA KUMAR YADAV MD Community Medicine & Tropical Diseases, BPKIHS
- 2. Classification of food on the basis of chemical composition:
- 4. Sources of Zinc: 1. Animal Food: Fish, Meat, Milk 2. Vegetable: Low Bioavailability The average adult body contains 1.4 to 2.3 g of zinc. RDA: Adult (10mg/day) Pregnancy & lactation (15-20mg/day)
- 5. Functions of Zinc: Required for: Synthesis of Insulin by Pancreas Normal growth & Wound Healing Important for the immune system Sexual development Antioxidant
- 6. Clinical manifestations of Zn deficiency: Loss of Taste ( Ageusia) Loss of Appetite Skin: Acrodermatitis Enteropathica, Acne, Eczema, Xerosis Decreased Insulin Synthesis by Pancreas Growth Failure Delayed Wound Healing Dwarfism & Hypogonadism Sexual Infantilism in adolescent
- 7. Clinical manifestations of Zn deficiency: Cont.… Impaired cell-mediated immunity: RTI (Pneumonia), gastrointestinal infection(diarrhoea) Pernicious Anemia/ Megaloblastic Anemia Thalassemia Myocardial Infraction Hepatosplenomegaly Maternal Zinc deficiency: Spontaneous abortion, LBW, IUGR, Preterm delivery, Anencephaly
- 8. Diarrhoea in children: Zinc supplementation in combination with ORS reduces the Duration and severity of Diarrhoea: Dose: < 6 Months 10 mg/day > 6 Months 20mg/day Zinc Toxicity: Pulmonary Fibrosis
- 9. MCQ Q. Zinc deficiency leads to all except: A. Delayed Sexual Maturation B. Impaired Immune function C. Skeletal Abnormalities D. Excessive Appetite
- 10. Ans: D (Excessive Appetite) Zn Deficiency Causes: Loss of Appetite
- 11. MCQ Q. Zinc deficiency is characterized by: A. Sexual infantilism B. Poor growth C. Poor wound healing D. All of the above
- 12. Ans: D (All of the above)
- 13. MCQ Q. One of the following is not reported to be a clinical manifestation of Zinc deficiency in children: A. Increased insulin synthesis B. Liver and spleen enlargement C. Impaired cell-mediated immunity D. Macrocytic anemia
- 14. Ans: A (Increased insulin synthesis) Zn Deficiency Causes: Decreased Insulin Synthesis by Pancreas
- 15. MCQ Q. Zinc supplement given in 12 month baby: A. 20mg/day B. 10 mg/day C. 5 mg/day D.15 mg/day
- 16. Ans: A (20mg/day) < 6 Months 10 mg/day > 6 Months 20mg/day
- 17. The End