Xmatrx ELITE is BioGenx's All-in-One and All-at-Once fully automated system that provides an adaptable workflow solution for efficiency, productivity and profitability. The system consists of platform technology that standardizes complete automation from microtome to microscope in three simple steps (load, click and view) for any slide-based assays such as immuno-histochemistry (IHC), in situ hybridization (ISH), fluorescence in situ hybridization (FISH), co-detection and multiplex applications (double and triple stains; IHC/ISH), in situ PCR, micro-RNA and special staining. Hence, Xmatrx ELITE maximizes testing capacity, minimizes hands-on time, reduces errors and produces consistent results.
For more information contact Customer support at customer.service@biogenex.com
Fluoresence In Situ Hybridization Workflow Solution - Xmatrix NANO AutomationBioGenex
BioGenex eFISHiency system is the only integrated FISH workflow solution in the market offering an affordable, yet fast and accurate FISH automation. This system reduces hands-on processing time to less than 30 minutes, has the ability to run up to 10 different FISH protocols simultaneously and provides validated reagents and protocols for optimal results.
CATEX™ 3 gas detection device is GAZOMAT™'s latest generation explosimeter-catharometer. This high precision detection technology ensures optimal safety when operating in hazardous atmospheres.
Fluoresence In Situ Hybridization Workflow Solution - Xmatrix NANO AutomationBioGenex
BioGenex eFISHiency system is the only integrated FISH workflow solution in the market offering an affordable, yet fast and accurate FISH automation. This system reduces hands-on processing time to less than 30 minutes, has the ability to run up to 10 different FISH protocols simultaneously and provides validated reagents and protocols for optimal results.
CATEX™ 3 gas detection device is GAZOMAT™'s latest generation explosimeter-catharometer. This high precision detection technology ensures optimal safety when operating in hazardous atmospheres.
The Serinus 57 Total Reduced Sulfur analyser delivers precise and reliable performance at excellent value. It uses proven UV fluorescent radiation technology and an external thermal converter to measure TRS in ambient air (LDL <0.3 ppb, Range 0-10 ppm).
The Serinus range of analysers has been designed using our experience and knowledge gained from operating large air quality monitoring networks for more than 35 years. The result: instruments that integrate seamlessly into continuous monitoring networks.
Little Master Transit (LM Transit) series are one-time use portable temperature data loggers.
Ideal for recording temperature during shipping and transport, LM Transit series are easy to use, accurate and affordable solutions for your requirements. Waterproof (IP65) ensures that you can place them in the most demanding of environments. EN 12830 compliance assures you the quality and the reliability.
The bright fluorescent like color makes it easy to identify at destination for easy retrieval.
Validation Dataloggers: Trends, considerations, along with the various dataloggers that are used for different purposes. Staying on top of emerging trends is key to being in compliance in order to pass an FDA audit..
Jason Daoust is the Business Development Manager for Masy Systems, Inc. He has been with Masy for over 8 years and has an in-depth knowledge of industry trends and technology. Jason has worked with multiple data logger manufacturers and is heavily involved in testing the functional capabilities to determine form and fit for validation use in cGMP environments. He works closely with hundreds of validation and calibration service companies and departments listening to their needs and providing the right products for them to be successful in completing their work. Jason regularly performs training on the use of validation data loggers in cGxP environments to some of the largest and smallest companies in North America. Prior to Masy, Jason worked as an independent business consultant working with product evaluations and release.
The highly sensitive detector tubes are designed for evaluation of the potential presence of ultra toxic chemical substances in the air and are resistant to interfering substances
PGM-IR - Central to a grocery store’s refrigeration management approach
- portable leak detection
- ultra-sensitive infrared sensor
- capable of detecting refrigerant levels as low as 1ppm
Superior performance and functionality for low ppm level leak detection of refrigerants, including carbon dioxide
- immune to sudden changes in temperature or humidity
- audible tick-rate
- real-time ppm display
- built-in library of 50 refrigerants
- data logging capacity of up to 200 readings
- rechargeable Li-ion battery for a minimum of 8 hours runtime
- pinpoint leaks at their source!
The PGM-IR accurately detects the smallest leaks at their source. The unit is immune to sudden changes in temperature or humidity and to over-exposure. The PGM-IR requires no zeroing of positive readings with extended exposure to gas.
With its high flow rate, real-time ppm concentrations or TWA values are displayed instantly with corresponding audible tick-rate indicator to quickly and precisely pinpoint leaks, minimizing costs of labor and lost refrigerant. Rapid clearing time enables accurate ambient-air leak detection using the probe along a chiller or display-case. A re-zeroing algorithm and filter/bladder system allows the unit to be used in contaminated areas without affecting target gas readings.
The Exactus BAM is a real-time beta gauge built to satisfy users, regulators and those from the health community by providing truly accurate, precise, real time measurement of fine particulate matter automatically, it is a permanent installation with the capacity to be portable when needed.
FEATURES & SPECIFICATIONS
Real-time, accurate results without correction factors, regardless of season or geographic location
True ambient sampling provides accurate measurement of semi-volatile nitrates and organic compounds
Lightweight, rugged construction is easily mounted on a tripod in minutes
All-weather construction allows for true ambient sampling
Operates on AC power.
The GAZOTRACK 4, multigas detector. This new generation handheld device can detect four gases at the same time- offering an all in one solution. The GAZOTRACK 4 can be used for a wide range of detection situation.
The all new ANALECT® RefinIR™ is a fully integrated laboratory autosampler and FTIR instrument. The RefinIR delivers automated spectral data acquisition of multiple liquid refinery stream samples from crude oils to blended gasoline and diesel.
Intrinsically Safe ATEX, unsurpassed certified oxygen analyser for all hazardous areas. The EC91 Process Oxygen Transmitter will detect levels of oxygen as low as 1ppm, up to higher percent levels and can be used on most industrial gases and atmospheres.
OriGene Technologies Capabilities Overview Feb 2011mwatson26
Opportunity overview with OriGene Technologies. OriGene is looking to identify strategic collaboration partners for its full-length human proteins, validated monoclonal antibodies and "gene centric" tool box.
The Serinus 57 Total Reduced Sulfur analyser delivers precise and reliable performance at excellent value. It uses proven UV fluorescent radiation technology and an external thermal converter to measure TRS in ambient air (LDL <0.3 ppb, Range 0-10 ppm).
The Serinus range of analysers has been designed using our experience and knowledge gained from operating large air quality monitoring networks for more than 35 years. The result: instruments that integrate seamlessly into continuous monitoring networks.
Little Master Transit (LM Transit) series are one-time use portable temperature data loggers.
Ideal for recording temperature during shipping and transport, LM Transit series are easy to use, accurate and affordable solutions for your requirements. Waterproof (IP65) ensures that you can place them in the most demanding of environments. EN 12830 compliance assures you the quality and the reliability.
The bright fluorescent like color makes it easy to identify at destination for easy retrieval.
Validation Dataloggers: Trends, considerations, along with the various dataloggers that are used for different purposes. Staying on top of emerging trends is key to being in compliance in order to pass an FDA audit..
Jason Daoust is the Business Development Manager for Masy Systems, Inc. He has been with Masy for over 8 years and has an in-depth knowledge of industry trends and technology. Jason has worked with multiple data logger manufacturers and is heavily involved in testing the functional capabilities to determine form and fit for validation use in cGMP environments. He works closely with hundreds of validation and calibration service companies and departments listening to their needs and providing the right products for them to be successful in completing their work. Jason regularly performs training on the use of validation data loggers in cGxP environments to some of the largest and smallest companies in North America. Prior to Masy, Jason worked as an independent business consultant working with product evaluations and release.
The highly sensitive detector tubes are designed for evaluation of the potential presence of ultra toxic chemical substances in the air and are resistant to interfering substances
PGM-IR - Central to a grocery store’s refrigeration management approach
- portable leak detection
- ultra-sensitive infrared sensor
- capable of detecting refrigerant levels as low as 1ppm
Superior performance and functionality for low ppm level leak detection of refrigerants, including carbon dioxide
- immune to sudden changes in temperature or humidity
- audible tick-rate
- real-time ppm display
- built-in library of 50 refrigerants
- data logging capacity of up to 200 readings
- rechargeable Li-ion battery for a minimum of 8 hours runtime
- pinpoint leaks at their source!
The PGM-IR accurately detects the smallest leaks at their source. The unit is immune to sudden changes in temperature or humidity and to over-exposure. The PGM-IR requires no zeroing of positive readings with extended exposure to gas.
With its high flow rate, real-time ppm concentrations or TWA values are displayed instantly with corresponding audible tick-rate indicator to quickly and precisely pinpoint leaks, minimizing costs of labor and lost refrigerant. Rapid clearing time enables accurate ambient-air leak detection using the probe along a chiller or display-case. A re-zeroing algorithm and filter/bladder system allows the unit to be used in contaminated areas without affecting target gas readings.
The Exactus BAM is a real-time beta gauge built to satisfy users, regulators and those from the health community by providing truly accurate, precise, real time measurement of fine particulate matter automatically, it is a permanent installation with the capacity to be portable when needed.
FEATURES & SPECIFICATIONS
Real-time, accurate results without correction factors, regardless of season or geographic location
True ambient sampling provides accurate measurement of semi-volatile nitrates and organic compounds
Lightweight, rugged construction is easily mounted on a tripod in minutes
All-weather construction allows for true ambient sampling
Operates on AC power.
The GAZOTRACK 4, multigas detector. This new generation handheld device can detect four gases at the same time- offering an all in one solution. The GAZOTRACK 4 can be used for a wide range of detection situation.
The all new ANALECT® RefinIR™ is a fully integrated laboratory autosampler and FTIR instrument. The RefinIR delivers automated spectral data acquisition of multiple liquid refinery stream samples from crude oils to blended gasoline and diesel.
Intrinsically Safe ATEX, unsurpassed certified oxygen analyser for all hazardous areas. The EC91 Process Oxygen Transmitter will detect levels of oxygen as low as 1ppm, up to higher percent levels and can be used on most industrial gases and atmospheres.
OriGene Technologies Capabilities Overview Feb 2011mwatson26
Opportunity overview with OriGene Technologies. OriGene is looking to identify strategic collaboration partners for its full-length human proteins, validated monoclonal antibodies and "gene centric" tool box.
ACH Processing and Reconciliation GuideDiamond Mind
The following guide provides a primer on how Automated Clearing House (ACH) payments, deposits, rejections, and withdrawals are processed and reconciled. Based on the variables described in this guide, the average processing and reconciliation timeline can fluctuate. This guide is designed to improve your understanding of the process.
Find out why B2B companies are making the move from paper checks to electronic payments. And in the process, they are dramatically reducing transaction costs and earning rebates at the same time.
Same Day ACH Allows Payments to Move FasterLexisNexis
For the millions of Americans who receive electronic payments directly into their bank accounts, a new system is about to go into place that will allow those payments to be made faster than ever. For banking executives and the legal counsel who advise them, the stakes are very high for successful compliance with this new system.
The presented Same Day ACH infographic showcases Same Day ACH related important facts, phases of implementation, projected transaction volume, benefits, Same Day ACH fraud and its solutions. It also outlines the strategies for mitigating fraud risk with Quatrro’s fraud prevention solutions. Quatrro's transaction monitoring with an added layer of human intelligence support will provide financial institutions a quick, simple and secure way to deal with the fraud challenges with efficient fraud prevention services.
Click to know more: http://quatrroprocessing.com/same-day-ACH-fraud-prevention.php
On-line, in-situ, and at-line monitoring of batch and continuous processes
Displays up to 15 properties at once and measures up to 30 properties per stream
Optical multiplexing capabilities provide analysis of up to 16 process streams using fiber optic or extractive stream switching
Utilizes process-proven ANALECT® Diamond 20™ Transept™ optical head
SpectraRTS™ software engineered exclusively for on-line monitoring, allowing use by engineers, maintenance personnel, and chemists
All ANALECT® lab and on-line systems share core optical technology, allowing instrument-to-instrument calibration transfers
When it comes to improving process efficiency for E-Business Suite, customers are often faced with many options: mobile apps, barcoding on various mobile devices, RFID, and so on. This presentation shares CSX and BullsEye’s experience on using mobile technologies to achieve the desired process efficiency improvement, including some less glamorous yet powerful solutions.
CSX will use the following case studies to share its corporate goals for investing in these projects, its process for solution evaluation, the implementation experience, the process efficiency achieved, and lessons learned.
1. Mobile barcode solution at 10 mechanical shops nationwide
2. RFID solution for automated asset tracking at the coal pier
3. Offline-enabled mobile barcode solution for remote work-order equipment trailers
Using CSX and other customer case studies, we will also provide guiding principles and tips on how to select the most appropriate mobile and other hardware devices for optimal efficiency gains while minimizing total cost of ownership.
1. Handheld barcode/RFID scanners
2. Vehicle mounts
3. Ruggedized vs. consumer grade tablets
4. Other less glamorous but powerful options
Last but not least, we will discuss factors beyond technology that contribute to successful process improvement initiatives such as corporate sponsorship, management support, and overcoming users’ initial fear and resistance to change.
Wastewater Collection System & Results-Oriented Management Using Autonomous R...OHM Advisors
At OHM Advisors' October 2015 Asset Management Planning Workshop in Midland, Michigan, RedZone's Matt Horton presents simple methodology and tools that enable simplified collection system management and smarter spending. Encouraging complete upfront system understanding, Horton talks about the benefit of using Multi-Sensor Inspection Technology over CCTV Inspection, autonomous robotic inspection technology, and planning for predicted results.
HI-SCAN 7555aTiX is the first system to allow explosives detection at security checkpoints. HI-SCAN 7555aTiX uses several, independent multi-energy generators, each of which is connected to its own sophisticated and state-of-the-art X-ray sensor technology.
Pachube: an open, easy to use, secure & scalable platform for building the 'I...pachube
Pachube (http://www.pachube.com/) is a data brokerage platform for the internet of things, managing millions of datapoints per day from thousands of individuals, organisations & companies around the world.
Pachube's powerful and scalable infrastructure enables you to build 'Internet of Things' products and store, share & discover realtime sensor, energy and environment data from objects, devices & buildings around the world.
LIMS from WINGLO
Sample Tracking: LIMS allows for the tracking of samples throughout their lifecycle, from collection to analysis and storage. This helps in maintaining the integrity of data associated with each sample.
Data Management: LIMS facilitates the organization and storage of various types of data, including test results, experiment details, and sample information. It often includes tools for data analysis and reporting.
Workflow Automation: LIMS can automate and streamline laboratory workflows, reducing manual errors and improving overall efficiency. This includes automated scheduling, sample processing, and data validation.
Inventory Management: LIMS helps in managing laboratory inventory, including reagents, consumables, and equipment. This ensures that the laboratory has the necessary resources for experiments and tests.
Audit Trail: LIMS typically includes an audit trail feature that tracks changes made to data, ensuring accountability and compliance with regulatory standards.
Integration with Instruments: LIMS can be integrated with various laboratory instruments, allowing for direct data transfer and reducing the risk of transcription errors.
User Access Control: LIMS provides role-based access control, ensuring that only authorized personnel have access to sensitive data and functionalities.
Compliance and Reporting: LIMS helps laboratories adhere to regulatory requirements by providing tools for compliance monitoring and generating reports for regulatory submissions.
Overall, LIMS plays a crucial role in modern laboratories by improving efficiency, data accuracy, and compliance with industry regulations.
Centum VP - Evolution of Yokogawa System Solutions (2014)Yokogawa
Yokogawa’s system platforms combined with proven execution experience provide the highest quality and innovative solutions for secure and optimized process automation and management. Yokogawa’s global customer centric focus together with strong local support reduces users’ business risks and provides the lowest total cost of ownership. With a long history of progressive compatibility, Yokogawa is your dependable automation partner.
In Situ Polymerase Chain Reaction (In situ PCR) is a powerful method that detects minute quantities of rare or single-copy number nucleic acid sequences in frozen or paraffin-embedded cells or tissue sections for the localization of those sequences within the cells. The principle of this method involves tissue fixing (to preserve the cell morphology) and subsequent treatment with proteolytic digestion (to provide access for the PCR reagents to the target DNA). The target sequences are amplified by those reagents and then detected by standard immunocytochemical protocols. In situ PCR combines the sensitivity of PCR or RT-PCR amplification along with the ability to perform morphological analysis on the same sample, and thus it is an attractive tool in diagnostic applications. One of the most prominent applications is the detection of infectious disease agents including HIV-1, HBV, HPV, HHV-6, CMV, and EBV.
Xmatrx Infinity is a fully automated molecular pathology workstation designed to accelerate life sciences research and drug discovery and development. It is an open system that allows simultaneous optimization of 40 assay parameters in a single run. The 40 independently thermal cyclable workstations enable any slide-based staining assays, including IHC, ISH, CISH, FISH, multiplexing and co-detection, special stain, in situ PCR and miRNA. The Infinity system adapts and completely automates any manual protocols such as denaturation, hybridization, stringency washes, counter stain and final coverslip to maximize testing capacity, minimize hands-on time and ensure consistent results every time.
microRNA for Clinical Research and Tumor AnalysisBioGenex
The discovery of microRNAs [miRNAs] has been one of the defining developments in cancer biology over the past decade. miRNAs are short, single stranded 20-22 nucleotide long, non-coding RNAs that regulate gene expression and have fundamental roles in Cancer growth and metastasis. miRNAs exert their function via base pairing with complementary mRNA molecules, resulting in gene silencing via transcriptional repression or target degradation. BioGenex solved the inherent difficulties in visualizing miRNAs in spatial context by using a propriety technology to synthesize modified, high-affinity oligonucleotides, labelling miRNA probes with multiple reporter molecules and developing a fully-integrated miRNA-ISH workflow solution allowing high throughput analysis of miRNA in the spatial context.
Immunohistochemistry (IHC) is a highly sensitive method that allows the localization of antigen within a cell or a tissue with high resolution. The method is based on the use of a primary antibody that specifically binds to its complementary antigen. The bound antibody may then be visualized by a variety of methods such as colorimetric end points.
Pathology Special Stains for FFPE Tissue StainingBioGenex
Special stains refer to alternative staining techniques that are used when H&E stains do not provide all the cellular information required. These techniques use a variety of dyes and methods so that pathologists can visualize tissue morphology and detect the presence of particular cell types, structures or pathogens (e.g. bacteria).BioGenex offers broadest special stain menu anywhere (over 30 special stains), including:
Grocott’s Methenamine Silver (GMS) Stain
Reticulin Stains
Trichrome Stains
Giemsa Stain
Periodic Acid-Schiff (PAS) Stains
Hematoxylin and Eosin (H&E) staining is a routine staining technique that reveals exceptional detail of tissue structure and makeup of the cells. Stained cell structures (e.g. nucleus, cytoplasm, organelles, extra-cellular components) provide important information for tissue-based cancer diagnosis. Special stains refer to alternative staining techniques that are used when H&E stains do not provide all the cellular information required. These techniques use a variety of dyes and methods so that pathologists can visualize tissue morphology and detect the presence of particular cell types, structures or pathogens (e.g. bacteria). We have the broadest special stain† menu anywhere (over 30 special stains), including:
Grocott’s Methenamine Silver (GMS) Stain
Reticulin Stains
Trichrome Stains
Giemsa Stain
Periodic Acid-Schiff (PAS) Stains
For More information Contact Customer support at customer.service@biogenex.com or follow the link http://biogenex.com/us/applications/special-stains/special-stains-controls.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. 2
All-in-One All-at-Once
• All-in-One All-at-Once – IHC, ISH, SS,
Multiplexing and Co-detection
• FISH*
• Fully Automated System from
Microtome to Microscope
3. Structural Components
3
A True Fully Automated Molecular Pathology Workstation
for Laboratories of Today, Tomorrow and Beyond…
4. Key Features & Benefits
• Fully Automated System from Microtome to
Microscope
• All-in-One All-at-Once – IHC, ISH, SS, Multiplexing
and Co-detection
• FISH*
• Standardized process from baking through final glass
cover slip in 3 simple steps: Load – Click – View slides
• Automates technologies of Today…IHC, ISH, SS,
FISH*, Multiplexing and Co-detection of Nucleic Acid
and Protein Biomarkers
• Designed to automate the technologies of Tomorrow
and Beyond…Gene Expression Profiling, In Situ PCR,
miRNA… and more
• Meets Global regulator requirements and safety
standards
*Optional Software
5. Key Features & Benefits
• Multi-functional system – IHC, ISH, FISH*, SS,
Multiplexing and Co-detection
• Clean, intense, reliable and reproducible stains with
standardized process for complete automation
from Baking to final cover slip
• Multiple slide processing options – Random,
Continuous and STAT
• Multi-format specimen processing – Frozen and
FFPE sections, Cell preparations, Smears and FNAs
• Optimized protocols and ready-to-use reagents
• Efficient resource utilization
• Predictable, reliable and transparent cost structure
*Optional Software
6. Efficient, Productive and Profitable System
• High throughput - 100 slides per day (60 slides in
eight hour shift and 40 slide in a overnight run)
• Start overnight run and return to view completed
slides the next morning
• Low cost of ownership
6
7. Compliance
7
• Meets Globally accepted safety standards
• ISO 13485:2003 (CMDCAS)
• ISO 9001:2008
• Regulatory Compliant
• USFDA
• IVD - CE
8. Easy to Use
• Top loading of slides and reagents
• Color coded GUI with real time assay parameters
display
• Real time audio and visual alerts
• Color coded bulk reagent carboys
• Complete information log for every slide
• Short learning curve allows cross-training and
rotation of personnel
*Optional Software
9. Reproducible, Reliable and Consistent Results
• User defined customized protocols – Clean, intense
stain with Ready-to-use reagents
• Factory protocols for ease of use
• User defined protocols for convenience
• Liquid level sensor for accurate dispensing and real
time reagent tracking – avoid false results
*Optional Software
10. On-Board Dehydration and
Final Coverslip
Reaction Micro-chamber
and Micro-fluidics
eXACT™ Temperature
Control on Every Slide
Liquid Level Sensor &
Reagent Dispensing System LIS Enabled
RFID and Barcode
Enabled
Enabling Technologies
11. Reaction Micro-Chamber with Micro-fluidics
• Reaction micro-chamber: 25 µL to 100 µL
• Reduced reagent consumption up to 75%
• Even distribution of reagents for uniform staining
without edge effect
• Overnight incubation/hybridization without drying
of specimen
12. eXACTTM Temperature Control on Every Slide
• 40 independent thermocyclable (PCR) work
stations
• No cross talk - High precision active heating and
cooling maintains accurate temperature on each
slide at all times
• Temperature uniformity + 2°C
• Temperature range from Ambient to 105°C for
robust antigen retrieval
• Thermocycling - Ambient 95°C
< 2 min
13. RFID and Barcode Enabled Technology
• RFID tagged reagent vials – Accurate and precise
real time reagent usage tracking irrespective of
Xmatrx system
• Barcoded slides – eliminates human errors, correct
protocols on each slide delivering accurate results
14. Liquid Level Sensor and Reagent Dispensing System
• Redundant automated process to eliminate human
errors
• Accurate dispensing of micro-reagent volumes
• Error free reagent dispensing – delivers optimum
stains, eliminates false negatives
• Disposable pipette tips allows multiple
technologies on the same platform without cross
contamination
15. On-board Dehydration and Final Coverslip
• Dehydration
• Clearing
• Permanent mounting with glass cover slip
16. Intuitive Software System - LIS Enabled
• Easy to use user friendly GUI
• Multiple standardized and custom reporting
capabilities
• Usage tracking
• Inventory management
• Regulatory compliant
• LIS Enabled data tracking and management*
*Optional
17.
18. Xmatrx ELITE – A Unique Value Proposition
• All-in-One All-at-Once
• Multiple technologies on a single platform - IHC,
ISH, SS, Multiplexing and Co-detection
• FISH*
• Fully automated system with standardized process
from baking through final glass cover slip in
3 simple steps: Load – Click – View slides
• Reduced reagent consumption by up to 75%
through the use of Reaction Micro-chamber with
Micro-fluidics
• Walkaway Automation through RFID and Barcode
enabled platform
• Disposable pipette tips allow multiple technologies
on the same platform
*Optional Software
19. Value Proposition - Pathologist
• All-in-One All-at-Once
• Multiple technologies on a single platform -
IHC, ISH, SS, Multiplexing and Co-detection
• FISH*
• Clean, intense, consistent and reproducible results
• High throughput system - 100 slides per day, 60
slides in eight hour shift and 40 slides in a
overnight run
• Disposable pipette tips allow multiple technologies
on the same platform
• Wide variety of antibodies, different clones and
compatible reagents provide complete portfolio
for the system
• Multiple technologies on the same system
*Optional Software
20. Value Proposition - Management
• Fully automated All-in-One All-at-Once system
• Low cost of ownership
• Eliminate requirement to purchase multiple
instruments for different technologies
• High throughput, efficient, productive and
profitable system
• Optimize resource utilization and cross training
• Predictable, reliable and transparent cost structure
• Eco-friendly and Cost savings – up to 75% reduced
reagent consumption and waste generation
through cutting edge technologies
• LIS enabled intuitive software system for accurate
usage tracking, inventory management and
generating regulatory compliant reports
*Optional Software
TIME
COST
QUALITY
21. Value Proposition - Lab Personnel (1/2)
• All-in-One All-at-Once
• Multiple technologies on a single platform - IHC,
ISH, SS, Multiplexing and Co-detection
• FISH*
• Fully automated system with standardized process
from Baking through final glass cover slip in 3
simple steps: Load – Click – View slides
• High throughput - 100 slides per day, 60 slides in
eight hour shift and 40 slide in a overnight run
• Advanced Enabling Technologies - RFID, Barcode,
Liquid Level Sensor, eXACT Temperature Control
and Reaction Micro-chamber with Micro-fluidics
• On-board dehydration, clearing and permanent
mounting with glass cover slip
*Optional Software
22. Value Proposition - Lab Personnel (2/2)
• Multiple slide processing options – Random,
Continuous and STAT
• Multi-format specimen processing – Frozen and
FFPE sections, Cell preparations, Smears and FNAs
• Easy to use user friendly GUI
• Factory protocols for ease of use
• User defined customized protocols for
convenience
• Real time audio and visual alerts
• Short learning curve allows cross-training and
rotation of personnel
• Multiple standardized and custom reporting
capabilities for Usage tracking, Inventory
management and Regulatory compliance
*Optional Software