Which of the following is MOST responsible for maintaining the double-stranded structure of DNA? A. Attractive interactions between positively charged purines and negatively charged pyrimidines. B. Hydrogen bonding between the 3\'-OH of deoxyribose and purine and pyrimidine ring nitrogens. C. Hydrophobic interactions between contiguous base pairs and hydrogen bonding between complementary bases on opposite strands. D. Interactions between the phosphate groups in separate chains. E. Hydrophilic interactions between the pentoses in separate chains. Solution A. Attractive interactions between positively charged purines and negatively charged pyrimidines. Explanation- Attractive interactions between partial positive charge on purines and partial negative charge on pyrimidines is responsible for maintaining stability of DNA. Hydrogen bonds in the DNA strands are individually weak but are collectively strong. These bonds between complementary base pairs stabilize the helical structure of DNA. Adenine is paired through two hydrogen bonds with thymine. Guanidine is paired through three hydrogen bonds with cytosine..