What types of cells do Endostatins go after? Solution Endostatin is a cleaved product from the carboxyl-terminal of collagen XVIII. It become firstly located in conditioned media from a murine endothelial tumor cell line, hemangio-endothelioma. Endostatin inhibits endothelial cellular migration in vivo and in vitro and induces endothelial cell apoptosis. It inhibits tumor growth and impairs blood vessel maturation in wound healing. Endostatin has an vital position in endothelial cellular adhesion and cytoskeletal organization. Endostatin may be located in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin remedy outcomes in apoptosis of HUVE and HMVE cells..