Cancer is a life-taking disease typically characterized by uncontrollable growth of cells. There are more than 100 types of identified cancers and all these types are classified according to the type of cells that are affected initially.
Cancer Stem Cells (CSCs) have become a vital target for biologists and researchers.
The following presentation focuses on the treatment of cancer through targeting CSCs and its advantages.
In simple terms, cancer is a group of more than 100 diseases that develop across time and involve the uncontrolled division of the body’s cells. Cancers arise when critical genes are mutated, causing unregulated proliferation of cells. These rapidly dividing cells pile up on top of each other to forming a lesion or a lump in some part of the body. This mass of abnormal cells is tumour. When it grows in confined area we call is a benign tumour and when it develops capability of invading surrounding tissues it becomes a malignant tumour. Cellular condition where tumour cells invade neighboring tissues and spread via body fluids to other parts of the body is called cancer.
Origin of cancer, Definition of Cancer, Differences Between Cancer Cells And Normal Cells, The First Documented Case, How Does Cancer Develop? , The First Documented Case, Symptoms, Preventable cancers, Types of Cancer, Type of cancer treatments
LECTURE 11 CANCER DRUGS, IMMUNOCHEMISTRY and CHEMOCHEMISTRY.docxmanningchassidy
LECTURE 11 CANCER: DRUGS, IMMUNOCHEMISTRY and CHEMOCHEMISTRY
A dividing breast cancer cell.
Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues.
Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Normally, human cells grow and divide to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place.
When cancer develops, this orderly process breaks down. As cells become more and more abnormal, old or damaged cells survive when they should die, and new cells form when they are not needed. These extra cells can divide without stopping and may form growths called tumors.
Many cancers form solid tumors, which are masses of tissue. Cancers of the blood, such as leukemia, generally do not form solid tumors.
Cancerous tumors are malignant, which means they can spread into, or invade, nearby tissues. In addition, as these tumors grow, some cancer cells can break off and travel to distant places in the body through the blood or the lymph system and form new tumors far from the original tumor.
Unlike malignant tumors, benign tumors do not spread into, or invade, nearby tissues. Benign tumors can sometimes be quite large, however. When removed, they usually don’t grow back, whereas malignant tumors sometimes do. Unlike most benign tumors elsewhere in the body, benign brain tumors can be life threatening.
What are the differences between cancer cells and normal cells?
Cancer cells differ from normal cells in many ways that allow them to grow out of control and become invasive. One important difference is that cancer cells are less specialized than normal cells. That is, whereas normal cells mature into very distinct cell types with specific functions, cancer cells do not. This is one reason that, unlike normal cells, cancer cells continue to divide without stopping.
In addition, cancer cells are able to ignore signals that normally tell cells to stop dividing or that begin a process known as programmed cell death, or apoptosis, which the body uses to get rid of unneeded cells.
Cancer cells may be able to influence the normal cells, molecules, and blood vessels that surround and feed a tumor, an area known as the microenvironment. For instance, cancer cells can induce nearby normal cells to form blood vessels that supply tumors with oxygen and nutrients, which they need to grow. These blood vessels also remove waste products from tumors.
Cancer cells are also often able to evade the immune system, a network of organs, tissues, and specialized cells that protects the body from infections and other conditions. Although the immune system normally removes damaged or abnormal cells from the body, some cancer cells are able to “hide” from the immune system.
Tumors can also use the immune system to stay alive and grow. For example, with.
Introduction to Cancer Epidemiology and CarcinogenesisPUBH 6.docxbagotjesusa
Introduction to Cancer Epidemiology and Carcinogenesis
PUBH 6550/8550
Chronic Disease Epidemiology
1
Cancer is a term describing malignant diseases. Cancer should not be thought of as a single disease but rather a group of diseases which may have many characteristics in common but not necessarily the same causative agents, etiology or molecular profiles. In general, cancer defines diseases that have the capacity to invade surrounding normal tissue, metastasize (spread to distant sites) and kill the host in which it originates.
Objectives
What is the definition of cancer?
Benign vs. Malignant
Most common cancer types in men and women
Learn how to obtain cancer-related data using Internet sources
Understand cancer staging
Understand the basics of how carcinogenesis occurs
Describe inherited cancer syndromes
2
Causation and Cancer
Examples of Identified Causes and
Future Efforts in Cancer Prevention
Tobacco use and lung cancer
Infectious agents (e.g., HPV) and cervical cancer
Ionizing radiation and leukemia
Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor
4
4
The concept of causation has long had a central role in the application of epidemiologic evidence for controlling cancer. Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor. Though the concept of causation remains a matter of continuing discussion, use of the term in public health implies that the evidence supporting causality of association has reached a critical threshold of certainty and that reduced exposure can be expected to be followed by reduced disease occurrence. In other words, if there is “enough” evidence supporting a particular risk factor (or a preventive or prognostic factor), it seems to be considered ‘causal’. Keep in mind, though, that risk factor is the most proper term.
What is cancer?
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death.
Characteristics: Abnormality, Uncontrollability, invasiveness
5
5
According to the American Cancer Society (ACS), cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Although cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. These diseases are characterized by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. Breast cancer, for example, has different characteristics than lung cancer. It is important to understand that cancer originating in one body organ takes its characteristics with it even if it spreads to another part of the body. For example, metastatic br.
Project ideas for class 12 students ...you can can find well prepared projects on topics from the CBSE school curriculum.
Your project work for class 12 students provides a platform for students to explore their interests and deepen their understanding of a particular subject. It may cover various topics, including science, humanities, languages, or social sciences, and may involve a wide range of methodologies and approaches.
My project works for class 12 students may take several forms, including research papers, case studies, presentations, or practical experiments. It may also include the use of technology or multimedia tools to enhance the learning experience.
By uploading project work for class 12 students, i provide them with an opportunity to showcase their talents and develop essential skills that will be valuable in their academic and professional careers. It also helps students to become independent learners and critical thinkers, who can analyze and interpret information to draw their conclusions.
Overall, my initiative to upload project work for class 12 students is an excellent contribution to the education community. It provides students with a platform to showcase their creativity, develop critical thinking skills, and prepare for their future academic and professional pursuits.
Here you will find stuffs related to jee , neet and CBSE board project work here.
Cancer Stem Cells (CSCs) have become a vital target for biologists and researchers.
The following presentation focuses on the treatment of cancer through targeting CSCs and its advantages.
In simple terms, cancer is a group of more than 100 diseases that develop across time and involve the uncontrolled division of the body’s cells. Cancers arise when critical genes are mutated, causing unregulated proliferation of cells. These rapidly dividing cells pile up on top of each other to forming a lesion or a lump in some part of the body. This mass of abnormal cells is tumour. When it grows in confined area we call is a benign tumour and when it develops capability of invading surrounding tissues it becomes a malignant tumour. Cellular condition where tumour cells invade neighboring tissues and spread via body fluids to other parts of the body is called cancer.
Origin of cancer, Definition of Cancer, Differences Between Cancer Cells And Normal Cells, The First Documented Case, How Does Cancer Develop? , The First Documented Case, Symptoms, Preventable cancers, Types of Cancer, Type of cancer treatments
LECTURE 11 CANCER DRUGS, IMMUNOCHEMISTRY and CHEMOCHEMISTRY.docxmanningchassidy
LECTURE 11 CANCER: DRUGS, IMMUNOCHEMISTRY and CHEMOCHEMISTRY
A dividing breast cancer cell.
Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues.
Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Normally, human cells grow and divide to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place.
When cancer develops, this orderly process breaks down. As cells become more and more abnormal, old or damaged cells survive when they should die, and new cells form when they are not needed. These extra cells can divide without stopping and may form growths called tumors.
Many cancers form solid tumors, which are masses of tissue. Cancers of the blood, such as leukemia, generally do not form solid tumors.
Cancerous tumors are malignant, which means they can spread into, or invade, nearby tissues. In addition, as these tumors grow, some cancer cells can break off and travel to distant places in the body through the blood or the lymph system and form new tumors far from the original tumor.
Unlike malignant tumors, benign tumors do not spread into, or invade, nearby tissues. Benign tumors can sometimes be quite large, however. When removed, they usually don’t grow back, whereas malignant tumors sometimes do. Unlike most benign tumors elsewhere in the body, benign brain tumors can be life threatening.
What are the differences between cancer cells and normal cells?
Cancer cells differ from normal cells in many ways that allow them to grow out of control and become invasive. One important difference is that cancer cells are less specialized than normal cells. That is, whereas normal cells mature into very distinct cell types with specific functions, cancer cells do not. This is one reason that, unlike normal cells, cancer cells continue to divide without stopping.
In addition, cancer cells are able to ignore signals that normally tell cells to stop dividing or that begin a process known as programmed cell death, or apoptosis, which the body uses to get rid of unneeded cells.
Cancer cells may be able to influence the normal cells, molecules, and blood vessels that surround and feed a tumor, an area known as the microenvironment. For instance, cancer cells can induce nearby normal cells to form blood vessels that supply tumors with oxygen and nutrients, which they need to grow. These blood vessels also remove waste products from tumors.
Cancer cells are also often able to evade the immune system, a network of organs, tissues, and specialized cells that protects the body from infections and other conditions. Although the immune system normally removes damaged or abnormal cells from the body, some cancer cells are able to “hide” from the immune system.
Tumors can also use the immune system to stay alive and grow. For example, with.
Introduction to Cancer Epidemiology and CarcinogenesisPUBH 6.docxbagotjesusa
Introduction to Cancer Epidemiology and Carcinogenesis
PUBH 6550/8550
Chronic Disease Epidemiology
1
Cancer is a term describing malignant diseases. Cancer should not be thought of as a single disease but rather a group of diseases which may have many characteristics in common but not necessarily the same causative agents, etiology or molecular profiles. In general, cancer defines diseases that have the capacity to invade surrounding normal tissue, metastasize (spread to distant sites) and kill the host in which it originates.
Objectives
What is the definition of cancer?
Benign vs. Malignant
Most common cancer types in men and women
Learn how to obtain cancer-related data using Internet sources
Understand cancer staging
Understand the basics of how carcinogenesis occurs
Describe inherited cancer syndromes
2
Causation and Cancer
Examples of Identified Causes and
Future Efforts in Cancer Prevention
Tobacco use and lung cancer
Infectious agents (e.g., HPV) and cervical cancer
Ionizing radiation and leukemia
Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor
4
4
The concept of causation has long had a central role in the application of epidemiologic evidence for controlling cancer. Designation of a risk factor as “causal” has been the starting point for initiating cancer prevention programs based on reducing exposure to the risk factor. Though the concept of causation remains a matter of continuing discussion, use of the term in public health implies that the evidence supporting causality of association has reached a critical threshold of certainty and that reduced exposure can be expected to be followed by reduced disease occurrence. In other words, if there is “enough” evidence supporting a particular risk factor (or a preventive or prognostic factor), it seems to be considered ‘causal’. Keep in mind, though, that risk factor is the most proper term.
What is cancer?
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death.
Characteristics: Abnormality, Uncontrollability, invasiveness
5
5
According to the American Cancer Society (ACS), cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Although cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. These diseases are characterized by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. Breast cancer, for example, has different characteristics than lung cancer. It is important to understand that cancer originating in one body organ takes its characteristics with it even if it spreads to another part of the body. For example, metastatic br.
Project ideas for class 12 students ...you can can find well prepared projects on topics from the CBSE school curriculum.
Your project work for class 12 students provides a platform for students to explore their interests and deepen their understanding of a particular subject. It may cover various topics, including science, humanities, languages, or social sciences, and may involve a wide range of methodologies and approaches.
My project works for class 12 students may take several forms, including research papers, case studies, presentations, or practical experiments. It may also include the use of technology or multimedia tools to enhance the learning experience.
By uploading project work for class 12 students, i provide them with an opportunity to showcase their talents and develop essential skills that will be valuable in their academic and professional careers. It also helps students to become independent learners and critical thinkers, who can analyze and interpret information to draw their conclusions.
Overall, my initiative to upload project work for class 12 students is an excellent contribution to the education community. It provides students with a platform to showcase their creativity, develop critical thinking skills, and prepare for their future academic and professional pursuits.
Here you will find stuffs related to jee , neet and CBSE board project work here.
According to the National Cancer Institute, a tumor is an unusual tissue mass that results from cell division beyond what is naturally expected. Tumors may also develop when divided cells do not die as due. Tumors sometimes look like cancers. However, not all tumors are cancerous.
The human body is made up of cells that grow, multiply and take the place of each other. As new cells appear, old cells disappear. So cancers are formed when the body starts to produce cells that it does not need. When these cells become too much, swellings and tumors begin to develop.
Different types of tumors might develop in the human body. There are three broad categories of tumors: malignant, premalignant, and benign tumors. Malignant tumors are cancerous, and when not adequately treated, they can spread to other parts of the body. Benign tumors, on the other hand, are non-cancerous cells.
Benign tumors, otherwise called non-cancerous tumors, pose little to no threat to a person's health. Unlike malignant tumors, they do not usually spread to other body parts. It has been noted that most benign tumors do not need to be treated as long as they are not painfully pressing against other body parts.
Different types of benign tumors can grow in the human body. One of them is benign bone tumors like osteomas. While osteomas are not cancerous, they might result in a severe kind of pain if it does not receive instant medical attention. Similarly, brain tumors like meningiomas and schwannomas are also examples of benign tumors. Meninges are tissues that cover the brain and the spinal cord, and they are also hosted.
On the other hand, malignant tumors, otherwise known as cancerous tumors, tend to spread to other tissues or organs. For instance, they could spread to other body parts like organs and tissues. The newly formed cells are known as metastases. While most people tend to remove malignant tumors, they might reappear through a process known as cancer recurrence.
There are different types of malignant tumors. Osteosarcoma and chordomas are two types of m, malignant tumors that grow in the brain. On the other hand, the various organs in the body might develop tumors like pancreatic cancer and lung cancer. Similarly, the skin might also develop malignant cancers like squamous cell carcinoma.
Premalignant tumors are also a type of tumor. Unlike both tumors mentioned earlier, this kind of tumor can either be malignant or none malignant. So its malignancy is based on whether it is treated as soon as possible. Premalignant tumors need to be closely m monitored by a doctor, or they might become cancerous.
An example of a premalignant tumor is actinic keratosis or solar keratosis. Actinic keratosis leaves the skin with patches and scaly swellings. Excess sun exposure is one of the risk factors associated with arctic keratosis, and it affects people with a fairer skin than it does other skin types.
Cervical dysplasia is another premalignant tumor that might grow in the h
Cancer may be an unwellness within which a number of the body’s cells grow uncontrollably and unfold to alternative elements of the body.
Cancer will begin nearly anyplace within the flesh, that is formed from trillions of cells. Normally, human cells grow and multiply (through a method referred to as cell division) to create new cells because the body desires them. once cells get older or become broken, they die, and new cells take their place.
Cancer causes cell to divide uncontrollably. Cancer is the second-leading cause of death in the world. But survival rates are improving for many types of cancer, thanks to improvements in cancer screening, treatment and prevention. Cancer is caused by changes (mutations) to the DNA within cells.
More than 900 hospitals are listed in Cancer. All are experienced in treating difficult cases — a hospital is listed only if at least 251 inpatients in need of high level of expertise in this specialty were treated there in 2009, 2010 and 2011. The top 50 hospitals are ranked, based on score. The rest are listed alphabetically.
Pennsylvania has more than 250 hospitals, 13 of which are nationally ranked. Thirty other hospitals met standards for strong performance within the state. U.S. News also ranks hospitals in the Philadelphia and Pittsburgh metro areas.
Cancer Treatment Centers of America® (CTCA) at Southwestern Regional Medical Center (Southwestern) is located in Tulsa, Oklahoma. The hospital serves much of the Southwestern United States, including the major metropolitan areas of Tulsa, Oklahoma City, Kansas City, Dallas and Houston.
Mammograms should be started at the age of 40, according to research. Doing so will help in reducing the rate of deaths caused by breast cancer, bringing it down by up to 24 percent. At this stage, it is important to mention that mammograms can definitely outweigh potential risks of developing cancer.
Juvenile Osteochondritis Dissecans (JOCD) is one of the recognized entities for over 100 years now. Inspite of long recognition of this typical joint deformity, its natural history and effective therapies are not understood properly.
Most women fail to recognize the signs and symptoms of gynecological cancers, and are usually unaware of the alarming signals unrelated to their reproductive organs, like increased urination and back pain, reveal a recent study.
Side effects of chemotherapy are the most dreaded of all times. Fortunately, there are different ways to prevent, treat and manage the side effects today, and cancer specialists take special care to make sure that their patients don’t suffer.
Chemotherapy is a widely used treatment for cancer. More specifically, this therapy is administered to destruct cancer cells. However, it may also include some antibiotics along with other medications for treating severe infection or illness.
Cancer support groups are becoming an integral part of lives of most cancer patients, survivors, and their families. Support groups are the greatest pillars of strengths for patients who have survived cancer and look forward to a new life.
Will Resier was diagnosed with a rare form of spinal cancer at the age of 25, was experiencing strange symptoms, including weight loss, a horrible fatigue and night sweats.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
What is that causes cancer
1.
2. Cancer is a life-taking
disease typically
characterized by
uncontrollable growth of
cells.
There are more than 100
types of identified cancers
and all these types are
classified according to the
type of cells that are
affected initially.
3. Cancer can harm the body while damaged cells
start dividing beyond control to develop masses
or lumps of tissue known as tumors.
However, there are some exceptions, such as
leukemia – a type of blood cancer that prohibits
normal function of blood by causing abnormal
division of cells in blood stream.
4. Tumors start growing and
interfering with the
functions of the body
affecting the nervous
circulatory and digestive
systems and they may also
release hormones to alter
the functions of the body.
There are tumors that may
remain in one spot
demonstrating limited or
no growth and are
considered benign, or non-
cancerous.
5. There are some tumors that are more
serious, typically malignant, when there are two
things present:
cancerous cells manage to pass throughout the
body with the use of lymph and blood systems
thus destroying most of the healthy tissues
through a process known as invasion
The cell starts dividing and growing, thus
forming new blood vessels for feeding itself in
the process called angiogenesis.
6. When a classic tumor starts
spreading successfully, to
other parts of the body,
growing rapidly and invading
healthy tissues to destroy
them, it is metastasized.
The process is known as
metastatic which results in a
serious condition often
difficult to cure.
7. Why and how cancer cells
spread, has been a common
cause of concern.
According to the reports of
Nature Communications
released in October 2012,
scientists reported that they
have successfully discovered a
vital clue that suggests how
cancer cells start spreading.
8. The adhesion properties (stickiness) of the cells are
responsible in some ways. There are some molecular
interactions between the cells and scaffolding that
will hold them right in lace and make them unstuck
to the site of tumor; they are gradually dislodged and
they move to reattach themselves at another site.
Researchers hold that this discovery has been
significant as cancer mortality is primarily attributed
to the metastatic tumors – the ones that start growing
from cells having traveled from the original site to
other parts of the body. Only about 10 percent of all
deaths caused by cancer are due to the primary stage
of tumors.
9. Cancer, ultimately, is the result
of cells growing out of control
and that don’t die. Normal
cells found in the body start
following a regular cycle –
growth, division, and eventual
death.
Apoptosis is the process of
programmed death of cells;
when the process breaks down,
or fails cancer starts forming.
10. Unlike the normal or regular cells, cancer cells
don’t experience a programmatic death but rather
grows consistently and divides. This causes a
mass of uncontrollable and abnormal cells that
start growing out of control.
There are many other factors responsible for
causing cancer, such as genes and DNA
carcinogens and various other medical factors.