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BioIndustrial Partnership of
              Minnesota

Environmental Initiative Chemicals Regulation Working
                         Group
                     July 20, 2011
Project Sponsors




    Enriching Minnesota’s Future through the Biosciences
Agenda
•  Introduction
•  Project Overview
•  Biorefinery Development

•  Agriculture-based opportunities
•  Downstream market Development




      Enriching Minnesota’s Future through the Biosciences
The BioBusiness Alliance of Minnesota
•  Industry led, non-profit organization
•  Partners with industry, academia and economic
   development groups to stimulate growth in Minnesota
•  Supports growth in six targeted industries


            Medical Devices                  Food

            Biologics/Biopharma              Renewable Energy

            Animal Health                    Renewable Materials




      Enriching Minnesota’s Future through the Biosciences
Project Partners
•  Great Plains Institute           •  LifeScience Alley

  Non-partisan, non-                    Largest state-based
  profit corporation based              trade association
  in Minneapolis                        focused on serving the
                                        life sciences industry.
  Mission: to accelerate the
  transition to a sustainable,
  prosperous, low-carbon
  economy.




      Enriching Minnesota’s Future through the Biosciences
Renewable Materials Value Chain Overview




                                                   Biorefinery
          Farmers/Foresters
                                                   Development




Chemicals Industry-            End Product                Retail, End Uses
   Formulators                 Manufacturing
         Enriching Minnesota’s Future through the Biosciences
D2025 Recommendations
   Renewable Materials
   •  Support market development efforts for the renewable
      materials value chain
        » Renewable Materials Summit: Emerging Markets in the
          Upper Midwest
   •  Position Minnesota as a world leader in biorefinery
      operations
                                      Liquid Fuels
                                        Markets
Farmers/Foresters    Biorefinery
                                   Chemical Industry-   End Product
                                                                        Retail, End Uses
                                      Formulators       Manufacturing

             Enriching Minnesota’s Future through the Biosciences
Project Description
The BioIndustrial Partnership of MN
•  Hypothesis: The industry is commercializing
   technologies, and there are enough companies forming that
   any MN biorefinery could find a partner to enter the
   industry.

•  Expected Implementation Actions:
   » Education of business and community leaders.
   » Identify assets and market MN to external partners.
   » Policy development.
     •    Regulatory issues.
     •    Financial assistance.

      Enriching Minnesota’s Future through the Biosciences
Project Methodology
•  Q2 2011: Project Definition
   » Assemble Core Team and develop clear understanding
     of industry

•  Q3 2011: Community Dialogue
   » Share global trends and gather information
•  Q4 2011: Publication
   » Minnesota Roadmap for BioIndustrial Development
•  2012: Education and Implementation
   » Act on strategic direction

      Enriching Minnesota’s Future through the Biosciences
Core Team
•  ~21 Members across value chain
   » Biochemical companies
   » Ethanol General Managers
   » Engineering/Design Firms
   » Legal and Financial Service Providers
   » Government
•  Industry Dominated




      Enriching Minnesota’s Future through the Biosciences
Building an industry…


               $                          $
Feedstock             Technology                  Off-take




                         Policy

     Enriching Minnesota’s Future through the Biosciences
Roadmap Preview
Roadmap Outline
•  Biorefinery Development
      •    Trends
      •    Opportunities                                 Biorefinery
      •    Strategic Direction

•  Downstream Market Development
   »  Chemicals
   »  Fuels
                                 Chemicals Industry-    End Product
      •    Trends                                                             Retail, End Uses
                                    Formulators         Manufacturing
      •    Opportunities
      •    Strategic Direction

•  Agricultural-based Supply Chain Partnerships
      •    Trends
      •    Opportunities                     Farmers/Foresters         Biorefinery
      •    Strategic Direction

•  Forest-based Supply Chain Partnerships
      •    Trends
      •    Opportunities                     Farmers/Foresters         Biorefinery
      •    Strategic Direction

•  Policy Analysis and Recommendations
Biorefinery
                                   Development




                                       Liquid Fuels
                                         Markets
Farmers/Foresters    Biorefinery
                                    Chemical Industry-   End Product
                                                                         Retail, End Uses
                                       Formulators       Manufacturing

             Enriching Minnesota’s Future through the Biosciences
Integrated Biorefinery

                             •  DDGs
                   Food/Feed •  Nutraceuticals
                             •  Food grade oil


                                  •  Ethanol
                          Fuels   •  Butanol
                                  •  Drop-in fuels


                   Chemicals •  Materials
                      and    •  Additives
                    Plastics •  Solvents
Example: Bio Iso-butanol

                                              •  Iso-butanol
                               Drop-in        •  Jet Fuel
                                Fuels         •  Diesel
                                              •  Gasoline




                              Chemicals
                                 and          •  C4 Platform
                               Plastics



    Enriching Minnesota’s Future through the Biosciences
Volatile and increasing fossil fuel prices




Source: ICIS;
http://www.icis.com/Articles/2011/06/27/9471601/Bio-based-intermediates-will-reduce-price-
volatility.html
The signals of momentum?
      •  8 IPO’s in the last year2
             » Financial markets are supporting the industry
      •  Green chemistry sector lead MN in VC investments for
         Q2 2011
      •  Global biochemicals industry: $585 billion by 20301
             » Up to 17% of global chemicals market
             » 5-10% average annual growth
      •  5 billion pounds of chemicals by ~20153

      •  RFS2: 22 billion gallons of advanced biofuels by 2022
1 http://www.icis.com/Articles/2010/06/21/9368973/biochemical-market-forecasts-suggest-strong-growth.html
2 http://biofuelsdigest.com/bdigest/2011/06/03/myriants-125m-ipo-the-complete-digest-analysis/
3 PiperJaffray Analysis
New targets for bio-based chemicals
•  Innovation is enabling new commodity chemicals
   » New to the world chemicals
     •    Segetis’ Javelin Technology
     •    Reluceo’s XLK Polymer

   » Improved access to existing chemicals
     •    Succinic Acid
     •    Glucaric Acid

•  “New” chemicals can depend on other innovations in
   the final products
   » Risk for slower growth
   » Without significant improvement in functionality, they
     may not have the critical mass to survive
Minnesota Biobased Materials Family Tree
                             Rivertop                 BioAmber                     Reluceo               XL Terra
2009 - 2011                 Renewables                  Est. 2009                  Est. 2009             Est. 2009
                                Est. 2010               Plymouth                  Golden Valley         Golden Valley



                                                                                                             Green Harvest
                    Draths                  Segetis           Pine River                      Gevo
                                                                                                             Technologies
2005 - 2009     Est. 2005, 20 emp.     Est. 2006, 30 emp.   Petrochemicals              Est. 2009, 50 emp.
                                                                                                              Est. 2007, 1 emp.
                Okemos, Michigan         Golden Valley              Est. ~2009.        Luverne, MN and CO
                                                                                                                Bloomington



                             Cargill BioH          Natureworks                    Elevance            Cargill
1997 - 2004                Est. 2003, 35 emp.    est. 1997, ~100 emp.       Est. 2004, 45 emp.     Industrial Oils
                                Plymouth              Minnetonka                Chicago, IL           Minnetonka




                                                              Cargill Resins
1980s - 1990s
                                                                    Minnetonka




      Currently not located in Minnesota
Opportunities and Concerns
•  Opportunities
   » Intermediate chemicals the key targets
   » MN Strengths to build on:
     •    Cluster of companies has developed in the state
     •    Use the medical device industry as a proxy
     •    Strong suite of service providers that understand and support the industry

•  Concerns
   » MN lacks experienced chemical industry executives
   » Scale-up capital and speed
   » Cost of regulatory compliance and toxicity testing can
     squelch innovation
Strategic Needs- BioIndustrial Manufacturing
•  Assistance in financing through “valley of death”
   » Government grants are difficult
   » Lack of focused venture capital
   » Other states are moving more aggressively to support the
     industry
•  Regulatory issues

•  University policies to encourage faculty start-ups
•  More clean-tech incubators in the state
Agriculture
                                   Opportunities




                                        Liquid Fuels
                                          Markets
Farmers/Foresters    Biorefinery
                                     Chemical Industry-   End Product
                                                                          Retail, End Uses
                                        Formulators       Manufacturing

             Enriching Minnesota’s Future through the Biosciences
Agricultural-based Supply Chain
•  Biorefinery Development
      •    Trends
      •    Opportunities
      •    Strategic Direction

•  Downstream Market Development
   »  Chemicals
   »  Fuels
      •    Trends
      •    Opportunities
      •    Strategic Direction

•  Agricultural-based Supply Chain Partnerships
      •    Trends
      •    Opportunities          Farmers/Foresters   Biorefinery
      •    Strategic Direction

•  Forest-based Supply Chain Partnerships
      •    Trends
      •    Opportunities
      •    Strategic Direction

        Enriching Minnesota’s Future through the Biosciences
•  Policy Analysis and Recommendations
Agriculture Biorefineries
End Market
                                   Development




                                       Liquid Fuels
                                         Markets
Farmers/Foresters    Biorefinery
                                    Chemical Industry-   End Product
                                                                         Retail, End Uses
                                       Formulators       Manufacturing

             Enriching Minnesota’s Future through the Biosciences
Downstream Market Development
•  Biorefinery Development
      •    Trends
      •    Opportunities
      •    Strategic Direction

•  Downstream Market Development
   »  Chemicals                     Liquid Fuels
   »  Fuels                           Markets
      •    Trends
      •    Opportunities         Chemicals Industry-   End Product
           Strategic Direction                                         Retail, End Uses
      •                             Formulators        Manufacturing

•  Agricultural-based Supply Chain Partnerships
      •    Trends
      •    Opportunities
      •    Strategic Direction

•  Forest-based Supply Chain Partnerships
      •    Trends
      •    Opportunities
      •    Strategic Direction

        Enriching Minnesota’s Future through the Biosciences
•  Policy Analysis and Recommendations
Proposal for coordination

•  Targeted discussions on regulatory impacts


•  Perspectives and ideas to grow the industry


•  Participate in implementation efforts




      Enriching Minnesota’s Future through the Biosciences
Thank You!
          Tim Welle
twelle@biobusinessalliance.org
        952-746-3845
Biofuels becoming biochemicals companies.

                                                           •  Replace the
                                                              entire barrel
                                                              of oil




Source: Peter Keeling. Center For Biorenewable Chemicals

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Welle - Bioindustrial Partnership of Minnesota

  • 1. BioIndustrial Partnership of Minnesota Environmental Initiative Chemicals Regulation Working Group July 20, 2011
  • 2. Project Sponsors Enriching Minnesota’s Future through the Biosciences
  • 3. Agenda •  Introduction •  Project Overview •  Biorefinery Development •  Agriculture-based opportunities •  Downstream market Development Enriching Minnesota’s Future through the Biosciences
  • 4. The BioBusiness Alliance of Minnesota •  Industry led, non-profit organization •  Partners with industry, academia and economic development groups to stimulate growth in Minnesota •  Supports growth in six targeted industries Medical Devices Food Biologics/Biopharma Renewable Energy Animal Health Renewable Materials Enriching Minnesota’s Future through the Biosciences
  • 5. Project Partners •  Great Plains Institute •  LifeScience Alley Non-partisan, non- Largest state-based profit corporation based trade association in Minneapolis focused on serving the life sciences industry. Mission: to accelerate the transition to a sustainable, prosperous, low-carbon economy. Enriching Minnesota’s Future through the Biosciences
  • 6. Renewable Materials Value Chain Overview Biorefinery Farmers/Foresters Development Chemicals Industry- End Product Retail, End Uses Formulators Manufacturing Enriching Minnesota’s Future through the Biosciences
  • 7. D2025 Recommendations Renewable Materials •  Support market development efforts for the renewable materials value chain » Renewable Materials Summit: Emerging Markets in the Upper Midwest •  Position Minnesota as a world leader in biorefinery operations Liquid Fuels Markets Farmers/Foresters Biorefinery Chemical Industry- End Product Retail, End Uses Formulators Manufacturing Enriching Minnesota’s Future through the Biosciences
  • 9. The BioIndustrial Partnership of MN •  Hypothesis: The industry is commercializing technologies, and there are enough companies forming that any MN biorefinery could find a partner to enter the industry. •  Expected Implementation Actions: » Education of business and community leaders. » Identify assets and market MN to external partners. » Policy development. •  Regulatory issues. •  Financial assistance. Enriching Minnesota’s Future through the Biosciences
  • 10. Project Methodology •  Q2 2011: Project Definition » Assemble Core Team and develop clear understanding of industry •  Q3 2011: Community Dialogue » Share global trends and gather information •  Q4 2011: Publication » Minnesota Roadmap for BioIndustrial Development •  2012: Education and Implementation » Act on strategic direction Enriching Minnesota’s Future through the Biosciences
  • 11. Core Team •  ~21 Members across value chain » Biochemical companies » Ethanol General Managers » Engineering/Design Firms » Legal and Financial Service Providers » Government •  Industry Dominated Enriching Minnesota’s Future through the Biosciences
  • 12. Building an industry… $ $ Feedstock Technology Off-take Policy Enriching Minnesota’s Future through the Biosciences
  • 14. Roadmap Outline •  Biorefinery Development •  Trends •  Opportunities Biorefinery •  Strategic Direction •  Downstream Market Development »  Chemicals »  Fuels Chemicals Industry- End Product •  Trends Retail, End Uses Formulators Manufacturing •  Opportunities •  Strategic Direction •  Agricultural-based Supply Chain Partnerships •  Trends •  Opportunities Farmers/Foresters Biorefinery •  Strategic Direction •  Forest-based Supply Chain Partnerships •  Trends •  Opportunities Farmers/Foresters Biorefinery •  Strategic Direction •  Policy Analysis and Recommendations
  • 15. Biorefinery Development Liquid Fuels Markets Farmers/Foresters Biorefinery Chemical Industry- End Product Retail, End Uses Formulators Manufacturing Enriching Minnesota’s Future through the Biosciences
  • 16. Integrated Biorefinery •  DDGs Food/Feed •  Nutraceuticals •  Food grade oil •  Ethanol Fuels •  Butanol •  Drop-in fuels Chemicals •  Materials and •  Additives Plastics •  Solvents
  • 17. Example: Bio Iso-butanol •  Iso-butanol Drop-in •  Jet Fuel Fuels •  Diesel •  Gasoline Chemicals and •  C4 Platform Plastics Enriching Minnesota’s Future through the Biosciences
  • 18. Volatile and increasing fossil fuel prices Source: ICIS; http://www.icis.com/Articles/2011/06/27/9471601/Bio-based-intermediates-will-reduce-price- volatility.html
  • 19. The signals of momentum? •  8 IPO’s in the last year2 » Financial markets are supporting the industry •  Green chemistry sector lead MN in VC investments for Q2 2011 •  Global biochemicals industry: $585 billion by 20301 » Up to 17% of global chemicals market » 5-10% average annual growth •  5 billion pounds of chemicals by ~20153 •  RFS2: 22 billion gallons of advanced biofuels by 2022 1 http://www.icis.com/Articles/2010/06/21/9368973/biochemical-market-forecasts-suggest-strong-growth.html 2 http://biofuelsdigest.com/bdigest/2011/06/03/myriants-125m-ipo-the-complete-digest-analysis/ 3 PiperJaffray Analysis
  • 20. New targets for bio-based chemicals •  Innovation is enabling new commodity chemicals » New to the world chemicals •  Segetis’ Javelin Technology •  Reluceo’s XLK Polymer » Improved access to existing chemicals •  Succinic Acid •  Glucaric Acid •  “New” chemicals can depend on other innovations in the final products » Risk for slower growth » Without significant improvement in functionality, they may not have the critical mass to survive
  • 21. Minnesota Biobased Materials Family Tree Rivertop BioAmber Reluceo XL Terra 2009 - 2011 Renewables Est. 2009 Est. 2009 Est. 2009 Est. 2010 Plymouth Golden Valley Golden Valley Green Harvest Draths Segetis Pine River Gevo Technologies 2005 - 2009 Est. 2005, 20 emp. Est. 2006, 30 emp. Petrochemicals Est. 2009, 50 emp. Est. 2007, 1 emp. Okemos, Michigan Golden Valley Est. ~2009. Luverne, MN and CO Bloomington Cargill BioH Natureworks Elevance Cargill 1997 - 2004 Est. 2003, 35 emp. est. 1997, ~100 emp. Est. 2004, 45 emp. Industrial Oils Plymouth Minnetonka Chicago, IL Minnetonka Cargill Resins 1980s - 1990s Minnetonka Currently not located in Minnesota
  • 22. Opportunities and Concerns •  Opportunities » Intermediate chemicals the key targets » MN Strengths to build on: •  Cluster of companies has developed in the state •  Use the medical device industry as a proxy •  Strong suite of service providers that understand and support the industry •  Concerns » MN lacks experienced chemical industry executives » Scale-up capital and speed » Cost of regulatory compliance and toxicity testing can squelch innovation
  • 23. Strategic Needs- BioIndustrial Manufacturing •  Assistance in financing through “valley of death” » Government grants are difficult » Lack of focused venture capital » Other states are moving more aggressively to support the industry •  Regulatory issues •  University policies to encourage faculty start-ups •  More clean-tech incubators in the state
  • 24. Agriculture Opportunities Liquid Fuels Markets Farmers/Foresters Biorefinery Chemical Industry- End Product Retail, End Uses Formulators Manufacturing Enriching Minnesota’s Future through the Biosciences
  • 25. Agricultural-based Supply Chain •  Biorefinery Development •  Trends •  Opportunities •  Strategic Direction •  Downstream Market Development »  Chemicals »  Fuels •  Trends •  Opportunities •  Strategic Direction •  Agricultural-based Supply Chain Partnerships •  Trends •  Opportunities Farmers/Foresters Biorefinery •  Strategic Direction •  Forest-based Supply Chain Partnerships •  Trends •  Opportunities •  Strategic Direction Enriching Minnesota’s Future through the Biosciences •  Policy Analysis and Recommendations
  • 27. End Market Development Liquid Fuels Markets Farmers/Foresters Biorefinery Chemical Industry- End Product Retail, End Uses Formulators Manufacturing Enriching Minnesota’s Future through the Biosciences
  • 28. Downstream Market Development •  Biorefinery Development •  Trends •  Opportunities •  Strategic Direction •  Downstream Market Development »  Chemicals Liquid Fuels »  Fuels Markets •  Trends •  Opportunities Chemicals Industry- End Product Strategic Direction Retail, End Uses •  Formulators Manufacturing •  Agricultural-based Supply Chain Partnerships •  Trends •  Opportunities •  Strategic Direction •  Forest-based Supply Chain Partnerships •  Trends •  Opportunities •  Strategic Direction Enriching Minnesota’s Future through the Biosciences •  Policy Analysis and Recommendations
  • 29. Proposal for coordination •  Targeted discussions on regulatory impacts •  Perspectives and ideas to grow the industry •  Participate in implementation efforts Enriching Minnesota’s Future through the Biosciences
  • 30. Thank You! Tim Welle twelle@biobusinessalliance.org 952-746-3845
  • 31. Biofuels becoming biochemicals companies. •  Replace the entire barrel of oil Source: Peter Keeling. Center For Biorenewable Chemicals