The document discusses various abnormalities in white blood cells (WBCs) and their clinical significance, primarily focusing on neutrophils. Key abnormalities include toxic granulation, vacuoles, Dohle bodies, hypersegmentation, hyposegmentation, Auer bodies, and smudge cells, with descriptions of their appearances and associated conditions. These abnormalities can indicate severe infections, hereditary disorders, and malignancies.

1. WBC ABNORMALITY
Ms Ankita R Bhatiya
Assistant Professor
Shree P.M.Patel COLLEGE OF
PARAMEDICAL SCIENCE N TECHNOLOGY

2. WBC ABNORMALITY
 Abnormalities in WBC & Their clinical
significance
 Most of the abnormalities in white cells are
seen in neutrophils, only the most common
ones have been discussed here.

3. WBC ABNORMALITY
1. Toxic granulation
a) Neutrophils contain prominent granules
b) It may be due to severe bacterial
infection and also in some hereditary
disorders

4. WBC ABNORMALITY
2. Vacuoles
a) Occurrence of vacuoles in the cytoplasm
and nucleus
b) It is observed in conditions such as
severe infections, burns, chemical
poisoning and in malignancy

5. WBC ABNORMALITY
3. Dohle bodies
a) Appearance of small round or oval light
blue stained bodies in the cytoplasm
b) Appear in severe infections, burns and on
exposure to toxic agent

6. WBC ABNORMALITY
4. Hyper segmentation
a) In segmented Neutrophils more than 4
lobes are seen
b) May be due to inherited disorder. Also
seen in macrocytic anaemias

7. WBC ABNORMALITY
5. Hypo segmentation
a)Failure of normal lobe development (Less
than 3).
b) It occurs in acute myelocytic Leukaemia,
severe infections, toxic states and in
hereditary disorders

8. WBC ABNORMALITY
6.Auer bodies:
a)Needle like red-purple cytoplasmic
inclusions
b) Found in myeloblasts with Roimanowsky
stains, in case of acute myelogenous
leukaemia

9. WBC ABNORMALITY
7.Smudge cells
a) Basket like cells with no cellular wall.
These are degenerated lymphocytes
Presence of few smudge cells is probably
due to faulty technique and it is considered
normal. However, appearance of large
nullifier is associated with chronic
lymphocytic leukaemia.