Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets)

Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets)
© The Swiss Pharmacy

are used for the treatment of various herpes virus infections.
In children, it is used to treat cold sores around the mouth
(caused by herpes simplex) and chickenpox (caused by
varicella zoster). In adults, it is used to treat shingles (caused
by herpes zoster) and Cold sores (caused by herpes labialis).
Valacyclovir is also used to treat outbreaks of genital herpes.
In people with frequent outbreaks, this medication is used to
reduce the number of future episodes.

Valcivir Tablets are manufactured by Cipla Limited, India in
the strengths of 500 mg and 1000 mg.

Chemical Structure

The active ingredient contained in Valcivir tablets is Valacyclovir
Hydrochloride.
Each film-coated Valcivir tablet contains Valacyclovir Hydrochloride
equivalent to 500 mg or 1000 mg of Valacyclovir.

Uses of Valcivir 500 mg and 1000 mg Tablets:
Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets) belong
to a group of medicines called antivirals. They are used for the
treatment of genital herpes, shingles (herpes zoster), ophthalmic
zoster (shingles affecting the eye region) and cold sores (herpes
labialis).
It is also used to treat chickenpox and cold sores in children.
Valacyclovir is also used to prevent cytomegalovirus (CMV) infection
and disease following solid organ transplantation. CMV is another
type of herpes virus that can cause symptoms similar to glandular
fever (high temperature, sore throat and swollen glands).
URL: https://www.theswisspharmacy.com/product_info.php?info=p9618_Valacyclovir-Tablets.html

Uses of Valcivir 500 mg and 1000 mg Tablets:
Valcivir tablets work by stopping the multiplication of the virus
which causes herpes, shingles and cold sores. It can reduce the
length and severity of an outbreak and duration of pain, and
shorten the healing time of crusts, associated with herpes,
shingles and cold sores.
In your body, Valacyclovir becomes the anti-herpes medicine,
Acyclovir. Although Valacyclovir will not cure shingles or
genital herpes, it does help relieve the pain and discomfort and
helps the sores heal faster.

Recommended Adult Dosage
Valcivir Tablets may be given with or without food. The dose of
Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets) for
various indications in adult patients is given below:
Cold Sores (Herpes Labialis): The recommended dosage of
Valacyclovir for the treatment of cold sores is 2 gm twice daily for 1
day, taken about 12 hours apart. Therapy should be initiated at the
earliest symptom of a cold sore (e.g. tingling, itching, or burning).
Genital Herpes Initial Episodes: The recommended dosage of
Valacyclovir for treatment of initial genital herpes is 1 gm twice daily
for 10 days. Therapy was most effective when administered within
48 hours of the onset of signs and symptoms.

The dose of Valcivir Tablets for various indications in adult patients is given
below:
Genital Herpes Recurrent Episodes: The recommended dosage of
Valacyclovir for the treatment of recurrent genital herpes is 500 mg twice
daily for 3 days. Initiate treatment at the first sign or symptom of an episode.
Genital Herpes Suppressive Therapy: The recommended dosage of
Valacyclovir for chronic suppressive therapy of recurrent genital herpes is 1
gm once daily in patients with normal immune function. In patients with a
history of nine or fewer recurrences per year, an alternative dose is 500 mg
once daily.
In HIV-infected patients with CD4+ cell count greater than 100 cells/mm3,
the recommended dosage of Valacyclovir for chronic suppressive therapy
of recurrent genital herpes is 500 mg twice daily.

The dose of Valcivir Tablets for various indications in adult patients is
given below:
Reduction of Transmission: The recommended dosage of
Valacyclovir for reduction of the transmission of genital herpes in
patients with a history of nine or fewer recurrences per year is 500
mg once daily for the source partner.
Herpes Zoster: The recommended dosage of Valacyclovir for the
treatment of herpes zoster is 1 gm orally, three times daily for 7 days.
Therapy should be initiated at the earliest sign or symptom of herpes
zoster and is most effective when started within 48 hours of the onset
of the herpes zoster rash.

Cold Sores (Herpes Labialis): The recommended dosage of Valcivir
Tablets (Generic Valacyclovir Hydrochloride Tablets) for the
treatment of cold sores in patients, 12 years of age and older, is 2 gm
twice daily for 1 day, taken 12 hours apart. Therapy should be initiated
at the earliest symptom of a cold sore (e.g. tingling, itching or
burning).
Chickenpox: The recommended dosage of Valacyclovir for treatment
of chickenpox in immunocompetent patients aged 2 to below 18
years is 20 mg/kg, administered three times daily for 5 days. The total
dose should not exceed 1 gm three times daily. Treatment should be
started at the earliest sign or symptom.

Contraindications
➔
Valcivir Tablets are contraindicated in patients with a known
hypersensitivity to Valacyclovir Hydrochloride, Acyclovir, or
any component of the tablet.

Storage Instructions
Valcivir Tablets (Generic Valacyclovir Hydrochloride
Tablets) have to be stored at controlled room
temperature i.e. from 20°C to 25°C (68°F to 77°F) with
excursions permitted between 15° to 30°C (59° to
86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome
(TTP/HUS): Has occurred in patients with advanced HIV disease and in
allogenic bone marrow transplant and renal transplant patients
receiving 8 grams per day of Valacyclovir tablets (Valcivir tablets) in
clinical trials. Discontinue treatment if clinical symptoms and laboratory
findings consistent with TTP/HUS occur.
Acute renal failure: May occur in elderly patients (with or without
reduced renal function), patients with underlying renal disease who
receive higher than recommended doses of Valcivir tablets for their
level of renal function, patients who receive concomitant nephrotoxic
drugs, or inadequately hydrated patients. Use with caution in elderly
patients and reduce dosage in patients with renal impairment.

Warnings
Central nervous system adverse reactions (e.g., agitation,
hallucinations, confusion, and encephalopathy): May occur in elderly
patients (with or without reduced renal function) and in patients with
underlying renal disease who receive higher than recommended
doses of Valcivir tablets for their level of renal function. Use with
caution in elderly patients and reduce dosage in patients with renal
impairment.

Possible Side Effects
The serious side effects reported with Valacyclovir Hydrochloride
(Valcivir tablets) are as follows: TTP/HUS, acute renal failure and
central nervous system effects.
The most common side effects reported in at least one indication by
greater than 10% of adult patients treated with Valacyclovir and
observed more frequently with Valacyclovir compared to placebo are
headache, nausea, and abdominal pain. The only side effect reported
in greater than 10% of paediatric patients aged less than 18 years was
headache.

Valcivir Tablets Overdosage
Acute renal failure and neurological symptoms, including confusion,
hallucinations, agitation, decreased consciousness and coma, have
been reported in patients receiving overdoses of Valacyclovir
Hydrochloride (Valcivir tablets). Nausea and vomiting may also occur.
Caution is required to prevent inadvertent overdosing. Many of the
reported cases involved renally impaired and elderly patients receiving
repeated overdoses, due to lack of appropriate dosage reduction.
Patients should be observed closely for signs of toxicity. Haemodialysis
significantly enhances the removal of Acyclovir from the blood and
may, therefore, be considered a management option in the event of
symptomatic overdose.

Valcivir Tablets During Pregnancy
Valacyclovir Hydrochloride (Valcivir tablets) has been classified by the
US FDA as Pregnancy Category B.
There are no adequate and well-controlled studies of Valacyclovir or
Acyclovir in pregnant women. Based on prospective pregnancy registry
data on 749 pregnancies, the overall rate of birth defects in infants
exposed to Acyclovir in-utero appears similar to the rate for infants in the
general population. Valcivir tablets should be used during pregnancy
only if the potential benefit justifies the potential risk to the fetus.
Animal reproduction studies performed at oral doses that provided up to
10 and 7 times the human plasma levels during the period of major
organogenesis in rats and rabbits, respectively, revealed no evidence of
teratogenicity.

Valcivir Tablets (Generic Valacyclovir Hydrochloride
Tablets) are manufactured by Cipla Limited, India.

Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets)

Recommended

Recommended

More Related Content

Similar to Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets)

Similar to Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets) (20)

More from The Swiss Pharmacy

More from The Swiss Pharmacy (20)

Recently uploaded

Recently uploaded (20)

Valcivir Tablets (Generic Valacyclovir Hydrochloride Tablets)