Famtrex (Generic Famciclovir Tablets)

Famtrex (Generic Famciclovir Tablets)
© The Swiss Pharmacy

In immunocompetent adult patients, Famtrex (Generic
Famciclovir Tablets) is used for the treatment of recurrent
herpes labialis (cold sores) and for the treatment of recurrent
episodes of genital herpes as well as for chronic suppressive
therapy of recurrent episodes of genital herpes.
In HIV-infected adult patients, this medicine is used to treat
recurrent episodes of orolabial or genital herpes in HIV-
infected adults.

Famtrex Tablets are
manufactured by Cipla
Limited, India in the strengths
of 250 mg and 500 mg.

The active ingredient contained in Famtrex
tablets is Famciclovir.
Each Famtrex tablet contains 250 mg or 500
mg of Famciclovir.

Chemical Structure - Famciclovir

Uses of Famtrex 250 mg and 500 mg tablets:
Famtrex (Generic Famciclovir Tablets) is used for treatment of herpes zoster
infection in adult patients who commence therapy within 72 hours of the onset of
rash. Greatest benefit occurs if the drug is started within 48 hours.
Treatment of recurrent episodes of genital herpes in adults and adolescents 12
years of age and older. It is also used for suppression of recurrent genital herpes
and treatment of recurrent herpes labialis (cold sores) in immunocompetent
adult patients.
Famciclovir is also used in immunocompromised patients for treatment of
uncomplicated herpes zoster, treatment of recurrent herpes simplex and
suppression of recurrent herpes simplex.

Recommended Adult Dosage
The recommended dose of Famtrex (Generic Famciclovir Tablets) to
treat immunocompetent adult patients for various indications is given
below:
Herpes Labialis (Cold Sores): The recommended dosage of Famciclovir
tablets for the treatment of recurrent herpes labialis is 1500 mg as a single
dose. Therapy should be started at the first sign or symptom of herpes
labialis (e.g., tingling, itching, burning, pain, or lesion).
Genital Herpes Recurrent Episodes: The recommended dosage of Famciclovir
tablets for the treatment of recurrent episodes of genital herpes is 1000 mg
twice daily for 1 day. Therapy should be initiated at the first sign or
symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or
lesion).

Recommended Adult Dosage
Genital Herpes Suppressive Therapy: The recommended dosage of
Famtrex tablets for chronic suppressive therapy of recurrent episodes of
genital herpes is 250 mg twice daily.
Herpes Zoster (Shingles): The recommended dosage of Famciclovir
tablets (Famtrex) for the treatment of herpes zoster is 500 mg every 8
hours for 7 days. Therapy should be started as soon as herpes zoster is
diagnosed.

Recommended Dosage in HIV-Infected Adult Patients
Recurrent Orolabial or Genital Herpes: The recommended dosage
of Famciclovir tablets for the treatment of recurrent orolabial or
genital herpes in HIV-infected patients is 500 mg twice daily for 7
days. Therapy should be initiated at the first sign or symptom of a
recurrent episode (e.g., tingling, itching, burning, pain, or lesion).

Contraindications
➔
Famtrex is contraindicated in patients with a
known hypersensitivity to Famciclovir, Penciclovir,
or any component of the tablet.

Storage Instructions
Famtrex (Generic Famciclovir Tablets) have to
be stored at controlled room temperature i.e.
from 20°C to 25°C (68°F to 77°F) with
excursions permitted between 15° to 30°C (59°
to 86°F).
Keep this as well as all other medicines away
from children and pets.

Warnings
Acute renal failure: Cases of acute renal failure have been
reported in patients with underlying renal disease who
have received inappropriately high doses of Famciclovir
(Famtrex tablets) for their level of renal function.
Dosage reduction is recommended when administering
Famciclovir to patients with renal impairment.

Warnings
In patients with impaired renal function dose adjustment is
necessary.
Famciclovir has not been studied in patients with severe hepatic
impairment. Conversion of Famciclovir to its active metabolite
Penciclovir may be impaired in these patients resulting in lower
Penciclovir plasma concentrations, and thus a decrease of efficacy of
Famciclovir may occur.
Clinical response should be closely monitored, particularly in
immunocompromised patients. Consideration should be given to
intravenous antiviral therapy when response to oral therapy is
considered insufficient.

Warnings
Patients should be advised to avoid intercourse when symptoms are
present even if treatment with an antiviral has been initiated.
During suppressive treatment with antiviral agents, the frequency of
viral shedding is significantly reduced.
However, transmission is still possible. Therefore, in addition to
therapy with Famciclovir (Famtrex tablets), it is recommended that
patients use safer sex practices.

Possible Side Effects
Most common Famciclovir (Famtrex tablets) side
effects with an incidence rate of greater than 10%
of adult patients are headache and nausea.

Possible Side Effects
The following side effects have been reported during postapproval use of
Famciclovir (Famtrex tablets):
Blood and lymphatic system disorders: Thrombocytopenia
Hepatobiliary disorders: Abnormal liver function tests, cholestatic jaundice
Immune system disorders: Anaphylactic shock, anaphylactic reaction
Nervous system disorders: Dizziness, somnolence, seizure
Psychiatric disorders: Confusion (including delirium, disorientation, and
confusional state occurring predominantly in the elderly), hallucinations
Skin and subcutaneous tissue disorders: Urticaria, erythema multiforme, Stevens-
Johnson syndrome, toxic epidermal necrolysis, angioedema (e.g., face, eyelid,
periorbital, and pharyngeal edema), hypersensitivity vasculitis
Cardiac disorders: Palpitations

Famtrex Tablets Overdosage
Overdose experience with Famciclovir (Famtrex tablets) is limited.
In the event of an overdose supportive and symptomatic therapy
should be given as appropriate.
Acute renal failure has been reported rarely in patients with
underlying renal disease where the Famciclovir dose has not been
appropriately reduced for the level of renal function.
Penciclovir is removed by hemodialysis.
Plasma concentrations are reduced by approximately 75%
following 4h haemodialysis.

Famtrex Tablets During Pregnancy
Famciclovir (Famtrex tablets) has been classified by the US FDA as
Pregnancy Category B.
After oral administration, Famciclovir (prodrug) is converted to Penciclovir
(active drug). There are no adequate and well-controlled studies of
Famciclovir or Penciclovir use in pregnant women.
No adverse effects on embryofetal development were observed in animal
reproduction studies using Famciclovir and Penciclovir at doses higher than
the maximum recommended human dose (MRHD) and human exposure.
Since animal reproduction studies are not always predictive of human
response, Famciclovir (Famtrex tablets) should be used during pregnancy
only if needed.

Famtrex Tablets are manufactured by Cipla
Limited, India.
For More details Click Here

Famtrex (Generic Famciclovir Tablets)

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