Acivir DT Tablets (Generic Acyclovir Dispersible Tablets)

Acivir DT Tablets (Generic Acyclovir Dispersible Tablets)
© The Swiss Pharmacy

Acivir DT (Generic Acyclovir Dispersible Tablets) are used for
the treatment of herpes simplex virus infections of the skin
and mucous membranes including initial and recurrent
genital herpes (excluding neonatal HSV and severe HSV
infections in immunocompromised children).
Acivir Tablets are indicated for the suppression (prevention
of recurrences) of recurrent herpes simplex infections in
immunocompetent patients.
Acivir Tablets are indicated for the prophylaxis of herpes
simplex infections in immunocompromised patients.
Acivir Tablets are indicated for the treatment of varicella
(chickenpox) and herpes zoster (shingles) infections.

Acivir DT Tablets (Generic Aciclovir Dispersible Tablets) are
manufactured by Cipla Limited, India in the strengths of 200
mg, 400 mg and 800 mg.

Chemical Structure

The active ingredient contained in Acivir DT tablets is Acyclovir
(Aciclovir).
Each Acivir DT dispersible tablet contains tablet contains 200 mg, 400
mg or 800 mg of Acyclovir in a flavoured base.

Uses of Acivir DT 200 mg, 400 mg or 800 mg Tablets:
Acivir DT Tablets (Generic Acyclovir Dispersible Tablets) are used for
the treatment of herpes simplex virus infections of the skin and
mucous membranes including initial and recurrent genital herpes
(excluding neonatal HSV and severe HSV infections in
immunocompromised children).
Acivir DT 200 mg, 400 mg and 800 mg Dispersible Tablets can be
used to:
treat chickenpox
treat shingles, and when started right after the rash appears, it can
help reduce the nerve pain that can exist after the shingles rash has
cleared.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9475_Acivir-Pills.html

Uses of Acivir DT 200 mg, 400 mg or 800 mg Tablets:
Acivir DT 200 mg, 400 mg and 800 mg Dispersible Tablets can be
used to:
treat cold sores, genital herpes and other herpes simplex
infections (but not to be used to treat herpes simplex infections in
newborn infants or severe herpes simplex infections in children
whose immune systems work less well, which means their bodies
are less able to fight infections)
stop cold sores and genital herpes returning after you have had
them.
prevent cold sores and genital herpes in people whose immune
systems work less well.

Recommended Adult Dosage
The dose of Acivir DT (Generic Acyclovir Dispersible
Tablets) for various indications is given below:
Herpes Zoster: For treatment of herpes zoster infections,
800 mg Acivir DT (Generic Acyclovir tablets) should be
taken five times daily at approximately 4-hourly intervals,
omitting the night-time dose. Treatment should continue for
7 days.
Dosing should begin as early as possible after the start of an
infection. Treatment yields better results if started as soon
as possible after onset of the rash.

Genital Herpes (Adult Dosage): For treatment of initial episodes
of genital herpes the dosage is 200 mg taken 5 times a day for
10 days
In case of treatment of episodic therapy of Genital Herpes the
dosage is 200 mg taken 5 times a day for 5 days.
For Suppressive therapy in immunocompetent adults the
dosage is 200 mg taken 4 times a day for 1 year or 400 mg
taken twice a day for 1 year
For Suppressive therapy in HIV-infected patients the dosage is
800 mg taken 4 times a day for 1 year

Recommended Dosage
Chickenpox (Paediatric Dosage): For treatment of chickenpox,
children over the age of 6 years can be given 800 mg Acivir DT
(Generic Acyclovir Tablets) four times daily, and children
between the ages of 2 and 6 years can be given 400 mg Acivir
DT four times daily.
Children below the age of 2 years can be given 200 mg Acivir
DT four times daily. Dosing can be more accurately calculated
as 20 mg Aciclovir/kg bodyweight (not to exceed 800 mg) four
times daily. Treatment should continue for 5 days.

Chickenpox (Adult Dosage): For the treatment of chickenpox in
adults, 800 mg Acivir DT should be taken five times daily at
approximately 4-hourly intervals, omitting the night-time dose.
Treatment should continue for 7 days.

Contraindications
➔
Acivir tablets are contraindicated in patients with a
known hypersensitivity to Acyclovir (Aciclovir),
Valacyclovir or any component of the tablet.

Storage Instructions
Acivir DT Tablets (Generic Acyclovir Dispersible
Tablets) have to be stored at controlled room
temperature i.e. from 20°C to 25°C (68°F to 77°F) with
excursions permitted between 15° to 30°C (59° to
86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
Aciclovir Dispersible Tablets (Acivir DT) is eliminated by renal
clearance, therefore the dose must be adjusted in patients with renal
impairment.
Elderly patients are likely to have reduced renal function and therefore
the need for dose adjustment must be considered in this group of
patients. Both elderly patients and patients with renal impairment are
at increased risk of developing neurological side effects and should be
closely monitored for evidence of these effects.
Prolonged or repeated courses of Acyclovir Dispersible Tablets (Acivir
DT) in severely immune-compromised individuals may result in the
selection of virus strains with reduced sensitivity, which may not
respond to continued Aciclovir treatment.

Warnings
Hydration status: Care should be taken to maintain adequate hydration
in patients receiving high oral doses of Acyclovir (Acivir DT).
The risk of renal impairment is increased by use with other nephrotoxic
medications.
The data currently available from clinical studies is not sufficient to
conclude that treatment with Aciclovir Dispersible Tablets reduces the
incidence of chickenpox-associated complications in
immunocompetent patients.

Possible Side Effects
The most frequent side effects reported during clinical trials of
treatment of genital herpes with Acyclovir 200 mg tablets (Acivir DT)
administered orally 5 times daily every 4 hours for 10 days were
nausea and/or vomiting in 8 of 298 patient treatments (2.7%).
The most frequent adverse events reported in a clinical trial for the
prevention of recurrences of genital herpes with continuous
administration of 400 mg (two 200 mg tablets) 2 times daily for one
year in 586 patients treated with acyclovir were nausea (4.8%) and
diarrhea (2.4%). The 589 control patients receiving intermittent
treatment of recurrences with Acyclovir for one year reported
diarrhea (2.7%), nausea (2.4%), and headache (2.2%).

In addition to side effects reported from clinical trials, the following
events have been identified during post-approval use of Acyclovir.
General: Anaphylaxis, angioedema, fever, headache, pain, peripheral
edema.
Nervous: Aggressive behavior, agitation, ataxia, coma, confusion,
decreased consciousness, delirium, dizziness, dysarthria,
encephalopathy, hallucinations, paresthesia, psychosis, seizure,
somnolence, tremors. These symptoms may be marked, particularly in
older adults or in patients with renal impairment.
Digestive: Diarrhea, gastrointestinal distress, nausea.
Hematologic and Lymphatic: Anemia, leukocytoclastic vasculitis,
leukopenia, lymphadenopathy, thrombocytopenia.

In addition to side effects reported from clinical trials, the following
events have been identified during post-approval use of Acyclovir.
Hepatobiliary Tract and Pancreas: Elevated liver function tests,
hepatitis, hyperbilirubinemia, jaundice.
Musculoskeletal: Myalgia.
Skin: Alopecia, erythema multiforme, photosensitive rash, pruritus, rash,
Stevens-Johnson Syndrome, toxic epidermal necrolysis, urticaria.
Special Senses: Visual abnormalities.
Urogenital: Renal failure, renal pain (may be associated with renal
failure), elevated blood urea nitrogen, elevated creatinine, hematuria

Acivir DT Tablets Overdosage
Overdoses involving ingestion of up to 20 grams have been reported.
Adverse events that have been reported in association with Acyclovir
(Acivir DT) overdosage include agitation, coma, seizures, and lethargy.
Precipitation of Acyclovir in renal tubules may occur when the
solubility (2.5 mg/mL) is exceeded in the intratubular fluid.
Overdosage has been reported following bolus injections or
inappropriately high doses and in patients whose fluid and electrolyte
balance were not properly monitored. This has resulted in elevated
BUN and serum creatinine and subsequent renal failure. In the event of
acute renal failure and anuria, the patient may benefit from
hemodialysis until renal function is restored.

Acivir DT Tablets During Pregnancy
Acyclovir (Acivir Dispersible Tablets) has been classified by the
US FDA as Pregnancy Category B.
There are no adequate and well controlled studies in pregnant
women.
There were 749 pregnancies followed in women exposed to
systemic Aciclovir during the first trimester of pregnancy,
resulting in 756 outcomes. The occurrence rate of birth defects
approximates that found in the general population.

Acivir DT (Generic Acyclovir Dispersible Tablets) is
manufactured by Cipla Limited, India.

Acivir DT Tablets (Generic Acyclovir Dispersible Tablets)

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