This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
Book reference: Essentials of Medical Pharmacology by K. D. Tripathi
Images and Charts: Google Search Results
Presentation for teaching in a 2nd Year MBBS class
Mumps virus is a common infectious agent of humans, causing parotitis, meningitis, encephalitis, and orchitis. Like other paramyxoviruses in the genus Rubulavirus, mumps virus catalyzes the proteasomal degradation of cellular STAT1 protein, a means for escaping antiviral responses initiated by alpha/beta and gamma interferons. We demonstrate that mumps virus also eliminates cellular STAT3, a protein that mediates transcriptional responses to cytokines, growth factors, nonreceptor tyrosine kinases, and a variety of oncogenic stimuli. STAT1 and STAT3 are independently targeted by a single mumps virus protein, called V, that assembles STAT-directed ubiquitylation complexes from cellular components, including STAT1, STAT2, STAT3, DDB1, and Cullin4A. Consequently, mumps virus V protein prevents responses to interleukin-6 and v-Src signals and can induce apoptosis in STAT3-dependent multiple myeloma cells and transformed murine fibroblasts. These findings demonstrate a unique cytokine and oncogene evasion property of mumps virus that provides a molecular basis for its observed oncolytic properties. more info on slides
Viruses are obligate intracellular parasites.Our arsenal of antivirals is dangerously small.Currently available antivirals are mainly against Herpes,Hepatitis and AIDS viruses.The treatment of HCV has shifted away from the use of Peg-IFN towards oral antivirals.Preventive vaccination is the key to global control of viral infections.
Penicillins are the beta lactam antibiotics used to treat various conditions like pharyngitis, tonsilitis, endocarditis, diphtheria, anthrax and syphilis.
Cephalosporins are the broad spectrum antibiotics derived from fungus. Mainly used to treat bacterial infections like meningitis, pneumonia, urinary tract infections and sepsis.
Sympathomimetics are the drugs that mimic effects of endogenous catecholamines. Used to treat various conditions. Includes Dobutamine, Dopamine, Norepinephrine, Epinephrine and Isoproterenol.
Oxytocin is a peptide hormone that activates receptors on Uterine smooth muscle leading to the increased frequency, strength and duration of Uterine Contraction..
Broncholytics or bronchial secretion inhibitors or medications to control airway secretions are used to treat nasal congestion, relieve chest congestion and for non productive cough.
Bronchodilators are group of medications that help breathing by keeping airways dilated through smooth muscle relaxation, dilation of narrowed airways and improved air flow.
Information about the importance of the platelet and functions.
Classification of drugs used for antiplatelet properties. And a brief discussion about the drugs.
A detailed information Thrombolytic or fibrinolytics. Comes under the Drugs affecting the blood and blood forming category. These drugs are used to lyse the clot.
A detailed information about the diuretics - classification of drugs, mechanism of action, side effects, dosage and indications.
Classification based on the efficacy of the diuretics.
1. High
2. Moderate
3. Weak
A brief introduction given about the nephron structure and its indications.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
18. VACCINES, PART 1
DRUG NAME
measles, mumps, rubella (MMR);
varicella zoster (Varivax); herpes zoster
(Shingrix), rotavirus (Rotarix); yellow
fever; smallpox; influenza
hepatitis A (Havrix); inactivated
polio (IPOL); rabies (Imovax);
influenza (Afluria Quadrivalent)
hepatitis B (Engerix-B); HPV;
pneumococcal (Pneumovax 23);
meningococcal (Menactra); varicella-
zoster (Varzig); SARS-CoV-2
CLASS Live attenuated vaccines Inactivated vaccines
Subunit, recombinant, polysaccharide,
and conjugated vaccines
MECHANISM
OF ACTION
Trigger a specialized immune response against pathogens, building up immunological memory to fight the infectious
disease if and when exposed to the pathogen in the future
INDICATIONS
•Primary prevention against infectious diseases
•Primary prevention of cervical and anal cancer (HPV vaccine)
ROA
•MMR-V, varicella, yellow fever: SUBQ
•Rotavirus: PO
•Smallpox: ID
•Live influenza: NAS
•IM
SIDE EFFECTS
•Local injection site reactions
•Systemic flu-like symptoms
•Rare, but severe adverse reactions - seizures, high fever, Guillain-Barré syndrome, thrombocytopenia, anaphylaxis
CONTRA-
INDICATIONS
& CAUTIONS
•Allergic reaction to previous dose of vaccine or any vaccine ingredient
•Moderate or severe active infections (wait until infection is resolved)
•Immunodeficient and pregnant individuals
•Rotavirus: contraindicated in clients with history
of intussusception
•MMR-V: caution in clients with history of
seizures or thrombocytopenia
•None
•HPV: contraindicated during
pregnancy
19. VACCINES, PART 2
DRUG NAME
diphtheria, tetanus, pertussis (DTaP);
tetanus, diphtheria, pertussis (Tdap);
tetanus, diphtheria (DT)
SARS-CoV-2 (Pfizer-BioNTech,
Moderna)
CLASS Toxoid vaccines mRNA vaccines
MECHANISM OF
ACTION
Trigger a specialized immune response against pathogens, building up immunological
memory to fight the infectious disease if and when exposed to the pathogen in the future
INDICATIONS
•Primary prevention against infectious diseases
•Primary prevention of cervical and anal cancer (HPV vaccine)
ROA •IM
SIDE EFFECTS
•Local injection site reactions
•Systemic flu-like symptoms
•Rare, but severe adverse reactions - seizures, high fever, Guillain-Barré syndrome,
thrombocytopenia, anaphylaxis
CONTRA-INDICATIONS
& CAUTIONS
•DTaP, TdaP: contraindicated if signs of
encephalopathy have occurred with a prior dose
of vaccine (e.g., coma, seizures, altered level of
consciousness)
•None
20. VACCINES
ASSESSMENT AND
MONITORING
•Assessment, intervention, and monitoring
Review the child’s immunization record
•Determine vaccine to be administered; cautions or contraindications to receiving the vaccine
•Select the correct needle length and injection site
•Use age-appropriate interventions to reduce pain
•Explain the procedure in age-appropriate language
•Record: month, day, and year of administration; the site of administration; the type of vaccine
given, along with the name of the manufacturer, lot number, and expiration date
•Monitor: observe for at least 15 minutes for severe reaction
CLIENT EDUCATION
•Purpose of vaccine: to help prevent infection and disease
•Review symptoms and complications of each disease
•Include older children in the conversation
•Review common side effects and management
•Review risk of the disease versus risk of side effects
•For rare severe allergic reactions: call emergency services immediately for itchy rash,
swelling of the face or throat, or difficulty breathing
•Listen to concerns, answer their questions, clarify any misconceptions
•Provide vaccine information statement
•Verify informed consent
•Remind them about the next scheduled vaccination
