Uterine factor infertility happens when the uterus is not present, the uterus is underdeveloped, or the uterus is present but is nonfunctional. There are two main causes of uterine factor infertility. These causes include: Being born without a functioning uterus. Having the uterus removed (hysterectomy).

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𝔽𝔸ℂ𝕋𝕆ℝ 𝕆𝔽
𝕀ℕ𝔽𝔼ℝ𝕋𝕀𝕃𝕀𝕋𝕐
MAVUMNKAL BIJU BRINCELET
GROUP 733

3. Uterine factor infertility happens when the
uterus is not present, the uterus is
underdeveloped, or the uterus is present but
is nonfunctional.
• There are two main causes of uterine factor
infertility. These causes include:
• Being born without a functioning uterus.
• Having the uterus removed (hysterectomy).

5. Being born without a uterus.

6. The original illustration by
Carl von Rokitansky (1838)
showing the uterovaginal
morphology in MRKH syndrome
with a shortened blind-ending
vagina and two rudimentary
uterine remnants. b A sagittal T2-
weighted MRI showing complete
uterovaginal absence in type II
MRKH syndrome associated with
renal agenesis and a solitary
pelvic kidney. c The pelvis of a
patient with MRKH syndrome
during surgical preparation for
uterus transplantation. The
forceps is holding the fibrous
uterine rudiment in the midline,
while it is dissected free from the
bladder. On the uterine buds,
located on the pelvic sidewalls,
small subserosal leiomyomas
are seen on both sides. The
ovaries are located medially
towards the Pouch of Douglas

8. Having the uterus removed (hysterectomy).
• Hemorrhage:
• Cancer:
.
• Severe endometriosis, fibroids, or adenomyosis:

11. (A) Showed multiple
fibroids on uterus
remnants, both ovaries
were normal; (B)
Fallopian tubes were
normal, largest uterine
fibroid; (C) Uterine
fibroids on right horn; (D)
Multiple uterine fibroids

13. Signs or Symptoms of
uterine factor infertility?
• In women who have absolute uterine
factor infertility (who have not had a
hysterectomy), the main symptom is
never having had menstrual periods.
This is often the sign that leads a
doctor to perform a physical exam or
an imaging test and reveal the
diagnosis.

14. How is uterine factor
infertility diagnosed?

15. How is uterine factor infertility
treated?

16. • Currently, uterus transplantation is not
widely available and is only through clinical
trials. In the future, there is hope that this
treatment will be widely available for
women with absolute uterine factor
infertility.A uterus transplant is similar to
many other organ transplants. The organ is
taken from a donor and surgically
implanted in a recipient, who must take
special medications to prevent their
immune system from rejecting the
transplanted organ. There are two types of
donors that can give a donor – living and
deceased.

18. PREVENTION
When uterine factor infertility is caused by a
congenital condition like MRKH, it’s unfortunately
not preventable. This condition happens before
birth and there’s currently no screening for it
during pregnancy.
In acquired cases of uterine factor infertility,
prevention centers around pre-surgery discussions
with the healthcare team. It’s important to be very
open and honest with your healthcare provider
about your wishes for future children. In some
cases, there are other options for treatment that
don’t involve a hysterectomy.

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