This document discusses challenges and opportunities around working with real-world data. It notes that while data is plentiful, real-world data is difficult to obtain due to issues like data silos and privacy concerns. It also discusses problems with data interoperability, quality, reliability, and needing more than just analytics to gain insights. The document advocates for linked open data streams with metadata and scalable analytics tools combined with domain knowledge to create actionable knowledge from real-world data. It concludes by listing challenges and opportunities in providing infrastructure, publishing and analyzing heterogeneous and private data at scale.