Understanding the Role of Exogenous Ketones
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Dominic D'Agostino, a University of South Florida professor, has extensively studied exogenous ketones and their ability to preserve muscle mass. Exogenous ketones are compounds that mimic the effects of fasting by raising blood ketones and lowering blood glucose without requiring dietary changes. They include ketone esters, which are either naturally or synthetically derived by adding acetoacetate or beta-hydroxybutyrate to a backbone molecule through an ester bond. Ketone esters are potent and can significantly increase ketone levels for an extended period of time, making them promising for therapeutic uses such as reducing seizures without the risks of excess electrolytes associated with ketone salt formulations.
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For nearly 10 years, Dr. Dominic D’Agostino has served as an assistant professor at the University of South Florida (USF), where he actively researches prospective solutions to managing cancer and to treating neuropathologies that prevent and impair muscle control, such as seizure disorders, Alzheimer’s and Lou Gehrig’s disease (ALS). In this effort, Dr. Dominic D’Agostino has focused on the effects of a ketogenic diet, ketone esters and ketone supplementation and recently contributed to a study published in the Nature Medicine journal that demonstrates the anti-inflammatory effects of nutritional ketosis.
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Based in Tampa, Florida, Dominic D’Agostino is an associate professor at the University of South Florida with over 15 years of experience. Interested in ketone research, Dominic D’Agostino supports the company AudaciousNutrition. With the launch of their KETOSTART powder, AudaciousNutrition offers customers the benefits of ketone supplementation at an affordable price and in an accessible form. This particular ketone electrolyte supplement has the highest potency, purity, tolerability, and is the best tasting product on the market.
KETOSTART contains the most effective ketones available by weight, and lacks artificial ingredients, colors, or preservatives. Normally, your body expends beta-hydroxybutyrate (BHB) salts when sugars like glucose are not readily available. KETOSTART gives your body access to BHB as easy as glucose, when normally, BHB is a resource your body produces in the context of fasting or the ketogenic diet. Many benefits of fasting and ketogenic diets are linked to the production of ketones, including BHB. Each serving contains 10 grams of BHB, which your body converts to energy more efficiently than glucose. In addition, BHB has appetite-suppressing, anti-inflammatory and neuroprotective functions in the body. KETOSTART can be used to boost or further augment the beneficial effect of the ketogenic diet and fasting. KETOSTART can also prevent the Keto flu, which is linked to a lack of ketones during the initial stages of starting a ketogenic diet.
In addition to ketones, KETOSTART contains electrolytes. Electrolytes help maintain normal nerve and muscle function, alongside hydration and the balance of acids and bases in the blood. Increasing electrolyte intake is important because the reduction of carbs, during the keto diet, causes the kidneys to release more sodium in a practitioner’s urine. The supplementary electrolytes in KETOSTART will offset the kidneys’ regulatory actions. For more information visit KetoNutrition.org and instagram.com/dominic.dagostino.kt.
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An associate professor at the University of South Florida, Dominic D’Agostino focuses his clinical research in areas such as muscle function, ketone supplementation, KetoNutrition, and ketone technologies. A respected voice in his field, Dominic D’Agostino is co-author of the article “Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen” (Aging, May 2020).
The paper focuses on the body’s ability to transition between glycolysis and ketosis. This process enables fat oxidation metabolism and is a survival mechanism during times of fasting. Also elicited by stress and carbohydrate restriction, metabolic switching is delayed among aged rats.
The study involved young and aged rats being administered time-restricted feeding (TRF) with either ketogenic diets (KD) or standard diets. Glycogen dynamics, as well as glycolysis and ketosis switching, were then measured. TRF alone had an effect in reversing insulin-related metabolic deficit markers and accelerated the metabolic switching process among aged rats. The KD+TRF combination added to these benefits, with abilities to keto-adapt shown as not correlated with glycogen levels.
While the reason for the age-related impairment and delayed Keto-adapting from glycolysis is still unknown, the study provides new insight. In particular, it helps define keto-adaptation mechanisms, and potential pathways across the lifespan, for treating metabolic impairment through dietary interventions.
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For nearly 10 years, Dr. Dominic D’Agostino has served as an assistant professor at the University of South Florida (USF), where he actively researches prospective solutions to managing cancer and to treating neuropathologies that prevent and impair muscle control, such as seizure disorders, Alzheimer’s and Lou Gehrig’s disease (ALS). In this effort, Dr. Dominic D’Agostino has focused on the effects of a ketogenic diet, ketone esters and ketone supplementation and recently contributed to a study published in the Nature Medicine journal that demonstrates the anti-inflammatory effects of nutritional ketosis.
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Based in Tampa, Florida, Dominic D’Agostino is an associate professor at the University of South Florida with over 15 years of experience. Interested in ketone research, Dominic D’Agostino supports the company AudaciousNutrition. With the launch of their KETOSTART powder, AudaciousNutrition offers customers the benefits of ketone supplementation at an affordable price and in an accessible form. This particular ketone electrolyte supplement has the highest potency, purity, tolerability, and is the best tasting product on the market.
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In addition to ketones, KETOSTART contains electrolytes. Electrolytes help maintain normal nerve and muscle function, alongside hydration and the balance of acids and bases in the blood. Increasing electrolyte intake is important because the reduction of carbs, during the keto diet, causes the kidneys to release more sodium in a practitioner’s urine. The supplementary electrolytes in KETOSTART will offset the kidneys’ regulatory actions. For more information visit KetoNutrition.org and instagram.com/dominic.dagostino.kt.
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An associate professor at the University of South Florida, Dominic D’Agostino focuses his clinical research in areas such as muscle function, ketone supplementation, KetoNutrition, and ketone technologies. A respected voice in his field, Dominic D’Agostino is co-author of the article “Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen” (Aging, May 2020).
The paper focuses on the body’s ability to transition between glycolysis and ketosis. This process enables fat oxidation metabolism and is a survival mechanism during times of fasting. Also elicited by stress and carbohydrate restriction, metabolic switching is delayed among aged rats.
The study involved young and aged rats being administered time-restricted feeding (TRF) with either ketogenic diets (KD) or standard diets. Glycogen dynamics, as well as glycolysis and ketosis switching, were then measured. TRF alone had an effect in reversing insulin-related metabolic deficit markers and accelerated the metabolic switching process among aged rats. The KD+TRF combination added to these benefits, with abilities to keto-adapt shown as not correlated with glycogen levels.
While the reason for the age-related impairment and delayed Keto-adapting from glycolysis is still unknown, the study provides new insight. In particular, it helps define keto-adaptation mechanisms, and potential pathways across the lifespan, for treating metabolic impairment through dietary interventions.
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A chronic condition of the central nervous system (CNS), neuroinflammation starts with the release of chemicals by the immune system that activate leukocytes (white blood cells) and combat infection. This is normally an acute process that enables tissue repair and the restoration of homeostasis over a period of a few hours.
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Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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