Our bodies were meant to burn ketones. We have a parallel system within us designed to use There was a time, however, that human beings moved in and out of a state of ketosis with the flux of scarcity and abundance. Prüvit’s KETO//OS (Ketone Operating System) is a revolutionary drink mix that is based on a proprietary ketone energy technology that delivers advanced macro nutritionals and promotes optimized cellular regeneration, energy and longevity. Ketones are a high energy product of fat oxidation that deliver a more efficient and higher energy yield than glucose which makes them the ideal fuel for powering the human body. Ketones are traditionally only produced during times of prolonged fasting and therefore have been limited in their availability as an alternative energy source.

1. Support Articles for “The Power of Ketone Supplementation
in Advancing the Quality of Your Life
 Ketosis and General Nutrition
 10 Significant Health Benefits of Low-Carb Ketogenic Diets:
http://authoritynutrition.com/10-benefits-of-low-carb-ketogenic-diets/
 Ketogenic diet helps weight loss, alzheimer’s, MS and starves cancer say experts
http://www.examiner.com/article/ketogenic-diet-aids-weight-loss-alzheimer-s-ms-
and-starves-cancer-say-experts
 Self Experiment in Nutritional Ketosis http://floriankugler.com/blog/2013/4/8/a-
self-experiment-with-nutritional-ketosis
 Ketones have therapeutic effects for diseases of substrate insufficiency or insulin
resistance: “The therapeutic implications of ketone bodies: the effects of ketone
bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin
resistance, and mitochondrial metabolism”
 Great Overall Resource on Ketosis
http://josepharcita.blogspot.com/2011/03/guide-to-ketosis.html
 Effects of ketogenic Mediterranean Diet with phytoextracts and low
carbohydrates/high protein meals on weight, cardiovascular risk factors, body
composition and diet compliance
http://www.ncbi.nlm.nih.gov/pubmed/21992535
 Low carbohydrate nutrition and metabolism
http://ajcn.nutrition.org/content/86/2/276.long
 Ketone Bodies: Potential Therapeutic Uses
http://onlinelibrary.wiley.com/store/10.1080/152165401753311780/asset/713803
796_ftp.pdf?v=1&t=idt8myef&s=e986e82c336ecca887627591430579c86b0383c
a

 Improves Physical Performance – Ketones plus Glucose provide superior energy
o NFL Linemen turn to ketogenic diet http://www.wsj.com/articles/nfl-linemen-
turn-to-all-fat-no-carb-diet-but-science-is-unclear-1440117028
 New ketone supplement all the rage in cycling
http://www.cyclingweekly.co.uk/news/latest-news/ketones-controversial-new-
energy-drink-next-big-thing-cycling-151877
 Enhanced Endurance in trained cyclists during moderate intensity exercise
following 2 weeks adaptation to a high fat diet
http://link.springer.com/article/10.1007/BF00392032


2. 2
o Ketogenic Diet Decreased body fat without Negative effects on Strength
Performance: “Ketogenic diet does not affect strength performance in elite artistic
gymnasts”
o No impaired endurance performance when in ketosis:
http://www.nutritionandmetabolism.com/content/1/1/2
http://eatingacademy.com/how-a-low-carb-diet-affected-my-athletic-performance
 Cognitive Improvement -
 Fatty acids as well as ketone bodies can be metabolized by the brain: “A ketone
ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while
decreasing food intake in the normal Wistar Rat”
 The Effects of Beta-Hydroxybutyrate on Cognition
http://www.ncbi.nlm.nih.gov/pubmed/15123336
 Dietary ketosis enhances memory in mild cognitive impairment
http://www.ncbi.nlm.nih.gov/pubmed/21130529/
 Increased plasma ketone bodies resulted in a corresponding reduction in cerebral
metabolic rates of glucose: http://www.ncbi.nlm.nih.gov/pubmed/23736643
 Under conditions of ketosis, glucose consumption is decreased in the cortex
and cerebellum: http://www.ncbi.nlm.nih.gov/pubmed/19227486
 Gluten free ketogenic diet with MCTs reverses autism and eliminates
seizures http://healthimpactnews.com/2013/gluten-free-ketogenic-diet-with-mcts-
reverses-autism-and-eliminates-seizures/

Multiple Sclerosis
 Doctor Reverses MS with Ketogenic Diet.
http://www.celebrityhealthfitness.com/29200/ketogenic-paleo-diet-
helps-physician-reverse-multiple-sclerosis-keto-also-fights-cancer/

 Ketogenic Diet helps Alzheimer, MS, and Fights Cancer
http://www.examiner.com/article/ketogenic-diet-aids-weight-loss-
alzheimer-s-ms-and-starves-cancer-say-experts

Epilepsy
 Epilepsy Foundation Web Site: Ketogenic Diet info:
http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/dietary-
therapies/ketogenic-diet

 Ketogenic Diet and other dietary treatments for Epilepsy
http://www.ncbi.nlm.nih.gov/pubmed/22419282
 Marked Seizure Reduction after MCT Supplementation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870649/
 NY Times: Epilepsy’s Big Fat Miracle
http://www.nytimes.com/2010/11/21/magazine/21Epilepsy-t.html?_r=0


3. 3
 Alzheimers Disease
 A new way to produce hyperketonemia: use of a ketone ester in a case of
Alzheimer’s http://www.ncbi.nlm.nih.gov/pubmed/25301680
 Ketosis Improves Cognitive Performance in Subjects with Alzheimer’s Disease:
“Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease:
a randomized, double-blind, placebo-controlled, multicenter trial”
 Effects of beta-hydroxybutyrate on cognition in memory impaired adults
http://www.ncbi.nlm.nih.gov/pubmed/15123336

 Neuroprotection for the Brain
 BRAIN, LIVIN’ ON KETONES – A MOLECULAR NEUROSCIENCE LOOK
AT THE KETOGENIC DIET “http://www.neurorexia.com/2013/03/24/brain-
livin-on-ketones-a-molecular-neuroscience-look-at-the-ketogenic-diet/
 Ketogenic Diet in Neuromuscular and Neurodegenerative diseases
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101992/

 Ketogenic Diet Provides Neuroprotective Effects Against Ischemic Stroke
Neuronal Damages http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312394/
 The mitochondrial permeability transition pore provides a key to the diagnosis
and treatment of traumatic brain injury
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272646/
 Ketone Bodies mediate antiseizure effects through mitochondrial permeability
transition http://onlinelibrary.wiley.com/doi/10.1002/ana.24424/abstract

 Neuroprotective and disease-modifying effects of the ketogenic diet
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/
 Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health
Outcomes in Military Personnel ( 2011 )
http://www.nap.edu/openbook.php?record_id=13121&page=140
 Clinical review: Ketones and brain injury http://ccforum.com/content/15/2/219
 Beneficial Effects of Ketosis on Neurological Disorders: “Therapeutic ketosis
with ketone ester delays central nervous system oxygen toxicity seizures in rats”
 Great information on how Ketones help a number of diseases
http://www.holistichelp.net/blog/what-is-ketosis-and-is-it-dangerous/

 Improving Insulin Insensitivity and Diabetes, Complications of Diabetes
 Treatment of diabetes and diabetic complications with a ketogenic diet
http://www.ncbi.nlm.nih.gov/pubmed/23680948
 Insulin Sensitivity and Glucose Tolerance Are Altered by Maintenance on a
Ketogenic Diet http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903931/
 Reversal of Diabetic Nephropathy by a ketogenic diet
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080383/


4. 4
 Ketogenic Diet Improves Insulin Sensitivity and Numerous Aging Markers
http://articles.mercola.com/sites/articles/archive/2014/02/02/ketogenic-diet-
health-
benefits.aspx?e_cid=20140202Z3_SNL_Art_1&utm_source=snl&utm_medium=
email&utm_content=art1&utm_campaign=20140202Z3&et_cid=DM39012&et_r
id=414716167
 Ketones have therapeutic effects for diseases of substrate insufficiency or insulin
resistance: “The therapeutic implications of ketone bodies: the effects of ketone
bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin
resistance, and mitochondrial metabolism”
 Long-term ketogenic diet reduces blood glucose:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/
 Improving Cellular Health and Longevity, Anti-aging
 Ketogenic Diet Could Delay the Effects of Aging
http://www.medindia.net/news/ketogenic-diet-could-delay-the-effects-of-aging-
111146-1.htm
 Scientists see a Ketogenic Diet for Aging and Longevity
http://longevitycentresofamerica.wordpress.com/2012/12/09/scientists-see-
potential-in-ketogenic-diet-for-aging-longevity/
 Ketosis cleans our cells http://www.proteinpower.com/drmike/ketones-and-
ketosis/ketosis-cleans-our-cells/
 Beta Hydroxybutyrate extends lifespan in C elegans.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169858/

 Weight Loss - Fat loss without muscle loss
 Mouse study identifies KE as a potential antiobesity supplement: “Mitochondrial
biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed
a ketone ester diet KE as a potential antiobesity supplement”
 Subjective Appetite Reduced on Ketogenic Diet: “Ketosis and appetite-mediating
nutrients and hormones after weight loss”
 Medium chain fatty acid acts in the liver to produce a signal that inhibits feeding
in rats: “Caprylic acid infusion acts in the liver to decrease food intake in rats”
 Ketogenic Diet Decreased body fat without Negative effects on Strength
Performance: “Ketogenic diet does not affect strength performance in elite artistic
gymnasts”
 Summary of the known central effects of BHBA: “Role of beta-hydroxybutyric
acid in the central regulation of energy balance”
Long-term ketogenic diet significantly reduced the body weight and body mass
index of the patients: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/
 Cancer Inhibiting – Cancer cells can’t live using ketones as a fuel source

5. 5
 http://www.naturalhealth365.com/stop_cancer/ketogenic_diet.html
 http://articles.mercola.com/sites/articles/archive/2013/03/10/ketogenic-diet.aspx
 Open access to Dr. D’Agostino’s recent study on Cancer: “The Ketogenic Diet
and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic
Metastatic Cancer”
 Ketogenic Diet and Cancer Benefits
 http://articles.mercola.com/sites/articles/archive/2013/06/16/ketogenic-diet-benefits.aspx
 Ketones and cancer: “What is the Origin of Cancer?”
 KetogenicDiet for Cancer-Clinical Trial http://coconutketones.blogspot.com/2013/01/ketogenic-diet-
for-cancer-clinical-trial.html
 Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric
oncology patients: two case reports.
http://www.ncbi.nlm.nih.gov/pubmed/7790697
