This exciting educational presentation shines light on the methylation cycle and discusses the role of nutrients as a clinical strategy. This event will be in a round table format including in-studio discussion surrounding the topics presented. In this round-table, Dino Celeda, Ph.D is accompanied by Amy Pieczarka, RD, LDN, CCN, CDE and Andrew Campbell, M.D.
Key Topics covered during this presentation:
• Learn about methylation and methylation potential
• Discover how methylation potential is correlated with neurotransmitter balance
• Learn the significance of the methionine and homocysteine ratio
• See how the MTHFR gene affects homocysteine balance
• Understand patient methylation with the Methyl Detox Profile
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Unlimited Counseling CEUs for $59 https://www.allceus.com/
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Live Webinars $5/hour https://www.allceus.com/live-interactive-webinars/
Patreon: https://www.patreon.com/CounselorToolbox
Pinterest: drsnipes
Provides a high-level overview of the main feel-good chemicals, practical and pharmacological ways to address chemical imbalances and how chemical imbalances can trigger a relapse.
It's about antiarrhythmic drugs, its mechanism, indications, contraindications, side effects and doses are also discussed. It's not possible to include all the details about antiarrhythmic drugs, but the general purpose will be served easily.
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Unlimited Counseling CEUs for $59 https://www.allceus.com/
Specialty Certificate tracks starting at $89 https://www.allceus.com/certificate-tracks/
Live Webinars $5/hour https://www.allceus.com/live-interactive-webinars/
Patreon: https://www.patreon.com/CounselorToolbox
Pinterest: drsnipes
Provides a high-level overview of the main feel-good chemicals, practical and pharmacological ways to address chemical imbalances and how chemical imbalances can trigger a relapse.
It's about antiarrhythmic drugs, its mechanism, indications, contraindications, side effects and doses are also discussed. It's not possible to include all the details about antiarrhythmic drugs, but the general purpose will be served easily.
Ramadan fasting is ritual for all muslims worldwide , where there is abstinace from eating , drinking and smoking from dawn to dusk , daily for one month, frequently , hypertensives asking about their fasting and medications during Ramadan, in the lecture , some focus on the effect of Ramadan on blood pressure , heart rate and other cardiovascular risk factors and lastly general instruction for hypertensives during Ramadan .
Slideshow is from the University of Michigan Medical
School's M2 Psychiatry sequence
View additional course materials on Open.Michigan: openmi.ch/med-M2Psych
Lecture 7 from a college level neuropharmacology course taught in the spring 2012 semester by Brian J. Piper, Ph.D. (psy391@gmail.com) at Willamette University.
Vortioxetine Brintellix Trintellix Clinical and Pre-clinical DataAmit Vishwakarma
Vortioxetine is indicated for the treatment of Major Depressive Disorder
Vortioxetine has several novel pharmacological properties
Vortioxetine is different from SSRIs/SNRIs due to direct effects at 5-HT receptors
In addition to being a SSRI, vortioxetine has modulating activity of a variety of serotonin receptors
Cognitive improvement is novel in series of antidepressant drugs
This Presentation Give You A brief Information About DPP4 And New Recommendations .This Presentation Guide You How To Treat Patients With Safety.
For Further Contact:03354999496
Event Details
This webinar will introduce the Advanced MethylDetox Profile, discuss the scientific underpinnings of methylation and detoxifications, and explain how this test can benefit your patients. Our speakers have a diverse range of backgrounds from research to clinical practice.
Key Learning Points
-Discover the critical genes in the methylation pathway
-Understand each gene’s role in patient methylation function
-See how the MethylDetox Profile can be used clinically
-Learn how to monitor treatment progress
Ramadan fasting is ritual for all muslims worldwide , where there is abstinace from eating , drinking and smoking from dawn to dusk , daily for one month, frequently , hypertensives asking about their fasting and medications during Ramadan, in the lecture , some focus on the effect of Ramadan on blood pressure , heart rate and other cardiovascular risk factors and lastly general instruction for hypertensives during Ramadan .
Slideshow is from the University of Michigan Medical
School's M2 Psychiatry sequence
View additional course materials on Open.Michigan: openmi.ch/med-M2Psych
Lecture 7 from a college level neuropharmacology course taught in the spring 2012 semester by Brian J. Piper, Ph.D. (psy391@gmail.com) at Willamette University.
Vortioxetine Brintellix Trintellix Clinical and Pre-clinical DataAmit Vishwakarma
Vortioxetine is indicated for the treatment of Major Depressive Disorder
Vortioxetine has several novel pharmacological properties
Vortioxetine is different from SSRIs/SNRIs due to direct effects at 5-HT receptors
In addition to being a SSRI, vortioxetine has modulating activity of a variety of serotonin receptors
Cognitive improvement is novel in series of antidepressant drugs
This Presentation Give You A brief Information About DPP4 And New Recommendations .This Presentation Guide You How To Treat Patients With Safety.
For Further Contact:03354999496
Event Details
This webinar will introduce the Advanced MethylDetox Profile, discuss the scientific underpinnings of methylation and detoxifications, and explain how this test can benefit your patients. Our speakers have a diverse range of backgrounds from research to clinical practice.
Key Learning Points
-Discover the critical genes in the methylation pathway
-Understand each gene’s role in patient methylation function
-See how the MethylDetox Profile can be used clinically
-Learn how to monitor treatment progress
DIYgenomics: an open platform for citizen scienceMelanie Swan
DIYgenomics (www.DIYgenomics.org) is a new platform bringing citizen scientists together to run peer cohort research studies and conduct novel research linking genetic data and physical biomarkers. Some norms are developing in response to the variety of community-based research issues that arise such as adaptive studies, informed consent, security, anonymity, and study design.
general information regarding single nucleotide polymorphism.
A Single Nucleotide Polymorphisms (SNP), pronounced “snip,” is a genetic variation when a single nucleotide (i.e., A, T, C, or G) is altered and kept through heredity.
3 Things Every Sales Team Needs to Be Thinking About in 2017Drift
Thinking about your sales team's goals for 2017? Drift's VP of Sales shares 3 things you can do to improve conversion rates and drive more revenue.
Read the full story on the Drift blog here: http://blog.drift.com/sales-team-tips
Epigenetics and it's relevance in crop improvementShamlyGupta
Epigenetics means ‘above’ or ‘on top of genetics’
A study of the changes in gene expression that are mitotically and/or meiotically heritable and do not involve a change in the DNA sequence
Gene-regulatory information that is not expressed in DNA sequences but transmitted from one generation (of cells or organisms) to the next
Coined by embryologist C. H. Waddington in 1942.
Personalized medicine involves the prescription of specific therapeutics best suited for an individual based on their genetic or proteomic profile. This talk discusses current approaches in drug discovery/development, the role of genetics in drug metabolism, and lawful/ethical issues surrounding the deployment of new health technology. I highlight some bioinformatic roles in the drug discovery process, and discuss the use of semantic web technologies for data integration and knowledge discovery..
genetic polymorphism new Presentation.pptxRumaMandal5
Genetic polymorphism was formerly applied to variants occurring at a frequency greater than 1%.
Types: SNPs,Insertions or deletions
Pharmacokinetic variations and pharmacodynamics variations
Application on G6PD deficiency
Fundamentals Of Genetic Toxicology In The Pharmaceutical Industry Sept 2010TigerTox
Historical and current perspectives on genetic toxicology, with commentary and slides on assay predictivity and shortcomings, regulatory guidance, and high-throughput screens to enhance preclinical drug safety.
Drug metabolite impurities, pathways and analytical techniquesVeeprho Laboratories
Metabolites:
Metabolites are the intermediate products of metabolic reactions catalysed by various enzymes that naturally occur within cells. The term metabolite is usually used for small molecules.
Metabolites forms may be integral or pharmacological and formed during natural biochemical process of degrading and eliminating the compounds from chemical compounds. It is important to know that how the drug products are metabolised and what are its probable side effects. e.g. Sugars are metabolites into fructose or glucose, which are both present in the metabolic pathways.
Regulatory Guidance documents ICH Q3A (R2) and ICH Q3B (R2) state that "impurities that are also significant metabolites present in animal and/or human studies are generally considered qualified". But no guidance is provided regarding data requirements for qualification.
Genetic polymorphisms are variations in gene sequences that occur in at least 1% of the general population, resulting in multiple alleles or variants of a gene sequence.
The most commonly occurring form of genetic variability is the single nucleotide polymorphism (SNP, often called “snip”)
Similar to Understanding Methylation, Gene Regulation and the MethylDetox Profile (20)
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. As Always…
Tonight’s discussion does not take into consideration
your patient’s medical history, drug/supplement
interactions and/or allergies/sensitivities. It is the
responsibility of the practitioner to determine
appropriate supplement and dosing choices for each
patient.
3. About the Commentators
Amy Pieczarka, RD,LDN,CCN,CDE
Director of Nutrition Services
PreviMedica
Andrew W. Campbell, M.D.
Medical Advisor
Cell Science Systems
4. About the Speaker
• Friedrich Schiller Universitaet – Heidelberg, Germany
• Institut National de La Recherche Agronomique - France
• Krankenhaus Harlaching -Germany
Dr. Dino Celeda holds a Ph.D in Biology specialized in
Human Genetics from the Ruprecht Karls Universitaet,
Heidelberg, Germany. He completed his training and held
positions at many renowned institutions including:
Dr. Celeda has authored numerous publications in the field of Human Genetics. Included in
his experience are Senior R&D, Scientific Advisor, Director of Genetic Testing and Director of
Science positions.
Dr. rer. nat. Dino Celeda (Ph.D)
Scientific Officer
7. Genetic Polymorphism (SNP)
A SNP can lead to a change in protein sequence and thus influence the 3-D conformation. In
the example here, the SNP disrupts hemoglobin formation and causes sickle cell anemia.
8. Functional Genetic Test Results
The individual’s functional genetic test results are shown on a level
of functionality and/or expression of the corresponding enzyme.
• homozygous positive, -;-, both alleles from both parents show
mutation. Reduced function/expression.
• heterozygous +;-, one allele from one parent shows mutation,
the other allele shows the normal, wild-type. 50% of the genes
are normal
• homozygous negative +;+, both alleles from both parents have
no mutation and show the normal, wild type. 100% of the genes
are normal.
9. Genomic Insights TM
– TEST
Individual’s current status: testing of relevant SNPs and
corresponding metabolic markers in blood
– TARGET
Targeted intervention: personalized, specific supplementation
according to individual results of relevant of SNPs, and
corresponding metabolic markers in blood
– MONITOR
Individual progress: monitoring and maintaining the progress
of personalized, specific supplementation with measurement
of metabolic markers in blood
Applying Functional Genetics for targeted intervention by
personalized, specific supplementation
10. Genomic Insights TM
Importance of personalized targeted nutrition
Overload of Supplements
can impact metabolic process and lead to side effects.
Individual Genetic SNPs
may require personalized supplementation of specific vitamins, minerals, trace elements and
/or amino acids for the maintenance and optimization of metabolic processes.
Side Effects
can influence a variety of functions in the organism like immune responses (reduced NK-
cytotoxicity).
11. Genes in the Methionine/Homocysteine Cycle
• MTHFR (Methylenetetrahydrofolate reductase)
C677T and A1298C mutations in the MTHFR gene are known to cause a diminished methylation
capacity, by a reduction in 5-MethylTHF synthesis.
• Methionine synthase (MS)
MS is encoded by the 5-methyltetrahydrofolate-homocysteine-methyltransferase gene (MTR). Its task
is to generate methionine from homocysteine by using methylcobalamin (methylated vitamin B12)
obtained when 5-MethylTHF donates its methyl group to vitamin B12. The mutation at position
C3518T in the gene is described with a reduced activity of the resulting enzyme.
• COMT (Catechol-O-Methyltransferase)
COMT is responsible for the transfer of the methyl group from SAMe to specific substances (e.g.
catecholamines) for removal. COMT is also involved in drug metabolism/clearance, neurotransmitter
regulation, gene expression as well as in the detoxification of a variety of environmental toxins.
The mutations at position G472A (Val108/158Met) and G304A (Ala52/102Thr) are described with a
reduced activity of the resulting enzyme.
31. Pre-Webinar Survey Questions
• What would be a ‘red flag’ for a practitioner to prompt the ordering of the
Methyl Detox Profile?
• How do you know when someone is under or over methylating?
• Does someone with a SNP require lifelong supplementation?
• How does the SAD vs. Paleo diet affect this?
• How does one decide which methylating supplement to use?
• How do I specifically use the MTHFR results on pharmacogenomics
testing to help mental health patients?