This document discusses multi-armed bandit algorithms like Upper Confidence Bound (UCB) for balancing exploration and exploitation. UCB works by selecting the option with the highest measured reward rate plus a confidence interval based on the number of impressions to encourage exploration of seemingly suboptimal options. The document provides formulas for UCB and discusses how it can be used for both exploration and exploitation in multi-armed bandit problems like A/B testing multiple options to learn their unknown payoff rates.
Multi-armed bandit queen" is likely a playful twist on the term "multi-armed bandit problem." The multi-armed bandit problem is a classic dilemma in probability theory and decision-making. It's named after a hypothetical scenario where a gambler faces multiple slot machines (bandits) with different payout probabilities and must decide which machines to play in order to maximize their total reward over time
Combining UCT and Constraint Satisfaction Problems for MinesweeperOlivier Teytaud
@inproceedings{buffet:hal-00750577,
hal_id = {hal-00750577},
url = {http://hal.inria.fr/hal-00750577},
title = {{Optimistic Heuristics for MineSweeper}},
author = {Buffet, Olivier and Lee, Chang-Shing and Lin, Woanting and Teytaud, Olivier},
abstract = {{We present a combination of Upper Con dence Tree (UCT) and domain speci c solvers, aimed at improving the behavior of UCT for long term aspects of a problem. Results improve the state of the art, combining top performance on small boards (where UCT is the state of the art) and on big boards (where variants of CSP rule).}},
language = {Anglais},
affiliation = {MAIA - INRIA Nancy - Grand Est / LORIA , Department of Computer Science and Information Engineering - CSIE , National University of Tainan - NUTN , TAO - INRIA Saclay - Ile de France , Laboratoire de Recherche en Informatique - LRI , Department of Electrical Engineering and Computer Science - Institut Montefiore},
booktitle = {{International Computer Symposium}},
address = {Hualien, Ta{\"\i}wan, Province De Chine},
audience = {internationale },
year = {2012},
pdf = {http://hal.inria.fr/hal-00750577/PDF/mines3.pdf},
}
Multi-armed bandit queen" is likely a playful twist on the term "multi-armed bandit problem." The multi-armed bandit problem is a classic dilemma in probability theory and decision-making. It's named after a hypothetical scenario where a gambler faces multiple slot machines (bandits) with different payout probabilities and must decide which machines to play in order to maximize their total reward over time
Combining UCT and Constraint Satisfaction Problems for MinesweeperOlivier Teytaud
@inproceedings{buffet:hal-00750577,
hal_id = {hal-00750577},
url = {http://hal.inria.fr/hal-00750577},
title = {{Optimistic Heuristics for MineSweeper}},
author = {Buffet, Olivier and Lee, Chang-Shing and Lin, Woanting and Teytaud, Olivier},
abstract = {{We present a combination of Upper Con dence Tree (UCT) and domain speci c solvers, aimed at improving the behavior of UCT for long term aspects of a problem. Results improve the state of the art, combining top performance on small boards (where UCT is the state of the art) and on big boards (where variants of CSP rule).}},
language = {Anglais},
affiliation = {MAIA - INRIA Nancy - Grand Est / LORIA , Department of Computer Science and Information Engineering - CSIE , National University of Tainan - NUTN , TAO - INRIA Saclay - Ile de France , Laboratoire de Recherche en Informatique - LRI , Department of Electrical Engineering and Computer Science - Institut Montefiore},
booktitle = {{International Computer Symposium}},
address = {Hualien, Ta{\"\i}wan, Province De Chine},
audience = {internationale },
year = {2012},
pdf = {http://hal.inria.fr/hal-00750577/PDF/mines3.pdf},
}
Scott Clark, Software Engineer, Yelp at MLconf SFMLconf
Abstract: Introducing the Metric Optimization Engine (MOE); an open source, black box, Bayesian Global Optimization engine for optimal experimental design.
In this talk we will introduce MOE, the Metric Optimization Engine. MOE is an efficient way to optimize a system’s parameters, when evaluating parameters is time-consuming or expensive. It can be used to help tackle a myriad of problems including optimizing a system’s click-through or conversion rate via A/B testing, tuning parameters of a machine learning prediction method or expensive batch job, designing an engineering system or finding the optimal parameters of a real-world experiment.
MOE is ideal for problems in which the optimization problem’s objective function is a black box, not necessarily convex or concave, derivatives are unavailable, and we seek a global optimum, rather than just a local one. This ability to handle black-box objective functions allows us to use MOE to optimize nearly any system, without requiring any internal knowledge or access. To use MOE, we simply need to specify some objective function, some set of parameters, and any historical data we may have from previous evaluations of the objective function. MOE then finds the set of parameters that maximize (or minimize) the objective function, while evaluating the objective function as few times as possible. This is done internally using Bayesian Global Optimization on a Gaussian Process model of the underlying system and finding the points of highest Expected Improvement to sample next. MOE provides easy to use Python, C++, CUDA and REST interfaces to accomplish these goals and is fully open source. We will present the motivation and background, discuss the implementation and give real-world examples.
Abstract:
In this talk we will introduce MOE, the Metric Optimization Engine. MOE is an efficient way to optimize a system's parameters, when evaluating parameters is time-consuming or expensive. It can be used to help tackle a myriad of problems including optimizing a system's click-through or conversion rate via A/B testing, tuning parameters of a machine learning prediction method or expensive batch job, designing an engineering system or finding the optimal parameters of a real-world experiment.
MOE is ideal for problems in which the optimization problem's objective function is a black box, not necessarily convex or concave, derivatives are unavailable, and we seek a global optimum, rather than just a local one. This ability to handle black-box objective functions allows us to use MOE to optimize nearly any system, without requiring any internal knowledge or access. To use MOE, we simply need to specify some objective function, some set of parameters, and any historical data we may have from previous evaluations of the objective function. MOE then finds the set of parameters that maximize (or minimize) the objective function, while evaluating the objective function as few times as possible. This is done internally using Bayesian Global Optimization on a Gaussian Process model of the underlying system and finding the points of highest Expected Improvement to sample next. MOE provides easy to use Python, C++, CUDA and REST interfaces to accomplish these goals and is fully open source. We will present the motivation and background, discuss the implementation and give real-world examples.
Scott Clark Bio:
After finishing my PhD in Applied Mathematics at Cornell University in 2012 I have been working on the Ad Targeting team at Yelp Inc. I've been employing a variety of machine learning and optimization techniques from multi-armed bandits to Bayesian Global Optimization and beyond to their vast dataset and problems. I have also been trying to lead the charge on academic research and outreach within Yelp by leading projects like the Yelp Dataset Challenge and open sourcing MOE.
Raimundo Soto - Catholic University of Chile
ERF Training on Advanced Panel Data Techniques Applied to Economic Modelling
29 -31 October, 2018
Cairo, Egypt
2022/10/30 BESC2022: Parameter Tuning Method for Multi-agent Simulation using...Masanori HIRANO
Masanori HIRANO, Kiyoshi IZUMI,
“Parameter Tuning Method for Multi-agent Simulation using Reinforcement Learning,”
The 9th International Conference on Behavioral and Social Computing (BESC 2022), Matsuyama, Ehime, Japan, Oct. 30th, 2022.
Permutations and Combinations IIT JEE+Olympiad Lecture 1 Parth Nandedkar
Follows JEE Advanced syllabus, covering these topics:
Goal of the chapter,
The basic logic of counting,
Visual demonstrations of counting using Graphs,
Counting and Mathematical Logic,
Combinations as stacked ANDs,
Sequences of Alphabets,
Concept of Causal Independence,
Permutations as stacked ORs,
Permutations of Distinguishable objects,
Permutations of Indistinguishable objects,
Problem Session
Scott Clark, Software Engineer, Yelp at MLconf SFMLconf
Abstract: Introducing the Metric Optimization Engine (MOE); an open source, black box, Bayesian Global Optimization engine for optimal experimental design.
In this talk we will introduce MOE, the Metric Optimization Engine. MOE is an efficient way to optimize a system’s parameters, when evaluating parameters is time-consuming or expensive. It can be used to help tackle a myriad of problems including optimizing a system’s click-through or conversion rate via A/B testing, tuning parameters of a machine learning prediction method or expensive batch job, designing an engineering system or finding the optimal parameters of a real-world experiment.
MOE is ideal for problems in which the optimization problem’s objective function is a black box, not necessarily convex or concave, derivatives are unavailable, and we seek a global optimum, rather than just a local one. This ability to handle black-box objective functions allows us to use MOE to optimize nearly any system, without requiring any internal knowledge or access. To use MOE, we simply need to specify some objective function, some set of parameters, and any historical data we may have from previous evaluations of the objective function. MOE then finds the set of parameters that maximize (or minimize) the objective function, while evaluating the objective function as few times as possible. This is done internally using Bayesian Global Optimization on a Gaussian Process model of the underlying system and finding the points of highest Expected Improvement to sample next. MOE provides easy to use Python, C++, CUDA and REST interfaces to accomplish these goals and is fully open source. We will present the motivation and background, discuss the implementation and give real-world examples.
Abstract:
In this talk we will introduce MOE, the Metric Optimization Engine. MOE is an efficient way to optimize a system's parameters, when evaluating parameters is time-consuming or expensive. It can be used to help tackle a myriad of problems including optimizing a system's click-through or conversion rate via A/B testing, tuning parameters of a machine learning prediction method or expensive batch job, designing an engineering system or finding the optimal parameters of a real-world experiment.
MOE is ideal for problems in which the optimization problem's objective function is a black box, not necessarily convex or concave, derivatives are unavailable, and we seek a global optimum, rather than just a local one. This ability to handle black-box objective functions allows us to use MOE to optimize nearly any system, without requiring any internal knowledge or access. To use MOE, we simply need to specify some objective function, some set of parameters, and any historical data we may have from previous evaluations of the objective function. MOE then finds the set of parameters that maximize (or minimize) the objective function, while evaluating the objective function as few times as possible. This is done internally using Bayesian Global Optimization on a Gaussian Process model of the underlying system and finding the points of highest Expected Improvement to sample next. MOE provides easy to use Python, C++, CUDA and REST interfaces to accomplish these goals and is fully open source. We will present the motivation and background, discuss the implementation and give real-world examples.
Scott Clark Bio:
After finishing my PhD in Applied Mathematics at Cornell University in 2012 I have been working on the Ad Targeting team at Yelp Inc. I've been employing a variety of machine learning and optimization techniques from multi-armed bandits to Bayesian Global Optimization and beyond to their vast dataset and problems. I have also been trying to lead the charge on academic research and outreach within Yelp by leading projects like the Yelp Dataset Challenge and open sourcing MOE.
Raimundo Soto - Catholic University of Chile
ERF Training on Advanced Panel Data Techniques Applied to Economic Modelling
29 -31 October, 2018
Cairo, Egypt
2022/10/30 BESC2022: Parameter Tuning Method for Multi-agent Simulation using...Masanori HIRANO
Masanori HIRANO, Kiyoshi IZUMI,
“Parameter Tuning Method for Multi-agent Simulation using Reinforcement Learning,”
The 9th International Conference on Behavioral and Social Computing (BESC 2022), Matsuyama, Ehime, Japan, Oct. 30th, 2022.
Permutations and Combinations IIT JEE+Olympiad Lecture 1 Parth Nandedkar
Follows JEE Advanced syllabus, covering these topics:
Goal of the chapter,
The basic logic of counting,
Visual demonstrations of counting using Graphs,
Counting and Mathematical Logic,
Combinations as stacked ANDs,
Sequences of Alphabets,
Concept of Causal Independence,
Permutations as stacked ORs,
Permutations of Distinguishable objects,
Permutations of Indistinguishable objects,
Problem Session
I am using DL & Actor critic tools for solving Variational inference problem. The intriguing part from my hand is that the likelihood has a Beta distribution.Thus we handle both VI issues and a non common distributions
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. Challenge Description
• RL –serves the option that aims to maximize the reward
(e.g. if we measure clicks we wish to serve the option that will to be
clicked with the biggest probability )
Problem: After a certain duration there is a stronger option that will
always be served.
4. Multi –Armed Bandit (bandit)
• The problem :
Consider a casino with many slot machines. Each with a certain
unknown pay-out rates (e.g. 0.6 ,0.3, 0.4).
We aim to maximize our reward, hence we should learn the rates.
Exploration – We explore over the payouts
Exploitation – We assume that we have learned and we take the optimal
Q: How to balance between Exploration & Exploitation ?
Bandit algorithms verify that exploration will always take place
5. Bandit (Cont.)
• We can do A/B testing
1. Consider K machines
2. Play each of them randomly and measure the reward
3. Take the best measured rate.
• We can do UCB
• Impressions
• Responses (Positive responses)
• Opportunities
6. UCB – How does it work?
• We measure the pay-out rate of each option as in A/B
• Rather taking the biggest rate we take the rate+std
• It can be used as exploration mechanism (We follow this mechanism)
• It can be used in exploitation (explore and while exploiting using this
mechanism)
9. Chernoff Hoefding (cont)
• For UCB needs we take :
• ε = 2log(t) /s where t is the amount of samples and s the amount of
impressions for a single arm .
• With some manipulations we get
• P(µi + 2log(t) /s ≤ µi) ≤ exp(-4log(t)) =-𝑡4
10. Formulas
• UCB= P +sqrt( (1-p) * p /impressions)
• Auer improvement
UCB =P +sqrt((1-p)*P*log(opportunities) /impressions))
• Next improvement
• UCB = P +sqrt((1-p)*P*log(opportunities) /impressions)) +log(opportunities
)/impressions -
• Note that this correction term may go to infinity thus we have a window,
• Further reading – Chernoff/Hoeffding inequality
11. Where it is used?
• In Causata’s engine –Exploration and solely exploration
• One can use the current exploration mechanism and use UCB as
exploitation (i.e. rather taking the best mean take the best UCB)