This document discusses tumor dormancy and mechanisms by which cancer cells can evade immune detection and elimination. It describes how some cancer cells enter a dormant state after disseminating from primary tumors and residing long-term in bone marrow niches without proliferating. These dormant disseminated tumor cells can later reactivate and form metastases. The document also outlines a mouse model using E0771 breast cancer cells expressing a model antigen (ovalbumin) to study interactions between dormant tumor cells in bone marrow and antigen-specific T cells, with the goal of developing non-toxic therapies to eliminate dormant tumor cells or prevent their outgrowth into metastases.