Tumor antigens are substances produced by tumor cells that can be used to identify specific tumors. There are two main types of tumor antigens: tumor specific transplantation antigens that are unique to cancer cells and mediate immune responses; and tumor associated transplantation antigens that are expressed in fetal and some adult cells but can be reactivated in tumors through oncofetal proteins. Tumor antigens are useful markers because certain types are abundantly expressed in different tumors.

1. Tumor antigen and its types
Submitted by
G.Janani
B841008

2. Definition and Types
• It is an antigenic substance produced in tumor
cells.
• Tumor antigens, because of their relative
abundance in tumor cells are useful in identifying
specific tumor cells. Certain tumors have certain
tumor antigens in abundance.
• Types
1)Tumor specific transplantation antigen(TSTA)
2)Tumor associated transplantation antigen(TATA)

4. TSTA
• Unique to cancer cells.
• It mediates cell mediated immune response.

5. TATA
• These are expressed in fetal cells and not
unique to tumor cells.
• Not mostly seen in adults but its reactivation
of oncofetal proteins express the TATA.

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