This document summarizes information about Trypanosoma parasites and the diseases they cause. It discusses:
1) Trypanosoma brucei, which causes sleeping sickness in humans, and exists as two subspecies transmitted by tsetse flies. 2) The life cycles of T. brucei within the tsetse fly and human host. 3) Signs and symptoms of sleeping sickness in humans, which can develop over many years and lead to death if untreated. 4) Trypanosoma cruzi, which causes Chagas disease and is transmitted by triatomine bugs in Central and South America.
This is the presentation on Trypanosomiasis that covers classification and diseases caused by Trypanosoma, its life cycle, Geographical distribution, Transmission, diagnosis and treatment and finally its scenario in India.
Some flow charts have been taken from published articles, that can be searched directly from net.
This is the presentation on Trypanosomiasis that covers classification and diseases caused by Trypanosoma, its life cycle, Geographical distribution, Transmission, diagnosis and treatment and finally its scenario in India.
Some flow charts have been taken from published articles, that can be searched directly from net.
What is toxoplasmosis? Toxoplasmosis is an infection caused by a single-celled parasite called Toxoplasma gondii. While the parasite is found throughout the world, more than 40 million people in the United States may be infected with the Toxoplasma parasite.
Leishmaniasis is caused by a protozoa parasite from over 20 Leishmania species. Over 90 sandfly species are known to transmit Leishmania parasites. There are 3 main forms of the disease:
Visceral leishmaniasis (VL), also known as kala-azar is fatal if left untreated in over 95% of cases. It is characterized by irregular bouts of fever, weight loss, enlargement of the spleen and liver, and anaemia. Most cases occur in Brazil, East Africa and in South-East Asia. An estimated 50 000 to 90 000 new cases of VL occur worldwide each year out of which only an estimated 25–45% are reported to WHO. In 2017, more than 95% of new cases reported to WHO occurred in 10 countries: Bangladesh, Brazil, China, Ethiopia, India, Kenya, Nepal, Somalia, South Sudan and Sudan.
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and causes skin lesions, mainly ulcers, on exposed parts of the body, leaving life-long scars and serious disability or stigma. About 95% of CL cases occur in the Americas, the Mediterranean basin, the Middle East and Central Asia. In 2017 over 95% of new CL cases occurred in 6 countries: Afghanistan, Algeria, Brazil, Colombia, Iran (Islamic Republic of), Iraq and the Syrian Arab Republic. It is estimated that between 600 000 to 1 million new cases occur worldwide annually.
Mucocutaneous leishmaniasis leads to partial or total destruction of mucous membranes of the nose, mouth and throat. Over 90% of mucocutaneous leishmaniasis cases occur in Bolivia (the Plurinational State of), Brazil, Ethiopia and Peru.
Transmission
Leishmania parasites are transmitted through the bites of infected female phlebotomine sandflies, which feed on blood to produce eggs. The epidemiology of leishmaniasis depends on the characteristics of the parasite and sandfly species, the local ecological characteristics of the transmission sites, current and past exposure of the human population to the parasite, and human behaviour. Some 70 animal species, including humans, have been found as natural reservoir hosts of Leishmania parasites.
(WHO, 2019)
https://www.who.int/news-room/fact-sheets/detail/leishmaniasis
What is toxoplasmosis? Toxoplasmosis is an infection caused by a single-celled parasite called Toxoplasma gondii. While the parasite is found throughout the world, more than 40 million people in the United States may be infected with the Toxoplasma parasite.
Leishmaniasis is caused by a protozoa parasite from over 20 Leishmania species. Over 90 sandfly species are known to transmit Leishmania parasites. There are 3 main forms of the disease:
Visceral leishmaniasis (VL), also known as kala-azar is fatal if left untreated in over 95% of cases. It is characterized by irregular bouts of fever, weight loss, enlargement of the spleen and liver, and anaemia. Most cases occur in Brazil, East Africa and in South-East Asia. An estimated 50 000 to 90 000 new cases of VL occur worldwide each year out of which only an estimated 25–45% are reported to WHO. In 2017, more than 95% of new cases reported to WHO occurred in 10 countries: Bangladesh, Brazil, China, Ethiopia, India, Kenya, Nepal, Somalia, South Sudan and Sudan.
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and causes skin lesions, mainly ulcers, on exposed parts of the body, leaving life-long scars and serious disability or stigma. About 95% of CL cases occur in the Americas, the Mediterranean basin, the Middle East and Central Asia. In 2017 over 95% of new CL cases occurred in 6 countries: Afghanistan, Algeria, Brazil, Colombia, Iran (Islamic Republic of), Iraq and the Syrian Arab Republic. It is estimated that between 600 000 to 1 million new cases occur worldwide annually.
Mucocutaneous leishmaniasis leads to partial or total destruction of mucous membranes of the nose, mouth and throat. Over 90% of mucocutaneous leishmaniasis cases occur in Bolivia (the Plurinational State of), Brazil, Ethiopia and Peru.
Transmission
Leishmania parasites are transmitted through the bites of infected female phlebotomine sandflies, which feed on blood to produce eggs. The epidemiology of leishmaniasis depends on the characteristics of the parasite and sandfly species, the local ecological characteristics of the transmission sites, current and past exposure of the human population to the parasite, and human behaviour. Some 70 animal species, including humans, have been found as natural reservoir hosts of Leishmania parasites.
(WHO, 2019)
https://www.who.int/news-room/fact-sheets/detail/leishmaniasis
Common Systemic Protozoan Diseases.pptxOsmanHassan35
Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Introduction
Trypanosoma is flagellated pathogenic parasite
Caues fatal disease in humens and and animals.
The process of disease causing known as
trypanosomiasis.
It has digentic life cycle
1. In blood of veterbrates
2. In alimentary canal of invertebrates.
2
3. HAT
• Human African trypanosomiasis (HAT), also called
sleeping sickness.
• It is caused by the flagellate protozoan Trypanosoma
brucei
• which exists in 2 morphologically identical subspecies:
1. Trypanosoma brucei rhodesiense (East African
trypanosomiasis)
2. Trypanosoma brucei gambiense (West African or
Gambian African trypanosomiasis).
• Both of these parasites are transmitted to human hosts by
bites of infected tsetse flies
3
4. Life cycle
The trypanosomes multiply over a period of 2-3 weeks
in the fly midgut then the trypanosomes migrate
to the salivary gland, where they develop into
epimastigotes. The metacyclic trypomastigotes infect
humans
Epimastigote is a stage in the life cycle of certain
trypanosomatids wherein the unicellular organism has
a flagellum along the length of its cell body
Trypomastigote A stage in unicellular life-cycle,
typically trypanosomes, where the flagellum is
posterior of the nucleus, and connected to the cell
body by a long undulating membrane.
4
6. SIGN AND SYMPTOMS
In humans the tsetse fly bite erupts into a red sore and
within a few weeks the person can : Fever
Swollen lymph glands
Aching muscles and joints
Headaches
irritability
Slurred speech
Seizures and difficulty in walking and talking
These problems can develop over many years and if not
treated
• “Leading over many years to death”
6
8. IN ANIMALS SIGNS
Cattle may show enlarged lymph nodes and internal
organs.
Hemolytic anemia is a characteristic sign.
Systemic and reproductive disease are common in
cattle and appear to waste away.
Horses with dourine show signs of ventral and genital
edema and urticaria.
Infected dogs and cats may show severe systemic
signs.(fever, Red urine)
8
9. PREVENTION AND TREATMENT
Preventive measures are aimed at minimizing contact
with tsetse flies.
Diminazene
Homidium
9
10. DX
Parasites can easily be found in blood.
They can also be found in lymph node fluid or in fluid
or biopsy of a chancre.
Serologic testing is not widely available and is not used
in the diagnosis, since microscopic detection of the
parasite is straight forward.
10
12. Chagas disease is caused by the parasite Trypanosoma
cruzi.
Infection is most commonly acquired through contact
with the feces of an infected triatomine bug (or "kissing
bug"), a blood-sucking insect that feeds on humans and
animals.
infection can also occur from:
mother-to-baby (congenital),
contaminated blood products (transfusions),
an organ transplanted from an infected donor,
laboratory accident, or
contaminated food or drink (rare)
12
13. Epidemiology
Chagas disease is endemic throughout much of
Mexico, Central America, and South America
The triatomine bug thrives under poor housing
conditions (for example, mud walls, thatched roofs) so
people living in rural areas are at greatest risk for
acquiring infection
13
14. Life Cycle
The protozoan parasite, Trypanosoma cruzi, a
zoonotic disease that can be transmitted to humans by
blood-sucking triatomine bugs.
14
15. Disease
Chagas disease has an acute and chronic phase. If
untreated, infection is lifelong.
Acute Chagas disease occurs immediately after
infection
may last up to a few weeks or months
parasites may be found in the circulating blood.
Infection may be mild or asymptomatic.
There may be fever or swelling around the site of
inoculation.
Acute infection may result in severe inflammation of
the heart muscle or the brain and lining around the
brain.
15
16. Laboratory Diagnosis
It almost always yields positive results, and can be achieved by:
Microscopic examination:
1. of fresh anticoagulated blood, or its buffy coat, for motile
parasites;
2. thin and thick blood smears stained with Giemsa, for
visualization of parasites.
Isolation of the agent:
1. inoculation in culture with specialized media (e.g. NNN, LIT)
2. inoculation into mice
3. c) xenodiagnosis, where uninfected triatomine bugs are fed on
the patient's blood, and their gut contents examined for
parasites 4 weeks later.
16
17. Durgs
The two drugs used to treat infection with
Trypanosoma cruzi are
nifurtimox
benznidazole.
17
18. Dosage and durationAge groupDrug
10 mg/kg per day orally in 2
divided doses for 60 days.
5-7 mg/kg per day orally in 2
divided doses for 60 days
< 12 years
12 years or older
Benznidazole
15-20 mg/kg per day orally in
3 or 4 divided doses for 90
days
12.5-15 mg/kg per day orally
in 3 or 4 divided doses for 90
days
8-10 mg/kg per day orally in
3 or 4 divided doses for 90
days
≤ 10 years
11-16 years
17 years or older
Nifurtimox
18