The document describes a transgenic mouse that was engineered to express the Par-4 gene, which causes cancer cells to self-destruct while leaving normal cells unharmed. The gene was implanted into mouse eggs and expressed in the offspring mice, which grew normally and lived longer than mice without the gene. This cancer-resistant mouse could provide insights toward developing safer human cancer treatments.

1. Transgenic
Organisms:
Cancer-
Resistant Mouse
By: Kari Watts

2. What is a transgenic organism?
An organism whose genome has been
improved by introduction of new DNA from a
different organism.

3. How Does It Work?
In this case, the gene Par-4 was
implanted into mouse eggs, then put in the
surrogate mother. The mother had offspring,
and the offspring expressed the gene. Par-4
causes cells to self-destruct when they are
cancerous. It will not kill normal cells. This
gene is expressed in all cell types.

4. What Does It Contribute To
Science?
 We can hopefully find a cure for all cancer
types in humans.
 A treatment for cancer in humans is
possible.
 This experiment
could be vital to
the development
of safer
treatments for
cancer.

5. Advantages
 As of now, there are no harmful side
effects.
 The mice tested grew normally and lived
longer than mice without the gene.
 The gene is expressed in all cell types.
 Doesn’t kill normal cells;
only cancer cells.

6. Disadvantages
 Thegene could react
differently in humans
and potentially be
harmful.

7. Ethical Concerns
 Messes with nature.
 Could cause stress for the mouse.

8. Future Implication
In the future, the Par-4 molecule could
be transplanted through the bone marrow of
humans. Par-4 could potentially be used to
fight cancer instead of using chemotherapy or
radiation therapy.