Translational research aims to improve healthcare by translating scientific findings into clinical practice and policy. It involves multiple stages: from basic research to clinical trials to implementation in communities and policy development. Nurse-led translational research can help advance the role of nurses globally by applying evidence-based practices universally. It requires collaboration between researchers and clinicians to effectively incorporate new knowledge into care decisions and speed adoption of best practices. Initiatives to improve translational research include increased research funding and partnerships between healthcare organizations and research institutions.

1. By,
Dr. Chakrapani Chaturvedi
Associate Professor
Faculty of Nursing
Banasthali Vidyapith University (NAAC- A++)
Rajasthan, India

3. Making evidenced based practices
universal : translational research

4. What is translational research ?
• Translational research is the process of transforming knowledge from
fundamental research to large-scale clinical trials, followed by policy
development for tested data and its incorporation into evidence-
based guidelines for caregivers.

5. Goal of
translational
research
• Translational research aims to improve the long-
term viability of high-quality living. Nurse-led
Translational research can upgrade position,
image of research Nurse and Nurse Scientist
(Kathleen Potempa, 2012; Kathleen T. Hickey,
2018) globally in developing countries.
• The goal of "translational research," a rapidly
growing field of study, is to apply scientific
findings to clinical practice.

6. Need of
translational
research
Basic research investigations in healthcare
science aid in advancing more profound
discoveries about both health and disease
mechanisms.
Numerous evidence-based studies have been
conducted to date, but many remain
unincorporated into healthcare policy
(Krishnasamy M) .
basic research alone is ineffective and has no
discernible impact (Padilha, 2011).

7. Need of
translational
research
The Journal of the American Medical Association (JAMA, 2003) addressed translational research for the
first time,
emphasizing the need to translate new knowledge, mechanisms, and techniques generated toward
advancing basic research to offer new possibilities for disease prevention, diagnosis, and treatment.
Many studies have been tried out in developed countries, and these projects have underlined the necessity
of connecting nurse scientists in academic settings with nurses in practice to speed the utilization of
research findings in directing nursing care decisions (MG, The Evidence for Evidence-Based Practice
Implementation., 2008 )
. In hospitals, clinical nurses will usually do single-hospital research studies that are limited in scope, have
small sample sizes, and lack s
cientific rigour (Curtis, 2017)

8. Need of translational research
• The path to this professional advancement begins with a Research
Nurse at the entry level with minimum of B.Sc. Nursing degree and
progresses to a Nurse Scientist with a PhD and post-doctoral degree
(Kathleen T. Hickey, 2018).
• The intention is to construct a bridge that connects the research
laboratory benches with the bedside to achieve this goal (MG, 2007).
• In this way, it brings together a diverse group of scholars who are
working together to improve the quality of life and longevity of
communities.

9. Terminology differences in evidence based and
translational research
The transition from primary to translational nursing research can
be explained by a shift in terminology: "research utilization" in the
1980s, "EBP" in the 1990s, and "translation" after 2000 (Titler,
2018).
Incorporating evidence-based practise (EBP) projects with rigorous
translational research can help organisations.

10. Terminologies
• Translation science, often known as effectiveness science, is an emerging
study in science (Potempa K, 2012).
• To promote and sustain the adoption of evidence-based practices,
collaborative efforts are required in intervention testing (EBPs) which can
be achieved by its translation at large population.
• Nurse scientist: a person in nursing field with doctorate and post doctorate
degree.

11. Basic model of nurse-led translational research
in nursing practices
• Basic model of nurse-led translational research in nursing
practices: There are several stages of translation in
translational research which can be applied in nurse-led
research (Titler, 2018).
• The first (T1): is applying preclinical research findings to the
establishment of clinical trials and investigations in patients
it is the basic research (Rubio, 2010).

12. • The second area of translation (T2): is research focused on
improving community adoption of best practices (Rubio,
2010) also known as community -research. Prevention and
treatment techniques with cost-effectiveness play a key role
in translational science.
• Third (T3): which is a "practice-oriented" stage of
translational science, tests the effect of interventions on
encouraging and maintaining the adoption of EBPs (MG,
Methods in Translation Science, 2004).

13. • Fourth type (T4) :translational research is based on policy
research approaches to suggest how to reach clinicians and
patients with a state-wide policy that caregivers can
understand and begin using effectively for patient care.
• This phase is known as population research.
• we can understand that translational research aids in the
connection between basic research and clinical practice.
• As a result, nurse scientists should find practical techniques
for initiating and developing translational research.

14. Three b’s in translational research
Phases of translational research, a basic model framework, and
components of translational sciences in this paper. The three b's
(bench, bedside, and back again).
(Marita.G.Titler,2012).
1. Basic ideas originate in the bench phase, which are then put into
clinical practice. It is simply a simple, evidence-based strategy that
has not been evaluated on a big scale.

15. 2. The second phase, the bed phase, compares the clinical
effectiveness of a new finding or scientific tool, multi-cite research
project with one intervention as an experiment and one intervention as
a comparison and marked.
3. Returning to the third step, the establishment of a relationship
between clinical research and practice takes place.
• On the basis of scientific knowledge generated in the bench and
bed phases, findings relating to breakthroughs in care are
communicated, and new health policies are developed.

16. Nature of transdisciplinary research in nursing
practices:
Nature of transdisciplinary research in nursing practices:
Translational research in Nursing might be interdisciplinary,
transdisciplinary, or multidisciplinary in nature, nurse scientists
(Potempa K, 2012) (Feldman, 2015) (Chesla, 2008)
can collaborate with any scientist from any background to attain the
desired results.
• Multidisciplinary: When conducting research, scientists from
various fields and backgrounds collaborate with each other and Nurse
scientist will remain the principal investigator (Kathleen T. Hickey,
2018).

17. • Interdisciplinary: A collection of scientists who collaborate
on problems that cut across disciplines of nursing sciences.
• Transdisciplinary: Collaborative studies in which data is
shared, scientific procedures are improved, and scientists
from several disciplines are brought together to advance
research toward a common scientific goal.

18. Translational sciences in nursing education
• translational sciences in nursing education will help in learning basic
of translational research.
• Basic or fundamental research, clinical sciences, implementation
sciences, and dissemination sciences are all components in
translation sciences.
• The following sciences can help comprehend translational sciences.

19. Basic sciences
• Basic sciences: Any evidence or rational generated by normal
healthcare activities might be classified as basic sciences.
• It is known as the bench phase, and it can be found in some reference
books or observed in some translational research projects.

20. • Clinical sciences: A randomized clinical trial of a certain sort
conducted over a broad population at various places is considered a
crucial step in translational sciences.
• Dissemination sciences: involving stakeholders and policymakers and
presenting research results in a generalized fashion in the social
system so that it may be understood and recognized by everyone and
gain community participation (Meissner P, 2020).

21. Implementation sciences: Refers to the use of identified evidence in
the creation of new evidence guidelines or in large-scale changes to
past practices. The term "translation science" is sometimes used to
refer to "implementation science" (Feldman, 2015)

22. Methods of translational research
• Nonexperimental and experimental methods can both be used in nursing
studies using translational research design, but experimental methods are
more trustworthy.
• It is critical to figure out which implementation tactics work best for
promoting the usage of EBPs and the mechanisms that make them function
When doing TRIP (translational research in practice) investigations.
• Expectation from nurse-led translating studies is that The experimental
group's effective outcome should be greater than the standard outcome
given to the patient, and the study's focus should always be on testing the
effectiveness of adherence to demonstrated instructions in the experimental
group (BJ, 2013) (MG, 2008).

23. • Regressive studies, which typically need extended work projects of many
years for more than 10 years in the field research, create useful evidence in
the implementation phase.
• Nurse scientists collaborate with clinical researchers and fundamental
researchers to undertake translational research studies. People who work
with the principal investigator include nurse scientists,
opinion leaders, policymakers, and community leaders the chief investigator
is still a nurse scientist (Kathleen T. Hickey, 2018) (Titler, 2018).
• Researchers will begin by adopting evidence-based nursing care to
create universal evidence that can be used by health care practitioners all
around the world.

24. Initiatives for the improvement of translational
research in nursing education and nursing
Research
1. Nursing's future requires a unified approach in research, education,
and practice So nurses must practice to the full extent of their
education and training; to improve educational systems that allow
for seamless progression to higher levels of education; and for
nurses to be full partners with physicians and other healthcare
professionals .

25. 2. Nursing organizations must be prepared to go all-in to create best
practice protocols with their research that explores the processes and
outcomes of those protocols being put into practice to speed up the
implementation of cutting-edge research.
3. Local knowledge can be used to establish basic idea about evidence;
however, reaching group consensus on research is more difficult; it
needs translation of knowledge and practice (Feldman, 2015).

26. 5. Hospitals with active nursing research programs, internationally
accredited Hospitals, as well as institutions pursuing accreditation
designation, should operate as research laboratories for assessing the
implementation of EBP best practise procedures.
6. Translational research will bring Nursing excellence and expected
outcomes for patients and families.

27. Clinical and Translational Science Awards (CTSAs) (Rubio, 2010).
. Western countries have developed a consortium with health care and
research institutions involved in translational research to create the The
idea of this consortium is to finance translational research throughout
the country, attempting to accelerate the "translation" of laboratory
treatment discoveries for patients, integrating local communities in
research, and training a new generation of translational researchers,
clinicians nurse scientists (Padilha, 2011).
NIH clinical research centre emphasize nurse-led translational research
projects, working collaboratively in many areas; with many researchers
and communities. (Rubio, 2010).

28. Scope of Translational research in Nursing:
Translational research in nursing is required in many areas of nursing
practice, including palliative care, prevention, and control of infectious
disease, NCD prevention, geriatric care, paediatric care, cardiovascular
nursing, population-based issues in community health nursing and many
more.
With translational designs, nurses can participate in multidisciplinary
research projects (Kathleen T. Hickey, 2018).
Nurses can progress from research nurse to transdisciplinary nurse
scientist in their research careers.
Scholarships are available to them if they participate in
transdisciplinary research initiatives (Kathleen T. Hickey, 2018).

29. • Although all research should be shared, not all research is easily
translated (Kathleen T. Hickey, 2018) . For translational research to be
successful, a strong body of data addressing a big societal problem
must be established first.
• Second, translational scientific activities should be based on a shared
knowledge of the goals and the right techniques to attain these goals in
order for them to be successful.

30. Third, strengthening this burgeoning sector will necessitate the
development of capacity, collaborations with all stakeholders, and
nursing leaders who are committed to the development of a learning
health system.
fourthly the main benefit of translational science is improved health and
healthcare for those who rely on us (Naylor, May 31, 2018).

31. Conclusion
• Nurse-led Translation research findings inform the wider community
of practise on new developments and strategies to improve practises
and patient outcomes.
• Countries' policymakers must foster nurse-led translational research
by establishing training centres and awarding grants and scholarships
to scholars and researchers engaged in translational research.