In an interview, Tim O'Reilly discusses the transformative impact of digital technologies, emphasizing the role of the Internet of Things and how it changes human interactions with machines. He advises CXOs to adapt to disruptions rather than fight them, citing examples from various industries, including automotive and healthcare, and points towards successful companies like Amazon that embrace technology-centric business models. O'Reilly highlights the importance of creating value for others within ecosystems and suggests that the future will be shaped by big data and the merging of hardware and software.