This document summarizes the major muscles of the upper and lower extremities. It describes the muscles of the arm, forearm, thigh, and leg, organized by anatomical compartment. For each region, it lists the superficial and deep muscle groups from lateral to medial and their main actions. The upper extremity sections cover the muscles of the arm's anterior, posterior, and lateral compartments and the forearm's anterior and posterior groups. The lower extremity sections discuss the thigh muscles that act on the femur and the anterior, posterior, and lateral muscle compartments of the leg and their actions on the ankle.