This document discusses the global challenges of food security and rural poverty reduction. It summarizes the goals of the Challenge Program on Water and Food (CPWF) which aims to increase the resilience of social and ecological systems through better water management. The CPWF is focusing its strategy on six basin development challenges in key river basins around the world. It also conducts cross-basin science through topic working groups. The document outlines the CPWF's assets and opportunities moving forward, including engaging with decision-makers, marketing past outcomes, and operationalizing its basin development challenges and program. It briefly discusses potential integration with the CGIAR Research Program on Water, Land and Ecosystems.