This document discusses alternatives to traditional lecture-based college instruction. It provides several key findings from research on how people learn: 1) Students come to class with preexisting understandings that must be engaged; 2) To develop expertise, students must have in-depth knowledge within a conceptual framework and be able to apply and retrieve their knowledge; 3) Students must learn metacognition, or thinking about their own thinking. The document advocates for student-centered instruction using techniques like interactive videos, demonstrations, worksheets, and clicker questions to actively engage students in class.