The document discusses three cloud pilot projects funded by the NCI to address challenges with large cancer genomics datasets. It describes the FireCloud, Cancer Genomics Cloud, and Seven Bridges Genomics Cancer Genomics Cloud platforms, which provide co-located storage and computation of datasets like TCGA to enable broader access and analysis of the data. Key goals are making the data usable, supporting collaboration, ensuring reproducibility, and allowing integration of public and private data with analysis tools.