The document provides guidance on using the new NIH biosketch format called SciENcv. It explains that SciENcv allows researchers to create and maintain their biosketch online by automatically populating sections from their eRA Commons profile and linked publications. The document outlines how to create a biosketch using SciENcv, including leveraging existing data, writing the required sections, and downloading the biosketch for inclusion in grant applications. Researchers must use the new biosketch format for all applications submitted to NIH on or after May 25, 2015.