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The Biological Mind
Chapter 4
Biological PsychologyBiological Psychology: a rich,
interdisciplinary field of study that combines the methods and
theories of psychology with those of biology, physiology,
biochemistry, the neurosciences, and related fieldsStudies the
relationship between behavior and bodily processes and
systemsNeuroscience: the study of the nervous system,
especially the brain
*
Lays foundation for the rest of the text… if we do not have a
basic understanding of the body, we can never begin to
understand behavior and mental processes. Our DNA, disease
processes, chemical in our nervous system (neurotransmitters)
and in our blood (hormones) can all influence our behavior and
mental processes.
Methods that allow scientists to observe the activity of the
living brain are beginning to answer questions that were once
impossible to study.
The Nervous SystemCentral Nervous System (CNS): the brain
and spinal cordPeripheral Nervous System (PNS): the nerves
exiting the central nervous system that carry sensory and motor
information to and from the rest of the body
*
There are two major components of the nervous system:The
central nervous system consists of the brain and spinal cordThe
spinal cord and brain are cushioned by cerebrospinal fluid,
which is generated by the ventriclesThe peripheral nervous
system consists of the somatic nervous system and the
autonomic nervous system (discussed in the next section)
The Structures of the BrainstemThe hindbrain is composed of
the:Medulla: life-sustaining functionsPons: sleep, arousal, and
facial expressionCerebellum: motor coordinationThe midbrain
is involved in sensory reflexes, movement, and pain; connects
hindbrain to upper brain areas.Together, the hindbrain and
midbrain make up the brainstem.Reticular Formation: runs the
length of the brainstem’s core; participates in the control of
mood, arousal, and sleep
*
The hindbrain is composed of the medulla, pons, and cerebellum
The medulla merges with the spinal cordContains large bundles
of axons traveling to and from higher levels of the
brainManages many essential functions, such as heart rate and
blood pressure, and thus, damage to the medulla usually results
in quick death
The pons sits above the medullaInvolved with the management
of sleep, arousal, and facial expressions Connects the
cerebellum to the rest of the brain
The cerebellumEssential for maintaining balance and motor
coordination and one of the first brain structures to be affected
by alcoholRecent research suggests the cerebellum is involved
in a wide range of functions including language, cognition, and
perception
The midbrain sits above the ponsContains a number of
structures involved in sensory reflexes, movement, and pain
The reticular formationRuns the length of the brainstem’s core
from the upper medulla into the midbrain Participates in the
control of mood, arousal, and sleep
Learn more about the brainstem and the cerebellum at
https://www.youtube.com/watch?v=yS3wJF1wnRA (9:02)
*
Subcortical Structures and Their FunctionsMajor
Structures:Thalamus: sensory relay centerHypothalamus:
involved with motivation and homeostasisAmygdala: plays a
role in identifying, remembering, and responding to fear and
aggressionHippocampus: essential to the formation, storage, and
retrieval of long-term memoriesOther Structures: Basal Ganglia:
involved in voluntary movementCingulate Cortex: important in
decision making, emotion, empathy, memory, vision
Amygdala
Basal Ganglia
Thalamus
Amygdala
Hypothalamus
Hippocampus
Cingulate Cortex
*
Early anatomists collected some of the subcortical structures
into the limbic system Sometimes referred to as the “emotional”
brainThis term is losing popularity as the full range of functions
in which subcortical structures play roles becomes better
understood
ThalamusOften referred to as the “gateway to the cortex,” as
input from most of our sensory systems (vision, hearing, touch,
and taste) travels first to the thalamusInvolved with memory
and states of consciousness
Basal gangliaCollection of large structures involved with
voluntary movementDegeneration of the basal ganglia occurs in
Parkinson’s disease, a condition that makes the initiation of
voluntary movement extremely difficultInvolvement of the basal
ganglia is also suspected in a number of other conditions,
including obsessive- compulsive disorder (OCD) and attention
deficit hyperactivity disorder (ADHD)
AmygdalaAppears to have a role in identifying, remembering,
and responding to fear and aggressionLearn about the role of
the amygdala in the development of PTSD:
https://www.youtube.com/watch?v=fx5_vldZ1_I (2:22)
HypothalamusCollection of structures involved with motivation
and homeostasis, or the regulation of body functions such as
temperature, thirst, hunger, biological rhythms, and sexual
activitiesCarries out its motivational and homeostatic tasks by
directing the autonomic nervous system and the endocrine
system and its hormones
HippocampusEssential to the formation of long-term
memoriesInvolved in the storage and retrieval of memories
located elsewhere in the brain
Cingulate cortexForward two-thirds of this structure, known as
the anterior cingulate cortex (ACC), participates along with the
hypothalamus in the control of the autonomic nervous
systemACC also important in decision making, emotion,
anticipation of reward, and empathyThe rear third, or posterior
cingulate cortex (PCC), participates in memory and visual
processing
Nucleus accumbensImportant part of the brain’s reward and
pleasure circuitry
Listen to a TED talk about the hippocampus and memory at
https://www.ted.com/talks/neil_burgess_how_your_brain_tells_
you_where_you_are
(8:59) (Neil Burgess)
The Cerebral Hemispheres and the Corpus CallosumThe corpus
callosum is a large bundles of axons that connects the two
cerebral hemispheres.The cerebral cortex is the thin layer of
cells covering the outer surface of the hemispheres. The
cerebrum, hypothalamus, and thalamus are collectively referred
to as the forebrain.
*Above the brainstem, we find the two large cerebral
hemispheresThe corpus callosum is a large bundles of axons
that connects these hemispheresThe Corpus Callosum is
basically millions of myelinated axons that connect the brain’s
hemispheres which provides a pathway for communication
between the hemispheres. If surgically severed for treatment of
epilepsy (split brain surgery), hemispheres cannot communicate
directly.The cerebral cortex is the thin layer of cells covering
the outer surface of the cerebral hemispheres The cerebral
cortex is what you normally think of when you think of brain,
but it is really just the outer layer of the brain and is less than a
quarter of an inch thick. It contains all of the brain centers
required for movement, perception and all higher order
functions (making decisions, writing, reading, doing math,
creating music, etc… basically everything). The rest of the
brain is just gray matter and fluid filled ventricles that provide
structure and nourishment for the cerebral cortex.The cerebrum
(the two cerebral hemispheres and the corpus callosum),
hypothalamus, and thalamus are collectively referred to as the
forebrainIntelligence of an animal is related to the ratio of
forebrain to body size. Imagine a fish and a bird that are
approximately the same size… the bird’s forebrain is much
bigger… birds are wayyyyy smarter than fish
Lobes of the Cerebral CortexFrontal Lobe: executive function;
motor cortex; Broca’s AreaTemporal Lobe: primary auditory
cortex; complex visual stimuli; Wernicke’s AreaParietal Lobe:
somatosensory cortex; sensory processingOccipital Lobe:
primary visual cortex
*
Frontal lobe Home of the primary motor cortexHas a number of
important, sophisticated cognitive functionsThe most forward
portion of each frontal lobe, known as the prefrontal cortex, is
involved with the planning of behavior, attention, and
judgmentThe orbitofrontal cortex, a part of the prefrontal cortex
located just behind the bony orbits protecting the eyes, plays an
important role in our emotional livesBroca’s area: responsible
for language production
Occipital lobe Located at the back of the brainHome to the
primary visual cortexTwo important pathways link the occipital
lobe with the rest of the brainA pathway connecting the
occipital lobe with the temporal lobe allows us to recognize
objects we seeThe second pathway connects the occipital lobe
with the parietal lobe and allows us to process the movement of
objects
Temporal lobe Has a number of areas that are specialized for
particular functions Home to our primary auditory cortex, which
allows us to process incoming soundsProcesses some higher
visual system tasks including the recognition of objects and the
faces of familiar peopleWernicke’s area: responsible for
language comprehension
Parietal lobe Home to our primary somatosensory cortex, which
helps us localize touch, pain, skin temperature, and body
positionProcesses input about taste and, like the temporal lobe,
engages in some complex processing of vision
The Body’s Representation in the BrainHomunculus: ‘little
man’More area on the cortex is assigned to body parts that
move the most (motor cortex) and that are the most sensitive
(somatosensory cortex).
*These brain representations are called a homunculus
(homunculi) which translates ‘little man.’ Notice how in the
motor cortex, parts of the body that do not move independently
that move the most have the largest brain area to process their
signals (e.g. the hands, tongue, lips, etc.). The same thing
happens in the sensory cortex with skin areas that are served by
many nerves (the fingertips, face, and genitalia) have more
representation than skin areas that do not have as many nerves
feeding them (the back, thighs, arms, etc.).The diagrams above
show (in cross section) the relative amounts of cortex
“assigned” to the sensory and motor control of various parts of
the body. (Each cross section, or “slice,” of the cortex has been
turned 90 degrees so that you see it as it would appear from the
back of the brain.)
Highlight different areas of the brain at
http://www.pbs.org/wgbh/nova/body/mapping-the-brain.html
Studying the BrainTechnologyProcedureWhat Questions Can
We Answer?electroencephalogram (EEG)electrodes (to track
electrical activity) What is a person’s state of arousal?positron
emission tomography (PET)radioactively tagged
glucose or oxygen (to track chemical activity)What parts of the
brain are active during a
particular task?functional magnetic resonance imaging
(fMRI)magnets (to track the flow of oxygen)What parts of the
brain are active during a
particular task?
*
Early studies of brain functioning utilized case studies, and
stimulating, damaging, or removing portions of the cortex
Modern technologies allow us to collect information about the
brain.An electroencephalogram (EEG) measures the brain’s
electrical activity using electrodes placed on the
scalpComputerized Axial Tomography (CAT) involves the
production of a large number of x-rays interpreted by a
computerA positron emission tomography (PET) scan uses the
accumulation of radioactively tagged glucose or oxygen to
identify activity levels in parts of the brain Magnetic resonance
imaging (MRI) uses magnetism to form images of the
brainFunctional magnetic resonance imaging (fMRI) identifies
active parts of the brain using magnetism to track the flow of
oxygen
Our understanding of the correlations between brain and
behavior leaped forward with continuing improvements in
research methods. In particular, methods that allow scientists to
observe the activity of the living brain, including positron
emission tomography (PET) and functional magnetic resonance
imaging (fMRI), began to answer questions that were
impossible to study previously.
Because of these improved methods, today we can talk about
how the brain responds differently to images of faces and places
(Downing, Chan, Peelen, Dodds, & Kanwisher, 2006), “feels”
the pain of social exclusion (Eisenberger, Lieberman, &
Williams, 2003; Eisenberger, 2011), and develops abnormally in
teens diagnosed with schizophrenia (Thompson et al., 2001).
Moving into the 21st century, the ranks of neuroscientists
continue to grow, from 500 members of the Society for
Neuroscience in 1969 to more than 40,000 members today
(Society for Neuroscience, 2011).
Learn more about fMRI at
https://www.youtube.com/watch?v=lLORKtkf2n8 (4:00)
Compare the methods of studying the brain at
https://www.youtube.com/watch?v=nFmYvp-NT1w (3:12)
*
The Spinal ChordTogether, with the brain, makes up the central
nervous systemMotor neurons, sensory neurons, and
interneuronsProtections:Encased entirely in boneSuspended in
cerebrospinal fluidSpinal Reflexes: simple, automatic behaviors
that are processed in the spinal chord
*Spinal cord: Thirty-one pairs of spinal nerves exit between the
bones of the vertebrae to bring sensory information back to the
central nervous system and to carry motor commands to
musclesLearn more about the spinal cord and its importance at
https://www.youtube.com/watch?v=zxpb1-okVig (3:28)A
number of important reflexes are initiated by the spinal cord
without the assistance of the brain Spinal reflexes give us an
opportunity to look at the functions of three different types of
neuronsSensory neurons carry information from the external
environment or from the body back to the CNSMotor neurons
carry commands from the CNS back to the muscles and glands
of the bodyInterneurons, which have neither sensory nor motor
functions, play important roles in more complex reflexes and
throughout the nervous systemWatch an examination of reflexes
at https://www.youtube.com/watch?v=cYOnWQHxJts (3:14)
The Peripheral Nervous SystemPeripheral Nervous System
(PNS): includes all of the nerves lying outside the CNSSomatic
DivisionAutonomic divisionsympathetic
divisionparasympathetic division
*
Peripheral: all nerves outside the brain and spinal chord
Broken down into two parts:Somatic Division: controls all
voluntary movement (things we choose to do and
say)Autonomic: ‘automatic’; controls involuntary functions in
the body such as digestion, waste removal, etc.also has
specialized divisions that help us survive in an emergency
(sympathetic and parasympathetic divisions) Sympathetic: fight
or flight – allows increased strength and endurance when
needed for survivalParasympathetic: returns body to normal
functioning when crisis is over
The Somatic Nervous System and the Cranial NervesSomatic
Nervous System:transmits commands for voluntary movement
from the central nervous system to the muscles brings sensory
input back to the CNS for further processing
*The somatic nervous system is the part of the peripheral
nervous system that transmits commands for voluntary
movement from the central nervous system to the muscles and
brings sensory input back to the CNS for further processing.
These functions are carried out by the 31 pairs of spinal nerves
serving the torso and limbs, and the 12 pairs of cranial nerves
serving the head, neck, and some internal organs.Learn more
about the cranial nerves at
https://www.youtube.com/watch?v=vFp_qNifHzw (12:39)
*
The Autonomic Nervous SystemThe autonomic nervous system
is responsible for:homeostasis: the regulation of important body
functions such as temperature and thirstParasympathetic
Divisionour fight-or-flight response to emergenciesSympathetic
division
*
The autonomic nervous system is responsible for homeostasis –
the regulation of important body functions such as temperature
and thirst, and our fight-or-flight response to emergencies
The ANS contains two subdivisions, the sympathetic division
and the parasympathetic division. Nerve cells participating in
the sympathetic division are found in the middle regions of the
spinal cord in the torso and lower back Nerve cells participating
in the parasympathetic division are located either in the brain or
in the lowest segments of the spinal cordThe sympathetic
division prepares the body for situations requiring the
expenditure of energyThe parasympathetic division directs the
storage of energyThe operation of the internal organs in
response to environmental stimuli reflects a sophisticated
combination of inputs from both the sympathetic and
parasympathetic divisions
The nature of the autonomic nervous system is important to our
understanding of stress The sympathetic division was designed
to deal with emergencies that could be resolved relatively
quickly Worrying about far distant dangers, like next month’s
rent or upcoming exams is a luxury that human beings did not
have until quite recentlyWhenever you identify something as a
significant threat, the sympathetic division goes into action
Learn more about the sympathetic and parasympathetic nervous
system at https://www.youtube.com/watch?v=H8ItFuDgYKw
(4:34)
Neurons process and transmit informationDendrites: portions of
neurons that receive signalsAxon: portions of neurons that send
signals Glial Cells: support cells that assist neurons
The Structure and Function of Neurons
Glia
Blood Vessel
Neuron
Myelin
*
A neuron is a specialized nerve cell that processes and transmits
informationNeurons are like other types of animal cellsThe cell
body contains the nucleusThe fatty membrane separates
intracellular and extracellular fluids Neurons perform the usual
tasks of all cellsBasic housekeeping Metabolic functionsProtein
manufacturingNeurons are unlike other cells in a few
waysInclude specialized branches (axons and dendrites), which
pass information to and receive information from other
cellsAxon: branch of a neuron that is usually responsible for
transmitting information to other neurons Dendrite: branch from
the neural cell body that usually receives input from other
neuronsThe human brain is estimated to have 100 billion
neuronsMyelin Sheath: Whitish, fatty protein substance,
composed of glial cells, that covers some axons and increases
the speed of neural transmission – covers the axon except at
small, regularly spaced gaps, called nodes of Ranvier
Glial Cells: support cells that assist neurons by providing
structural support, nutrition, and waste removal; manufacture
myelinForm the framework that holds neurons in placeCreate
tight connections with blood vessels serving the brain, the
blood-brain barrierClean up debris where neurons have been
damaged Outnumber neurons 3 to 1
Learn about the structure, function, and types of neurons at
https://www.youtube.com/watch?v=cUGuWh2UeMk (4:08)
Learn more about the functions of glial cells at
https://www.youtube.com/watch?v=64MgiEDWyRg (8:00)
*
Axons Transmit InformationAxon: portions of neurons that send
signals Axon Terminals: contain synaptic vesicles which store
and release neurotransmitters
*An axon is the branch of a neuron that is usually responsible
for transmitting information to other neuronsSome axons are
myelinated and some are not – myelin speeds up electrical
transmissionmany dendrites-only one axonaxons can vary
greatly in length – some in brain are microscopic/axon of motor
neuron can stretch from the spinal chord all the way to your
hand or footThe axon terminal contains synaptic vesicles, which
contain chemical messengers called neurotransmitters that
transmit signals between neurons These neurotransmitters
communicate with receptors on the dendrites of other neurons
*
Dendrites Receive InformationDendrites: portions of neurons
that receive signalsNeurotransmitters communicate with
receptors on the dendrites.
*
A dendrite is a branch from the neural cell body that usually
receives input from other neuronsNeurotransmitters from the
sending neuron communicate with receptors on the dendrites of
other neuronsNerve impulses usually travel from the dendrites
and soma (cell body) to the branching ends of the axonMost
neurons have many (even thousands) of dendritesa single neuron
can receive signals from many other neuronsNeurotransmitters
communicate with receptors on the dendrites
*
Electrical signaling: action potential Chemical signaling:
neurotransmitters
Neural Communication: A Two-Step Process
*
There are two steps in the transmission of information between
neuron
First step:Takes place in the signaling neuron’s axonNeuron
generates an electrical signal known as an action
potentialSignal travels the length of the axon from its junction
with the cell body to its terminal
Second stepTakes place between two neuronsArrival of an
action potential at the axon terminal of the first neuron signals
the release of neurotransmittersNeurotransmitters float across
the extracellular fluid separating the two neuronsOn the
influence of neurotransmitters, the second neuron may respond
with its own action potential and send the message along
Read an overview of neurotransmission at
http://science.education.nih.gov/supplements/nih2/addiction/acti
vities/lesson2_neurotransmission.htm
*
Electrical Signaling: Generating an Action PotentialResting
Potential: electrical charge when the neuron is not being
stimulated or inhibitedAction Potential: a brief, electrical
impulse by which information is transmitted along the axon of a
neuronall-or-none regenerativeAbsolute Refractory Period: time
during which another action potential is impossible
*
Now let’s look at the action potential in more detail:When a
neuron is not processing information, we say that it is at rest
When a cell is at rest, the difference between the readings from
the interior of the axon and the external fluid is known as the
resting potential The interior of the neuron is negatively
charged relative to its exterior Neurons can respond to incoming
chemical signals by becoming either depolarized or
hyperpolarizedWhen a neuron is depolarized by sufficient input,
it will reach a thresholdReaching the threshold initiates a
sequence of events that reliably produces an action potentialThe
size and shape of action potentials are always the sameEither an
action potential occurs, or the cell remains at rest—there is no
middle ground. Because of this consistency, we say that action
potentials work in an all-or-none fashion
Watch this video to understand neurotransmission from a more
physiological standpoint:
http://www.dnatube.com/video/1310/Physiology-of-an-Action-
Potential
*
Electrical Signaling: Propagating an Action
PotentialPropagation: the duplication of the electrical signal
down the length of the axon to the axon terminalmyelinated
axonsNodes of Ranvierunmyelinated axonsOnce the action
potential reaches the axon terminal, the neural communication
system switches from an electrical signaling system to a
chemical signaling one.
*Action potentials do not affect the entire axon all at once The
next step is propagation, or the duplication of the electrical
signal down the length of the axon to the axon
terminalPropagation takes place differently in myelinated and
unmyelinated axonsIn an unmyelinated axon, action potentials
occur in a step-by-step manner, from one small section of the
axon to the nextAction potentials in myelinated axons are
formed only at the sections of the axon membrane between
adjacent segments of myelin, known as nodes of Ranvier;
propagation in myelinated axons can “skip” the sections covered
in myelin, and is fast and efficient.Once the action potential
reaches the axon terminal, the neural communication system
switches from an electrical signaling system to a chemical
signaling one
Chemical Signaling: Releasing NeurotransmittersWhen an
action potential arrives at the axon terminal, neurotransmitters
are released.Neurotransmitters are stored in tiny sacs called
synaptic vesicles.When a nerve impulse reaches the end of an
axon, vesicles move to the surface and release neurotransmitters
into the synapse.
*
When an action potential arrives at a terminal, neurotransmitters
are releasedNeurotransmitters are chemical substances that
enable the signal from one neuron to be relayed to other
neuronsNeurotransmitters are stored in tiny sacs called synaptic
vesiclesWhen a nerve impulse reaches the end of an axon, the
vesicles move to the surface and release these chemical
messengers across the synapse (or synaptic gap)The synapse is a
small gap that separates neurons; neurotransmitters are released
into the synapse in order to continue neural impulses. To send
messages, terminal buttons must be near the dendrites of
neighboring neuronsThe space between terminal buttons and
dendrites-synapseWhen signal reaches the end of the axon of a
neuron, the terminal buttons release synaptic vesicles carrying
neurotransmitters (chemical signal) into the synapse.
(Presynaptic membrane)The neurotransmitter than contacts the
postsynaptic membrane (dendrite) of the next neuron and binds
to it at specially shaped receptor sites, thus transmitting the
neural signal.Whole process – Synaptic TransmissionReuptake –
The process by which neurotransmitters are detached form a
postsynaptic neuron and are reabsorbed by the presynaptic
neuron so they can be recycled and used again
Video that shows how the release of a specific neurotransmitter,
dopamine, results in feelings of pleasure:
https://www.youtube.com/watch?v=M55co-GYTxQ
Chemical Signaling
Synapse
Presynaptic
Neuron
Postsynaptic
Neuron
*
The neuron that sends a signal across the gap is called the
presynaptic neuron.
The neuron that receives the signal is called the postsynaptic
(receiving) neuron.
Receptors are special channels on the receiving neuron
a flashbulb memory
According to the levels of processing theory, who will be able
to remember the most definitions of the vocabulary words in a
given chapter?
Pat, who takes turns with her roommate defining and explaining
each term
-Varying states of awareness are best monitored using ____,
which provides an overall measure of brain activity.
an electroencephalogram
-Marietta has memorized the capital cities of all 50 states. This
is an example of ____ memory.
semantic
-In experienced meditators, EEG recordings of the frontal lobes
of the brain during meditation feature increased levels of which
type of brain waves?
theta waves
-Long ago (in the dark ages of television), ---the last image that
was on the screen to fade away. This is most like
iconic memory
-Patti finds her husband Derek asleep--------, “Patti, I am
awake!” Derek was most likely in ____.
Stage 1 N-REM
-The component of working memory that is responsible for
verbal and auditory information is the _____.
phonological loop
-Drugs that speed up the functioning of the nervous system are
called _____________
stimulants
-Melatonin is to ___________ as an aspirin is to ____________
insomnia; headache
-In order to demonstrate the extent to which classical----, John
Watson and Rosalie Raynor conducted a study where ______.
a young boy was taught to fear a white rat
-Azul studies for her upcoming molecular biology midterm. ----
brain is likely to show ____ wave activity.
beta
-An implicit memory for how to carry out a motor skill or
action is called ____.
procedural memory
-Keller and Marion Breland, two of B. F. Skinner’s ----animals
for entertainment, encountered ____.
biological boundaries
-Normally, when food is placed in the mouth of any animal,
salivation would be referred to as ______
an unconditioned response
-What is a key distinction between classical conditioning and
operant conditioning?
Classical conditioning generally works best with involuntary,
reflexive behaviors;
-Jess is fast asleep, and her roommate ---such that Crystal reacts
to the stimulus while Jess does not?
the reticular formation
-John Watson and his colleague, Rosalie Rayner---The white rat
served as the ___________ in their study
conditioned stimulus
-What type of learning is most influential in developing and
maintaining culture?
observational learning
-Caffeine is a _______________
Stimulant
-What delays the process of extinction?
Chemical Signaling: Synaptic Transmission
*
The neurotransmitters are released when a vesicle fuses with the
membrane of the presynaptic cell and its contents spill into the
synaptic cleft. After their release, neurotransmitters diffuse
across the synaptic cleft to the membrane of the receiving cell.
The neurotransmitters released across the synaptic gap come
into contact with special channels on the receiving neuron,
known as receptors Receptors work with the neurotransmitters
like locks and keys Neurotransmitters do not stay bound to
receptors very long
the partial reinforcement effect
-Moishe can remember only the first two items----This is an
example of the ___________
serial position effect
-Roger is preparing for his final exam in Bioethics--- in terms
of memory retrieval, will most likely be
essay
-Tao wakes up his roommate Don so that he doesn’t miss his
morning--Don was most likely in ____.
REM sleep
-After Little Albert acquired a conditioned fear to a rat--
whether or not ___________ had occurred
stimulus generalization
-Interpretation of the ________ content of a dream is expected
to reveal the ________ content
manifest; latent
-Shalissa has two exams today---Shalissa’s memory is suffering
from _______
proactive interference
-When a stimulus is removed-- the probability of response, it is
known as ___________
punishment by removal
-When experienced practitioners---experience produced by
meditation, they describe ____.
a conscious state without thought, accompanied by a blissful
emotional state
-Lucia, who experiences extreme anxiety when taking an exam--
is an example of ____.
negative reinforcement
-Tao wakes up his roommate --- waveforms did Don display
right before being awakened?
beta wave
-Fred is studying vocabulary for his biomedical class while
lying---will likely be best while ____.
lying down with background noise
-Dennis buys a lottery ticket every Saturday-- of which schedule
of reinforcement.
variable ratio
-Michael has a flashbulb memory --What is most likely to be
true about this memory?
Retrieval of this memory will be more accurate than of everyday
events around the same time.
-Which memory system provides us with a very brief
representation of all the stimuli present at a particular .
sensory memory
-What type of stimulus elicits a response without prior
experience—that is, without learning having taken place?
Unconditioned
-Someone asks you to name the twenty-second president--- In
this situation, the hint acted as a(n)__
retrieval cue
-Liz failed her math test,---she could not play video games until
her grade improved. Her parents are using
punishment by removal
-Experienced whale trainer Dawn Brancheau was killed ---whale
behavior; illustrating ____.
1
Synthesis and storage of
neurotransmitter molecules
in synaptic vesicles
2
Release of neurotransmitter
molecules into synaptic cleft
3
Binding of neurotransmitters
at receptor sites on
postsynaptic membrane
Chemical Signaling: Synaptic Transmission
5
Reuptake of neurotransmitters
sponged up by the
presynaptic neuron
4
Inactivation (by enzymes) or
removal (drifting away) of
neurotransmitters
*The neurotransmitters released across the synaptic gap come
into contact with special channels on the receiving neuron,
known as receptors Receptors work with the neurotransmitters
like locks and keys Neurotransmitters do not stay bound to
receptors very long Once they pop out of the receptor binding
site, neurotransmitter molecules either drift away from the gap,
are broken down by enzymes, or return to the axon terminal
from which they were released in a process called reuptake
After producing postsynaptic potentials, some neurotransmitters
either become inactivated by enzymes, or drift away. Most
neurotransmitters, however, are reabsorbed into the presynaptic
neuron through reuptake - a process in which neurotransmitters
are sponged up from the synaptic cleft by the presynaptic
membrane.
For a stylized animation of a synapse, see:
https://www.youtube.com/watch?v=90cj4NX87Yk
instinctive drift
-A graph of the serial position effect,--- takes the shape of a(n)
____.
U-shaped curve
-Which of the following neurotransmitters are associated with
alcohol
GABA
-The tendency to respond to stimuli that are similar to an
original conditioned stimulus is called ____.
Generalization
-Inevitable, involuntary responses to stimuli that are primarily
controlled--brainstem are referred to as __
Reflexes
-Manuel is teaching his 3-year-old son --- Joey sings “A B C D
J R P X Y Z.” This is an example of ____.
the primacy and recency effects
-Jonah is playing on his tablet one evening, ---“voices” from his
father illustrates _____.
Discrimination
-When Edie studies her psychology terms--- explain Edie's
approach to encoding memories
levels-of-processing
Important Neurotransmitters and Their
EffectsAcetylcholineDopamineSerotoninNorepinephrineGABA
– gamma-aminobutyric acidEndorphins
*
There are more than 50 different neurotransmittersAcetylcholine
is a neurotransmitter found in a number of systems important to
behavior, e.g., at the neuromuscular junction, the synapse at
which the nervous system commands muscles; they are also
intimately involved in the brain circuits related to learning and
memoryNorepinephrine is released in the brain and leads to
arousal and vigilanceDopamine is a neurotransmitter involved
with systems that govern movement, planning, and
rewardSerotonin is involved with systems regulating sleep,
appetite, and mood Endorphins (short for “endogenous
morphine,” or morphine produced by the body) modify our
natural response to pain (see also hormones, as endorphins act
as both) Gamma amino butryic acid (GABA) – Inhibitory
transmitter – acts like the brakes to a signal/ without the brakes,
seizures occur
The Endocrine SystemEndocrine system: a system of glands that
controls secretion of blood-borne chemical
messengersHormones: blood-borne chemical messengers that
influence target tissues and glands
*
The endocrine system is comprised of a number of glands that
release chemical messengers known as hormones into the
bloodstream to communicate with other body partsResponds to
input from the nervous system and from the hypothalamus in
particularEspecially involved with arousal, metabolism, growth,
and sexImportant glands of the endocrine system include the
pineal gland, the pituitary gland (known as the “master gland”
due to its role in regulating the functioning of other glands), the
thyroid gland, and the adrenal glands.In males, the major
reproductive glands are the testes.They are responsible for
secreting testosterone, which influences sexual function and
plays a critical role in puberty.In females, the major
reproductive glands are the ovaries.They are responsible for
secreting estrogen, which influences sexual function, plays a
critical role in puberty, and is one of the major hormones
involved in the menstrual cycle.Pineal Gland – located deep in
the brain – Produces melatonin – regulator of the sleep wake
cycle: sleep-melatonin increases/wake-melatonin
decreasesHypothalamus – deep in brain – sends signals to the
pituitary and contains key centers for aggression, fleeing,
sexual activity, and hungerPituitary gland – in brain below the
thalamus and hypothalamus; called the master gland because its
secretions control many other glandsreleases somatotropin – a
growth hormone-acts directly on bones and muscles to produce
growth spurt during pubertyStimulates thyroid to regulate the
release of thyroxineCauses adrenal glands to produce cortisol –
accelerates production of glucose during stressInterplay
between nervous and endocrine systemThyroid gland – located
below the larynx – regulates growth and metabolismPancreas –
lies between the stomach and the small intestine – releases
insulin which regulates the levels of glucose in the body – In
diabetic patients, the body either does not produce the needed
insulin or the cells do not respond to the insulin that is
presentAs food breaks down, the rise in glucose levels in the
blood signals the pancreas to produce insulin; as glucose levels
drop, insulin secretion decreasesAdrenal glands – located ate
the top of each kidney – release a wide range of hormones
including epinephrine and norepinephrine, which power
sympathetic nervous system activityFight and flight – triggered
by nervous system – sustained by endocrine system
Part 1:
Summarize all comments listed on your evaluation forms (
Attachment second and third one ), good, bad and ugly.
Identify any common themes that were present in your
comments and respond to them. For example, if multiple people
commented on the applicability of a specific objective, this
would qualify as a common theme. This section should be no
shorter than one page,
Part 2:
Comment on the results of your evaluation. Is this what you
expected? Why or why not? How will this impact solving your
problem going forward? Do you feel you’ll need to adjust any
of your solutions? If so, how? If not, why not? This section
should be between 1-2 pages.
Page 1

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The Biological MindChapter 4Biological Psycholog.docx

  • 1. The Biological Mind Chapter 4 Biological PsychologyBiological Psychology: a rich, interdisciplinary field of study that combines the methods and theories of psychology with those of biology, physiology, biochemistry, the neurosciences, and related fieldsStudies the relationship between behavior and bodily processes and systemsNeuroscience: the study of the nervous system, especially the brain * Lays foundation for the rest of the text… if we do not have a basic understanding of the body, we can never begin to understand behavior and mental processes. Our DNA, disease processes, chemical in our nervous system (neurotransmitters) and in our blood (hormones) can all influence our behavior and mental processes. Methods that allow scientists to observe the activity of the living brain are beginning to answer questions that were once impossible to study. The Nervous SystemCentral Nervous System (CNS): the brain and spinal cordPeripheral Nervous System (PNS): the nerves exiting the central nervous system that carry sensory and motor
  • 2. information to and from the rest of the body * There are two major components of the nervous system:The central nervous system consists of the brain and spinal cordThe spinal cord and brain are cushioned by cerebrospinal fluid, which is generated by the ventriclesThe peripheral nervous system consists of the somatic nervous system and the autonomic nervous system (discussed in the next section) The Structures of the BrainstemThe hindbrain is composed of the:Medulla: life-sustaining functionsPons: sleep, arousal, and facial expressionCerebellum: motor coordinationThe midbrain is involved in sensory reflexes, movement, and pain; connects hindbrain to upper brain areas.Together, the hindbrain and midbrain make up the brainstem.Reticular Formation: runs the length of the brainstem’s core; participates in the control of mood, arousal, and sleep * The hindbrain is composed of the medulla, pons, and cerebellum The medulla merges with the spinal cordContains large bundles of axons traveling to and from higher levels of the brainManages many essential functions, such as heart rate and blood pressure, and thus, damage to the medulla usually results in quick death The pons sits above the medullaInvolved with the management of sleep, arousal, and facial expressions Connects the cerebellum to the rest of the brain The cerebellumEssential for maintaining balance and motor coordination and one of the first brain structures to be affected by alcoholRecent research suggests the cerebellum is involved
  • 3. in a wide range of functions including language, cognition, and perception The midbrain sits above the ponsContains a number of structures involved in sensory reflexes, movement, and pain The reticular formationRuns the length of the brainstem’s core from the upper medulla into the midbrain Participates in the control of mood, arousal, and sleep Learn more about the brainstem and the cerebellum at https://www.youtube.com/watch?v=yS3wJF1wnRA (9:02) * Subcortical Structures and Their FunctionsMajor Structures:Thalamus: sensory relay centerHypothalamus: involved with motivation and homeostasisAmygdala: plays a role in identifying, remembering, and responding to fear and aggressionHippocampus: essential to the formation, storage, and retrieval of long-term memoriesOther Structures: Basal Ganglia: involved in voluntary movementCingulate Cortex: important in decision making, emotion, empathy, memory, vision Amygdala Basal Ganglia Thalamus Amygdala Hypothalamus Hippocampus Cingulate Cortex * Early anatomists collected some of the subcortical structures into the limbic system Sometimes referred to as the “emotional” brainThis term is losing popularity as the full range of functions
  • 4. in which subcortical structures play roles becomes better understood ThalamusOften referred to as the “gateway to the cortex,” as input from most of our sensory systems (vision, hearing, touch, and taste) travels first to the thalamusInvolved with memory and states of consciousness Basal gangliaCollection of large structures involved with voluntary movementDegeneration of the basal ganglia occurs in Parkinson’s disease, a condition that makes the initiation of voluntary movement extremely difficultInvolvement of the basal ganglia is also suspected in a number of other conditions, including obsessive- compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) AmygdalaAppears to have a role in identifying, remembering, and responding to fear and aggressionLearn about the role of the amygdala in the development of PTSD: https://www.youtube.com/watch?v=fx5_vldZ1_I (2:22) HypothalamusCollection of structures involved with motivation and homeostasis, or the regulation of body functions such as temperature, thirst, hunger, biological rhythms, and sexual activitiesCarries out its motivational and homeostatic tasks by directing the autonomic nervous system and the endocrine system and its hormones HippocampusEssential to the formation of long-term memoriesInvolved in the storage and retrieval of memories located elsewhere in the brain Cingulate cortexForward two-thirds of this structure, known as the anterior cingulate cortex (ACC), participates along with the hypothalamus in the control of the autonomic nervous systemACC also important in decision making, emotion, anticipation of reward, and empathyThe rear third, or posterior cingulate cortex (PCC), participates in memory and visual processing Nucleus accumbensImportant part of the brain’s reward and pleasure circuitry Listen to a TED talk about the hippocampus and memory at
  • 5. https://www.ted.com/talks/neil_burgess_how_your_brain_tells_ you_where_you_are (8:59) (Neil Burgess) The Cerebral Hemispheres and the Corpus CallosumThe corpus callosum is a large bundles of axons that connects the two cerebral hemispheres.The cerebral cortex is the thin layer of cells covering the outer surface of the hemispheres. The cerebrum, hypothalamus, and thalamus are collectively referred to as the forebrain. *Above the brainstem, we find the two large cerebral hemispheresThe corpus callosum is a large bundles of axons that connects these hemispheresThe Corpus Callosum is basically millions of myelinated axons that connect the brain’s hemispheres which provides a pathway for communication between the hemispheres. If surgically severed for treatment of epilepsy (split brain surgery), hemispheres cannot communicate directly.The cerebral cortex is the thin layer of cells covering the outer surface of the cerebral hemispheres The cerebral cortex is what you normally think of when you think of brain, but it is really just the outer layer of the brain and is less than a quarter of an inch thick. It contains all of the brain centers required for movement, perception and all higher order functions (making decisions, writing, reading, doing math, creating music, etc… basically everything). The rest of the brain is just gray matter and fluid filled ventricles that provide structure and nourishment for the cerebral cortex.The cerebrum (the two cerebral hemispheres and the corpus callosum), hypothalamus, and thalamus are collectively referred to as the forebrainIntelligence of an animal is related to the ratio of forebrain to body size. Imagine a fish and a bird that are approximately the same size… the bird’s forebrain is much
  • 6. bigger… birds are wayyyyy smarter than fish Lobes of the Cerebral CortexFrontal Lobe: executive function; motor cortex; Broca’s AreaTemporal Lobe: primary auditory cortex; complex visual stimuli; Wernicke’s AreaParietal Lobe: somatosensory cortex; sensory processingOccipital Lobe: primary visual cortex * Frontal lobe Home of the primary motor cortexHas a number of important, sophisticated cognitive functionsThe most forward portion of each frontal lobe, known as the prefrontal cortex, is involved with the planning of behavior, attention, and judgmentThe orbitofrontal cortex, a part of the prefrontal cortex located just behind the bony orbits protecting the eyes, plays an important role in our emotional livesBroca’s area: responsible for language production Occipital lobe Located at the back of the brainHome to the primary visual cortexTwo important pathways link the occipital lobe with the rest of the brainA pathway connecting the occipital lobe with the temporal lobe allows us to recognize objects we seeThe second pathway connects the occipital lobe with the parietal lobe and allows us to process the movement of objects Temporal lobe Has a number of areas that are specialized for particular functions Home to our primary auditory cortex, which allows us to process incoming soundsProcesses some higher visual system tasks including the recognition of objects and the faces of familiar peopleWernicke’s area: responsible for
  • 7. language comprehension Parietal lobe Home to our primary somatosensory cortex, which helps us localize touch, pain, skin temperature, and body positionProcesses input about taste and, like the temporal lobe, engages in some complex processing of vision The Body’s Representation in the BrainHomunculus: ‘little man’More area on the cortex is assigned to body parts that move the most (motor cortex) and that are the most sensitive (somatosensory cortex). *These brain representations are called a homunculus (homunculi) which translates ‘little man.’ Notice how in the motor cortex, parts of the body that do not move independently that move the most have the largest brain area to process their signals (e.g. the hands, tongue, lips, etc.). The same thing happens in the sensory cortex with skin areas that are served by many nerves (the fingertips, face, and genitalia) have more representation than skin areas that do not have as many nerves feeding them (the back, thighs, arms, etc.).The diagrams above show (in cross section) the relative amounts of cortex “assigned” to the sensory and motor control of various parts of the body. (Each cross section, or “slice,” of the cortex has been turned 90 degrees so that you see it as it would appear from the back of the brain.) Highlight different areas of the brain at http://www.pbs.org/wgbh/nova/body/mapping-the-brain.html Studying the BrainTechnologyProcedureWhat Questions Can We Answer?electroencephalogram (EEG)electrodes (to track
  • 8. electrical activity) What is a person’s state of arousal?positron emission tomography (PET)radioactively tagged glucose or oxygen (to track chemical activity)What parts of the brain are active during a particular task?functional magnetic resonance imaging (fMRI)magnets (to track the flow of oxygen)What parts of the brain are active during a particular task? * Early studies of brain functioning utilized case studies, and stimulating, damaging, or removing portions of the cortex Modern technologies allow us to collect information about the brain.An electroencephalogram (EEG) measures the brain’s electrical activity using electrodes placed on the scalpComputerized Axial Tomography (CAT) involves the production of a large number of x-rays interpreted by a computerA positron emission tomography (PET) scan uses the accumulation of radioactively tagged glucose or oxygen to identify activity levels in parts of the brain Magnetic resonance imaging (MRI) uses magnetism to form images of the brainFunctional magnetic resonance imaging (fMRI) identifies active parts of the brain using magnetism to track the flow of oxygen Our understanding of the correlations between brain and behavior leaped forward with continuing improvements in
  • 9. research methods. In particular, methods that allow scientists to observe the activity of the living brain, including positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), began to answer questions that were impossible to study previously. Because of these improved methods, today we can talk about how the brain responds differently to images of faces and places (Downing, Chan, Peelen, Dodds, & Kanwisher, 2006), “feels” the pain of social exclusion (Eisenberger, Lieberman, & Williams, 2003; Eisenberger, 2011), and develops abnormally in teens diagnosed with schizophrenia (Thompson et al., 2001). Moving into the 21st century, the ranks of neuroscientists continue to grow, from 500 members of the Society for Neuroscience in 1969 to more than 40,000 members today (Society for Neuroscience, 2011). Learn more about fMRI at https://www.youtube.com/watch?v=lLORKtkf2n8 (4:00) Compare the methods of studying the brain at https://www.youtube.com/watch?v=nFmYvp-NT1w (3:12) * The Spinal ChordTogether, with the brain, makes up the central nervous systemMotor neurons, sensory neurons, and interneuronsProtections:Encased entirely in boneSuspended in cerebrospinal fluidSpinal Reflexes: simple, automatic behaviors that are processed in the spinal chord *Spinal cord: Thirty-one pairs of spinal nerves exit between the bones of the vertebrae to bring sensory information back to the
  • 10. central nervous system and to carry motor commands to musclesLearn more about the spinal cord and its importance at https://www.youtube.com/watch?v=zxpb1-okVig (3:28)A number of important reflexes are initiated by the spinal cord without the assistance of the brain Spinal reflexes give us an opportunity to look at the functions of three different types of neuronsSensory neurons carry information from the external environment or from the body back to the CNSMotor neurons carry commands from the CNS back to the muscles and glands of the bodyInterneurons, which have neither sensory nor motor functions, play important roles in more complex reflexes and throughout the nervous systemWatch an examination of reflexes at https://www.youtube.com/watch?v=cYOnWQHxJts (3:14) The Peripheral Nervous SystemPeripheral Nervous System (PNS): includes all of the nerves lying outside the CNSSomatic DivisionAutonomic divisionsympathetic divisionparasympathetic division * Peripheral: all nerves outside the brain and spinal chord Broken down into two parts:Somatic Division: controls all voluntary movement (things we choose to do and say)Autonomic: ‘automatic’; controls involuntary functions in the body such as digestion, waste removal, etc.also has specialized divisions that help us survive in an emergency (sympathetic and parasympathetic divisions) Sympathetic: fight or flight – allows increased strength and endurance when needed for survivalParasympathetic: returns body to normal functioning when crisis is over
  • 11. The Somatic Nervous System and the Cranial NervesSomatic Nervous System:transmits commands for voluntary movement from the central nervous system to the muscles brings sensory input back to the CNS for further processing *The somatic nervous system is the part of the peripheral nervous system that transmits commands for voluntary movement from the central nervous system to the muscles and brings sensory input back to the CNS for further processing. These functions are carried out by the 31 pairs of spinal nerves serving the torso and limbs, and the 12 pairs of cranial nerves serving the head, neck, and some internal organs.Learn more about the cranial nerves at https://www.youtube.com/watch?v=vFp_qNifHzw (12:39) * The Autonomic Nervous SystemThe autonomic nervous system is responsible for:homeostasis: the regulation of important body functions such as temperature and thirstParasympathetic Divisionour fight-or-flight response to emergenciesSympathetic division * The autonomic nervous system is responsible for homeostasis – the regulation of important body functions such as temperature and thirst, and our fight-or-flight response to emergencies The ANS contains two subdivisions, the sympathetic division and the parasympathetic division. Nerve cells participating in the sympathetic division are found in the middle regions of the spinal cord in the torso and lower back Nerve cells participating in the parasympathetic division are located either in the brain or in the lowest segments of the spinal cordThe sympathetic
  • 12. division prepares the body for situations requiring the expenditure of energyThe parasympathetic division directs the storage of energyThe operation of the internal organs in response to environmental stimuli reflects a sophisticated combination of inputs from both the sympathetic and parasympathetic divisions The nature of the autonomic nervous system is important to our understanding of stress The sympathetic division was designed to deal with emergencies that could be resolved relatively quickly Worrying about far distant dangers, like next month’s rent or upcoming exams is a luxury that human beings did not have until quite recentlyWhenever you identify something as a significant threat, the sympathetic division goes into action Learn more about the sympathetic and parasympathetic nervous system at https://www.youtube.com/watch?v=H8ItFuDgYKw (4:34) Neurons process and transmit informationDendrites: portions of neurons that receive signalsAxon: portions of neurons that send signals Glial Cells: support cells that assist neurons The Structure and Function of Neurons Glia Blood Vessel Neuron Myelin * A neuron is a specialized nerve cell that processes and transmits informationNeurons are like other types of animal cellsThe cell body contains the nucleusThe fatty membrane separates intracellular and extracellular fluids Neurons perform the usual tasks of all cellsBasic housekeeping Metabolic functionsProtein manufacturingNeurons are unlike other cells in a few waysInclude specialized branches (axons and dendrites), which
  • 13. pass information to and receive information from other cellsAxon: branch of a neuron that is usually responsible for transmitting information to other neurons Dendrite: branch from the neural cell body that usually receives input from other neuronsThe human brain is estimated to have 100 billion neuronsMyelin Sheath: Whitish, fatty protein substance, composed of glial cells, that covers some axons and increases the speed of neural transmission – covers the axon except at small, regularly spaced gaps, called nodes of Ranvier Glial Cells: support cells that assist neurons by providing structural support, nutrition, and waste removal; manufacture myelinForm the framework that holds neurons in placeCreate tight connections with blood vessels serving the brain, the blood-brain barrierClean up debris where neurons have been damaged Outnumber neurons 3 to 1 Learn about the structure, function, and types of neurons at https://www.youtube.com/watch?v=cUGuWh2UeMk (4:08) Learn more about the functions of glial cells at https://www.youtube.com/watch?v=64MgiEDWyRg (8:00) * Axons Transmit InformationAxon: portions of neurons that send signals Axon Terminals: contain synaptic vesicles which store and release neurotransmitters *An axon is the branch of a neuron that is usually responsible for transmitting information to other neuronsSome axons are myelinated and some are not – myelin speeds up electrical transmissionmany dendrites-only one axonaxons can vary greatly in length – some in brain are microscopic/axon of motor neuron can stretch from the spinal chord all the way to your hand or footThe axon terminal contains synaptic vesicles, which
  • 14. contain chemical messengers called neurotransmitters that transmit signals between neurons These neurotransmitters communicate with receptors on the dendrites of other neurons * Dendrites Receive InformationDendrites: portions of neurons that receive signalsNeurotransmitters communicate with receptors on the dendrites. * A dendrite is a branch from the neural cell body that usually receives input from other neuronsNeurotransmitters from the sending neuron communicate with receptors on the dendrites of other neuronsNerve impulses usually travel from the dendrites and soma (cell body) to the branching ends of the axonMost neurons have many (even thousands) of dendritesa single neuron can receive signals from many other neuronsNeurotransmitters communicate with receptors on the dendrites * Electrical signaling: action potential Chemical signaling: neurotransmitters Neural Communication: A Two-Step Process * There are two steps in the transmission of information between neuron
  • 15. First step:Takes place in the signaling neuron’s axonNeuron generates an electrical signal known as an action potentialSignal travels the length of the axon from its junction with the cell body to its terminal Second stepTakes place between two neuronsArrival of an action potential at the axon terminal of the first neuron signals the release of neurotransmittersNeurotransmitters float across the extracellular fluid separating the two neuronsOn the influence of neurotransmitters, the second neuron may respond with its own action potential and send the message along Read an overview of neurotransmission at http://science.education.nih.gov/supplements/nih2/addiction/acti vities/lesson2_neurotransmission.htm * Electrical Signaling: Generating an Action PotentialResting Potential: electrical charge when the neuron is not being stimulated or inhibitedAction Potential: a brief, electrical impulse by which information is transmitted along the axon of a neuronall-or-none regenerativeAbsolute Refractory Period: time during which another action potential is impossible * Now let’s look at the action potential in more detail:When a neuron is not processing information, we say that it is at rest When a cell is at rest, the difference between the readings from the interior of the axon and the external fluid is known as the resting potential The interior of the neuron is negatively charged relative to its exterior Neurons can respond to incoming chemical signals by becoming either depolarized or hyperpolarizedWhen a neuron is depolarized by sufficient input, it will reach a thresholdReaching the threshold initiates a
  • 16. sequence of events that reliably produces an action potentialThe size and shape of action potentials are always the sameEither an action potential occurs, or the cell remains at rest—there is no middle ground. Because of this consistency, we say that action potentials work in an all-or-none fashion Watch this video to understand neurotransmission from a more physiological standpoint: http://www.dnatube.com/video/1310/Physiology-of-an-Action- Potential * Electrical Signaling: Propagating an Action PotentialPropagation: the duplication of the electrical signal down the length of the axon to the axon terminalmyelinated axonsNodes of Ranvierunmyelinated axonsOnce the action potential reaches the axon terminal, the neural communication system switches from an electrical signaling system to a chemical signaling one. *Action potentials do not affect the entire axon all at once The next step is propagation, or the duplication of the electrical signal down the length of the axon to the axon terminalPropagation takes place differently in myelinated and unmyelinated axonsIn an unmyelinated axon, action potentials occur in a step-by-step manner, from one small section of the axon to the nextAction potentials in myelinated axons are formed only at the sections of the axon membrane between adjacent segments of myelin, known as nodes of Ranvier; propagation in myelinated axons can “skip” the sections covered
  • 17. in myelin, and is fast and efficient.Once the action potential reaches the axon terminal, the neural communication system switches from an electrical signaling system to a chemical signaling one Chemical Signaling: Releasing NeurotransmittersWhen an action potential arrives at the axon terminal, neurotransmitters are released.Neurotransmitters are stored in tiny sacs called synaptic vesicles.When a nerve impulse reaches the end of an axon, vesicles move to the surface and release neurotransmitters into the synapse. * When an action potential arrives at a terminal, neurotransmitters are releasedNeurotransmitters are chemical substances that enable the signal from one neuron to be relayed to other neuronsNeurotransmitters are stored in tiny sacs called synaptic vesiclesWhen a nerve impulse reaches the end of an axon, the vesicles move to the surface and release these chemical messengers across the synapse (or synaptic gap)The synapse is a small gap that separates neurons; neurotransmitters are released into the synapse in order to continue neural impulses. To send messages, terminal buttons must be near the dendrites of neighboring neuronsThe space between terminal buttons and dendrites-synapseWhen signal reaches the end of the axon of a neuron, the terminal buttons release synaptic vesicles carrying neurotransmitters (chemical signal) into the synapse. (Presynaptic membrane)The neurotransmitter than contacts the postsynaptic membrane (dendrite) of the next neuron and binds to it at specially shaped receptor sites, thus transmitting the neural signal.Whole process – Synaptic TransmissionReuptake – The process by which neurotransmitters are detached form a postsynaptic neuron and are reabsorbed by the presynaptic
  • 18. neuron so they can be recycled and used again Video that shows how the release of a specific neurotransmitter, dopamine, results in feelings of pleasure: https://www.youtube.com/watch?v=M55co-GYTxQ Chemical Signaling Synapse Presynaptic Neuron Postsynaptic Neuron * The neuron that sends a signal across the gap is called the presynaptic neuron. The neuron that receives the signal is called the postsynaptic (receiving) neuron. Receptors are special channels on the receiving neuron a flashbulb memory According to the levels of processing theory, who will be able to remember the most definitions of the vocabulary words in a given chapter? Pat, who takes turns with her roommate defining and explaining each term -Varying states of awareness are best monitored using ____, which provides an overall measure of brain activity.
  • 19. an electroencephalogram -Marietta has memorized the capital cities of all 50 states. This is an example of ____ memory. semantic -In experienced meditators, EEG recordings of the frontal lobes of the brain during meditation feature increased levels of which type of brain waves? theta waves -Long ago (in the dark ages of television), ---the last image that was on the screen to fade away. This is most like iconic memory -Patti finds her husband Derek asleep--------, “Patti, I am awake!” Derek was most likely in ____. Stage 1 N-REM -The component of working memory that is responsible for verbal and auditory information is the _____. phonological loop -Drugs that speed up the functioning of the nervous system are called _____________ stimulants -Melatonin is to ___________ as an aspirin is to ____________ insomnia; headache -In order to demonstrate the extent to which classical----, John Watson and Rosalie Raynor conducted a study where ______. a young boy was taught to fear a white rat -Azul studies for her upcoming molecular biology midterm. ---- brain is likely to show ____ wave activity. beta -An implicit memory for how to carry out a motor skill or action is called ____. procedural memory -Keller and Marion Breland, two of B. F. Skinner’s ----animals for entertainment, encountered ____. biological boundaries
  • 20. -Normally, when food is placed in the mouth of any animal, salivation would be referred to as ______ an unconditioned response -What is a key distinction between classical conditioning and operant conditioning? Classical conditioning generally works best with involuntary, reflexive behaviors; -Jess is fast asleep, and her roommate ---such that Crystal reacts to the stimulus while Jess does not? the reticular formation -John Watson and his colleague, Rosalie Rayner---The white rat served as the ___________ in their study conditioned stimulus -What type of learning is most influential in developing and maintaining culture? observational learning -Caffeine is a _______________ Stimulant -What delays the process of extinction? Chemical Signaling: Synaptic Transmission * The neurotransmitters are released when a vesicle fuses with the membrane of the presynaptic cell and its contents spill into the synaptic cleft. After their release, neurotransmitters diffuse across the synaptic cleft to the membrane of the receiving cell. The neurotransmitters released across the synaptic gap come into contact with special channels on the receiving neuron, known as receptors Receptors work with the neurotransmitters like locks and keys Neurotransmitters do not stay bound to receptors very long
  • 21. the partial reinforcement effect -Moishe can remember only the first two items----This is an example of the ___________ serial position effect -Roger is preparing for his final exam in Bioethics--- in terms of memory retrieval, will most likely be essay -Tao wakes up his roommate Don so that he doesn’t miss his morning--Don was most likely in ____. REM sleep -After Little Albert acquired a conditioned fear to a rat-- whether or not ___________ had occurred stimulus generalization -Interpretation of the ________ content of a dream is expected to reveal the ________ content manifest; latent -Shalissa has two exams today---Shalissa’s memory is suffering from _______ proactive interference -When a stimulus is removed-- the probability of response, it is known as ___________ punishment by removal -When experienced practitioners---experience produced by meditation, they describe ____. a conscious state without thought, accompanied by a blissful emotional state -Lucia, who experiences extreme anxiety when taking an exam-- is an example of ____. negative reinforcement -Tao wakes up his roommate --- waveforms did Don display right before being awakened? beta wave -Fred is studying vocabulary for his biomedical class while lying---will likely be best while ____. lying down with background noise -Dennis buys a lottery ticket every Saturday-- of which schedule
  • 22. of reinforcement. variable ratio -Michael has a flashbulb memory --What is most likely to be true about this memory? Retrieval of this memory will be more accurate than of everyday events around the same time. -Which memory system provides us with a very brief representation of all the stimuli present at a particular . sensory memory -What type of stimulus elicits a response without prior experience—that is, without learning having taken place? Unconditioned -Someone asks you to name the twenty-second president--- In this situation, the hint acted as a(n)__ retrieval cue -Liz failed her math test,---she could not play video games until her grade improved. Her parents are using punishment by removal -Experienced whale trainer Dawn Brancheau was killed ---whale behavior; illustrating ____. 1 Synthesis and storage of neurotransmitter molecules in synaptic vesicles 2 Release of neurotransmitter molecules into synaptic cleft 3 Binding of neurotransmitters
  • 23. at receptor sites on postsynaptic membrane Chemical Signaling: Synaptic Transmission 5 Reuptake of neurotransmitters sponged up by the presynaptic neuron 4 Inactivation (by enzymes) or removal (drifting away) of neurotransmitters *The neurotransmitters released across the synaptic gap come into contact with special channels on the receiving neuron, known as receptors Receptors work with the neurotransmitters like locks and keys Neurotransmitters do not stay bound to receptors very long Once they pop out of the receptor binding site, neurotransmitter molecules either drift away from the gap, are broken down by enzymes, or return to the axon terminal from which they were released in a process called reuptake After producing postsynaptic potentials, some neurotransmitters either become inactivated by enzymes, or drift away. Most neurotransmitters, however, are reabsorbed into the presynaptic neuron through reuptake - a process in which neurotransmitters are sponged up from the synaptic cleft by the presynaptic membrane. For a stylized animation of a synapse, see: https://www.youtube.com/watch?v=90cj4NX87Yk
  • 24. instinctive drift -A graph of the serial position effect,--- takes the shape of a(n) ____. U-shaped curve -Which of the following neurotransmitters are associated with alcohol GABA -The tendency to respond to stimuli that are similar to an original conditioned stimulus is called ____. Generalization -Inevitable, involuntary responses to stimuli that are primarily controlled--brainstem are referred to as __ Reflexes -Manuel is teaching his 3-year-old son --- Joey sings “A B C D J R P X Y Z.” This is an example of ____. the primacy and recency effects -Jonah is playing on his tablet one evening, ---“voices” from his father illustrates _____. Discrimination -When Edie studies her psychology terms--- explain Edie's approach to encoding memories levels-of-processing Important Neurotransmitters and Their EffectsAcetylcholineDopamineSerotoninNorepinephrineGABA – gamma-aminobutyric acidEndorphins * There are more than 50 different neurotransmittersAcetylcholine is a neurotransmitter found in a number of systems important to
  • 25. behavior, e.g., at the neuromuscular junction, the synapse at which the nervous system commands muscles; they are also intimately involved in the brain circuits related to learning and memoryNorepinephrine is released in the brain and leads to arousal and vigilanceDopamine is a neurotransmitter involved with systems that govern movement, planning, and rewardSerotonin is involved with systems regulating sleep, appetite, and mood Endorphins (short for “endogenous morphine,” or morphine produced by the body) modify our natural response to pain (see also hormones, as endorphins act as both) Gamma amino butryic acid (GABA) – Inhibitory transmitter – acts like the brakes to a signal/ without the brakes, seizures occur The Endocrine SystemEndocrine system: a system of glands that controls secretion of blood-borne chemical messengersHormones: blood-borne chemical messengers that influence target tissues and glands * The endocrine system is comprised of a number of glands that release chemical messengers known as hormones into the bloodstream to communicate with other body partsResponds to input from the nervous system and from the hypothalamus in particularEspecially involved with arousal, metabolism, growth, and sexImportant glands of the endocrine system include the pineal gland, the pituitary gland (known as the “master gland” due to its role in regulating the functioning of other glands), the thyroid gland, and the adrenal glands.In males, the major reproductive glands are the testes.They are responsible for secreting testosterone, which influences sexual function and plays a critical role in puberty.In females, the major reproductive glands are the ovaries.They are responsible for
  • 26. secreting estrogen, which influences sexual function, plays a critical role in puberty, and is one of the major hormones involved in the menstrual cycle.Pineal Gland – located deep in the brain – Produces melatonin – regulator of the sleep wake cycle: sleep-melatonin increases/wake-melatonin decreasesHypothalamus – deep in brain – sends signals to the pituitary and contains key centers for aggression, fleeing, sexual activity, and hungerPituitary gland – in brain below the thalamus and hypothalamus; called the master gland because its secretions control many other glandsreleases somatotropin – a growth hormone-acts directly on bones and muscles to produce growth spurt during pubertyStimulates thyroid to regulate the release of thyroxineCauses adrenal glands to produce cortisol – accelerates production of glucose during stressInterplay between nervous and endocrine systemThyroid gland – located below the larynx – regulates growth and metabolismPancreas – lies between the stomach and the small intestine – releases insulin which regulates the levels of glucose in the body – In diabetic patients, the body either does not produce the needed insulin or the cells do not respond to the insulin that is presentAs food breaks down, the rise in glucose levels in the blood signals the pancreas to produce insulin; as glucose levels drop, insulin secretion decreasesAdrenal glands – located ate the top of each kidney – release a wide range of hormones including epinephrine and norepinephrine, which power sympathetic nervous system activityFight and flight – triggered by nervous system – sustained by endocrine system Part 1: Summarize all comments listed on your evaluation forms ( Attachment second and third one ), good, bad and ugly. Identify any common themes that were present in your comments and respond to them. For example, if multiple people commented on the applicability of a specific objective, this
  • 27. would qualify as a common theme. This section should be no shorter than one page, Part 2: Comment on the results of your evaluation. Is this what you expected? Why or why not? How will this impact solving your problem going forward? Do you feel you’ll need to adjust any of your solutions? If so, how? If not, why not? This section should be between 1-2 pages. Page 1