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Detailed discussion on diagnosis and management of TMJ ankylosis. Surgical anatomy and applied aspects of TMJ is discussed. Reconstruction of ramus-condyle unit is also discussed. Compications of TMJ surgery are also discussed
TMJ is a ginglymo-diarthroidal joint that is freely mobile with superior and inferior joint spaces separated by articular disc.
The type of imaging technique depends upon the clinical problems associated, so either imaging of hard tissue (OSSEOUS) or soft tissue is desired.
Certain protocols are to be taken care before the imaging procedure:
the amount of diagnostic information available from particular imaging modality.
The cost of examination
The radiation dose
Detailed discussion on diagnosis and management of TMJ ankylosis. Surgical anatomy and applied aspects of TMJ is discussed. Reconstruction of ramus-condyle unit is also discussed. Compications of TMJ surgery are also discussed
TMJ is a ginglymo-diarthroidal joint that is freely mobile with superior and inferior joint spaces separated by articular disc.
The type of imaging technique depends upon the clinical problems associated, so either imaging of hard tissue (OSSEOUS) or soft tissue is desired.
Certain protocols are to be taken care before the imaging procedure:
the amount of diagnostic information available from particular imaging modality.
The cost of examination
The radiation dose
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. (Diseases of the Temporomandibular joint in childeren)
Names: -Seyedsaeid Seyedraoufi
Oct 2022
Lecturer: Dr.Emir Bayandurov
Subject: Pediatric Oral Surgery
Pediatric Oral And Maxillofacial Surgery, January 16, 2018
by Marshall M. Freilich, DDS, MSc, FRCD(C)
3. Congenital growth disturbances
• Unilateral disorders
Hemifacial microsomia
Hemifacial microsomia is unilateral hypoplasia or aplasia of the
TMJ, it is an asymmetric, progressive deficiency which relates
to both soft tissues and the bony skeleton of the scull. The
developmental problem of the first and second branchial
arches can cause this disease.
It is classified in three groups
– Type I. :”minimanbible” All parts of the mandible are
present and the arch is normal, but they are small
– Type II.: Small and anomalously arched ramus, and
hypoplastic, anteriorly and medially situated condyle
– Type III.: total unilateral absence of the condyle and
ramus
4. Congenital grows disturbances
• Bilateral developmental anomalies of the first and
second branchial arch
– Treacher Collins syndrome (mandibulofacial
dysostosis)
It is characterized by a bilateral hypoplastic TMJ a
short ramus and a decreased face height. This
syndrome is a dominantly inherited abnormality. Its
rate of occurrence is 1:10000. Clinical appearance
is always bilateral. Retractions may be observes on
eyelids, the lower eyelashes may be missing. The
external ear is hypoplastic, hearing disturbance
exists.
5. Acquired TMJ deformities
Condylar hyperplasia
It is the most frequent postnatal abnormality of
TMJ . It appears in the years before puberty.
It is assumed that the cause of the changes lies
in the more active metabolism of the condyle
Two different growth tendencies may be
distinguished
Vertical The mandible grows mainly in vertical
direction, which results vertically long ramus and
body.
Rotational Besides the enlarged condyle and
vertically long ramus, the convex enlargement of
the body leads to a crossbite and mouth opening
deviation. The enhanced metabolism may be
proved by bone scintigraphic examination.
6. Infections
• Before the advent of antibiotics, infectious diseases of the TMJ
were much common than today. Description from the 19th and
20th centuries revealed that infections of the ear and teeth often
spread to the joint. The primary causes of TMJ were infectious
diseases of childhood (scarlet fever, chickenpox, diphteria, etc.)
• Symptoms:
– Intense pain
– The most comfortable position for the patient is the opened
mouth
– Oedema, erythema above the joint, than fluctuation
– The cronic state was indicated by a fistula in the region of
TMJ.
7. • Trismus: This is an anomaly based on muscle spasm.
– Extracapsular process, the TMJ itself is not effected. Classic examples
of the lesion are the complications that arise in the course of
conduction anaesthetization. (infection, bleeding or nerve damage)
• Pseudo ankylosis:
– Intraarticular cause: fibrosus ankylosis.
– Extraarticular cause: Include the hyperplasia of the coronoid process
or its unification with the maxillary tuber or with the zygomatic
bone, or a fractured zygomatic arch. It may occur as a chronic scar
contracture of the temporal muscle as a consequence of irradiation or
surgery.
• Ankylosis: This is a bony unification of the condyle and the
glenoid fossa.
There is a lot of expression, which means the disability of the
movement of TMJ
trismus,
pseudo ankylosis,
ankylosis.
8. Ankylosis
• Etiology:
Trauma
Rheumatoid arthritis
Infection-This is now rare as a cause
Tumors- Are similarly rarely observed in the TMJ
• In childhood there are a lot of vessels in the joint, which runs between the
condyle and the capsule. In the event of trauma hemarthrosis will develop,
which undergoes ossification.
• In adulthood 51% of the cases of polyarticular rheumatoid arthritis affect the
TMJ. ( usually only one) In childhood, the most serious consequence of
ankylosis caused by RA is the facial deformity due to the damage to the growth
center. The development of the lower third of the face is retarded and a „bird
face” results.
10. Treatment
• In childhood there are 4 groups in ankylosis and
the treatment varies group to group,
On The X ray the articular gap is narrowed, but it can be
followed.
The lateral parts of the articular surface there are much
more synostosis but on the medial deeper parts of the TMJ
the cartilaginous surfaces are preserved and the disk may be
distinguished
There is a bridge-like synostosis between zygomatic arch
and ramus of the mandible. The medial part of the
capitulum is intact and able to function.
The extent of synostosis is such that the TMJ can no longer
be recognized.
11. Treatment
• In adulthood
To avoid re ossification some „interposed” is
recommended between the reformed articular
fossa and condyle. This may be the temporal
muscle, cartilage or alloplastic material.
The first step in treatment is surgery. The
TMJ is usually exposed from preauricular
incision.
In cases belonging to the first two groups the
TMJ can be easily recognized after exposure.
After closure and postoperative period the
second step is functional treatment.
12. Injuries
Dislocation-takes place most often in the anterior direction, the
condyle becomes positioned in front of the articular tubercule.
Subluxation- The dislocation is not complete, the condyle can return
to the glenoid fossa
Recurrent luxation - The luxation or subluxation occurs on a
number of occasions but there is no psychological factor inducting
compulsive movement.
Habitual luxation is caused by compulsive movements.
• The terms luxation, distortion and dislocation are used when the
articular surfaces are totally separated from one another and the joint
is fixed in this extraarticular position. It may be induced by an
external ( hit, extraction) or an internal action (huge yawn, vomiting,
singing, dental procedure).
The direct cause of spontaneous luxation is sudden disturbance of the
coordination of the muscles movement.
13. Symptoms
The patient cannot close his or her
mouth
The mandible is elastically fixated
The articular fossa is empty
Moderate pain in the joint
14. Treatment
• Acute: Reposition- The earlier the repositioning is attempted the
more easily succeeds. The thumbs are wrapped in gauze and
placed on the occlusal surface of the mandibular molars or
alveolar ridges. By pressing firmly on the molars and elevating
anteriorly with simultaneous backward pressure, the condyle is
relocated.
• Chronically persisting luxation: Reposition under general
anesthesia, when the reposition is unsuccessful, condylotomy may
be considered
• Recurrent: The reposition is generally easy but it is difficult to
avoid repetition of the luxation. Conservative or surgical
treatment.
• Habitual: It is difficult to know how to alter psychological
component that includes the compulsive movement.
15. Internal derangement
The internal derangement means intracapsular damage of
the TMJ which primary arises from the incorrect
movement of the articular disk together with the
secondary changes of movement.
The disease does not belong to developmental anomalies
or to other diseases of the TMJ
Symptoms
pain, deviation, repeated clicking when the mouth is
opened and reciprocal clicking when closed
Treatment is primary conservative and only rarely
surgical
Medication: NSAID, night bite guard (bite raising
appliances)
16. A further change occur if the disc stretches and
becomes thinner and the articular gap is reduced
progressively in both posterior and anterior direction
The following step is the rupture of the disc, so the
glenoid fossa and the condyle come into direct
contact
The condyle slowly becomes pointed in the anterior
and posterior direction and finally degenerative
changes occur in the bone
The healthy articular disc allows the appropriate
distance between the condyle and the glenoid fossa
Firstly the articular disc displaces, the posterior
fibers of the disc becomes loosened, the condyle
will be posteriorly positioned
Internal derangement
17. Degenerative diseases
Osteoarthrosis (arthrosis deformans, osteoarthritis).
– It is a non-inflammatory degenerative diseases which mainly affects the articular
surfaces but it also induces reconstruction of and changes in the bone beneath
the articular surface.
– Symptoms: Pain, crepitation, restriction of articular movement
Rheumatoid arthritis
– Autoimmune disease of the small periferial joints. In women it is three times
common than in men. In 10-15% of the cases involve a progressive variant with
articular destruction and deformities. The inflammation of the synovial
membrane is carasteristic. The inflammatoric process damages the joint and the
scar tissue impedes the movements.
– Symptoms: Intermittent pain, swelling and progressive restriction of the articular
movement. Typical that the small joints of the hand and foot become involve
first.
19. • Gout
This is a metabolic disease, uric acid crystals are deposited in
and around the joints and these causes inflammatory
symptoms. Above the joint the skin is red and swollen and in
particular movement gives rise to pain.
• Other degenerative diseases
Spondylitis accompanied by ankylosis:It differs from RA that here
primarily the ligaments around the joint undergo calcification and
ossification.
Psoriatic arthritis: symmetric polyarthritis and negative rheumatoid
factors
Post traumal arthritis: Arthritis may develop as a consequence of
trauma
Condyle resorption: after bilateral condyle fracture or as a consequence
of otitis media
20. Tumors of TMJ
The tumors of TMJ are very rare. These could develop from
some parts of the joint or may spread from the environment of
the joint.
Benign tumors The condyle may be enlarged for many
reasons, e.g.:
– acromegalia,
– fibrosus dysplasia,
– condylar hypertropia,
– osteoma, osteochondroma,
– chondroma stb.
Common typical symptoms:
– Slow restriction of the movement of the joint
– Painless swelling in the region
Metastases:
Primer tumor could be in
prostate, breast, kidney,
malignant melanoma, lung,
pancreas
etc.