This document summarizes the development of a world-class cosmetics cluster in Crema, Italy that was born from the reindustrialization of the historic Olivetti settlement. Key steps included mapping local industry specializations, analyzing the cosmetics value chain with local companies, prioritizing initiatives like improving visibility and training, and establishing a cluster organization called Polo Cosmesi with over 150 member firms that benefits from joint initiatives, services, and internationalization support. The success of the cluster is attributed to strong leadership, a willingness to evolve, active involvement from public and private partners, and a focus on building trust between members.