1. The document discusses different types of tablets including oral, compressed, layered, film-coated, and controlled release tablets. 2. It describes important considerations for tablet design like delivering the correct dose, withstanding mechanical stresses, and maintaining chemical and physical stability over time. 3. Excipients commonly used in tablet formulations are discussed, including diluents, binders, lubricants, disintegrants, and others to aid manufacturing, drug release, stability, and patient acceptance.

1. T
ablet
tablets
RCPIPER
Presented by:
Saurabh ManojMarathe
DipeshsanjeevePatil
Suvarnsing RajendraPardeshi
Jugal RavindraPatil

2. T
ablet
Introduction
Defination:-Tablets are solid unit dosage forms, in which one usual dose of drug has
been accurately placed
Advantages:-
Portability
Acquire less space
Attractive Design
Acurate dosing
Cheapest
Easily identified
Drug release modification is possible
Chemically&mechanically stable
microbiologically stable

3. T
ablet
Introduction
disadvantages:-
More likely to cause irritation
Slower acting
Uneven disintegration
Less palatable
requirecoating

4. T
abl
e
t
1. Oral tablets for ingestion
2. Compressed tablets
3. standard compressed tablets (CT)
4. Multiple compressed tablets (MCT)
5. Layered tablets
6. Compression-coated tablets
7. Chewable tablets
8. Sugar- and chocolate-coated
tablets
9. Film-coated tablets
10.Delayed-action
11.enteric coated tablets
11.Controlled release tablets
Types of tablets

5. 12.Buccal and sublingual tablets
13.Troches and lozenges
14.Dental cones
15.Implantation tablets
16.Vaginal tablets
17.Tablets used to prepare solutions Effervescent
18.Dispensing tablets (DT)
19.Hypodermic tablets (HT)
20.Tablet triturates (TT)
Types of tablets
T
ablet

6. T
ablet
TABLETDESIGNANDFORMULATION
Tablet Design:
Objectives:
•to deliver orally the correct amount of drug in the
proper form
at or over the proper time and in the desired location
Ideal characteristics of tablets:
• should be an elegant product havingits
own
identity while being freeof defects such as
chips, cracks, discoloration,
contamination,and the like
• should have the strength to withstand the
rigors of mechanical shocks encountered inits
production, packaging&shipping.
must be able to release the medicinal agent(s)
in the body in a predictable and reproducible

7. T
ablet
TABLETDESIGNANDFORMULATION
•musthaveasuitablechemicalstabilityovertimesoasnotto
allowalterationofthemedicinalagent(s).
•shouldhavethechemicalandphysicalstabilitytomaintainits
physicalattributesovertime.

8. T
ablet
TABLETDESIGNANDFORMULATION
FormulationComponentsorExcipients:-
• provideessentialmanufacturingtechnologyfunctions:-binders,
lubricants,glidants
• modifydrugrelease:-disintegrants,polymers
• enhancestability:-antioxidants
• enhancepatientacceptance:-flavours,sweeteners
• aidinproductidentification:-colorants
• Allnondrugcomponents
tabletexcipientsmustmeetcertaincriteria:
1.
Theymustbenontoxicandacceptabletotheregulatory
agenciesinallcountrieswheretheproductistobemarketed
2.Theymustbecommerciallyavailableinanacceptablegradein
allcountrieswheretheproductistobemanufactured.

9. T
ablet
TABLETDESIGNANDFORMULATION
Exciepients:-
1.Calciumcarbonate Cal-Carb,Millicarb.
2.Calciumphosphatedibasic Cyfos,Calstar,Calipharm.
3.Calciumphosphatetribasic T
ricafos,T
ri-Cal.
4.Cellulose,microcrystalline Avicel,Emcocel.
5.MCC silicifiedProsolv.

10. T
ablet
Binders&Adhesives;
TABLETDESIGNANDFORMULATION
1.Carbomer Carbopo.
2.Carboxymethylcellulose sodiumNymcel.
3.Cellulose,microcrystallineAvicel,Emcocel.
4.Ethylcellulose Aquacoat.
5.Hydroxyethyl Cellosize.
6.Hydroxypropylcellulose Klucel.
7.Polydextrose Litesse

11. T
ablet
TABLETDESIGNANDFORMULATION
Glidant-
1.Calciumsilicate
2.Cellulose[powdered]
3.Magnesiumcarbonate
4.Magnesiumoxide
5.Magnesiumsilicate

12. T
ablet
TABLETDESIGNANDFORMULATION
Lubricant
1.Calciumstearate
2.Fumaricacid
3.Glycerylbehenate
4.Magnesiumlauryl5.sulfate
6.Magnesiumstearate
7.Starch
8.Stearicacid

13. T
ablet
TABLETDESIGNANDFORMULATION
Disintegrant
1.Alginicacid
2.Carboxymethylcellulosesodium
3.Docusatesodium
4.Guargum
5.starch

14. T
ablet
TABLETDESIGNANDFORMULATION
T
abletpreparationtechniques
Compressiongranulation
Wetgranulation
Directcompression

15. T
ablet
TABLETDESIGNANDFORMULATION
Compressiongranulation
Excipients:-Diluents+Disintegrants
largesizetabletsludge
granules
disintegrant T
ablet
glident
lubricant
slugging
mixing
screening
compressi
o
n

16. T
ablet
TABLETDESIGNANDFORMULATION
Directcompression
Excipients;-Dcdelucent
Disintegrants
Glident
lubricant
compression
T
ablet

17. T
ablet
TABLETDESIGNANDFORMULATION
Wetgranulation
Excipents:-Diluents
disintegrants
mixing
Bindersolution
Granulation
Dow
Screening
Wetgranules
Drying
Drygranules
screeni
n
g
granules
mixing
T
ablet