Systems biology is the computational and mathematical modeling of complex biological systems, gaining popularity since 2000 in various biological contexts including cells and proteins. It focuses on the interactions among components within biological systems and holds promise for drug discovery through the analysis of complex relationships involving multiple genes. The document discusses the advantages, challenges, and tools related to systems biology while emphasizing its role in understanding biological networks.

1. TOPIC : SYSTEM’s
BIOLOG Y
TEAM : DOT TRIMATRIK

2. Submitted By:
I. Md. Ariful Islam (162-15-7885)
II. Pritam Chandra Shil (162-15-7882)
III. Sarwar Jahan Shajib (142-15-4045)

3. 
 What are systems Biology….??
Systems biology is
the Computational and Mathematical
modeling of complex biological
systems.
 Particularly from year 2000
onwards, the concept has been
used widely in biology in a variety
of contexts.
Example: Cells, Proteins

4. 
In molecular biology,
gene structure and
function
is studied at the
molecular level.
In systems biology,
specific interactions of
components in the biological
systems are studied –
cells, tissues, organs,
and ecological webs.
Molecular vs. Systems
Biology Biology

5. 

6. 
It is highly relevant in
discovering more complex
relationships involving multiple
genes.
This may create new
opportunities for drug discovery.
Advantages of Systems
Biology

7. 
Research has begun on larger-scale
simulations:
 Biochemical network level
 Simulation of Epidermal Growth
Factor (EGF)
 The Physio me Project
What’s to come?

8. 
Languages
Systems Biology Markup Language
CellML
Systems Biology Workbench
Databases
Kyoto Encyclopedia of Genes and Genomes
Alliance for Cellular Signaling
Signal Transduction Knowledge Environment
Databases and Tools

9. 
Protein 53
Produces 53 proteins kilo Daltons
Guardian of the genome
Detects DNA damages
p53

10. 
When multiple biological pathways
interact with each other, it is called
biological network.
Biological pathways are far more
complicated.
Have no real boundaries.
What’s the Biological Networks..?

11. 

12. Systems Biology
New?? NO and YES

13. 

14. 

15. 
Systems biology: studying living
cells/tissues/etc by exploring their
components and their interactions
Major challenge is to integrate knowledge
of kinetics and genome-scale networks
Even without detailed knowledge of
kinetics, genome-scale modeling is still
possible
Conclusions

16. 
ANY QUESTION….??

17. 
fashionable catchword?
a real new (philosophical) concept?
new discipline in biology?
just biology?
........
Hello Dear !! What is
systems Biology…??

18. 