Here are the key recommendations for backing up a business's systems and data: 1. Distinguish between backing up the operating system and applications for system recovery, and backing up important business data. 2. Identify the most crucial business data like customer lists and financials that cannot be lost, and store a duplicate off-site using an online backup service. 3. Schedule routine full backups weekly and incremental backups daily or nightly to capture file changes. 4. Make sure installation disks are available for all software, or back up a system image including all applications. 5. Claim a free data backup and recovery audit for more details on assessing backup needs.