The major salivary glands are the parotid, submandibular, and sublingual glands. The parotid gland is the largest and is located below and in front of the ear. The submandibular gland is beneath the jawbone and the sublingual gland is beneath the floor of the mouth. Each gland has specific blood supply, nerve innervation and ducts through which saliva passes. Imaging modalities like ultrasound and CT are useful for evaluating salivary gland disorders. Surgical procedures like gland excision require careful dissection to preserve structures like nerves and ducts.
This seminar explains about the development, relations, ligaments, various attachments, vascular and nervous supply and various surgical approaches and its modifications to TMJ
Detailed discussion on surgical anatomy of salivary glands with special focus on major glands. Relationship of facial nerve and its branhes to parotid gland is also discussed. Complications are also discussed. Surgical approaches are also discussed.
This seminar explains about the development, relations, ligaments, various attachments, vascular and nervous supply and various surgical approaches and its modifications to TMJ
Detailed discussion on surgical anatomy of salivary glands with special focus on major glands. Relationship of facial nerve and its branhes to parotid gland is also discussed. Complications are also discussed. Surgical approaches are also discussed.
INTRODUCTIONSalivary glands are compound tubuloacinar, exocrine gland and the ducts opens in the oral cavity.
Salivary glands secretes a fluid called saliva that coats the teeth and the mucosa.
Saliva is a complex fluid, produced by the salivary glands, the most important function of which is to maintain the well- being of mouth.
Individuals with a deficiency of salivary secretion experience difficulty in eating, speaking, and swallowing and become prone to mucosal infections and dental caries.
The region on the lateral surface of the face that comprises the parotid gland & the structures immediately related to it
Largest of the salivary glands
Located subcutaneously, below and in front of the external auditory meatus
Occupies the deep hollow behind the ramus of the mandible
Wedge-shaped when viewed externally, with the base above & the apex behind the angle of the mandible
The surgical anatomy of major salivary glands has many significant applications in maxillofacial surgery. Understanding these important anatomic relations- variations enables surgeons to perform the surgical procedures safely. Knowledge of these concepts helps us to recognize the problems and complications as and when they occur and manage them accordingly.
It contains following subheadings:
-maxilla and mandible anatomy
-TMJ(Temporo mandibular joint)
-Muscles of mastication
By:
Dr. Syed Irfan Qadeer
Prof. and HOD Department of Anatomy
SPIDMS,Lucknow
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. Introduction
The salivary glands are the exocrine glands, glands with ducts,
that produce saliva and pour their secretion in the oral cavity
.They are classified as:
1) Major (Paired) -Parotid
Submandibular
Sublingual
2) Minor -Those in the Tongue, Palatine Tonsil, Palate
Lips & Cheek
3.
4. Development of Salivary glands
• They originate from oral epithelium buds invading the
underlying ectomesenchyme.
• Origin of epithelial buds:
Ectodermal –Parotid gland,Minor salivary glands
Endodermal-Submandibular gland
Sublingual gland
5.
6.
7. Functions of Saliva
• The functions of saliva are:
• Chemical digestion: breaks down starch by the function of
“salivary amylase”
• Helps chewing and swallowing.
• Lubricating effect: moisturizes the inside of the mouth and
creates smoother speech.
• Solvent effect: dissolves food and allows the tongue to taste
food.
9. PAROTID GLAND
• Largest major Salivary gland
• Average Wt - 25gm
• Irregular lobulated mass lying mainly below the external
acoustic meatus between mandible and sternomastoid.
• On the surface of the masseter, small detached part lies b/w
zygomatic arch and parotid duct- accessory parotid gland or
‘socia parotidis’
10. • Parotid Capsule :
• Derived from investing layer of deep cervical fascia.
• Superficial lamina-thick, closely adherent-sends fibrous septa
into the gland.
• Deep lamina-thin- attached to styloid process, mandible and
tympanic plate.
• Stylomandibular ligament
11. External Features
-It resembles an inverted 3 sided pyramid having four surfaces –
• Superior(Base of the Pyramid)
• Superficial
• Anteromedial
• Posteromedial
-Separated by three borders :-
• Anterior
• Posterior
• Medial
12. Relations-
• Superior Surface –
• Concave
• Related to :
1) Cartilaginous part of external acoustic meatus
2) Post. Aspect of temperomandibular joint
3) Auriculotemporal Nerve
4) Sup. Temporal vessels
13. • Apex –
Overlaps posterior belly of digastric and adjoining part of
carotid triangle.
• Superficial Surface –
• Covered by : Skin
Superficial fascia containing facial branches of
Great Auricular nerve
Superficial parotid lymph nodes and post fibers
of Platysma
14. Anteromedial Surface –
• Grooved by posterior border of ramus of mandible
• Related to -
1)Masseter
2)Lateral Surface of temporomandibular joint
3) Medial pterygoid muscles
4)Emerging branches of Facial Nerve
15. • Posteromedial Surface :
• Related to-
1) Mastoid process with sternomastoid and posterior belly of digastric.
2) Styloid process with structures attached to it.
3) External Carotid artery which enters the gland through the surface
4) Internal Carotid artery which lies deep to styloid process
16. BORDERS
• Anterior border
• Separates superficial surface from anteromedial surface
• Structures which emerge at this border
-Parotid Duct
-Terminal Branches of facial nerve
-Transverse facial vessels
17. Posterior border
• Separates superficial surface from posteromedial surface
• Overlaps sternocleidomastoid muscule
Medial Border-
• Separates anteromedial surface from posteromedial surface
• Related to lateral wall of pharynx
22. • To expose the trunk of the facial nerve at the stylomastoid foramen the dissection
passes down the avascular plane between the parotid gland and the external
acoustic canal
• The nerve lies about 9 mm from the posterior belly of the digastric muscle and 11
mm from the bony external meatus
• The facial nerve then passes downward and forward over the styloid process and
associated muscles for about 1.3 cm
24. Parotid duct
• ductus parotideus; Stensen’s duct
• 5 cm in length
• Appears in the anterior border
of the gland
• Runs anteriorly and downwards on the
masseter b/w the upper and lower buccal
branches of Facial nerve.
25. • At the anterior border of masseter it pierces
• Buccal pad of fat
• Buccopharyngeal fascia
• Buccinator Muscle
• It opens into the vestibule of mouth opposite to the 2nd upper
molar.
26. Blood supply
• Arterial-
Branch of External Carotid artery
• Venous-
Into the External Juglar vein
• Lymphatic drainage-
Upper deep Cervical nodes via Parotid nodes
Nerve supply
Parasympathetic –Auriculotemporal nerve
Sympathetic- plexus around middle meningeal
27. Identifying Facial nerve
• Tragus pointer :1.0cm-1.5cm deep and slightly anterior and inferior to the tip
of the external auditory canal cartilage.
• The nerve bisects the angle made by the diagastric and tympanic plate.
• 1.0cm deep to attachment of the posterior belly of the diagastric groove of
the mastoid bone.
• The CN VII lies 6-8mm distal to the end point of the tympano mastoid
fissure.
• Nerve stimulator
• Magnifying loops
29. • During surgical removal of parotid gland for any tumour the
facial nerve is preserved by removing the glands in two parts
superficial and deep lobe separately.
• Retrograde approach to the trunk from either Mandibular
branch,where it passes over Retromandibular vein.
• Supravital staining of Parotid gland.
Preventing injury to Facial nerve
30. Complications
• Facial Nerve injury
• Frey's syndrome-(Gustatory sweating)-
It is a condition where sweating & sometimes flushing of skin
in the area of distribution of Auriculotemporal nerve that
occures;which is caused by stimulation to saliva secretion.
• It is caused due to damage to postganglionic parasympathetic
fibres from the otic ganglion,that became united to
sympathetic fibres arising from Superior cervical ganglion.
31. SUBMANDIBULAR SALIVARY GLANDS
• Irregular in shape
• Weigh about 15 grams and contribute
some 60–67% of unstimulated saliva
secretion.
• Large superficial and small deeper part continous with each
other around the posterior border of mylohyoid.
32. Superficial part-
• Situated in the digastric triangle
• Wedged b/w body of mandible and mylohyoid
• 3 surfaces –
Inferior, Medial, Lateral
33. Capsule
• Derived from deep cervical fascia .
• Superficial Layer is attached to base of mandible
• Deep layer attached to mylohyoid line of mandible
34. Relations
• Inferior- Covered by :
- Skin
- Superficial fascia containing Platysma and cervical
branches of Facial nerve
- Deep Fascia
- Facial Vein
- Submandibular Nodes
35. • Lateral surface -
-Related to submandibluar fossa on the mandible
-Mandibular attachment of Medial pterygoid
-Facial Artery
36.
37. • Medial surface-
• Anterior part is related to mylohyoid muscle, nerve and vessels.
• Middle part - Hyoglossus, styloglossus, lingual nerve,
Submandibular ganglion, Hypoglossal nerve and
Deep lingual vein.
• Posterior Part - Styloglossus, stylohyoid ligament, 9th nerve and
Wall of Pharynx
38. • Deep part:
- Small in size
- Lies deep to Mylohyoid and superficial to Hyoglossus
and Styloglossus
- Posteriorly continuous with superficial part around the posterior
border of Mylohyoid
39. • Submandibular Duct
-Whartons duct -
-5 cm long
-Emerges at the anterior end of deep part of the gland
-Runs forwards on Hyoglossus b/w lingual
and Hypoglossal nerve
-At the Anterior border of Hyoglossus it is crossed
by lingual nerve.
-Opens in the floor of mouth at the side of frenulum of
tongue.
40.
41. •SUBMANDIBULAR GANGLION (LANGLEY’S GANGLION)
-It’s a parasympathetic ganglion, which acts as a relay station for
secretomotor fibres supplying the submandibular and sublingual salivary
glands.
-Topographically, it’s linked to the trigeminal nerve (lingual nerve) but
functionally it’s related to the facial nerve (via its chorda tympani branch).
42. NERVE SUPPLY
• The submandibular ganglion has 3 roots, viz.:
parasympathetic, sympathetic and sensory.
• Parasympathetic root: From Chorda Tympani
• Sympathetic root:It’s originated from sympathetic plexus
around the facial artery.
• Sensory root: It’s originated from lingual nerve.
• BLOOD SUPPLY
• ARTERIAL: Branches of Facial & Lingual arteries
• VENOUS : Facial & Lingual Veins
43. Applied aspect
- The formation of calculus is more common in the Submandibular gland
than in the parotid
. - For excision of the Submandibular salivary gland( for calculus or tumour), a
skin crease incision is as a rule, given more than 1inch( 2.5cm) below the
angle of the jaw . Since the marginal mandibular branch of facial nerve
enters 1 inch posteroinferior to the angle of the mandible before crossing
its lower border, the incision so ought to be given 4 cm below the angle to
prevent injury to this nerve.
- A stone in the Submandibular duct (Wharton’s duct) can be palpated
bimanually in the floor of the mouth and can even be seen if sufficiently
large.
44. Submandibular gland excision
• Indications :
- Chronic sialoadenitis
- Stone in submandbular gland
- Submandibular gland tumors
• Incision :-
Placed 2-4 cm below the mandible, parallel to it •
Preserve :
- Marginal mandibular nerve
-Lingual nerve
- Hypoglossal nerve
45. Approaches
• Extraoral approach-
1)Lateral Transcervical -Incision of 4-5cm in length ,is taken in the
skin in Submandibular region.Incision to be placed parallel to skin
crease ,about 2cm below the Submandibular border.The wound is
then deepened through Platysma and deep fascia.
2) Submental approach
• The submental approach provides access to the submandibular
triangle via a midline horizontal incision just superior to the
submental-cervical crease at the level of the hyoid bone,
(4.5 ± 1.9 cm).
• Intraoral approach
49. SUBLINGUAL GLAND
• Smallest of the three glands
• Weighs nearly 3-4 gm
• Lies beneath the oral mucosa in contact with the sublingual
fossa on lingual aspect of mandible.
50. RELATIONS
Above
Mucosa of oral floor,
Below -
- Mylohyoid Infront
- Anterior end of its fellow
Behind -
-Deep part of Submandibular gland
Lateral - Mandible above the anterior part of mylohyoid line •
Medial - Genioglossus and separated from it by Lingual nerve
and Submandibular duct
51. DUCT OF SUBLINGUAL GLAND
• Ducts of Rivinus
• 8-20 ducts .
• Most of them open directly into the floor of mouth .
• Few of them join the Submandibular duct.
52. • BLOOD SUPPLY
• Arterial : From Sublingual and Submental
arteries.
• Veneous: Corresponding veins
53. APPLIED ASPECT
• The structures at risk during dissection of the gland are the
Submandibular duct and the Lingual nerve.
• The duct lies superficially in the floor of the mouth medial to
the sublingual fold, and is crossed inferiorly by the nerve
which then enters the tongue
• The Sublingual artery and vein also lie on the medial aspect
of the gland close to the Submandibular duct and Lingual
nerve.
54. Incision
• It is given in the Sublingual groove
• Structures closely associated are:-
Sublingual gland
Submandibular duct
Lingual nerve
Hypoglossal nerve
Sublingual vein
55. Diagnostic Imaging
• It plays an important role in evaluation of disorders
associated of major salivary gland.
• The modalities used for imaging are:-
• Conventional Radiography
• Sialography
• Ultrasonography
• Computed Tomography
• Radionuclide imaging
56. References
• Textbook and colour Atlas of Salivary gland
pathology; Eric Carlson
• Textbook of Oral & Maxillofacial surgery; Neelima
Malik
• Internet
Editor's Notes
STAGE 1 Bud formation: Introduction of the oral epithelium by underlying mesenchyme
STAGE 2 Formation and growth of epithelial cord
.STAGE 3 Initiation of branching in terminal parts of epithelial cord and continuation of glandular differentiation
.STAGE 4 Dichromatous branching of epithelial cord and lobule formation
STAGE 5 Canalization of presumptive ducts
STAGE 6 Cytodifferentiation
Ph=6.5-7
Taste is a chemical sense. Any substance, the taste of which has to be perceived, has to be in dissolved state to stimulate the taste receptors
Eca runs deeply within the parotid
Sup temporal artery &max –condyle level
Davis et el
Anastomototic pattern in 350
NERVE SUPPLY – CHORDA TYMPANI,LINGUAL
Cerpy in 1902
Phases-Ductal.acinar,post evacuation .normal-laefless tree.
Acinar-completion of ductal opacification
Evac-asses secretory function of gland
Sjogren- cHerry blossom branchless fruit tree
Tumour-hand holding ball