This document discusses corticosteroids (glucocorticoids), including their mechanism of action, indications for use, specific drugs, administration routes, contraindications, and side effects. Glucocorticoids have anti-inflammatory and immunosuppressive effects through both acute and long-term mechanisms. They are used to treat a wide range of inflammatory and autoimmune conditions. Common corticosteroids discussed are hydrocortisone, prednisone, methylprednisolone, and dexamethasone. Side effects can involve many organ systems and include skin atrophy, hypertension, diabetes, osteoporosis, and psychiatric issues. Tapering is important when stopping long-term use to