This document discusses blood stem cell transplantation. It begins by explaining how bone marrow produces blood-forming stem cells and how transplantation of healthy stem cells from sources like marrow, blood or cord blood can help patients whose hematopoietic cells have been damaged by diseases or treatments like cancer. It then covers topics like tissue typing to match donors and recipients, the risks of graft-versus-host disease, and how autologous, syngeneic and allogeneic transplants work. The document provides diagrams and explanations of these concepts over several slides.
Stem Cells And Potential Clinical ApplicationsArtit Ungkanont
This document discusses potential clinical applications of stem cells in 3 paragraphs:
1) Stem cells may be useful for regenerative medicine and treating degenerative conditions by replacing damaged cells. Sources of stem cells include embryonic, adult, and induced pluripotent stem cells.
2) Stem cells show promise for treating hematologic diseases through hematopoietic stem cell transplantation, as well as cardiovascular diseases through effects like angiogenesis and myocardial regeneration.
3) Stem cells also have potential applications in neurologic diseases like Parkinson's and strokes by generating new neurons, oligodendrocytes, and exploring brain repair mechanisms, as well as in diabetes by generating insulin-producing beta cells. However, many challenges remain
Hematopoietic stem cell transplant (HSCT) involves transplanting hematopoietic stem cells to re-establish normal bone marrow function in patients with blood disorders or cancer. HSCT has become an established treatment for many malignant and non-malignant blood diseases. HSCT sources include bone marrow, peripheral blood, and umbilical cord blood. The transplant process involves stem cell collection, processing, conditioning chemotherapy, stem cell infusion, and recovery. Complications can include graft-versus-host disease. Matching HLA antigens between donor and recipient is important for transplant success, especially in allogeneic HSCT. Advances have improved outcomes, but further progress is still needed.
Autologous bone marrow transplant involves harvesting a patient's own bone marrow stem cells, storing them, and later re-infusing them after high-dose chemotherapy or radiation treatment to destroy cancerous cells. The stem cells help repopulate the bone marrow and restore the immune system. Complications can include infections during the neutropenic phase, graft-versus-host disease, and mucositis. Long term effects may include secondary cancers or sterility. Autologous transplants are commonly used to treat blood cancers like lymphoma or multiple myeloma.
Stem cells can be obtained from embryos or adults. Embryonic stem cells are pluripotent and can become any cell type, while adult stem cells are multipotent and limited to certain lineages. Stem cell research offers promise for therapies but also ethical concerns. Alternatives to embryonic stem cells are being explored, such as stem cells from unfertilized eggs, dead embryos, or engineered structures. While progress is being made, many challenges remain before stem cell therapies can be directly translated from the laboratory.
Stem cell therapy involves three main concepts: direct injection of stem cells into damaged tissues, transplantation of differentiated cells derived from stem cells, and stimulation of endogenous stem cells to facilitate repair. Sources of stem cells for tissue repair include embryonic stem cells, induced pluripotent stem cells, umbilical cord blood stem cells, and somatic stem cells. Stem cell therapy is being studied as a potential treatment for various diseases and injuries, including heart disease, diabetes, neurological disorders, liver disease, and blood disorders. However, challenges remain regarding immune rejection, control of differentiation, and ethical issues with some stem cell sources.
Hematopoietic Stem Cells Transplantation for Multiple MyelomaWan Ning
Hematopoietic stem cells transplantation is a FDA-approved stem cells based therapy whereby it is usually performed for cancer patients. For an example, Multiple Myeloma.
This document provides an overview of bone marrow transplantation (BMT). It discusses the definition, sources, types, indications, preparations, complications, and outcomes of BMT. Key points include: BMT involves transferring stem cells to replace abnormal stem cells or reconstitute treated marrow. Sources include bone marrow, peripheral blood stem cells, and cord blood. Complications can include graft-versus-host disease and rejection. Outcomes have improved with advances like HLA matching and use of unrelated donors, though conditioning mortality remains up to 15%.
This document discusses hematopoietic stem cell transplantation in pediatrics. It defines hematopoietic stem cell transplantation as any procedure where stem cells from any donor or source are given to a recipient with the intention of repopulating or replacing their hematopoietic system. The document then reviews the history of stem cell transplantation, different stem cell sources including bone marrow, peripheral blood, and umbilical cord blood, and types of transplantation including autologous, allogeneic, and syngeneic. It also discusses procedures, conditioning regimens, and applications of autologous transplantation.
Stem Cells And Potential Clinical ApplicationsArtit Ungkanont
This document discusses potential clinical applications of stem cells in 3 paragraphs:
1) Stem cells may be useful for regenerative medicine and treating degenerative conditions by replacing damaged cells. Sources of stem cells include embryonic, adult, and induced pluripotent stem cells.
2) Stem cells show promise for treating hematologic diseases through hematopoietic stem cell transplantation, as well as cardiovascular diseases through effects like angiogenesis and myocardial regeneration.
3) Stem cells also have potential applications in neurologic diseases like Parkinson's and strokes by generating new neurons, oligodendrocytes, and exploring brain repair mechanisms, as well as in diabetes by generating insulin-producing beta cells. However, many challenges remain
Hematopoietic stem cell transplant (HSCT) involves transplanting hematopoietic stem cells to re-establish normal bone marrow function in patients with blood disorders or cancer. HSCT has become an established treatment for many malignant and non-malignant blood diseases. HSCT sources include bone marrow, peripheral blood, and umbilical cord blood. The transplant process involves stem cell collection, processing, conditioning chemotherapy, stem cell infusion, and recovery. Complications can include graft-versus-host disease. Matching HLA antigens between donor and recipient is important for transplant success, especially in allogeneic HSCT. Advances have improved outcomes, but further progress is still needed.
Autologous bone marrow transplant involves harvesting a patient's own bone marrow stem cells, storing them, and later re-infusing them after high-dose chemotherapy or radiation treatment to destroy cancerous cells. The stem cells help repopulate the bone marrow and restore the immune system. Complications can include infections during the neutropenic phase, graft-versus-host disease, and mucositis. Long term effects may include secondary cancers or sterility. Autologous transplants are commonly used to treat blood cancers like lymphoma or multiple myeloma.
Stem cells can be obtained from embryos or adults. Embryonic stem cells are pluripotent and can become any cell type, while adult stem cells are multipotent and limited to certain lineages. Stem cell research offers promise for therapies but also ethical concerns. Alternatives to embryonic stem cells are being explored, such as stem cells from unfertilized eggs, dead embryos, or engineered structures. While progress is being made, many challenges remain before stem cell therapies can be directly translated from the laboratory.
Stem cell therapy involves three main concepts: direct injection of stem cells into damaged tissues, transplantation of differentiated cells derived from stem cells, and stimulation of endogenous stem cells to facilitate repair. Sources of stem cells for tissue repair include embryonic stem cells, induced pluripotent stem cells, umbilical cord blood stem cells, and somatic stem cells. Stem cell therapy is being studied as a potential treatment for various diseases and injuries, including heart disease, diabetes, neurological disorders, liver disease, and blood disorders. However, challenges remain regarding immune rejection, control of differentiation, and ethical issues with some stem cell sources.
Hematopoietic Stem Cells Transplantation for Multiple MyelomaWan Ning
Hematopoietic stem cells transplantation is a FDA-approved stem cells based therapy whereby it is usually performed for cancer patients. For an example, Multiple Myeloma.
This document provides an overview of bone marrow transplantation (BMT). It discusses the definition, sources, types, indications, preparations, complications, and outcomes of BMT. Key points include: BMT involves transferring stem cells to replace abnormal stem cells or reconstitute treated marrow. Sources include bone marrow, peripheral blood stem cells, and cord blood. Complications can include graft-versus-host disease and rejection. Outcomes have improved with advances like HLA matching and use of unrelated donors, though conditioning mortality remains up to 15%.
This document discusses hematopoietic stem cell transplantation in pediatrics. It defines hematopoietic stem cell transplantation as any procedure where stem cells from any donor or source are given to a recipient with the intention of repopulating or replacing their hematopoietic system. The document then reviews the history of stem cell transplantation, different stem cell sources including bone marrow, peripheral blood, and umbilical cord blood, and types of transplantation including autologous, allogeneic, and syngeneic. It also discusses procedures, conditioning regimens, and applications of autologous transplantation.
Hematopoietic stem cell transplantation involves collecting stem cells from bone marrow, peripheral blood, or umbilical cord blood and infusing them into a patient after intensive chemotherapy or radiation treatment. There are three main types of transplants - autologous using the patient's own stem cells, allogeneic using a donor's stem cells, and syngeneic using an identical twin's stem cells. The goal is for the transplanted stem cells to engraft and repopulate the patient's bone marrow and immune system. Some potential complications after transplantation include graft-versus-host disease, infections, organ toxicities from the conditioning regimen, and secondary cancers later on.
Monoclonal antibodies are identical antibodies produced by identical immune cells that are clones of a single parent cell. They are produced by fusing antibody-producing cells with tumor cells to create a hybridoma cell line that continuously produces the same antibody. Monoclonal antibodies have important medical uses such as diagnosing pregnancy or HIV infection through detection of specific antigens, and treating cancer by targeting tumor-associated antigens on cancer cells. However, monoclonal antibodies produced in mice can trigger an immune response in humans, so genetically engineered antibodies are being developed to avoid this.
Principles of organ transplant and Renal transplantDr Navil Sharma
This document provides an overview of organ transplant principles. It defines different types of transplants and discusses transplant immunology, including graft rejection. The key principles covered are pre-operative (patient selection, counseling, informed consent), intra-operative (organ procurement and preservation), and post-operative (assessment, immunosuppression, follow up). Complications and ethical considerations are also mentioned. Overall, the document outlines the major concepts and steps involved in organ transplantation.
Hematopoietic stem cell transplantation involves intravenous infusion of stem cells collected from bone marrow, peripheral blood, or umbilical cord blood to reestablish hematopoietic function in patients with damaged bone marrow or immune systems. It is potentially curative for various disorders. Stem cells are collected via bone marrow harvest or apheresis and may be manipulated before infusion. Complications can include mucositis, sinusoidal obstructive syndrome, and graft-versus-host disease.
The bone marrow is the soft, fatty tissue inside bones that produces blood cells. It contains stem cells that give rise to red blood cells, white blood cells, and platelets. A bone marrow transplant replaces damaged or destroyed bone marrow with healthy stem cells from either the patient (autologous transplant) or a donor (allogenic transplant). Proper donor matching through HLA typing is important for success of an allogenic transplant to reduce graft-versus-host disease.
Adult stem cells can be found in many tissues and organs, including bone marrow, brain, blood vessels, and skin. Scientists identify adult stem cells by labeling them with molecular markers and observing what cell types they generate. Adult stem cells have been harvested since the 1960s to treat diseases like leukemia. The harvesting process begins with a donor providing blood that is then processed to extract stem cells, typically through a procedure called apheresis that separates stem cells from other blood components. Stem cell transplants are used for cancer treatment, and can be autologous, using the patient's own stem cells, or allogeneic, using donor stem cells.
Get information of what are stem cells, sources of stem cells, what is umbilical cord and the umbilical cord blood, what us HLS matching etc and many more.
The document discusses stem cell transplantation therapy and immunosuppressant therapy for hematological malignancies. It provides an overview of hematopoietic stem cells, the history and types of hematopoietic stem cell transplantation, the transplantation process including stem cell collection, cryopreservation, conditioning, and complications. The presentation also covers hematopoietic stem cell transplantation for different hematological malignancies and non-malignant conditions.
This document discusses stem cells and related techniques. It provides an overview of stem cell types including embryonic stem cells, adult stem cells, and induced pluripotent stem cells. It discusses stem cell differentiation and some history around the discovery of stem cells. Applications of stem cells mentioned include disease modeling, drug development, cell therapy, and 3D bioprinting using stem cells. Specific techniques discussed include genome editing, autophagy, tissue clearing, and optogenetics as they relate to stem cell research. Controversies around stem cell therapy are also briefly mentioned.
Stem cell transplantation replaces unhealthy cells with healthy ones. It has a history dating back to the mid-19th century when it was discovered that marrow was the source of blood cells. Modern stem cell transplantation uses stem cells from three sources: peripheral blood, marrow, or umbilical cord. The types of transplantation are syngeneic using identical twins, autologous using one's own stem cells, and allogeneic using donor stem cells which can cause graft-versus-host disease. Stem cell transplantation treats conditions like blood disorders and cancers.
Hematopoietic stem cell transplantation (HSCT) involves replacing a patient's bone marrow with healthy stem cells from a donor. The document provides an overview of HSCT, including its history, types of transplants, the transplant process, and potential complications. It discusses how stem cells are collected from bone marrow, peripheral blood, or umbilical cord blood and cryopreserved. The transplant process includes conditioning chemotherapy/radiation, stem cell infusion, and recovery. Complications can include graft-versus-host disease and infection. Careful donor matching and screening is important for transplant success.
Bone marrow transplantation replaces damaged or destroyed bone marrow with healthy stem cells. It is used to treat certain cancers, blood disorders, and chemotherapy side effects. There are three main types: autologous uses the patient's own stem cells; allogeneic uses a donor's stem cells; umbilical cord blood transplantation uses stem cells from umbilical cord blood. Preparations include testing and treatment for both the recipient and donor. Risks include infections, graft failure, and graft-versus-host disease. A multidisciplinary team oversees the transplant process.
This document provides an overview of principles of tissue engineering. It discusses why tissue engineering is needed due to limited organ transplantation availability. Tissue engineering uses regenerative medicine approaches including cell therapies, biomaterials, and tissue engineering to repair or replace damaged tissues. Various cell sources for therapy are described, including stem cells (embryonic, adult, perinatal), somatic cell nuclear transfer, and induced pluripotent stem cells. Biomaterials are discussed that can be used as scaffolds to support cell growth. The importance of vascularization for tissue volumes over 3mm is also highlighted.
The document summarizes current trends in cell therapy, including:
1) Attempts to expand hematopoietic stem cells for clinical use have not achieved long-term engraftment, though total CD34+ cells are expanded with benefits.
2) Cord blood banking trends involve improving quality over quantity, and cord blood may be used for non-hematological diseases.
3) Over 3000 patients have been treated safely for heart diseases with cell therapy, and the field is growing rapidly though mechanisms are better understood as trophic rather than differentiation.
1. Regenerative medicine aims to treat disease and injury by producing new cells to replace damaged or malfunctioning cells. This may involve stem cells, biological therapies, medical devices, or genes and cells.
2. There are three main types of stem cells: embryonic stem cells, adult stem cells, and induced pluripotent stem cells. Induced pluripotent stem cells can be created by reprogramming adult cells via gene transfer.
3. Stem cell therapies and tissue engineering hold promise for treating conditions where organs are damaged or in short supply, such as using a patient's own cells to regenerate skin or corneas.
Adult stem cells are undifferentiated cells found in the body after development that have the abilities of self-renewal and multipotency. They are mostly found in blood and bone marrow and can be used to treat degenerative diseases, autoimmune disorders, injuries, and cosmetic conditions. A stem cell transplant for leukemia involves finding a donor, extracting their stem cells, clearing the recipient's body of cancerous cells through chemotherapy or radiation, and transplanting the donor's healthy stem cells to repopulate the recipient's blood and immune system.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Hematopoietic stem cell transplantation involves collecting stem cells from bone marrow, peripheral blood, or umbilical cord blood and infusing them into a patient after intensive chemotherapy or radiation treatment. There are three main types of transplants - autologous using the patient's own stem cells, allogeneic using a donor's stem cells, and syngeneic using an identical twin's stem cells. The goal is for the transplanted stem cells to engraft and repopulate the patient's bone marrow and immune system. Some potential complications after transplantation include graft-versus-host disease, infections, organ toxicities from the conditioning regimen, and secondary cancers later on.
Monoclonal antibodies are identical antibodies produced by identical immune cells that are clones of a single parent cell. They are produced by fusing antibody-producing cells with tumor cells to create a hybridoma cell line that continuously produces the same antibody. Monoclonal antibodies have important medical uses such as diagnosing pregnancy or HIV infection through detection of specific antigens, and treating cancer by targeting tumor-associated antigens on cancer cells. However, monoclonal antibodies produced in mice can trigger an immune response in humans, so genetically engineered antibodies are being developed to avoid this.
Principles of organ transplant and Renal transplantDr Navil Sharma
This document provides an overview of organ transplant principles. It defines different types of transplants and discusses transplant immunology, including graft rejection. The key principles covered are pre-operative (patient selection, counseling, informed consent), intra-operative (organ procurement and preservation), and post-operative (assessment, immunosuppression, follow up). Complications and ethical considerations are also mentioned. Overall, the document outlines the major concepts and steps involved in organ transplantation.
Hematopoietic stem cell transplantation involves intravenous infusion of stem cells collected from bone marrow, peripheral blood, or umbilical cord blood to reestablish hematopoietic function in patients with damaged bone marrow or immune systems. It is potentially curative for various disorders. Stem cells are collected via bone marrow harvest or apheresis and may be manipulated before infusion. Complications can include mucositis, sinusoidal obstructive syndrome, and graft-versus-host disease.
The bone marrow is the soft, fatty tissue inside bones that produces blood cells. It contains stem cells that give rise to red blood cells, white blood cells, and platelets. A bone marrow transplant replaces damaged or destroyed bone marrow with healthy stem cells from either the patient (autologous transplant) or a donor (allogenic transplant). Proper donor matching through HLA typing is important for success of an allogenic transplant to reduce graft-versus-host disease.
Adult stem cells can be found in many tissues and organs, including bone marrow, brain, blood vessels, and skin. Scientists identify adult stem cells by labeling them with molecular markers and observing what cell types they generate. Adult stem cells have been harvested since the 1960s to treat diseases like leukemia. The harvesting process begins with a donor providing blood that is then processed to extract stem cells, typically through a procedure called apheresis that separates stem cells from other blood components. Stem cell transplants are used for cancer treatment, and can be autologous, using the patient's own stem cells, or allogeneic, using donor stem cells.
Get information of what are stem cells, sources of stem cells, what is umbilical cord and the umbilical cord blood, what us HLS matching etc and many more.
The document discusses stem cell transplantation therapy and immunosuppressant therapy for hematological malignancies. It provides an overview of hematopoietic stem cells, the history and types of hematopoietic stem cell transplantation, the transplantation process including stem cell collection, cryopreservation, conditioning, and complications. The presentation also covers hematopoietic stem cell transplantation for different hematological malignancies and non-malignant conditions.
This document discusses stem cells and related techniques. It provides an overview of stem cell types including embryonic stem cells, adult stem cells, and induced pluripotent stem cells. It discusses stem cell differentiation and some history around the discovery of stem cells. Applications of stem cells mentioned include disease modeling, drug development, cell therapy, and 3D bioprinting using stem cells. Specific techniques discussed include genome editing, autophagy, tissue clearing, and optogenetics as they relate to stem cell research. Controversies around stem cell therapy are also briefly mentioned.
Stem cell transplantation replaces unhealthy cells with healthy ones. It has a history dating back to the mid-19th century when it was discovered that marrow was the source of blood cells. Modern stem cell transplantation uses stem cells from three sources: peripheral blood, marrow, or umbilical cord. The types of transplantation are syngeneic using identical twins, autologous using one's own stem cells, and allogeneic using donor stem cells which can cause graft-versus-host disease. Stem cell transplantation treats conditions like blood disorders and cancers.
Hematopoietic stem cell transplantation (HSCT) involves replacing a patient's bone marrow with healthy stem cells from a donor. The document provides an overview of HSCT, including its history, types of transplants, the transplant process, and potential complications. It discusses how stem cells are collected from bone marrow, peripheral blood, or umbilical cord blood and cryopreserved. The transplant process includes conditioning chemotherapy/radiation, stem cell infusion, and recovery. Complications can include graft-versus-host disease and infection. Careful donor matching and screening is important for transplant success.
Bone marrow transplantation replaces damaged or destroyed bone marrow with healthy stem cells. It is used to treat certain cancers, blood disorders, and chemotherapy side effects. There are three main types: autologous uses the patient's own stem cells; allogeneic uses a donor's stem cells; umbilical cord blood transplantation uses stem cells from umbilical cord blood. Preparations include testing and treatment for both the recipient and donor. Risks include infections, graft failure, and graft-versus-host disease. A multidisciplinary team oversees the transplant process.
This document provides an overview of principles of tissue engineering. It discusses why tissue engineering is needed due to limited organ transplantation availability. Tissue engineering uses regenerative medicine approaches including cell therapies, biomaterials, and tissue engineering to repair or replace damaged tissues. Various cell sources for therapy are described, including stem cells (embryonic, adult, perinatal), somatic cell nuclear transfer, and induced pluripotent stem cells. Biomaterials are discussed that can be used as scaffolds to support cell growth. The importance of vascularization for tissue volumes over 3mm is also highlighted.
The document summarizes current trends in cell therapy, including:
1) Attempts to expand hematopoietic stem cells for clinical use have not achieved long-term engraftment, though total CD34+ cells are expanded with benefits.
2) Cord blood banking trends involve improving quality over quantity, and cord blood may be used for non-hematological diseases.
3) Over 3000 patients have been treated safely for heart diseases with cell therapy, and the field is growing rapidly though mechanisms are better understood as trophic rather than differentiation.
1. Regenerative medicine aims to treat disease and injury by producing new cells to replace damaged or malfunctioning cells. This may involve stem cells, biological therapies, medical devices, or genes and cells.
2. There are three main types of stem cells: embryonic stem cells, adult stem cells, and induced pluripotent stem cells. Induced pluripotent stem cells can be created by reprogramming adult cells via gene transfer.
3. Stem cell therapies and tissue engineering hold promise for treating conditions where organs are damaged or in short supply, such as using a patient's own cells to regenerate skin or corneas.
Adult stem cells are undifferentiated cells found in the body after development that have the abilities of self-renewal and multipotency. They are mostly found in blood and bone marrow and can be used to treat degenerative diseases, autoimmune disorders, injuries, and cosmetic conditions. A stem cell transplant for leukemia involves finding a donor, extracting their stem cells, clearing the recipient's body of cancerous cells through chemotherapy or radiation, and transplanting the donor's healthy stem cells to repopulate the recipient's blood and immune system.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
1. Understanding Cancer and Related Topics
Understanding Blood Stem Cell Transplantation
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Developed by:
Donna Kerrigan, M.S.
Kathryn Hollen
Jeanne Kelly
Brian Hollen
Discusses how bone marrow produces blood-
forming stem cells that include “starter” immune
cells. When diseases like cancer or its treatment
damage these hematopoietic cells, transplanting
healthy stem cells from marrow, peripheral blood,
or other sources can help some patients. Clarifies
how antigens that mark cells as “self” or “non-self”
are critical determinants of transplant success.
Explains autologous, syngeneic, and allogeneic
transplants as well as tissue typing.
2. Stem Cells
Gastrula
(14 to 16 days)
Fertilized egg
(1 day)
Outer cell mass
Inner cell mass
Blastocyst
(5 to 6 days)
Ectoderm
(external layer)
Skin
Neurons
Pituitary gland
Eyes
Ears
Endoderm
(internal layer)
Pancreas
Liver
Thyroid
Lung
Bladder
Urethra
Mesoderm
(middle layer)
Bone marrow
Skeletal, smooth
and cardiac muscle
Heart and
blood vessels
Kidney tubules
3. Blood Stem Cells
Bone graft
Multipotential
stem cell
Hematopoietic
stem cell
Platelets
Erythrocytes
Eosinophil
Neutrophil
Megakaryocyte
Basophil
T lymphocyte
Natural killer cell
Dendritic cell
B lymphocyte
Lymphoid progenitor cell
Myeloid
progenitor
cell
Monocyte
Marrow
Bone
4. From Bone Marrow to the Bloodstream
T lymphocyte
Hematopoietic
stem cell
Erythrocytes
Circulating
blood
Thymus
Lymph
nodes
Spleen
Bone
marrow
To
thymus,
tonsils,
and lymphoid
organs
1 in blood for every
100 in marrow
B lymphocyte
From
thymus
5. Blood Stem Cell Transplants: When?
No blood stem
cell production
Chemo
Radiation
X
6. Stem Cells from Self to the Rescue
Patient receives
chemotherapy
or radiation
Self-donated stem
cells are re-infused
into patient
Stem cells are
collected from
patient
7. Stem Cells from Donor to the Rescue
Stem cells
are collected
from donor
Stem cells are infused
into patient, where they
migrate to bone marrow
Patient receives
chemotherapy or
radiation
8. Not Just Any Blood Stem Cells Will Do
Self Non-self
9. Host vs. Graft/Graft vs. Host
Host versus graft reaction Graft versus host reaction
10. Tissue Typing Matches Donors to Patients
Allogeneic
Patient
= matches to patient
Conflict: only some
marker molecules match
No conflict: all
marker molecules match
Patient
Syngeneic
Autologous
Donor
Identical
twin donor
Unrelated
donor
Related
donor
Allogeneic
Patient
Donor
Patient
Donor
Patient
Donor
11. Many Names for the “Self” Antigens
Major
histocompatibility
complex (MHC) proteins
(“self” markers)
Blood cell
(leukocyte)
Body cell
Human
leukocyte
antigens (HLAs)
(“self” markers)
=
12. Haplotypes: Passing on Genes
for “Self” Antigens
DP DR
DQ
No.
of
possible
alleles
at
this
locus
Many Varieties of MHC “Self” Genes
Sample Haplotype: Chromosome 6
DP DQ
A
C
HLA alleles
DR
45
89
19 20
2
323
75
50
25
400
100
0
DP DQ DR
B
93
195
395
B C A
13. 6 Major Genes: 10,000 Antigens
HLA genes
Paternal
chromosome 6
Maternal
chromosome 6
Maternal
leukocyte
Paternal
leukocyte
HLA genes
D B C
D A
D
D B C
D A
D
* are MHC proteins
2 (of 6) major human
leukocyte antigens*
6 major
genes
6 major
genes
2 (of 6) major human
leukocyte antigens*
14. Three Most Important Antigens
3 most important
antigens for tissue
matching
Leukocyte
Human leukocyte antigens (MHC proteins)
DP
DQ
B
C
DR
A
No.
of
possible
alleles
at
this
locus
Many Varieties of MHC “Self” Genes
DP DQ DR
45
89
19 20
2
323
75
50
25
400
100
0
DP DQ DR
93
195
395
B C A
15. A “Clinical Match”
Child A (patient)
HLA-A
HLA-B
Child E (donor)
a perfect match
Child D
Haplotype 3
Child C
Sperm
Ovum
Child B
Haplotype 1
HLA-A HLA-DR
HLA-B
HLA-DR
HLA-A
HLA-B
Haplotype 4
Haplotype 2
HLA-A HLA-DR
HLA-B
HLA-DR
16. Some Haplotypes Occur More Often
25–30% chance
>90% chance
50–60% chance
40–50% chance
18. A Delicate Balance:
Graft vs. Tumor/Graft vs. Host
Stem cells plus
haplo-identical
white blood cells
Cancer cell
destroyed
Cancer
cell
Transplant attacks patient
Transplant attacks tumor
in patient
A Delicate Balance
Should I
give the patient
steroids?
19. Success in Matching
Varies With Population
Japanese
99%
African
American
50%
North
American
Caucasian
93%
Asian
50%
20. Preparing Patients for
Myeloablative Allogeneic Transplants
High-dose
radiation
and/or
High-dose
chemotherapy
Lymphocytes
destroyed
Cancer
cells
destroyed
21. Preparing Patients for Reduced-
Intensity Allogeneic Transplants
Before Transplant
Donor’s white
blood cells
Sometimes
After Transplant
Low-dose
or standard
radiation
and/or
Low-dose
or standard
chemotherapy
Immunosuppressant
drugs
22. Preparing Donors for
Allogeneic Transplants
Growth factor
to amplify and
mobilize stem cells
Allogeneic transplant
Stem cells
ready for
infusion
Stem cells
ready for
infusion
23. Apheresis: Harvesting Stem Cells
From Peripheral Blood
Whole
blood is
collected
from
donor
Blood,
minus stem
cells, is
returned to
donor
Stem
cells out
Whole
blood in
Blood-forming
stem cells
24. Preparing Patients for
Autologous/Syngeneic Transplants
Syngeneic:
Peripheral Blood
Growth factor
to amplify
and mobilize
stem cells
Patient
Autologous:
Peripheral Blood
Cells
for
infusion
into my
twin
Identical twin
donor
Cells for
re-infusion
Growth factor
to amplify
and mobilize
stem cells
25. Cord Blood as a Source of Stem Cells
Placenta
Umbilical cord
Placenta
Primitive
stem cells
Liver
Uterus
Umbilical
cord
26. Placental and Cord-Blood
Stem Cell Transplants
After the birth of
the baby, blood is
collected into a
special blood bag
Umbilical
cord
Placenta
Virus-free, tissue-typed
stem cells stored in
liquid nitrogen for
future transplant
Cryoprotectant added to minimize
damage during freezing
Stem cells transferred
to a new bag
27. Using More Than One Cord-Blood Donor
Cells from one unit
dominate the other; both
attack patient’s immune
system
Cord blood
from donor 2
Cord blood
from donor 1
No, I’m
in charge!
I’m in
charge!
2
1
28. Placental and Cord-Blood Transplants:
Pros and Cons
Cons
1/10 number of cells vs.
bone marrow transplant
Longer time for
transplant to “take”
Slight chance of
maternal cell/genetic
disease contamination
Adults need more than
one cord-blood donor
Pros
Lifesaver when there
is no eligible donor
Available quickly
(about 2 weeks)
Unlikely to harbor
cytomegalovirus
32. We would like to hear from you . . .
If you have questions about this tutorial’s content, suggestions for new topics, or
other feedback on the Web site, please send an e-mail to kerrigad@mail.nih.gov.
If you have questions about this tutorial’s artwork or want permission to use it,
please send an e-mail to beankelly@verizon.net.
Editor's Notes
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer
NCI Web site: http://cancer.gov/cancertopics/understandingcancer