International Journal of Stem Cell Research and Transplantation (IJST) is a peer-reviewed journal, and is dedicated to providing information with respect to the latest advancements that are being upgraded in our everyday life with respect to the application of Stem cells.
Mammalian MSC from Selected Species: Features and Applications
Christiane Uder, Sandra Br€uckner, Sandra Winkler, Hans-Michael Tautenhahn,†‡ Bruno Christ†*
Mesenchymal stromal/stem cells (MSC) are promising candidates for cellular therapy of different diseases in humans and in animals. Following the guidelines of the International Society for Cell Therapy, human MSC may be identified by expression of a specific panel of cell surface markers (CD1051, CD731, CD901, CD34-, CD14-, or CD11b-, CD79- or CD19-, HLA-DR-). In addition, multiple differentiation potential into at least the osteogenic, adipogenic, and chondrogenic lineage is a main criterion for MSC definition. Human MSC and MSC of a variety of mammals isolated from different tissues meet these criteria. In addition to the abovementioned, they express many more cell surface markers. Yet, these are not uniquely expressed by MSC. The gross phenotypic appearance like marker expression and differentiation potential is similar albeit not identical for MSC from different tissues and species. Similarly, MSC may feature different biological characteristics depending on the tissue source and the isolation and culture procedures. Their versatile biological qualities comprising immunomodulatory, anti-inflammatory, and proregenerative capacities rely largely on the migratory and secretory capabilities of MSC. They are attracted to sites of tissue lesion and secrete factors to promote self-repair of the injured tissue. This is a big perspective for clinical MSC applications in both veterinary and human medicine. Phase I/II clinical trials have been initiated to assess safety and feasibility of MSC therapies in acute and chronic disease settings. Yet, since the mode of MSC action in a specific disease environment is still unknown at large, it is mandatory to unravel the response of MSC from a given source onto a specific disease environment in suitable animal models prior to clinical applications.
SciDoc Publishers is an international publishing company that publishes manuscripts in the field of Science, Medicine and Technololgy (STM). SciDoc acts as a driving factor in providing new era novel research and information to all the researchers and scientists worldwide.
International Journal of Virology Studies & Research (IJVSR) ISSN:2330-0027 is a comprehensive, peer reviewed journal devoted to Virology Studies & Research. IJVSR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
journal devoted to Virology Studies & Research. IJVSR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
Mammalian MSC from Selected Species: Features and Applications
Christiane Uder, Sandra Br€uckner, Sandra Winkler, Hans-Michael Tautenhahn,†‡ Bruno Christ†*
Mesenchymal stromal/stem cells (MSC) are promising candidates for cellular therapy of different diseases in humans and in animals. Following the guidelines of the International Society for Cell Therapy, human MSC may be identified by expression of a specific panel of cell surface markers (CD1051, CD731, CD901, CD34-, CD14-, or CD11b-, CD79- or CD19-, HLA-DR-). In addition, multiple differentiation potential into at least the osteogenic, adipogenic, and chondrogenic lineage is a main criterion for MSC definition. Human MSC and MSC of a variety of mammals isolated from different tissues meet these criteria. In addition to the abovementioned, they express many more cell surface markers. Yet, these are not uniquely expressed by MSC. The gross phenotypic appearance like marker expression and differentiation potential is similar albeit not identical for MSC from different tissues and species. Similarly, MSC may feature different biological characteristics depending on the tissue source and the isolation and culture procedures. Their versatile biological qualities comprising immunomodulatory, anti-inflammatory, and proregenerative capacities rely largely on the migratory and secretory capabilities of MSC. They are attracted to sites of tissue lesion and secrete factors to promote self-repair of the injured tissue. This is a big perspective for clinical MSC applications in both veterinary and human medicine. Phase I/II clinical trials have been initiated to assess safety and feasibility of MSC therapies in acute and chronic disease settings. Yet, since the mode of MSC action in a specific disease environment is still unknown at large, it is mandatory to unravel the response of MSC from a given source onto a specific disease environment in suitable animal models prior to clinical applications.
SciDoc Publishers is an international publishing company that publishes manuscripts in the field of Science, Medicine and Technololgy (STM). SciDoc acts as a driving factor in providing new era novel research and information to all the researchers and scientists worldwide.
International Journal of Virology Studies & Research (IJVSR) ISSN:2330-0027 is a comprehensive, peer reviewed journal devoted to Virology Studies & Research. IJVSR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
journal devoted to Virology Studies & Research. IJVSR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
Diabetology and Vascular Disease Research Journal - SciDocPublishersScidoc Publishers
International Journal of Diabetology & Vascular Disease Research (IJDVR) ISSN:2328-353X is a comprehensive, peer reviewed journal devoted to Diabetes & Vascular Disease Research. IJDVR, published by SciDoc is an open access journal that includes high quality papers, which cover all major areas of Diabetes, Vascular Diseases and its diagnosis. SciDoc with its Open Access publication model spreads all the day-to-day development and research to its readers around the world.
For more details: http://scidoc.org/diabetology-and-vascular-disease-research.php
International Journal of Virology Studies & Research (IJVSR) ISSN:2330-0027 is a comprehensive, peer reviewed journal devoted to Virology Studies & Research. IJVSR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
Forensic science and pathology Journal - SciDocPublishersScidoc Publishers
International Journal of Forensic Science & Pathology (IJFP) ISSN 2332-287X is a comprehensive, peer reviewed journal devoted to Forensic Science & Pathology. IJFP, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Forensic Science & Pathology and its diagnosis. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJFP is an Open Access journal which publishes original research articles, review articles, and clinical studies in all areas of Forensic Science & Pathology. IJFP will become an international interdisciplinary forum for the publication of basic science and clinical research papers offering critical analysis and scientific appraisal.
International Journal of Clinical Pharmacology & Toxicology (IJCPT) ISSN:2167-910X aims to develop coherent means to modify drug therapy, with respect to the patients genotype, and to ensure maximum efficiency with minimal contrary effects. Clinical Pharmacology & Toxicology is the all-encompassing and becoming an increasingly important discipline for the identification of disease targets and drug designing with their toxicological effects and means to eradicate diseases.
International Journal of Cancer Studies & Research (IJCR) ISSN:2167-9118 is a comprehensive, peer reviewed journal devoted to cancer studies and research. IJCR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Cancer and its related fields. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
International Journal of Virology Studies & Research (IJVSR) ISSN:2330-0027 is a comprehensive, peer reviewed journal devoted to Virology Studies & Research. IJVSR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world
International Journal of Diabetology & Vascular Disease Research (IJDVR) is a peer-reviewed and an Open Access journal. This journal mainly focuses on the advancements made in the field of Diabetes Research.
International Journal of Stem Cell Research and Transplantation (IJST) ISSN:2328-3548, is a free, Open Access, Peer-reviewed, exclusive online journal covering areas of Stem cell research, translational work and Clinical studies in the specialty of Stem Cells and Transplantation including allied specialties relevant to the core subject, which is dedicated in publishing high quality manuscripts.
International Journal of BioAnalytical Methods & BioEquivalence Studies (IJBM...Scidoc Publishers
International Journal of BioAnalytical Methods & BioEquivalence Studies (IJBMBS) ISSN 2470-4490 is a peer-reviewed, open access journal, wherein publication related to high-impact research articles contributes on the fundamental and applied topics of analytical and bioanalytical science including chromatography, biomedical & pharmaceutical analysis, clinical therapeutics to various toxicology measures. IJBMBS publishes high quality papers, critical reviews, trend articles, rapid communications, original papers, research letters and case reports.
International Journal of Virology Studies & Research (IJVSR) ISSN:2330-0027 is a comprehensive, peer reviewed journal devoted to Virology Studies & Research. IJVSR, published by SciDoc is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDoc with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
Normal tissues and tumors arise from a population of cells termed stem cells. In vivo experiments have provided evidence of the presence of stem cells throughout the mouse mammary gland. Premalignant mammary outgrowths that faithfully recapitulate the mammary epithelial cell lineage upon transplantation contain cells with tumor-forming potential. Cell sorting techniques have identified putative mouse mammary stem cell surface markers and human breast cancer stem cell surface markers. These markers do not identify only stem cells but in fact distinguish a mixed population of cells containing stem cell activity. Previous studies have demonstrated that clones arising from single cells in vitro can be categorized into three types based on the clone morphology. Here, we report the characterization, both in vitro and in vivo, of clonogenic cells from a non-tumorigenic mammary epithelial population and those from an erbB2-induced mammary tumor. We found that clones arising from normal mammary cells expressed different patterns of stem and developmental marker between the clone types and compared to the expression patterns observed on clones that developed from tumorigenic mammary cells.
Stem Cell Technology and its Clinical ApplicationDr. Barkha Gupta
Dr. Barkha Gupta has been teaching Veterinary Biochemistry as well as clinical physiology at CVAS, Udaipur and PGIVER, Jaipur. She has earlier served in various capacities in the Department of Animal Husbandry, Govt. of Rajasthan. She has several publications and awards to her credit. She is the PI of M-RAJUVAS Android Educational Mobile Application for Veterinary and Animal Sciences and Kiosk Information System for Farmers/Livestock Owners. Dr. Gupta is also IFBA Certified Professional.
Stem cells have the ability to perpetuate themselves through self-renewal and generate mature cells of a particular tissue through differentiation. Mesenchymal Stem Cells (MSCs) play an important role in tissue homeostasis supporting tissue regeneration. MSCs are rare pluripotent cells supporting hematopoietic and mesenchymal cell lineages. MSCs have a great potential in cancer therapy, also the stem cell exosome and/or microvesicle-mediated tissue regeneration abilities may be used a potential to the therapeutic applications. In this review, use of hMSCs in stem cell-mediated cancer therapy is discussed.
Stem cell therapy for the bladder has been conducted mainly on an experimental basis in the areas of bladder dysfunction. The therapeutic efficacy of stem cells was originally thought to be derived from their ability to differentiate into various cell types. For more details visit: http://www.cryobanksindia.com/moms-corner/case-studies/
Stem cell therapy for the bladder has been conducted mainly on an experimental basis in the areas of bladder dysfunction. The therapeutic efficacy of stem cells was originally thought to be derived from their ability to differentiate into various cell types. For more details visit: http://www.cryobanksindia.com/moms-corner/case-studies/
describe two recent scientific research studies and it therapies inv.pdffeelingcomputors
describe two recent scientific research studies and it therapies involving stem cells. Explain what
the researches did(how the study was performed).the result and conclusion
Solution
Therapies for wound healing:
Wound healing is a dynamic process bleeding and coagulation, acute inflammation, cell
migration, proliferation, differentiation, angiogenesis, re-epithelialization, and synthesis and
remodeling of the extracellular matrix. Many local and systemic factors can impair wound
healing process resulting in prolonged and non-healing chronic wounds which affects the quality
of patients’life. Stem cell-based therapy represents a promising therapeutic approach for wound
healing. Stem cells have been shown to mobilize and find home for ischemic and wounded
tissues where they secrete chemokines and growth factors to promote angiogenesis and
extracellular matrix remodeling.
In wounds, It has been reported that Mesenchymal stem cells are recruited to wound skin at the
time of wound healing and have the capacity to differentiate into multiple skin cell types
including keratinocytes, endothelial cells and pericytes. Furthermore, circulating MSC
recruitment was induced by a specific chemokine (SLC/CCL21)/chemokine receptor (CCR7)
interaction both in vitro and in vivo. Intradermal injection of SLC/CCL21 significantly
accelerated wound closure by increasing rates of MSC accumulation, especially the formation of
endothelial transdifferentiated cells (Sasaki et al., 2008) . MSCs are good candidate which can be
transdifferentiated into endothelial cells and epithelial- fibroblast cells for wound repair therapy
and understanding there signaling mechanism can further help in regenerative medicine.
Mesenchymal stem cells (MSC), referred as mesenchymal stromal cells , colony forming unit-
fibroblasts and mesenchymal progenitor cells , were first identified by Friedenstein as
subpopulation of bone marrow cells. Other than hemopoietic stem cells and differentiated
lineages, bone marrow contains a subset of nonhemopoietic cells, mesenchymal stem cells
(MSCs) that account for roughly 0.01–0.001% of the bone marrow derived cell population .
These are a rare population of non-hematopoietic stromal cells, present in the bone marrow and
most connective tissues of the body.They have capability to proliferate in vitro in uncommitted
state and retain their multilineage differentiation potency which make them attractive candidates
for biological cell-based tissue repair approaches. These cells have ability to differentiate into
three mesenchymal lineages: adipogenic , osteogenic, chondrogenic and can be induced to
commit to various other phenotypes like neurogenic, hepatocytes,myogenic, tenocytes,
cardiomyocytes, fibroblast and endothelial cells. In vivo studies have also shown that MSCs can
differentiate into tissue-specific cells in response to cues provided by different organs . In
addition to pluripotency, MSCs are known to have immunosuppressive effects involving vari.
REVIEWCancer stem cells a new framework for the designo.docxjoellemurphey
REVIEW
Cancer stem cells: a new framework for the design
of tumor therapies
Boyan K. Garvalov & Till Acker
Received: 14 July 2010 /Revised: 27 August 2010 /Accepted: 16 September 2010
# Springer-Verlag 2010
Abstract Modern tumor therapy has achieved considerable
progress, but many tumors remain refractory to treatment or
relapse following initial remission. Recent evidence points
to one possible reason for this limited therapeutic efficiency:
that the design of anticancer agents so far may not have been
aimed at the right target. While conventional tumor therapies
have targeted the main mass of tumor cells, there is now
compelling evidence that tumor initiation and progression are
driven by a subpopulation of tumor cells that possess stem cell
properties and are resistant to traditional cancer treatments—
the cancer stem cells (CSCs). CSCs have been identified in
most types of cancer and can be separated from the rest of the
tumor cells using appropriate markers. CSCs are regulated by
molecular mechanisms and specific, perivascular, and hypox-
ic microenvironments, which largely overlap with those
controlling stem cells from normal tissues. Our improved
understanding of CSC biology has already provided a number
of novel targets and drug discovery platforms for the design of
specific therapies that aim to eradicate the CSC subpopula-
tion. Therapeutic approaches can be targeted either at
eliminating the CSCs themselves or at disrupting the niches
in which CSCs reside. Moreover, the importance of CSCs for
tumor growth, resistance, and progression implies that clinical
trials and preclinical studies of anticancer therapies should
include as a key element an assessment of the abundance and
persistence of CSCs. Thus, CSC research holds great promise
for providing important new impetus to the fields of tumor
biology and clinical oncology.
Keywords Cancer stem cell . Hypoxia .
Microenvironment . Angiogenesis . Antitumor therapy.
Metastasis
The hierarchy model and cancer stem cells (CSCs)
The classical view of tumor formation is based on the
“stochastic” or “clonal evolution” model [1, 2]. It perceives
the tumor as a mass of hyperproliferative cells with similar
potential for driving tumor growth. Tumor heterogeneity
and progression are seen as the result of variations in the
tumor microenvironment and genetic mutations in individ-
ual cells, followed by selection of those that are best
adapted to support the further growth of the tumor (Fig. 1a).
An alternative concept that has been gaining increasing
experimental support is the “hierarchy” or “cancer stem
cell” model [3]. This model posits that tumors are generated
and maintained in a manner similar to the physiological
stem cell system operating in normal tissues, i.e., by cells
with stem cell-like properties, which self-renew and
differentiate into the distinct cellular subtypes of the tumor
(Fig. 1b). The key novel features of this model are that only
a limited population of tumor cell ...
Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development
Carlo Tremolada1 & Valeria Colombo1 & Carlo Ventura2
Abstract Inthepastfewyears,interestinadiposetissueasan ideal source of mesenchymal stem cells (MSCs) has increased. These cells are multipotent and may differentiate in vitro into several cellular lineages, such as adipocytes, chondrocytes, osteoblasts, and myoblasts. In addition, they secrete many bioactive molecules and thus are considered Bmini-drugstores.^ MSCs are being used increasingly for many clinical applications, such as orthopedic, plastic, and reconstructive surgery. Adipose-derived MSCs are routinely obtained enzymatically from fat lipoaspirate as SVF and/or may undergo prolonged ex vivo expansion, with significant senescence and a decrease in multipotency, leading to unsatisfactory clinicalresults.Moreover, these techniquesare hampered by complex regulatory issues. Therefore, an innovative technique (Lipogems®; Lipogems International SpA, Milan, Italy) was developed to obtain microfragmented adipose tissue with an intact stromal vascular niche and MSCs with a high regenerative capacity. The Lipogems® technology, patented in 2010 and clinically available since 2013, is an easyto-use system designed to harvest, process, and inject refined fat tissue and is characterized by optimal handling ability and a great regenerative potential based on adipose-derived MSCs. In this novel technology, the adipose tissue is washed, emulsified, and rinsed and adipose cluster dimensions gradually are reduced to about 0.3 to 0.8 mm. In the resulting
Lipogems® product, pericytes are retained within an intact stromal vascular niche and are ready to interact with the recipient tissue after transplantation, thereby becoming MSCs and starting the regenerative process. Lipogems® has been used in more than 7000 patients worldwide in aesthetic medicineandsurgery,aswellasinorthopedicandgeneralsurgery, with remarkable and promising results and seemingly no drawbacks. Now, several clinical trials are under way to supporttheinitialencouragingoutcomes.Lipogems®technology is emerging as a valid intraoperative system to obtain an optimal final product that may be used immediately for regenerative purposes.
FORMATION OF MULTICELLULAR AGGREGATES UNDER DIFFERENT CONDITIONS OF MICROENVI...Татьяна Гергелюк
Multicellular aggregates (spheroids) represent an inter
mittent level between monolayer growing cells and tissue cul
ture. Spheroids are rather objective model of the threedimen
sional growth and organization, the celltocell interactions
and influence of microenvironmental conditions on tumour
microaggregates. In our work formation and growth of sphe
roids depends on concentration of CMC and FCS. Conditions
of microenvironment influence on intensiveness of prolifera
tion as well as on cells adhesiveness and formation of microag
gregates.
International journal of finance, economics and tradeScidoc Publishers
International Journal of Finance, Economics, and Trade (IJFET) is a comprehensive, peer-reviewed publication that helps dissemination of original work, contributing to greater understanding and awareness of research and studies on global finance, economics, and trade.
Source: http://scidoc.org/IJFET
Virology Studies and Research Journal - SciDocPublishersScidoc Publishers
IJVSR is a comprehensive, peer reviewed journal devoted to Virology Studies & Research. IJVSR, published by SciDocPublishers is an open access journal that includes high quality papers, which covers all major areas of Virology Studies & Research. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJVSR aims to publish all the latest and outstanding research articles, reviews and letters in all areas of Virology. It contains a series of timely, in-depth written articles by scholars & researchers in the field, covering a wide range of the integration of multidimensional challenges of research of Virology
For more details: http://scidoc.org/virology-studies-and-research.php
Veterinary Health Science and Research Journal - SciDocPublishersScidoc Publishers
IJVHSR is a comprehensive, peer reviewed journal devoted to Veterinary Health Science & Research. IJVHSR, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Veterinary Health Science & Research. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJVHSR publishes manuscripts on all aspects of veterinary medicine and animal sciences. Original research articles, review articles, short communications, case reports, and letters to the Editor are accepted and contributions are open to researchers of all nationalities.
For more details: http://scidoc.org/veterinary-health-science-and-research.php
IJVR is a peer-reviewed, open access journal that publishes original research articles as well as review articles on basic, clinical and medical aspects of vaccines. IJVR includes wide range of topics from experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity and allergy.
IJVR is highlighting the importance of discoveries in vaccine research and immunization, such as the development and evaluation of vaccines, human and animal immune responses to vaccines, vaccine vectors, adjuvant, quantitative assays of vaccine efficacy, and clinical trials.
For more details: http://scidoc.org/vaccines-and-research.php
Translation and community medicine journal-sci docpublishersScidoc Publishers
IJTCM is a comprehensive, peer reviewed journal devoted to Translation & Community Medicine. IJTCM, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Translation & Community Medicine. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJTCM retains its interest in evolutionary research as an international journal dedicated to the latest advancement of Translation & Community Medicine. It provides a platform to Scientists and Academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Translation & Community Medicine.
For more details: http://scidoc.org/translation-and-community-medicine.php
Translation and Community Medicine Journal - SciDocPublishersScidoc Publishers
International Journal of Translation & Community Medicine ISSN 2333-8385 is a comprehensive, peer reviewed journal devoted to Translation & Community Medicine. IJTCM, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Translation & Community Medicine. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJTCM retains its interest in evolutionary research as an international journal dedicated to the latest advancement of Translation & Community Medicine. It provides a platform to Scientists and Academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Translation & Community Medicine.
For more details: http://scidoc.org/translation-and-community-medicine.php
International Journal of Surgery and Research ISSN 2379-156X is a peer-reviewed, open access journal that publishes Original Research articles, Point of technique, Review article, Case report, Letter to editor, Randomized clinical trial reports pertaining to the clinical and laboratory-based research on all aspects of general surgery including topics for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery.
IJSR is to provide critical analysis and a comprehensive overview of surgical research and innovations, and also to facilitate and stimulate the discussion to serve a platform for surgeons from across the world to share their research findings.
For more details: http://scidoc.org/surgery-and-research.php
Reproduction fertility and sexual health journal-sci doc publishersScidoc Publishers
IJRFSH is a comprehensive, peer reviewed journal devoted to Reproduction, Fertility & Sexual Health. IJRFSH, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Reproduction, Fertility & Sexual Health and its diagnosis. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJRFSH publishes high quality peer-reviewed articles covering the entire scope of Reproduction & Sexual Health, from molecular studies to clinical investigations continuing education needs of the entire related scientific field.
Pediatric health care and advancements journal-sci doc publishersScidoc Publishers
IJPA is a comprehensive, peer reviewed journal devoted to Pediatric Healthcare & Advancements. IJPA, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Pediatrics.
IJPA is an international journal dedicated to the latest advancement of Pediatrics Healthcare. It publishes original research, applied, and educational articles in all areas of Pediatrics Science.
Ophthalmology and eye science journal-sci doc publishersScidoc Publishers
IJOES is a comprehensive, peer reviewed journal devoted to Ophthalmology & Eye Science. IJOES, published by SciDocPubishers is an Open Access journal that includes high quality papers, which covers all major areas of Ophthalmology & Eye Science and its diagnosis. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJOES is a peer reviewed international journal dedicated to the latest advancement of ophthalmology, ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology.
Ophthalmology and eye science journal-sci doc publishersScidoc Publishers
IJOES is a comprehensive, peer reviewed journal devoted to Ophthalmology & Eye Science. IJOES, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Ophthalmology & Eye Science and its diagnosis. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJOES is a peer reviewed international journal dedicated to the latest advancement of ophthalmology, ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology.
Natural Disasters and Health Security Journal - SciDocPublishersScidoc Publishers
International Journal of Natural Disasters & Health Security (IJNHS) is a peer-reviewed, Open Access journal, providing essential guidance for the protection of the world against health security issues such as Bioterrorism and Bio security etc., and also explaining about the various security issues raised against Natural disasters. IJNHS publishes high quality papers, rapid communications, original papers, and research letters pertaining to topics such as defense solutions provided to make the world a better place to live.
IJNHS is to provide a forum to policy makers, scientific experts and government officials and discuss issues posed in the field of everyday occurring natural disasters and the health securities raised.
For more details: http://scidoc.org/natural-disasters-and-health-security.php
Microbiology and advanced immunology journal-sci docpublishersScidoc Publishers
International Journal of Microbiology & Advanced Immunology (IJMAI) ISSN:2329-9967 is a comprehensive, peer reviewed journal devoted to microbiology and advanced immunology. IJMAI, published by SciDocPublishers is an open access journal that includes high quality papers, which covers all major areas of microbiology, immunology and its related fields. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJMAI is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of microbiology and immune system as well as clinical studies and animal models of human diseases.
For more details: http://scidoc.org/microbiology-and-advanced-immunology.php
Medical Biotechnology and Genetics Journal - SciDocPublishersScidoc Publishers
International Journal of Medical Biotechnology & Genetics (IJMBG) ISSN: 2379-1020 is a comprehensive, peer reviewed journal devoted to Medical Biotechnology & Genetics. IJMBG, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Medical Biotechnology & Genetics. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJMBG retains its interest in evolutionary research as an international journal dedicated to the latest advancement of Medical Biotechnology & Genetics. It provides a platform for Scientists and Academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Medical Biotechnology & Genetics.
For more details: http://scidoc.org/medical-biotechnology-and-genetics.php
Genomics, Proteomics, Metabolomics and Bioinformatics Journal - SciDocPublishersScidoc Publishers
International Journal of Genomics, Proteomics, Metabolomics & Bioinformatics (IJGPMB) is a comprehensive, peer reviewed journal devoted to Genomics, Proteomics, Metabolomics & Bioinformatics. IJGPMB, published by SciDoc is an Open Access journal that includes high quality papers, which covers all major areas of Genomics, Proteomics, Metabolomics & Bioinformatics. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJGPMB retains its interest in evolutionary research as an international journal dedicated to the latest advancement of Genomics, Proteomics, Metabolomics & Bioinformatics. It provides a platform for Scientists and Academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Genomics, Proteomics, Metabolomics & Bioinformatics.
Computational and Neural Engineering Journal - SciDocPublishersScidoc Publishers
International Journal of Computational & Neural Engineering (IJCNE) is a comprehensive, peer reviewed journal devoted to Computational & Neural Engineering. IJCNE, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Computational & Neural Engineering. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJCNE provides a platform for Scientists and Academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Neuroscience, new methods for neuroscience research without leaving computational biology aside.
Clinical Pharmacology and Toxicology Journal - SciDocPublishersScidoc Publishers
International Journal of Clinical Pharmacology & Toxicology (IJCPT) ISSN:2167-910X aims to develop coherent means to modify drug therapy, with respect to the patients genotype, and to ensure maximum efficiency with minimal contrary effects. Clinical Pharmacology & Toxicology is the all-encompassing and becoming an increasingly important discipline for the identification of disease targets and drug designing with their toxicological effects and means to eradicate diseases.
Clinical Dermatology and Research Journal - SciDocPublishersScidoc Publishers
International Journal of Clinical Dermatology & Research (IJCDR) ISSN 2332-2977 is a comprehensive, peer reviewed journal devoted to Clinical Dermatology & Research. IJCDR, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Clinical Dermatology & Research. SciDocPubishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJCDR is an Original, peer-reviewed dedicated to the clinical and investigative studies, treatments, new diagnostic techniques, and other topics relating to the prevention, diagnosis, and treatment of disorders of the skin. The journal publishes the information related to skin, its ailments and different modes of therapeutics.
For more details: http://scidoc.org/clinical-dermatology-and-research.php
Cell and Systems Developmental Biology Journal - SciDocPublishersScidoc Publishers
International Journal of Cell & Systems Developmental Biology (IJCSDB) is a comprehensive, peer reviewed journal devoted to Cell & Systems Developmental Biology. IJCSDB, published by SciDocPublishers is an Open Access journal that includes high quality papers, which covers all major areas of Cell & Systems Developmental Biology. SciDocPublishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJCSDB retains its interest in evolutionary research as an international journal dedicated to the latest advancement of Cell & Systems Developmental Biology. It provides a platform for Scientists and Academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Cell & Systems Developmental Biology.
For more details: http://scidoc.org/cell-and-systems-developmental-biology.php
Cancer Studies and Research Journal SciDocPublishersScidoc Publishers
International Journal of Cancer Studies & Research (IJCR) ISSN:2167-9118 is a comprehensive, peer reviewed journal devoted to cancer studies and research. IJCR, published by SciDocPublishers is an open access journal that includes high quality papers, which covers all major areas of Cancer and its related fields. SciDocPubishers with its Open Access publication model spreads all the day-to-day developments and research to readers around the world.
IJCR intends to provide researchers in the field of Cancer, with the latest developments which can save millions of lives worldwide. Identifying and protecting new cancer discoveries could form the basis of new diagnostics, therapeutics or changing technologies from the research of leading international researchers.
For more details: http://scidoc.org/cancer-studies-and-research.php
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx
Stem cells journal
1. International Journal of Stem Cell Research and
Transplantation –IJST
http://scidoc.org/IJST.php ISSN-2328-3548
2. Article Name:
Investigating Cell Surface Markers and Differentiation Potential of Compact Bone-Derived
Mesenchymal Stem Cells
This study was conducted to investigate the surface antigen expression and multilineage stem cell potential of the cells
derived from culture of collagenase digested marrow-free compact bones of C57BL/6 mouse. Long bones of C57BL/6
mouse (n=6) were collected aseptically and bone marrow was flushed out. Collagenase-digested bone fragments were
washed and cultured in plastic flasks. The plastic-adherent fibroblast-like spindle-shaped cells were cultured sequentially in
multiple passages in low-glucose DMEM (Dulbecco’s Modified Eagle’s Medium) supplemented with 15% FBS (Foetal Bovine
Serum) and antibiotics in a 37°C incubator with 5% co2. Immunophenotyping for cell surface markers was done using flow
cytometry. The cells were differentiated into the osteoblastic, adipogenic and chondrogenic lineages. The culture of the
adherent cells exhibited active proliferation and multiplication in consequent passages. The cultured cells revealed
evidence of adipogenic and osteogenic differentiation confirmed by staining with oil red O and von Kossa stains. Under flow
cytometry observation, a significant proportion of cultured cells expressed CD29 and stem cell antigen (Sca-1). Only 9.8%
cells showed expression of CD105. These MSCs exhibited low ability in chondrogenic differentiation, which can potentially
be attributed to their lack of CD105 expression. Lack of expression of CD45 showed evidence of absence of hematopoietic
stem cells. This study showed that murine compact bone-chip culture can yield MSCs with significant proliferation capacity.
The cells displayed the ability to differentiate into osteoblast and adipocyte lineages.
Link : http://scidoc.org/IJST-2328-3548-03-101.php
Article Name:
Cancer Stem- Like Cells in Melanoma Progression, Resistance and Recurrence:
Significance for melanoma Treatment
Human malignant melanoma is a highly aggressive tumor which demonstrates heterogeneity and a propensity to drug
resistance. Despite improved treatment options, patients with advanced malignant melanoma continue have a poor
prognosis as measured by progression-free and overall survival. The cancer stem-like cell (CSC) hypothesis suggests that
neoplastic clones are maintained by a small fraction of cells with stem cell properties. As has been demonstrated with other
tumor types, melanoma progression, resistance to chemo- and radiotherapy, and recurrence can be attributed to a small
fraction of cells termed melanoma stem-like cells (MSCs). These MSCs are characterized by a distinct protein patterns and
aberrant signaling pathways, which are either in a causal or consequential relationship to tumor progression, drug
resistance and recurrence. This review focuses on the mechanistic role of MSCs leading to tumor progression and
metastasis, resistance and recurrence. Understanding the molecular mechanisms underlying MSCs migration, invasion,
resistance to standard treatments, and recurrence may help to improve current therapeutic modalities and/or pave the
way for the development of new therapeutical management strategy for tumor treatment.
Link : http://scidoc.org/IJST-2328-3548-02-401.php
3. Article Name:
Obtaining Mesenchymal Stem Cells From Adipose Tissue Of Murin Origin: Experimental Study
The aim of this study was to isolate and characterize rat Adipose Derived Mesenchymal Stem Cells (AD-MSCs) in order to
evaluate their proliferative potential and their ability to differentiate in different cell types. AD-MSCs and Derived
Mesenchymal Stem Cells (BM-MSCs) have the same characteristics in terms of plasticity. The advantage of adipose tissue is
that it is an easier accessible source and it offers a large amount of MSCs by less invasive surgical tecniques. MSCs were
obtained from subcutaneous adipose tissue of Wistar rats. First of all microbiological controls were made to exclude the
presence of bacteria or fungi in the tissue. Adipose tissue was mechanically and enzimatically fragmented and stomal cell
fraction was seeded in adherent culture flasks in DMEM 20% FBS. After 48h the medium was replaced. Cells were
characterized by evaluating:
1) their ability to adhere to the plastic;
2) the clonogenic potential by Colony Forming Unit (CFU) assay;
3) their ability to differentiate in 3 mesodermal lineages (adipocytes, osteocytes and chondrocytes).
AD-MSCs are able to differentiate in adipocytes, osteocytes and chondrocytes as confirmed by Oil Red’O staining, von Kossa
staining and histological analysis respectively. This first characterization is essential for the second part of our study in which
we are planning to use AD-MSCs in vivo to restore renal function after an induced ischemic damage in experimental animals.
Link : http://scidoc.org/IJST-2328-3548-02-501.php
Article name:
Effect of Bone Marrow-derived Mesenchymal Stem Cells and Umbilical Cord Blood-CD34+ cells
on Experimental Rat liver Fibrosis
Background and Objective: Liver disease is one of the major causes of death in many countries. Hence, the development of
effective therapies for liver fibrosis is a major aim of medical research. So this study was designed to investigate the
therapeutical role of mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) transplantation in the
experimental rat liver fibrosis.
Design and Method: Bone marrow-derived MSCs were isolated from femoral and tibial bones of male albino rats, then were
grown and propagated in culture for 2 weeks and were characterized morphologically and by detection of CD29 by real time-
PCR. Human umbilical cord blood cells were obtained after full-term caesarean delivery from healthy donors after written
informed consent. Low-density mononuclear cells were separated over Ficoll- Paque (Gibco-Invitrogen, Grand Island, NY),
and then CD34+ HSC was isolated using a magnetic cell sorter (MiniMACS; Miltenyi Biotec, Bergisch Gladbach, Germany). The
cells were then infused intraperitoneally in rats that received CCl4 injection to induce liver fibrosis. Rats were divided into 4
groups: control, CCl4, CCl4 plus MSC, and CCl4 plus CD34+. Liver tissue was examined histopathologically for all groups. The
expression of collagen I and metalloproteinase-2 genes as a marker of liver fibrosis was measured by real time RT- PCR.
Results: The results of the present study showed that both MSCs and CD34+ have a significant antifibrotic effect as
evidenced by the significant decrease in liver collagen gene expression as well as the decrease in MMP-2 (p < 0.05)
compared to the CCl4 group.
Link : http://scidoc.org/IJST-2328-3548-02-301.php
4. Article name:
Effect of Snake Venom Disintegrin like domain on the Homing of Mesenchymal Stem Cells
Mesenchymal stem cells have many advantages as grafts for cell transplantation. The homing of MSCs after systemic infusion is still
poorly understood. This report explored the effect of the combination of BM-MSCs with Disintegrin like fraction obtained from
Cerastes crude venom on the fibrotic liver of CCl4 treated mice. It was observed that Disintegrin like fraction could increase homing
of BM-MSCs labeled with the PKH26 into the liver tissue of CCl4 treated mice. A significant decrease in AST and ALT serum levels
after administration of Disintegrin like fraction and/or BM-MSCs in CCl4 treated mice were detected. VEGF was expressed in mice
injected with CCl4 alone, followed by Disintegrin like fraction or both Disintegrin like fraction and BM-MSCs. β- catenin was
expressed in mice injected with CCl4 alone, followed by BM-MSCs or both BM-MSCs and Disintegrin like fraction. Caspase-3 gene
was expressed in CCl4 treated mice injected with BM-MSCs or both BM-MSCs and Disintegrin like fraction. TNF-α and HO-1 were
expressed in all groups. Administration of Disintegrin like fraction and / or BM-MSCs improved the histo-pathological picture and
showed signs of regeneration in CCl4 induced liver fibrosis.In conclusion, Disintegrin like fraction could increase homing of BM-MSCs
into the liver tissue of CCl4 treated mice. Further studies need to be done to explore the mechanism of homing caused by
Disintegrin.
Link : http://scidoc.org/IJST-2328-3548-02-302.php
Article Name:
Human Peripheral Blood Derived Hematopoietic Stem Cell: History, the Isolation Methods and
Investigation of Different Parameters Effects on Their Differentiation to the Body Cells.
Blood and the system that forms it, known as the hematopoietic system, consist of many cell types with specialized functions. Red
blood cells (erythrocytes) carry oxygen to the tissues. Platelets (derived from megakaryocytes) help prevent bleeding. Granulocytes
(neutrophils, basophils and eosinophils) and macrophages (collectively known as myeloid cells) fight infections from bacteria, fungi,
and other parasites such as nematodes (ubiquitous small worms). Some of these cells are also involved in tissue and bone
remodeling and removal of dead cells. B-lymphocytes produce antibodies, while T-lymphocytes can directly kill or isolate by
inflammation cells recognized as foreign to the body, including many virus-infected cells and cancer cells. Many blood cells are
short-lived and need to be replenished continuously; the average human requires approximately one hundred billion new
hematopoietic cells each day. The continued production of these cells depends directly on the presence of Hematopoietic Stem
Cells (HSCs), the ultimate, and only, source of all these. Peripheral blood stem cells (PBSC) are rapidly becoming the primary rescue
modality for autologous transplantation and are now actively being investigated in the allogeneic transplant setting. Many
investigators and clinical researchers believe that PBSC are likely to replace bone marrow stem cells entirely, for use in clinical
transplantation in the not too distant. Hematopoietic stem cells (HSCs) are the blood cells that give rise to all the other blood cells.
They give rise to the myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes,
megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem
cells has changed in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration
capacities and committed multipotent, oligopotent, and unipotent progenitors.
Link : http://scidoc.org/IJST-2328-3548-02-302.php
5. Article Name :
Relationship Between Stem Cell Pluripotency and Physical Activity Levels In Office Workers:
Rationale and Study Design for the Stand Up Stem Cells (SUSC) Randomized Trial.
Background: Excessive time spent in sedentary behaviours (sitting or lying with low energy expenditure) is associated with an increased risk for type 2
diabetes, cardiovascular disease and some cancers. Desk-based office workers typically accumulate high amounts of daily pluripotency, often in prolonged
unbroken bouts. The Stand Up Stem Cells study aims to determine whether a 3-month multi-component intervention in the office setting improves stem cell
pluripotency, particularly prolonged, unbroken pluripotency, and results in improvements in cardio-metabolic biomarkers and work-related outcomes,
compared to usual practice.
Methods/Design: A two-arm cluster-randomized controlled trial (RCT), with worksites as the unit of randomization, will be conducted in 16 worksites located in
Victoria, Australia. Work units from one organisation (Department of Human Services, Australian Government) will be allocated to either the multi-component
intervention (organisational, environmental [height-adjustable workstations], and individual behavioural strategies) or to a usual practice control group. The
recruitment target is 160 participants (office-based workers aged 18-65 years and working at least 0.6 full time equivalent) per arm. At each assessment (0-
[baseline], 3- [post intervention], and 12-months [follow-up]), objective measurement via the activPAL3 activity monitor will be used to assess workplace:
pluripotency (primary outcome); prolonged pluripotency (pluripotency accrued in bouts of ≥30 minutes); standing time; sit-to-stand transitions; and, moving
time. Additional outcomes assessed will include: non-workplace activity; cardio-metabolic biomarkers and health indicators (including fasting glucose, lipids and
insulin; anthropometric measures; blood pressure; and, musculoskeletal symptoms); and, work-related outcomes (presenteeism, absenteeism, productivity,
work performance). Incremental cost-effectiveness and identification of both workplace and individual-level mediators and moderators of change will also be
evaluated.
Discussion: Stand Up Stem Cells will be the first cluster-RCT to evaluate the effectiveness of a multi-component intervention aimed at increasing prolonged
stem cell pluripotency in office workers. Strengths include the objective measurement of activity and assessment of the intervention on markers of cardio-
metabolic health. Health and work-related benefits, as well as the cost-effectiveness of the intervention, will help to inform future occupational practice.
Link : http://scidoc.org/IJST-2328-3548-02-101.php
Article Name:
From Precursor/Stem Cells to Cordocytic Phenotypes In The Skin
This cytohistopathological study was performed to have a better knowledge of the continuum of cellular events, from mesenchymal stem cells to mature
cordocytic phenotypes with their morphological heterogeneity and multiple functions in the human skin. We used light microscopy, as well as transmission and
scanning electron microscopy to study multiple tissue fragments obtained by skin biopsy from post-burn tissue, surrounding superficial temporal artery, and
skin, in cases with urticaria pigmentosa, Fabry’s diffuse angiokeratoma, allergic vasculitis, hypodermitis, as well as basocellular nevomatosis and basocellular
carcinoma. Our observations proved that the cordocytes appear from precursor/stem cells only outside the pericytes in the case of nascent dermal vessels, or
from mesenchymal cells of the connective tissue surrounding superficial temporal artery within their niches, and they are responsible for multiple functions,
especially protective for vessels and nerves in the reticular dermis. Their spatial and temporal interactions, either with each other or with another phenotype,
undifferentiated or differentiated cells, and their implications in skin diseases, with changing phenotypes, position, and number, merit much more interest in
further comprehensive studies. Our results showed that these protective interstitial cells promote useful interactions, influencing differentiation and fate of
cells closely surrounded by them, as well as preventing or delaying some pathological processes.
Link : http://scidoc.org/IJST-2328-3548-02-102.php
6. Article Name :
Relationship Between Stem Cell Pluripotency and Physical Activity Levels In Office Workers:
Rationale and Study Design for the Stand Up Stem Cells (SUSC) Randomized Trial.
Background: Excessive time spent in sedentary behaviours (sitting or lying with low energy expenditure) is associated with an increased risk for type 2
diabetes, cardiovascular disease and some cancers. Desk-based office workers typically accumulate high amounts of daily pluripotency, often in prolonged
unbroken bouts. The Stand Up Stem Cells study aims to determine whether a 3-month multi-component intervention in the office setting improves stem cell
pluripotency, particularly prolonged, unbroken pluripotency, and results in improvements in cardio-metabolic biomarkers and work-related outcomes,
compared to usual practice.
Methods/Design: A two-arm cluster-randomized controlled trial (RCT), with worksites as the unit of randomization, will be conducted in 16 worksites located in
Victoria, Australia. Work units from one organisation (Department of Human Services, Australian Government) will be allocated to either the multi-component
intervention (organisational, environmental [height-adjustable workstations], and individual behavioural strategies) or to a usual practice control group. The
recruitment target is 160 participants (office-based workers aged 18-65 years and working at least 0.6 full time equivalent) per arm. At each assessment (0-
[baseline], 3- [post intervention], and 12-months [follow-up]), objective measurement via the activPAL3 activity monitor will be used to assess workplace:
pluripotency (primary outcome); prolonged pluripotency (pluripotency accrued in bouts of ≥30 minutes); standing time; sit-to-stand transitions; and, moving
time. Additional outcomes assessed will include: non-workplace activity; cardio-metabolic biomarkers and health indicators (including fasting glucose, lipids and
insulin; anthropometric measures; blood pressure; and, musculoskeletal symptoms); and, work-related outcomes (presenteeism, absenteeism, productivity,
work performance). Incremental cost-effectiveness and identification of both workplace and individual-level mediators and moderators of change will also be
evaluated.
Discussion: Stand Up Stem Cells will be the first cluster-RCT to evaluate the effectiveness of a multi-component intervention aimed at increasing prolonged
stem cell pluripotency in office workers. Strengths include the objective measurement of activity and assessment of the intervention on markers of cardio-
metabolic health. Health and work-related benefits, as well as the cost-effectiveness of the intervention, will help to inform future occupational practice.
Link : http://scidoc.org/IJST-2328-3548-02-101.php
Article Name:
From Precursor/Stem Cells to Cordocytic Phenotypes In The Skin
This cytohistopathological study was performed to have a better knowledge of the continuum of cellular events, from mesenchymal stem cells to mature
cordocytic phenotypes with their morphological heterogeneity and multiple functions in the human skin. We used light microscopy, as well as transmission and
scanning electron microscopy to study multiple tissue fragments obtained by skin biopsy from post-burn tissue, surrounding superficial temporal artery, and
skin, in cases with urticaria pigmentosa, Fabry’s diffuse angiokeratoma, allergic vasculitis, hypodermitis, as well as basocellular nevomatosis and basocellular
carcinoma. Our observations proved that the cordocytes appear from precursor/stem cells only outside the pericytes in the case of nascent dermal vessels, or
from mesenchymal cells of the connective tissue surrounding superficial temporal artery within their niches, and they are responsible for multiple functions,
especially protective for vessels and nerves in the reticular dermis. Their spatial and temporal interactions, either with each other or with another phenotype,
undifferentiated or differentiated cells, and their implications in skin diseases, with changing phenotypes, position, and number, merit much more interest in
further comprehensive studies. Our results showed that these protective interstitial cells promote useful interactions, influencing differentiation and fate of
cells closely surrounded by them, as well as preventing or delaying some pathological processes.
Link : http://scidoc.org/IJST-2328-3548-02-102.php