1. Vertex Pharmaceuticals announced the first successful case of stem cell therapy treating type 1 diabetes. A patient achieved stable recovery of islet cell function after receiving VX-880, pancreatic islet cells derived from stem cells.
2. VX-880 aims to restore glucose regulation by providing islet cells to produce insulin, replacing insulin injections. No serious side effects have been reported.
3. Stem cell therapy offers advantages over traditional diabetes treatments by repairing pancreatic islet function, allowing patients to reduce or stop insulin use and better control blood sugar levels.
Type 1 Diabetes Mellitus is a form of diabetes mellitus that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Genetic factors are believed to be a major com- ponent for the development of type 1diabetes, but the con- cordance rate for the development of diabetes in identical twins is only about 40%, suggesting that non-genetic factors play an important role in the expression of the disease. Viruses are one environmental factor that is implicated in the pathogenesis of type 1 diabetes mellitus.
Shashikiran Umakanth made this presentation at the "First Endocrine Update Program” – ENDO EGYPT 2015, from 17-20 December 2015 in the Historic City of Luxor, Egypt. This endocrine update was organised by the Egyptian Association of Endocrinology , Diabetes and Atherosclerosis (EAEDA) in collaboration with the Endocrine Society, USA.
Type 1 Diabetes Mellitus is a form of diabetes mellitus that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Genetic factors are believed to be a major com- ponent for the development of type 1diabetes, but the con- cordance rate for the development of diabetes in identical twins is only about 40%, suggesting that non-genetic factors play an important role in the expression of the disease. Viruses are one environmental factor that is implicated in the pathogenesis of type 1 diabetes mellitus.
Shashikiran Umakanth made this presentation at the "First Endocrine Update Program” – ENDO EGYPT 2015, from 17-20 December 2015 in the Historic City of Luxor, Egypt. This endocrine update was organised by the Egyptian Association of Endocrinology , Diabetes and Atherosclerosis (EAEDA) in collaboration with the Endocrine Society, USA.
Diabetes is one of the leading metabolic disorder with life style problems, causing severe abnormalities which can worsen with respect to time. This ppt. will be helpful for D.Pharm, B.Pharm, M.Pharm students
Type 2 diabetes - A 2016 update by Zeena NackerdienZeena Nackerdien
The International Diabetes Federation maintains that one in two adults are undiagnosed for diabetes and that estimates that one in eleven people had diabetes in 2015. If one takes into account that most of the cases involves the preventable condition of Type 2 diabetes, it comes as no surprise that many countries are being hit by staggering socioeconomic costs. Diabetes sites, chat rooms, aps, and ads for ever-evolving and increasingly complex disease management schemes are commonplace on Google. But what does all the information mean? The American Diabetes Association, American Association of Clinical Endocrinologists, The Canadian Diabetes Association, WebMD, and the International Diabetes Federation resources served as the major resources for this accompanying slide deck that tries to unpack some of the major subtopics related to prediabetes and Type 2 diabetes. The slide deck is organized according to disease definition, epidemiology, etiology/pathophysiology, diagnosis, treatment, and prevention. Particular topics such as the early use of insulin could be expanded into several separate slide decks narrating benefits and risks with supporting evidence. However, this deck is meant to provide interested readers with an overview of the Type 2 diabetes literature landscape, with the caveat that specific cases and Type 2 diabetes-related complications should always be discussed with a healthcare provider.
Image credits: slideteam.net; Wikimedia
"Insulin Independence" Summit on Capitol HillDavid Edelman
These slides are from the April 24, 2013 "Insulin Independence" summit at the Canon House Office Building on Capitol Hill in Washington, DC. The event previewed the future of combination therapies to restore insulin production to people living with type 1 diabetes.
Something remarkable happens when some women with type 1 diabetes become pregnant: they start producing completely normal levels of insulin.
You read that correctly: one third of pregnant women, including those who’ve had it for 20 years or more, have reduced insulin needs during pregnancy. Some need no injected insulin at all. This knowledge may soon help everyone living with type 1 diabetes. How is this possible?
Two special things happen during pregnancy. First, the body relaxes the immune system to prevent it from harming the fetus. Second, it floods the body with hormones that promote growth. This causes something that researchers long thought was impossible: brand new islet cells start forming and producing insulin.
The combination therapy approach looks to mimic this effect and transform the treatment of diabetes.
Diabetes is a multifactorial disease leading to several complications, and therefore demands a multiple therapeutic approach. Patients of diabetes either do not make enough insulin or their cells do not respond to insulin. In case of total lack of insulin, patients are given insulin injections. Whereas in case of those where cells do not respond to insulin many different drugs are developed taking into consideration possible disturbances in carbohydrate-metabolism. For example, to manage post-prandial hyper-glycaemia at digestive level, glucosidase inhibitors such as acarbose, miglitol and voglibose are used. These inhibit degradation of carbohydrates there by reducing the glucose absorption by the cells. To enhance glucose uptake by peripheral cells biguanide such as metformin is used. Sulphonylureas, like glibenclamide, is insulinotropic and work as secretogogue for pancreatic cells. Although several therapies are in use for treatment, there are certain limitations due to high cost and side effects such as development of hypoglycemia, weight gain, gastrointestinal disturbances, liver toxicity etc. Based on recent advances and involvement of oxidative stress in complicating diabetes mellitus, efforts are on to find suitable antidiabetic and antioxidant therapy.
Medicinal plants are being looked upon once again for the treatment of diabetes. Many conventional drugs have been derived from prototypic molecules in medicinal plants. Metformin exemplifies an efficacious oral glucose-lowering agent. To date, over 400 traditional plant treatments for diabetes have been reported, although only a small number of these have received scientific and medical evaluation to assess their efficacy. The hypoglycemic effect of some herbal extracts has been confirmed in human and animal models of type 2 diabetes. The World Health Organization Expert Committee on diabetes has recommended that traditional medicinal herbs be further investigated. The present paper Reviews the Role of Insulike tablets developed by R&D cell of Lactonova Nutripharm Pvt Ltd. Hyderabad in the role of herbal nutraceutical drug INSULIKE, A nutriphenotypic approach for the treatment of diabetes.
Diabetes is one of the leading metabolic disorder with life style problems, causing severe abnormalities which can worsen with respect to time. This ppt. will be helpful for D.Pharm, B.Pharm, M.Pharm students
Type 2 diabetes - A 2016 update by Zeena NackerdienZeena Nackerdien
The International Diabetes Federation maintains that one in two adults are undiagnosed for diabetes and that estimates that one in eleven people had diabetes in 2015. If one takes into account that most of the cases involves the preventable condition of Type 2 diabetes, it comes as no surprise that many countries are being hit by staggering socioeconomic costs. Diabetes sites, chat rooms, aps, and ads for ever-evolving and increasingly complex disease management schemes are commonplace on Google. But what does all the information mean? The American Diabetes Association, American Association of Clinical Endocrinologists, The Canadian Diabetes Association, WebMD, and the International Diabetes Federation resources served as the major resources for this accompanying slide deck that tries to unpack some of the major subtopics related to prediabetes and Type 2 diabetes. The slide deck is organized according to disease definition, epidemiology, etiology/pathophysiology, diagnosis, treatment, and prevention. Particular topics such as the early use of insulin could be expanded into several separate slide decks narrating benefits and risks with supporting evidence. However, this deck is meant to provide interested readers with an overview of the Type 2 diabetes literature landscape, with the caveat that specific cases and Type 2 diabetes-related complications should always be discussed with a healthcare provider.
Image credits: slideteam.net; Wikimedia
"Insulin Independence" Summit on Capitol HillDavid Edelman
These slides are from the April 24, 2013 "Insulin Independence" summit at the Canon House Office Building on Capitol Hill in Washington, DC. The event previewed the future of combination therapies to restore insulin production to people living with type 1 diabetes.
Something remarkable happens when some women with type 1 diabetes become pregnant: they start producing completely normal levels of insulin.
You read that correctly: one third of pregnant women, including those who’ve had it for 20 years or more, have reduced insulin needs during pregnancy. Some need no injected insulin at all. This knowledge may soon help everyone living with type 1 diabetes. How is this possible?
Two special things happen during pregnancy. First, the body relaxes the immune system to prevent it from harming the fetus. Second, it floods the body with hormones that promote growth. This causes something that researchers long thought was impossible: brand new islet cells start forming and producing insulin.
The combination therapy approach looks to mimic this effect and transform the treatment of diabetes.
Diabetes is a multifactorial disease leading to several complications, and therefore demands a multiple therapeutic approach. Patients of diabetes either do not make enough insulin or their cells do not respond to insulin. In case of total lack of insulin, patients are given insulin injections. Whereas in case of those where cells do not respond to insulin many different drugs are developed taking into consideration possible disturbances in carbohydrate-metabolism. For example, to manage post-prandial hyper-glycaemia at digestive level, glucosidase inhibitors such as acarbose, miglitol and voglibose are used. These inhibit degradation of carbohydrates there by reducing the glucose absorption by the cells. To enhance glucose uptake by peripheral cells biguanide such as metformin is used. Sulphonylureas, like glibenclamide, is insulinotropic and work as secretogogue for pancreatic cells. Although several therapies are in use for treatment, there are certain limitations due to high cost and side effects such as development of hypoglycemia, weight gain, gastrointestinal disturbances, liver toxicity etc. Based on recent advances and involvement of oxidative stress in complicating diabetes mellitus, efforts are on to find suitable antidiabetic and antioxidant therapy.
Medicinal plants are being looked upon once again for the treatment of diabetes. Many conventional drugs have been derived from prototypic molecules in medicinal plants. Metformin exemplifies an efficacious oral glucose-lowering agent. To date, over 400 traditional plant treatments for diabetes have been reported, although only a small number of these have received scientific and medical evaluation to assess their efficacy. The hypoglycemic effect of some herbal extracts has been confirmed in human and animal models of type 2 diabetes. The World Health Organization Expert Committee on diabetes has recommended that traditional medicinal herbs be further investigated. The present paper Reviews the Role of Insulike tablets developed by R&D cell of Lactonova Nutripharm Pvt Ltd. Hyderabad in the role of herbal nutraceutical drug INSULIKE, A nutriphenotypic approach for the treatment of diabetes.
Diabetes mellitus (DM) is a disease of inadequate control of blood levels of glucose. It has many subclassifications, including type 1, type 2, maturity-onset diabetes of the young (MODY), gestational diabetes, neonatal diabetes, and steroid-induced diabetes. Type 1 and 2 DM are the main subtypes, each with different pathophysiology, presentation, and management, but both have a potential for hyperglycemia. This activity outlines the pathophysiology, evaluation, and management of DM and highlights the role of the interprofessional team in managing patients with this condition.
Objectives:
Describe the pathophysiology of diabetes mellitus.
Outline the epidemiology and risk factors of diabetes mellitus.
Review the treatment considerations and common complications of diabetes mellitus.
Identify the importance of improving collaboration and care coordination amongst the interprofessional team to enhance the delivery of care for patients affected by diabetes mellitus.
Access free multiple choice questions on this topic.
Go to:
Introduction
Diabetes mellitus is taken from the Greek word diabetes, meaning siphon - to pass through and the Latin word mellitus meaning sweet. A review of the history shows that the term "diabetes" was first used by Apollonius of Memphis around 250 to 300 BC. Ancient Greek, Indian, and Egyptian civilizations discovered the sweet nature of urine in this condition, and hence the propagation of the word Diabetes Mellitus came into being. Mering and Minkowski, in 1889, discovered the role of the pancreas in the pathogenesis of diabetes. In 1922 Banting, Best, and Collip purified the hormone insulin from the pancreas of cows at the University of Toronto, leading to the availability of an effective treatment for diabetes in 1922. Over the years, exceptional work has taken place, and multiple discoveries, as well as management strategies, have been created to tackle this growing problem. Unfortunately, even today, diabetes is one of the most common chronic diseases in the country and worldwide. In the US, it remains as the seventh leading cause of death.
Diabetes mellitus (DM) is a metabolic disease, involving inappropriately elevated blood glucose levels. DM has several categories, including type 1, type 2, maturity-onset diabetes of the young (MODY), gestational diabetes, neonatal diabetes, and secondary causes due to endocrinopathies, steroid use, etc. The main subtypes of DM are Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM), which classically result from defective insulin secretion (T1DM) and/or action (T2DM). T1DM presents in children or adolescents, while T2DM is thought to affect middle-aged and older adults who have prolonged hyperglycemia due to poor lifestyle and dietary choices. The pathogenesis for T1DM and T2DM is drastically different, and therefore each type has various etiologies, presentations, and treatments.
The Presentation gives a detailed idea of Medicinal Chemistry and Pharmacology of Hypoglycemic agents useful for undergraduate and postgraduate students in Pharmacy, Medicine, Nursing, Pharmacology and Medicinal Chemistry
Anti-Diabetic Activity of Some Medicinal Plants IIJSRJournal
Diabetes mellitus is generally a chronic disease which is a main reason for deaths in whole world. It is not easy to control the delayed complication of diabetes even with progress in the medical management of the syndrome. The disease is spreading day by day. The main trait element of diabetes is hyperglycemia, which reflects the drop in the use of glucose due to a poor reaction to insulin discharge. There are many plants are used to cure diabetes because of the antidiabetic action. Hypoglycemic and anti-hyperglycemic actions have been saved with abundant plants, a lot of which are worn as an established herbal treatment of diabetes. A huge number of substances are obtained from plants that suggest antidiabetic potential, while others may affect hypoglycemia as a bad result due to their toxicity, mainly their hepatotoxicity. This review shows the importance of plants and the action of some plants to act against diabetes that is used as a natural medicine for this disease.
Heal with Hope: The Future of Diabetes Care with Stem Cell | Dr David Greene ...Dr. David Greene Arizona
Dr. David Greene delves into groundbreaking stem cell therapies, illuminating their transformative potential for diabetes care. Unravel the science and hope behind these cutting-edge treatments as Arizona's leading expert bridges the gap between innovation and patient well-being. A glimpse into the future of holistic diabetes management.
Diabetes is a chronic health condition that affects how the body converts food into energy. There are two main types of diabetes: type 1 and type 2. In type 1 diabetes, the body doesn't produce enough insulin, a hormone that regulates blood sugar levels. In type 2 diabetes, the body becomes resistant to insulin or doesn't produce enough insulin.
High blood sugar levels associated with diabetes can cause a range of health problems, including nerve damage, kidney disease, and heart disease. Managing diabetes involves monitoring blood sugar levels, taking medications, and making lifestyle changes such as eating a healthy diet and exercising regularly.
If you have diabetes, it's important to work closely with your healthcare provider to develop a treatment plan that meets your individual needs. This may include regular blood sugar testing, taking medications as prescribed, and making lifestyle changes to help manage your condition.
Future Of Nanomedicine In Diabetes Treatment.pdfPharmacy 7065
Future Of Nanomedicine In Diabetes Treatment||Nanomedicine||Diabetes||Classification Of Diabetes||Nanomedicine application for Glucose monitoring||Nanomedicine in management of diabetes||Diabetes test||LBL Technique||Glucose nanosensors||Carbon nanotubes||Quantum dots||Oral insulin||Microsphere||Microsphere for oral insulin production||Artificial pancreas||Nanopumps||Future of Nanomedicines||Introduction of Nanomedicines||Nanotechnology||
Newer Anti-Hyperglycemic agents in type 2 Diabetes Mellitus e Expanding the h...Apollo Hospitals
Diabetes mellitus is a common, chronic and progressive disease resulting in micro and macrovascular complications. Many classes of drugs are available for treatment but still the search for newer anti-hyperglycemic agents continues to combat significant adverse effect profile, loss of efficacy, progressive nature of disease and improve patient compliance. New emerging therapies in pipeline include drugs targeting various pathophysiologic mechanisms like incretin based therapies, sodium glucose co-transporter inhibitors, glucokinase inhibitors, 11b hydroxy steroid dehydrogenase inhibitors, drugs modulating fatty acid metabolism, selective PPARg receptor modulators and anti inflammatory agents.
R3 Stem Cell brings hope to diabetes patients with revolutionary stem cell therapies. Our innovative treatments offer a lifeline to those seeking effective diabetes management solutions. Discover a world where cutting-edge science meets healing, and hope is restored for individuals battling this relentless disease. Welcome to the future of care
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Stem cell therapy first successful in treatment of type 1 diabetes
1. Biochempeg https://www.biochempeg.com
Stem Cell Therapy First Successful
In Treatment of Type 1 Diabetes
2021 is the 100th anniversary of the discovery of insulin. In 1921, insulin was discovered
by Sir Frederick G Banting, Charles H Best and JJR Macleod at the University of Toronto.
It was first used in a human to treat diabetes in 11 January 1922. Before 1921, it was
exceptional for people with type 1 diabetes to live more than a year or two. It is one of the
greatest medical discoveries of the 20th century, and it remains the only effective way to
treat type 1 diabetes today.
The discovery of insulin has saved millions of diabetic patients, especially those with type
1 diabetes. For patients with type 1 diabetes, it can only be maintained by insulin therapy,
and there is no other way to solve the fundamental problem that causes the disease -
pancreatic islet cells cannot produce insulin by themselves. Type 1 diabetes must be
treated with insulin, so it is also called insulin-dependent diabetes.
On October 18, 2021, Vertex Pharmaceuticals Incorporated announced that a patient with
severe type 1 diabetes has achieved a "stable recovery" of islet cell function after
receiving fully differentiated pancreatic islet cell replacement therapy derived from its stem
cell called VX-880. These restored pancreatic islet cells can make patients to regulate
insulin and even produce insulin by themselves, reducing their daily insulin consumption
by 91% and significantly improving blood sugar control. This is the world's first successful
case of stem cell therapy for type 1 diabetes.
About the VX-880
VX-880 is a stem cell-derived pancreatic islet cell replacement therapy, which aims to
restore the body's ability to regulate glucose by providing patients with pancreatic islet
cells derived from donor stem cells to produce insulin to replace insulin injection therapy
2. Biochempeg https://www.biochempeg.com
and long-term care. The safety of this therapy is similar to that of typical
immunosuppressive therapy, and no serious side effects related to the treatment have
been reported. Although there is only one patient's successful case, this is still enough to
prove the feasibility of this therapy.
Encapsulated stem cell-derived islets could shield β cells from the immune system (source:
reference [4])
In recent years, stem cell technology has been widely used in the intervention and
treatment of diabetes. As a cutting-edge technology in the clinical treatment of diabetes,
stem cell technology has attracted widespread attention. Many hospitals have
accumulated a lot of experience in rich clinical applications. How do stem cells work in the
treatment of type 1 diabetes?
3. Biochempeg https://www.biochempeg.com
The mechanism of stem cell therapy in the
treatment of diabetes
Stem cell therapy is currently recognized as the ultimate hope for a radical cure for
diabetes. Mesenchymal stem cells can secrete a variety of immunoregulatory factors and
nutritional factors to restore and repair a variety of damaged tissues. Due to easy
separation and low immunogenicity, mesenchymal stem cells are currently the most
widely used stem cells in clinical practice.
1. Type 1 diabetes and stem cells
Type 1 diabetes is an autoimmune response mediated by T cells, which leads to a lack of
pancreatic islet cells. The reason why it is difficult to overcome is due to the polyclonal
characteristics of the autoimmune response of type 1 diabetes and the characteristics of
multiple immune regulation disorders. Therefore, how to effectively control autoimmunity
is a key problem to be solved urgently in the treatment of type 1 diabetes. The treatment
shows that stem cells have immunomodulatory effects. Using the immunomodulatory
4. Biochempeg https://www.biochempeg.com
effect of stem cells to correct the autoimmunity of type 1 diabetes has been clinically
applied and achieved remarkable results as a novel therapy.
2. Type 2 diabetes and stem cells
The occurrence of type 2 diabetes is closely related to the significant decrease in the
sensitivity of insulin receptors in peripheral tissues, which leads to a decrease in the
utilization of blood sugar by tissue cells, and ultimately manifests as a significant increase
in blood sugar levels that are common in clinical practice. Mesenchymal stem cells have
strong migration and differentiation ability and can secrete a variety of good cytokines.
These factors can stimulate mesenchymal stem cells to exert immunosuppressive
functions, and a large number of well-grown stem cells can promote the survival of
damaged cells in a short time. Treatment with mesenchymal stem cells takes advantage
of their supportive role in secreting multiple cytokines and their ability to differentiate into
vascular endothelial cells.
Disadvantages of traditional treatments for
diabetes
Diabetes is a group of metabolic diseases characterized by hyperglycemia.
Hyperglycemia is caused by defective insulin secretion or impaired biological effects, or
both. The prolonged presence of hyperglycemia in diabetes leads to chronic damage and
dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and
nerves. There are generally two traditional methods of diabetes treatment, both of which
have obvious disadvantages.
One is the drug therapy. Although oral medications and insulin injections can improve
symptoms, they cannot precisely regulate blood sugar, reverse insulin resistance and
β cell dysfunction, reduce tissue and organ damage, and fundamentally treat diabetes.
5. Biochempeg https://www.biochempeg.com
The other one is transplantation of pancreas and islets. This kind of treatment is
expensive and the donors are very limited. It requires long-term administration of immune
preparations. It has large side effects, low operability, and cannot be widely used.
Compared with traditional treatments for diabetes, stem cell therapy is to repair one's own
pancreatic islet function and improve the symptoms of diabetes. With the stem cell
treatment, about 65% of patients have gotten rid of their dependence on insulin or oral
medications. More than 90% of patients have reduced the application dose of insulin or
oral drugs, or changed the injection of insulin to oral drug therapy, which greatly controlled
or slowed down the occurrence and development of complications.
Advantages of stem cell therapy for diabetes
◆Stem cell therapy can make diabetic patients stop using insulin or reduce insulin
dosage.
◆The safety of stem cell therapy in the treatment of diabetes has been effectively tested.
◆Stem cell therapy can effectively control fasting blood glucose, postprandial blood
glucose and hemoglobin (HbA1c) and other biochemical indicators.
◆Stem cell therapy can effectively prevent diabetic complications, such as diabetic foot.
Conclusion
The treatments showed that insulin-producing cells can be obtained from stem cells. Stem
cells represent an infinite source of cells and solve the problem of lack of donors. Diabetes
is a metabolic disease caused by the disorder of autoimmune processes. Only by solving
the original causes and mechanisms can the problem be solved. With the development of
scientific research, stem cell treatment of diabetes will make greater breakthroughs.
6. Biochempeg https://www.biochempeg.com
Stem cell technology is widely used now. In addition to treating diabetes, it can also be
used in muscle tissue regeneration, certain eye diseases, heart diseases, etc. In the
future, stem cell technology can also be used to cultivate organs in vitro.
For people with type 1 diabetes, the disease can only be controlled with insulin treatment.
For people with type 2 diabetes, it can be maintained by taking medication and dietary
controls. Semaglutide is an anti-diabetic medication used for the treatment of type 2
diabetes and chronic weight management. As a reliable PEG supplier, Biopharma
PEG provides four kind of semaglutide intermediates to support your R&D research or
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References:
[1] First time: Stem cells successfully treat diabetic patients to regenerate insulin
[2] Vertex Announces Positive Day 90 Data for the First Patient in the Phase 1/2 Clinical Trial Dosed With
VX-880, a Novel Investigational Stem Cell-Derived Therapy for the Treatment of Type 1 Diabetes
[3] Mesenchymal stem cells: a future experimental exploration for recession of diabetic nephropathy
[4] How stem cells could fix type 1 diabetes