This document provides an overview of diabetes mellitus (DM), including its types, signs and symptoms, and pathophysiology. DM is a metabolic disorder characterized by high blood sugar levels over a prolonged period. There are two main types of DM: type 1 DM results from the body's inability to produce insulin due to the destruction of pancreatic beta cells, while type 2 DM involves insulin resistance where cells do not properly respond to insulin. The pathophysiology section explains insulin's role in metabolic processes and the effects of insulin deficiency or resistance. Pharmacological management of DM is also briefly mentioned.