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腎功能不好需
小心的保健食品
周孫鴻藥師
維他命
維他命 C
• >1g/ 天 會增加腎臟結石風險 , 尤其是有結
石病史的人
Curhan GC, Willett WC, Speizer FE, et al. Intake of
vitamins B 6 and C and the risk of kidney stones in
women. Am Soc Nephrol.1999;10:840-845.
Curhan GC. A prospective study of the intake of vitamin C
and vitamin B 6 and the risk of kidney stones in men. J
Urol.1996;155:1847-1851.
Simon JA, Hudes ES. Relation of serum ascorbic acid to
serum vitamin B12, serum ferritin, and kidney stones in
US adults. Arch Intern Med. 1999;159:619-624.
維他命 B6 、 B12
• > 葉酸 2,500 mcg/ 天 +B6 25 mg/ 天
+B12 1,000 mcg/ 天 會增加糖尿病 + 腎功
能不好的人中風 , 心臟病機率
https://jamanetwork.com/journals/jama/full
article/185758
葉酸
• 長期過量 ( 天然 > 1000 mcg/ 天 ; 合成 >
600 mcg/ 天 ) 會傷害腎臟
礦物質
鉀、鎂、鈣、磷
• 腎臟不好會無法排除 , 需要限制甚至避免食
用
鉻
• 長期服用 chromium picolinate 600~2,400
mcg/ 天可能造成腎臟炎
Wasser WG, Feldman NS, D’Agati VD: Chronic renal failure
after ingestion of over-the-counter chromium picolinate. Ann
Intern Med 126: 410, 1997
泌尿道用
蔓越莓
• 增加腎臟結石風險
https://www.ncbi.nlm.nih.gov/pubmed/11164137
關節炎用
薑黃
• 正在服用免疫抑制劑 ( 例如 tacrolimus), 若
也服用大量的薑黃 , 會造成藥物濃度過高而
傷害腎臟
貓爪藤 (Cat's claw)
• 可能引發過敏性間質性腎炎
Hilepo JN, Bellucci AG, Mossey RT: Acute renal failure
caused by ‘cat’s claw’ herbal remedy in a patient with
systemic lupus erythematosus. Nephron 77: 361, 1997
柳樹皮 (Willow bark )
• 和消炎藥一樣造成腎臟受損
Schwarz A: Beethoven’s renal disease based on his
autopsy: A case of papillary necrosis. Am J Kidney Dis 21:
643– 652, 1993
止咳用
甘草( Licorice )
• 若長期和藥物 毛地黃 (digoxin) 或 利尿劑
(thiazide,loop) 併用 , 可能引發低血鉀 , 造
成心血管疾病 , 腎臟疾病
Conn JW, Rovner DR, Cohen EL: Licorice-induced 764 Clinical
Journal of the American Society of Nephrology Clin J Am Soc Nephrol
2: 757–765, 2007 pseudoaldosteronism. Hypertension, hypokalemia,
aldosteronopenia, and suppressed plasma renin activity. JAMA 205:
492– 496, 1968 65.
Saito T, Tsuboi Y, Fujisawa G, Sakuma N, Honda K, Okada K, Saito
K, Ishikawa S, Saito T: An autopsy case of licoriceinduced
hypokalemic rhabdomyolysis associated with acute renal failure:
Special reference to profound calcium deposition in skeletal and
cardiac muscle. Nippon Jinzo Gakkai Shi 36: 1308 –1314, 1994
運動配方
肌酸( creatine )
• 腎臟疾病,特別是洗腎,應避免使用 ~ 因
為可能導致腎臟損傷
Pritchard NR, Kalra PA: Renal dysfunction accompanying
oral creatine supplements. Lancet 351: 1252–1253, 1998
減肥配方
麻黃( Ephedra )
• 會產生含麻黃素的腎結石
Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes
again: ephedrine nephrolithiasis. Am J Kidney Dis.
1998;32:153-159.
皮膚用
離胺酸 (L-lysine)
• 長期 >3 克 / 天,會引發 Fanconi 綜合群和
腎衰竭
https://www.ncbi.nlm.nih.gov/pubmed/8840955
性功能障礙用
育亨賓樹 (Yohimbe)
• 曾發生腎功能衰竭和蛋白尿  
Sandler B, Aronson P: Yohimbine-induced
cutaneous drug eruption, progressive renal failure,
and lupus-like syndrome. Urology 41: 343–345, 1993
其他
小榭樹( Chaparral )
• 可能引發腫性腎疾病 , 甚至腎細胞癌
Smith AY, Feddersen RM, Gardner KD Jr, Davis CJ Jr:
Cystic renal cell carcinoma and acquired renal cystic
disease associated with consumption of chaparral tea: A
case report. J Urol 152: 2089 –2091, 1994
胡薄荷( Pennyroyal )
• 可能引發腎臟出血而造成肝腎症狀
Anderson IB, Mullen WH, Meeker JE, Khojasteh-
BakhtSC, Oishi S, Nelson SD, Blanc PD: Pennyroyal
toxicity: Measurement of toxic metabolite levels in two
cases and review of the literature. Ann Intern Med 124:
726 –734, 1996
硫酸肼 (Hydrazine)
• 可能引發腎臟組織溶解而造成肝腎症狀
D’Agati V: Does aspirin cause acute or chronic renal failure
in experimental animals and in humans? Am J Kidney Dis
28[Suppl 1]: S24 –S29, 1996
雷公藤 (Thunder god vine)
• 曾發生腎功能衰竭,低血壓和休克案例
Chou WC, Wu CC, Yang PC, Lee YT: Hypovolemic shock and
mortality after ingestion of Tripterygium wilfordii hook F: A case
report. Int J Cardiol 49: 173–177, 1995
艾草油 (Wormwood oil)
• 艾草中含有 thujone ,高劑量服用時有神經
毒性 ~ 引發癲癇 , 嚴重會造成橫紋肌溶解影
響腎臟
Weisbord SD, Soule JB, Kimmel PL: Poison on
line: Acute renal failure caused by oil of
wormwood purchased through the Internet. N
Engl J Med 337: 825– 827, 1997
黃色夾竹桃 (Yellow oleander )
• 可能引發腎臟組織壞死而造成肝腎症狀
Samal KK, Sahu HK, Kar MK, Palit SK, Kar BC, Sahu
CS: Yellow oleander (cerbera thevetia) poisoning with
jaundice and renal failure. J Assoc Physicians India 37:
232–233, 1989

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(保健食品) 腎臟疾病需注意的保健食品

  • 3. 維他命 C • >1g/ 天 會增加腎臟結石風險 , 尤其是有結 石病史的人 Curhan GC, Willett WC, Speizer FE, et al. Intake of vitamins B 6 and C and the risk of kidney stones in women. Am Soc Nephrol.1999;10:840-845. Curhan GC. A prospective study of the intake of vitamin C and vitamin B 6 and the risk of kidney stones in men. J Urol.1996;155:1847-1851. Simon JA, Hudes ES. Relation of serum ascorbic acid to serum vitamin B12, serum ferritin, and kidney stones in US adults. Arch Intern Med. 1999;159:619-624.
  • 4. 維他命 B6 、 B12 • > 葉酸 2,500 mcg/ 天 +B6 25 mg/ 天 +B12 1,000 mcg/ 天 會增加糖尿病 + 腎功 能不好的人中風 , 心臟病機率 https://jamanetwork.com/journals/jama/full article/185758
  • 5. 葉酸 • 長期過量 ( 天然 > 1000 mcg/ 天 ; 合成 > 600 mcg/ 天 ) 會傷害腎臟
  • 8. 鉻 • 長期服用 chromium picolinate 600~2,400 mcg/ 天可能造成腎臟炎 Wasser WG, Feldman NS, D’Agati VD: Chronic renal failure after ingestion of over-the-counter chromium picolinate. Ann Intern Med 126: 410, 1997
  • 12. 薑黃 • 正在服用免疫抑制劑 ( 例如 tacrolimus), 若 也服用大量的薑黃 , 會造成藥物濃度過高而 傷害腎臟
  • 13. 貓爪藤 (Cat's claw) • 可能引發過敏性間質性腎炎 Hilepo JN, Bellucci AG, Mossey RT: Acute renal failure caused by ‘cat’s claw’ herbal remedy in a patient with systemic lupus erythematosus. Nephron 77: 361, 1997
  • 14. 柳樹皮 (Willow bark ) • 和消炎藥一樣造成腎臟受損 Schwarz A: Beethoven’s renal disease based on his autopsy: A case of papillary necrosis. Am J Kidney Dis 21: 643– 652, 1993
  • 16. 甘草( Licorice ) • 若長期和藥物 毛地黃 (digoxin) 或 利尿劑 (thiazide,loop) 併用 , 可能引發低血鉀 , 造 成心血管疾病 , 腎臟疾病 Conn JW, Rovner DR, Cohen EL: Licorice-induced 764 Clinical Journal of the American Society of Nephrology Clin J Am Soc Nephrol 2: 757–765, 2007 pseudoaldosteronism. Hypertension, hypokalemia, aldosteronopenia, and suppressed plasma renin activity. JAMA 205: 492– 496, 1968 65. Saito T, Tsuboi Y, Fujisawa G, Sakuma N, Honda K, Okada K, Saito K, Ishikawa S, Saito T: An autopsy case of licoriceinduced hypokalemic rhabdomyolysis associated with acute renal failure: Special reference to profound calcium deposition in skeletal and cardiac muscle. Nippon Jinzo Gakkai Shi 36: 1308 –1314, 1994
  • 18. 肌酸( creatine ) • 腎臟疾病,特別是洗腎,應避免使用 ~ 因 為可能導致腎臟損傷 Pritchard NR, Kalra PA: Renal dysfunction accompanying oral creatine supplements. Lancet 351: 1252–1253, 1998
  • 20. 麻黃( Ephedra ) • 會產生含麻黃素的腎結石 Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis. 1998;32:153-159.
  • 22. 離胺酸 (L-lysine) • 長期 >3 克 / 天,會引發 Fanconi 綜合群和 腎衰竭 https://www.ncbi.nlm.nih.gov/pubmed/8840955
  • 24. 育亨賓樹 (Yohimbe) • 曾發生腎功能衰竭和蛋白尿   Sandler B, Aronson P: Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urology 41: 343–345, 1993
  • 26. 小榭樹( Chaparral ) • 可能引發腫性腎疾病 , 甚至腎細胞癌 Smith AY, Feddersen RM, Gardner KD Jr, Davis CJ Jr: Cystic renal cell carcinoma and acquired renal cystic disease associated with consumption of chaparral tea: A case report. J Urol 152: 2089 –2091, 1994
  • 27. 胡薄荷( Pennyroyal ) • 可能引發腎臟出血而造成肝腎症狀 Anderson IB, Mullen WH, Meeker JE, Khojasteh- BakhtSC, Oishi S, Nelson SD, Blanc PD: Pennyroyal toxicity: Measurement of toxic metabolite levels in two cases and review of the literature. Ann Intern Med 124: 726 –734, 1996
  • 28. 硫酸肼 (Hydrazine) • 可能引發腎臟組織溶解而造成肝腎症狀 D’Agati V: Does aspirin cause acute or chronic renal failure in experimental animals and in humans? Am J Kidney Dis 28[Suppl 1]: S24 –S29, 1996
  • 29. 雷公藤 (Thunder god vine) • 曾發生腎功能衰竭,低血壓和休克案例 Chou WC, Wu CC, Yang PC, Lee YT: Hypovolemic shock and mortality after ingestion of Tripterygium wilfordii hook F: A case report. Int J Cardiol 49: 173–177, 1995
  • 30. 艾草油 (Wormwood oil) • 艾草中含有 thujone ,高劑量服用時有神經 毒性 ~ 引發癲癇 , 嚴重會造成橫紋肌溶解影 響腎臟 Weisbord SD, Soule JB, Kimmel PL: Poison on line: Acute renal failure caused by oil of wormwood purchased through the Internet. N Engl J Med 337: 825– 827, 1997
  • 31. 黃色夾竹桃 (Yellow oleander ) • 可能引發腎臟組織壞死而造成肝腎症狀 Samal KK, Sahu HK, Kar MK, Palit SK, Kar BC, Sahu CS: Yellow oleander (cerbera thevetia) poisoning with jaundice and renal failure. J Assoc Physicians India 37: 232–233, 1989