This document summarizes best practices for using social media in media relations based on a presentation given at an NCI retreat. It discusses how journalists now use social networks and search to assist their reporting. It also outlines how NCI has modernized its media relations website to incorporate more social media tools like blogs, videos, and integration with Twitter, YouTube and Flickr. Key lessons are to engage the right target audience, be useful and responsive on social platforms while avoiding spammy or defensive behaviors that could spark backlash.