Esta pequeña ponencia titulada "Simulación para el apoyo de soluciones biomédicas", pretende mostrar como se interrelacionan los ambientes in silico, in vitro e in vivo en el espectro de la medicina y las tecnologías convergentes - NBIC. Se citan tres casos específicos: uso de plásmidos para la replicación de proteínas, diseño de stent para contrarrestar las enfermedades coronarias y los aneurismas, y modelado de la remodelación ósea en los implantes de cadera.

1. Simulación para el apoyo de soluciones biomédicas
Juan Pablo Ramírez Galvis, Ulises Donaldo Patiño Hernández
jramirezg10@ucentral.edu.co, upatinoh@ucentral.edu.co
II-2019
Maestría en Bioingeniería y
Nanotecnología
Asignatura:
Conceptos de Bioingeniería

2. In Silico, In Vitro, In Vivo
Synthetic Dynamic Networks Scheme (Plasmid interference)
Taken from: https://www.biorxiv.org/content/10.1101/018317v1.full
Important Aspects:
- In silico simulations allow to obtain
intuition about the biological
architectures / scenarios
- In vitro phase determines emergent
properties / functional mixes
- In vivo represents the final test, but
after the risks have been reduced

3. A Discretization Process Review
Finite Element Model of the Knee
Meniscus
Single Voxel
1. The continuous process is transformed into states /
elements
2. The variables of each state are characterized
(measurements and parameters)
3. Models of correlation between variables are designed
4. Mathematical modeling is performed (differential
equations, stochastic models, etc.)
5. Results extrapolation is done

4. What is a Stent?
Percutaneous transluminal coronary angioplasty
(PTCA) including a Stent to counteract coronary heart
disease (also for aneurism)
Taken from: https://www.cancercarewny.com/content.aspx?chunkiid=103947
Balloon catheter Stent
The struts (individual elements) constitute
rings, cells, crowns and connectors.

5. In Silico Stent Design
Different Stent architectures and deformation patterns.
Taken from: Researchgate
- Metallic Stent (MS)
- Pharmacoactive Stent (PAS) (1 & 2 generation)
- Bioabsorbable vascular frames (BF) (magnesium
or poly-L-lactic acid)
Problems to Solve
Neointimal hiperplasia, thrombosis & Intrastent restenosis.
A Solution
Cardiatis Multilayer Flow Modulator (MFM®) as porous material
which prevents strong blood turbulences.
- Struts thickness (tensegrity)
- Architecture bioadaptability
- Material behaviors
- Added medicines effectiveness
- Each patient implications

6. Hip Prosthesis Simulation
Input data:
- Internal tension states of the bone after surgery
- Initial anatomy of the patient (including, age and genre)
- Choice of the hip stem (model and size)
Softwares used:
- Modvox to create bone materials
- Autodesk AutoCAD to create the model
- Ansys for stress studies
Maximum iterative period:
- Between six months and two years

7. References
Ansys Inc. (2015). In vivo, in vitro, in silico! Obtenido de https://www.ansys.com/-
/media/Ansys/corporate/resourcelibrary/article/In-Vivo-In-Vitro-In-Silico-AA-V9-I1.pdf
Ansys Inc. (2016). Innovative at heart. Obtenido de https://www.ansys.com/about-ansys/dimensions-
magazine/volume-i-issue-1-2016/innovative-at-heart
Revista Española de Cardiología. (Mayo de 2018). A Brief History of Coronary Artery Stents. Obtenido de
https://www.revespcardiol.org/es-breve-historia-los-stents-coronarios-articulo-S0300893217307443
Roces García, J. (2016). Simulación de la Remodelación Ósea tras la Implantación de Vástagos de Cadera. Obtenido
de http://digibuo.uniovi.es/dspace/bitstream/10651/42049/1/InformeRemodelacionOsea.pdf