This study analyzed differential gene expression in the yeast Saccharomyces cerevisiae when exposed to varying concentrations of lead. The purpose was to use yeast as a model organism to study the molecular mechanisms behind the neurological effects of lead exposure in humans. Specifically, the expression of 10 genes expected to be affected by lead exposure based on human studies was analyzed. The results showed that two genes, HSP10 and DED81, were upregulated as the lead concentration increased, as expected based on their human homologs. However, DED81 expression decreased at the highest lead concentration, possibly due to toxicity effects on cell viability. Further testing is needed to better understand gene expression changes at different lead concentrations.