This document discusses the democratization of cellular agriculture through citizen science and startup businesses. It describes the Shojinmeat Project, a nonprofit citizen science community doing open source research into clean meat production. It also profiles Integriculture Inc., a venture-funded startup aiming to commercialize clean meat. The document outlines new technologies like the "Culnet System" that can produce a variety of cells without added growth factors. It envisions how local farmers and hobbyists could develop unique meat brands. Finally, it speculates how bioreactors and DIY tissue engineering could enable personalized and domestic meat production.

1. Democratized Cellular Agriculture
NIIJIMA MEGAFLOAT “ALGAVITA COMPLEX”, Earth A.D.2203

2. Cellular agriculture as a solution?
Protein source
sustainability?

3. What makes cell-ag a viable option?
Being
safe
(regulatory)
Feeling
safe
(cultural)
Technology is
coming but...

4. Regulatory and cultural discussions?
Being
safe
(regulatory)
Feeling
safe
(cultural)
Technology is
coming but...
Positive and accessible climate

5. Regulatory and cultural discussions?
←Factors that
people weigh
Besides taste and price,
Safety &
Trustbuilding

6. Shojinmeat Project and Integriculture Inc.
Citizen science community
“Open source clean meat”
Venture-funded startup company
“Commercialization of clean meat”

7. Shojinmeat Project
“Democratization of cellular agriculture”
Nonprofit non-corporate non-university citizen science community
No formal definition for membership - people just come and join
DIY bio/fab enthusiasts, students, researcher, artists, writers etc.
Open source cellular agriculture” by DIY bio Public communication by art and education

8. Past and recent, from Shojinmeat Project
Kitchen DIY cell culture ‘Zine,
Kids growing cells at home etc...
------------------------------------------------------------------
-Household fan centrifuge
-DIY cell incubator sold with the
‘Zine at Comic Market
-Bio Art at Tokyo Met. Gallery
“Cell-ag in the neighborhood”

9. Nationwide debut - and open discussions begin
-Recognized academics are
discussing DIY bio and
people’s cellular agriculture
-Advocacy by officials at
Ministry of Agriculture
Ministry of Agriculture,
Forestry and Fisheries
“DIY clean meat” featured Professor Iwasaki speakingDIY bio featured

10. Low cost cell culture by "Networked Coculture”
Cell culture medium Inter-cellular interactions
Basal
media
Sugar,
amino acids
Growth factors
(incl. in FBS)
Inexpensive Expensive
$0/L
⇒Clean meat at $2/kg
Liver cellsMuscle cells
Growth
factors
GF’s &
FBS
GF’s &
FBS
Invented by
“Dr. IKKO”
PCT/JP2016/067599
JP-Pat.6111510 granted

11. No externally added
FBS & growth factors
*
*
Liver cells Muscle stem cell Placental cells
Conventional“CulnetSystem”
”Culnet System"
Cellcount(ratio)
□Liver cells
■Pancreas cells
■Ovary cells
*p<0.01, **p<0.05
Variety of cells, with no added FBS or GF

12. “Culnet System” at a glacne
“General-purpose large-scale
cell culture system”
The technology to inexpensively
produce wide range of cells
Currently at > 1/100,
> 1/100,000 within sight
by economy of scale

13. “Cell-ag infrastructure”
Sugar &
amino acid
“Culnet System”
Cells
ingredients
supplements
foie gras
meat etc.
2020~
2023~
2025~?
2028~?
General-purpose
large-scale cell
culture platform

14. Prototype and $2.7M fundraise
Lead investor
VC specialized on
value adds for hard
science startups
Government fund
under Ministry of
Agriculture
・MTG Co., Ltd. Cosmetics & branding
・euglena Co., Ltd. Algae food and fuel
・Dr. Kitano Systems biology
2nd Lead
VC strong at value
adds for life science
startups
(CEO of Sony Computer
Science Laboratories, Inc.

15. Food grade culture medium
2018
LAUNCH
Contact
info@integriculture.jp
for quotes & details.

16. IP between Citizen Science and Business
How to make ⇒ Open
How to scale ⇒ Proprietary
Numberindemand
Degree of personalization
Product dev.
Citizen Science domain
Business domain
and other businesses
to come

17. ・Local farmers can develop
their own clean meat recipe.
・Brand ownership opportunity
opens up for local farmers.
・Hobbyists come up with unique
meat recipe.
Local farmers design their own meat brands

18. Beef branded on individual cows
Cell source
cow still alive
Scan the QR code
printed on package
See how the
cow is doing

19. “Democratized cellular agriculture”
Academia hints
the way
Citizens act and
set the direction
Businesses scale
and deliver

20. Myoblast grown
at 200t scale
20
Industrial meat brewery
Looks like a
beer factory?

21. 21
Single use
culture bags⇒
Steak grows inside⇒
Ready to ship⇒
Steak brewery

22. “Domestic meat culture vat”?

23. Why stop at meat? DIY tissue engineering?
Tastier
than meat
DIY
kidney!
DIY differentiation
& morphogenesis
to make heart
Is this even
“meat”!?
“Green meat” algae-
meat composite food
・Bioreactors improve over time,
enabling cell, tissue & organ culture
・DIY tissue engineering is ubiquitous,
innovative prototypes everywhere

24. Personalized domestic designer meat

25. And everyone get the share of cultured meat.

26. Acknowledgements
And all Shojinmeat
Project participants!