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CC: 53 y/o female with psychosis

HPI: 53 y/o Native American female brought to the ED from a NH this morning with
altered mental status and psychosis. She had been discharged from the hospital 4 days
prior after a right total hip arthroplasty. She was discharged to a rehab facility and was
doing well until the evening prior to admission. At 6am on day of admission, pt refused a
lab draw and stated “they can take it at the hospital, I’m waiting on the ambulance”.
Throughout the day, she continued to make non-sensical comments but remained
cooperative and responsive. She was noted to be talking to herself and to people that were
not present. Because of these symptoms, staff at rehab transferred to Regions for
evaluation. Continued to hallucinate in ED demonstrated as talking to imaginary people.
Became increasingly agitated. Given IV ativan with decreased both agitation and lucidity.

PMH:
Osteoarthritis
DJD
Multiple fractures 2/2 pedestrian vs vehicle MVA in 1980
HCV
Depression
ADHD

PSH:
s/p anterior cervical discectomy and fusion at C5-6, C6-7 May 2006
s/p right THA and hardware removal on 12/6/06 after failure of THA from 1980
s/p c-section 2/2 sepsis 1987
s/p ex lap 2/2 perforated colon 1975

ROS: unable to obtain secondary to mental status

Meds:
Cymbalta 30mg qday
Wellbutrin 300mg qday
Tramadol 40mg qid
Ambienc 10mg qhs
Adderall 20mg qday
Percocet 102 tabs q4h
Lorazepam 1mg qday
Hydroxyzine 25mg, 1-2 tabs q4h prn
Docusate
Hexavitamin
Calcium/vit D
Warfarin 1mg

Shx:
Living at rehab after recent hip surgery. Smokes 1 cigar/day. Divorced. No employment
secondary to MVA injuries from past.
Fhx: Mother had CAD and died of ruptured brain aneurysm/stroke. Father died of MI.

Exam:
VS: T 97.2F, BP 116/84, HR 120, RR 19, O2S 95% RA

Gen: Agitated and lying in bed. Opens eyes to voice intermittently. Tremulous and
diaphoretic.
HEENT: Normocephalic and atraumatic. PERRL. Pt will not cooperate with opening
mouth for OP exam.
Neck: No masses. Trachea midline. Carotids 2+
Lungs: CTA bil, no wheezing or rales
CV: Tachycardic, regular. S1 and S2 normal, no m/r/g
Abd: soft/nt/nd. Bowel sounds normal to hyperactive.
Ext: 1-2+ pitting edema in RLE. LLE without edema. Right hip surgical site is c/d/I with
mild serosanginous drainage. DP and PT pulses 2/2.
Neuro: Not able to follow commands. Opens eyes to pain, voice and touch. Visible
tremors in bil lower extremities. Spontaneous clonus in RLE, inducible clonus with
multiple beats in bil LE, but R>L. Patellar reflexes 3+ bilateral. Biceps reflexes 2-3+ bil.
Bil LE exhibit rigidity bilaterally. Unable to illicit babinski sign due to rigiditiy.

Labs:
   • CBC: WBC 10.9 (normal diff), HGb 9.2, Plt 256

   •   BMP: Na+ 138, K+ 4.0, Chl 107, CO2 25, BUN 12, Crt 0.8, Ca2+ 8.0

   •   Utox: preliminary presumed pos for amphetamines and THC

   •   CK 662

EKG: sinus tachycardia

Head Ct: exam was limited by motion. Ventricles and sulci normal. No obvious
intracranial abnormality.

Course:
Agitation/psychosis picture consistent with serotonin syndrome (agitation, rigitidy,
neuro findings).
           - started CIWA ativan parameters.
           - Attemped cyprohepatdine 12mg PO x1 dose.
           - Admitted to MICU
           - Started NS at 150ml/hr
           - Supportive cares

Libby Zion/Work Hours:
18 y/o female who presented to New York Hospital Cornell Medical Center with fever,
agitation, and “strange jerking motions” of her extremities. Ongoing treatment for
depression. Was admitted and evaluated by an intern and a resident. After discussing the
case with the pts PCP, decided she had a viral illness with “hysterical features” and she
was given mepiridine for pain and sedation. Pts status worsened overnight and crosscover
was notified. However, intern was covering 40-50 other patients some of whom were
very ill. Restraints and haldol were administered. Pt developed fever to 107F, had cardiac
arrest and died.
Family sued for inadequate staffing at teaching hospital. Claimed that long hours and too
many patients were to blame for poor care their daughter received. Father was journalist
at NY Times. Blaimed administration of mepiridine interaction with anti-depressant
caused serotonin syndrome and pt died.
After many trials and cases led to the Bell commission with recommendations for no
more than 24hours of patient care, limit of 80 hours in a work week, and presence of
attending physician in house at all time. New York state first to accept these restrictions
ACGME accepted 80 hour work hour restrictions with no more than 24 hours of active
patient care in 2003. Has caused great amount of discussion and changed through medical
training.


DDx:

Neuroleptic malignant syndrome- longer course, bradyreflexis, muscular rigidity, caused
by dopamine antagonist
Anticholinergic toxicity- muscular tone and reflexes are normal in AC toxicity
Malignant hyperthermia
Intoxication with sympathomimetic agents

Neuro:
         Meningitis
         Encephalitis

ID:
         bacteremia from hip
         endocarditis

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Serotoninsyndrome Ser

  • 1. CC: 53 y/o female with psychosis HPI: 53 y/o Native American female brought to the ED from a NH this morning with altered mental status and psychosis. She had been discharged from the hospital 4 days prior after a right total hip arthroplasty. She was discharged to a rehab facility and was doing well until the evening prior to admission. At 6am on day of admission, pt refused a lab draw and stated “they can take it at the hospital, I’m waiting on the ambulance”. Throughout the day, she continued to make non-sensical comments but remained cooperative and responsive. She was noted to be talking to herself and to people that were not present. Because of these symptoms, staff at rehab transferred to Regions for evaluation. Continued to hallucinate in ED demonstrated as talking to imaginary people. Became increasingly agitated. Given IV ativan with decreased both agitation and lucidity. PMH: Osteoarthritis DJD Multiple fractures 2/2 pedestrian vs vehicle MVA in 1980 HCV Depression ADHD PSH: s/p anterior cervical discectomy and fusion at C5-6, C6-7 May 2006 s/p right THA and hardware removal on 12/6/06 after failure of THA from 1980 s/p c-section 2/2 sepsis 1987 s/p ex lap 2/2 perforated colon 1975 ROS: unable to obtain secondary to mental status Meds: Cymbalta 30mg qday Wellbutrin 300mg qday Tramadol 40mg qid Ambienc 10mg qhs Adderall 20mg qday Percocet 102 tabs q4h Lorazepam 1mg qday Hydroxyzine 25mg, 1-2 tabs q4h prn Docusate Hexavitamin Calcium/vit D Warfarin 1mg Shx: Living at rehab after recent hip surgery. Smokes 1 cigar/day. Divorced. No employment secondary to MVA injuries from past.
  • 2. Fhx: Mother had CAD and died of ruptured brain aneurysm/stroke. Father died of MI. Exam: VS: T 97.2F, BP 116/84, HR 120, RR 19, O2S 95% RA Gen: Agitated and lying in bed. Opens eyes to voice intermittently. Tremulous and diaphoretic. HEENT: Normocephalic and atraumatic. PERRL. Pt will not cooperate with opening mouth for OP exam. Neck: No masses. Trachea midline. Carotids 2+ Lungs: CTA bil, no wheezing or rales CV: Tachycardic, regular. S1 and S2 normal, no m/r/g Abd: soft/nt/nd. Bowel sounds normal to hyperactive. Ext: 1-2+ pitting edema in RLE. LLE without edema. Right hip surgical site is c/d/I with mild serosanginous drainage. DP and PT pulses 2/2. Neuro: Not able to follow commands. Opens eyes to pain, voice and touch. Visible tremors in bil lower extremities. Spontaneous clonus in RLE, inducible clonus with multiple beats in bil LE, but R>L. Patellar reflexes 3+ bilateral. Biceps reflexes 2-3+ bil. Bil LE exhibit rigidity bilaterally. Unable to illicit babinski sign due to rigiditiy. Labs: • CBC: WBC 10.9 (normal diff), HGb 9.2, Plt 256 • BMP: Na+ 138, K+ 4.0, Chl 107, CO2 25, BUN 12, Crt 0.8, Ca2+ 8.0 • Utox: preliminary presumed pos for amphetamines and THC • CK 662 EKG: sinus tachycardia Head Ct: exam was limited by motion. Ventricles and sulci normal. No obvious intracranial abnormality. Course: Agitation/psychosis picture consistent with serotonin syndrome (agitation, rigitidy, neuro findings). - started CIWA ativan parameters. - Attemped cyprohepatdine 12mg PO x1 dose. - Admitted to MICU - Started NS at 150ml/hr - Supportive cares Libby Zion/Work Hours:
  • 3. 18 y/o female who presented to New York Hospital Cornell Medical Center with fever, agitation, and “strange jerking motions” of her extremities. Ongoing treatment for depression. Was admitted and evaluated by an intern and a resident. After discussing the case with the pts PCP, decided she had a viral illness with “hysterical features” and she was given mepiridine for pain and sedation. Pts status worsened overnight and crosscover was notified. However, intern was covering 40-50 other patients some of whom were very ill. Restraints and haldol were administered. Pt developed fever to 107F, had cardiac arrest and died. Family sued for inadequate staffing at teaching hospital. Claimed that long hours and too many patients were to blame for poor care their daughter received. Father was journalist at NY Times. Blaimed administration of mepiridine interaction with anti-depressant caused serotonin syndrome and pt died. After many trials and cases led to the Bell commission with recommendations for no more than 24hours of patient care, limit of 80 hours in a work week, and presence of attending physician in house at all time. New York state first to accept these restrictions ACGME accepted 80 hour work hour restrictions with no more than 24 hours of active patient care in 2003. Has caused great amount of discussion and changed through medical training. DDx: Neuroleptic malignant syndrome- longer course, bradyreflexis, muscular rigidity, caused by dopamine antagonist Anticholinergic toxicity- muscular tone and reflexes are normal in AC toxicity Malignant hyperthermia Intoxication with sympathomimetic agents Neuro: Meningitis Encephalitis ID: bacteremia from hip endocarditis