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December 9, 2021
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December 9, 2021
Powering Telemedicine Connectivity™
A company majority owned, founded, and led by women
December 9, 2021
Welcome to INVIZA®HEALTH
Kathy Ireland®, Chair, CEO and Chief
Designer, kathy ireland®
Worldwide and Chief Global Brand
Strategist, INVIZA®HEALTH
i of ii
https://vimeo.com/438733942
December 9, 2021
My energy harvesting background since 2007
 Ph.D. research at Cornell Nanoscale Science and Technology Facility on mechanical
piezoelectric energy harvester (piezo-EH) from 2007 to 2012
 Started MicroGen Systems, Inc. in 2010 – closed $8M Series A round and $4M grants
 Transferred piezo-EH process on 100-mm substrates from Cornell to high volume, 200-
mm Si substrate process at X-FAB MEMS Foundry in Germany
 Powered TPMS in Class 8 truck tires with Bridgestone – MicroGen acquired July 2017
3
December 9, 2021
What is energy harvesting?
 Energy harvesting is energy generation from ambient sources in
the environment:
4
Solar Thermal Mechanical
December 9, 2021
EH bender designs for thin profile insoles
“Flat Piezo-Elements for Wearables”
– patent pending, July 10, 2020
 Using PZT  operational thickness = 8.3-mm
 Using AlN  operation thickness = 3.5-mm
“Pre-shaped Piezo-Elements for Wearables”
– patent pending, August 3, 2020
 Using PZT  operational thickness = 6.3-mm
 Using AlN  operation thickness = 2.5-mm
5
No plunger needed
December 9, 2021
Aluminum nitride “AlN” -vs- Lead-based “PZT”
Mechanical energy generation
• Lead-based PZT produces energy U = 2-miliJoules (mJ) per step  U = 2-Joules per 1,000 steps
• AlN produces U = 4X to 20X as compared to PZT depending upon scandium (Sc) doping level*
– Two (2) AlN-based EH w/ Sc @ 0% doping  U = 4X  4 x (2-Joules) = 8-Joules in 1,000 steps
– Two (2) AlN-based EH w/ Sc @ 26% doping  U = 20X  20 x (2-Joules) = 40-Joules in 1,000 steps
6
SEM cross-section of AlN film showing required
highly orientated c-axis columnar grain structure
X-ray diffraction (XRD) of highly orientated AlN film with
(002) peak at 2Q = 36.2 degrees and FWHM < 3-degrees.
December 9, 2021
Large area (LA) fabrication lowers production cost per energy harvester component
using patent-pending EH/sensor/haptic designs and fabrication processes.
IBC Coatings, Indianapolis, IN, USA
• AB Advisor, Frank Papa
Fraunhofer IST, Braunschweig, Germany, EU
• AB Advisor, Dr. Ralf Bandorph, Head of Group
7
 EH-bender prototypes in fall 2021  EH-bender prototypes in winter 2021
R&D and manufacturing partners
December 9, 2021
What is sensor fusion and why is it important?
 Sensor fusion is combining 2 or more sensor’s data to obtain a
better result through software algorithms
8
 foot swing + foot pressure  step count  accurate result
low power + passive power  low energy usage!!
• watch/ arm swing measured via 3-axis accelerometer  step count  inaccurate result
• insole/ foot swing measured via 3-axis accelerometer  step count  inaccurate result
Example  step count:
December 9, 2021
Second example – SmartCalories™
• Top 7 smart watches on market are 27-93% inaccurate (Stanford University)
 Uses only pulse-ox / heart rate to calculate burned calories
9
• INVIZA HEALTH is < 5% inaccurate (lower body burned calories only):
 Pulse-ox / heart rate to calculate background burned calories (living calories)
plus
 Accelerometer A / motion in X, Y and Z to calculate mechanical power
Pmechanical = force Fmechanical x speed s = (mass M x AX,Y, or Z) x (AX,Y, or Z x time t)
Then, convert from Pmechanical to Phuman using known conversion factor to calories
December 9, 2021
InvizaSole 1.0 insole alpha and pre-beta development
Alpha-level InvizaSole 1.0 smart
insole and Inviza®Life 1.0 app
Pre-beta-level polyurethane (PU) Inviza®Sole 1.0
10
1st smart connected insole with all
components shown in alpha-level
insole in the picture to the left
inserted inside during thermal PU
process up to 163F (73C)
CEO/CTO wore the SmartHealth PU-insoles
for 1-week. I could not feel anything with
insole, including the 5-mm thick battery in
the arch area. Both insoles felt the same.
Co-founder,
CWO & EVP Fitness,
Monica Restrepo
Co-founder,
President & CEO/CTO,
Dr. Robert Andosca
December 9, 2021
InvizaSole 1.0 beta-level insole development 11
Double click for video
Semi rigid orthotic arch support foot cushion alignment shock absorber insole
3D CAD insole
Insole designed for
walking and comfort
Materials
1. Fabric w/ anti-bacterial agent
2. Ethylene vinyl acetate (EVA)
3. Polypropylene (PP)
4. Polyurethane (PU)
Using EVA as the footbed in an insole has now become common practice due to the
supportive and comforting nature of the material. It is a foam-based material, lending
itself naturally to supportive properties of an insole. EVA insoles are ideal as a shock-
absorber, protecting the foot from impact with the ground and helping to protect the
joints and ligaments in the foot. This rubber-like plastic has a high heat and cold
resistance on top of being particularly durable.
December 9, 2021
Inviza®Life 1.0 mobile app 12
Vital sign and
fitness parameter
globe carousel
(patent pending)
Your health
at-a-glance!
Double click for video
https://vimeo.com/manage/videos/645072125
December 9, 2021
Recommended sensor priority and sampling rates
1. 6-axis accelerometer/gyroscope  step count and
motion-mass-based burned calorie calculations
– every 3-seconds
2. IR temperature sensor  body temperature
– 2X per day morning and evening, and on demand
3. pulse-ox (red/IR LED)  blood oxygen saturation
– 1X per day, and on demand
4. pulse-ox (green LED)  heart rate  background “living” burned calorie calculations
– every 6-minutes
5. piezo-force sensors  weight trends  overall health, e.g., rapidly increasing weight
could indicate edema or pulmonary edema, which the latter is an early indicator of
congestive heart failure (CHF)
– every 1-hour (patent-pending design)
13
Vice Chair,
Telehealth Group
American Academy
Family Physicians
Dr. Laurie Montague, M.D.
Chief Medical Officer and EVP
Telehealth, INVIZA® HEALTH
December 9, 2021
Inviza®Sole 1.0 smart insoles – Energy consumption and generation 14
 3.0 x 6.0 cm2 Sc-AlN-based energy harvesters – energy generation in 1,000 steps = 40 Joules
 Inviza®Sole 1.0 smart insole sensors – energy consumption per 10-hour day = 40.8 Joules*
Inviza®Sole 1.0 components
No. quantity Component/ description manufacturer part number voltage (V) Typical Idd (mA) Typical Power (mW) Transmission Sampling On time (sec) Energy/hr(mJ) Energy/10-hr(mJ)
1 6 capacitors any Samsung; CL21B105KBFVPNE n/a n/a n/a n/a n/a n/a n/a n/a
2 2 capacitors any Samsung; CL21B104KBFWPNE n/a n/a n/a n/a n/a n/a n/a n/a
3 2 capacitors any Samsung; CL21B475KBFVPNE n/a n/a n/a n/a n/a n/a n/a n/a
4 1 capacitors any Cal-Chip; GMC31X5R106K25NTLF n/a n/a n/a n/a n/a n/a n/a n/a
5 1 capacitors any Cal-Chip; GMC21CG682J50NTLF n/a n/a n/a n/a n/a n/a n/a n/a
6 3 Schottkey ON Semi or Equiv ON Semi; MBRM140T1G n/a n/a n/a n/a n/a n/a n/a n/a
7 1 inductor Coil Craft or similar Coilcraft;LPS6235-682ML n/a n/a n/a n/a n/a n/a n/a n/a
8 1 inductor TDK or similar TDK; NLCV32T-1R0M-PF n/a n/a n/a n/a n/a n/a n/a n/a
9 1 n-channel transistor Diodes Inc or similar Diodes Inc; DMN2041L-7 n/a n/a n/a n/a n/a n/a n/a n/a
10 15 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a
11 1 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a
12 1 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a
13 1 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a
14 1 rechargeablecoin cell battery any 30-mA-Hr, 20-mm dia. n/a n/a n/a n/a n/a n/a n/a n/a
15 1 integratedcircuit Microchip MCP73871 n/a n/a n/a n/a n/a n/a n/a n/a
16 1 voltage regulator Linear Tech (ADI) LTC3528-2 n/a n/a n/a n/a n/a n/a n/a n/a
17 1 wireless charging coil any TBD n/a n/a n/a n/a n/a n/a n/a n/a
18 1 EH-converter Linear Tech (ADI) LTC3588EMSE-1#PBF 1.8-18.0 n/a n/a n/a n/a n/a n/a n/a
19 1 BLE radio / wireless communication Nordic NRF528040 3.0 5.7 17 every 10-mins --- 10 1020 10200
microcontroller 3.0 2.6 7.8 --- every 3-secs 0.3 2808 28080
20 1 6-axis IMU / burned calories ST Micro LIS2DTW12 3.6 5.6E-04 0.002 --- every 3-sec 0.3 0.72 7
21 1 pulse-ox (green) / heart rate Maxim (ADI) MAX30101 3.3 0.7 2.2 --- every 6-mins 10 220 2200
22 1 pulse-ox (red/IR) / blood oxygen saturation Maxim (ADI) MAX30100 3.3 0.7 2.2 --- 1X per day 10 0.9 9
23 1 IR temperature sensor / body temperature Melexis N.V. MLX90632 3.6 0.9 3.3 --- 2X per day 10 33 330
24 1 haptic motor / vibration feedback 产 品 规 格 书 1027 3.0 13.3 40 --- 6X per hour 1 240 2400
4323 43226 mJ
w/ separate haptic motor 43.2 J
w/o haptic motor, using INVIZA haptic devices 40.8 J
December 9, 2021
Summary
 Energy generated from harvesting must be greater than what is
consumed
– Choose low power sensors wisely
– Choose low BLE transmission and
sensor sampling rates and with
reasonable duty-cycles
– Choose AlN over PZT for piezoelectric mechanical energy harvesting
to produce significantly greater energy per step
 Use sensor fusion to reduce power consumption and obtain highly
accurate results
15
December 9, 2021
Thank you! Contact information
Dr. Robert Andosca
Co-founder, President and CEO/CTO
INVIZA HEALTH – Powering Telemedicine Connectivity™
Headquarters – Virtual w/ distributed remote workforce
Software Development – Primarily in New York w/ remote workers
Mobile and WhatsApp | +1 (617) 447-1876
Email | randosca@inviza.com
December 9, 2021
17
December 9, 2021
18
https://vimeo.com/manage/videos/645072125 mobile app demo password: 1nv1zahealth
December 9, 2021
Connected
Crew
Keep
Airline
Workers
and
Passengers
Healthy
and
Safe
invizahealth.com
December 9, 2021
20
December 9, 2021
21
December 9, 2021
22
December 9, 2021
23
December 9, 2021
24
December 9, 2021
25
December 9, 2021
26
December 9, 2021
Thank you! Contact information
Dr. Robert Andosca
Co-founder, President and CEO/CTO
INVIZA HEALTH – Powering Telemedicine Connectivity™
Headquarters – Virtual w/ distributed remote workforce
Software Development – Primarily in New York w/ remote workers
Mobile and WhatsApp | +1 (617) 447-1876
Email | randosca@inviza.com

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Self-charging, Highly Accurate Insole-Based Health Trackers for Medical Grade Applications

  • 2. December 9, 2021 Powering Telemedicine Connectivity™ A company majority owned, founded, and led by women
  • 3. December 9, 2021 Welcome to INVIZA®HEALTH Kathy Ireland®, Chair, CEO and Chief Designer, kathy ireland® Worldwide and Chief Global Brand Strategist, INVIZA®HEALTH i of ii https://vimeo.com/438733942
  • 4. December 9, 2021 My energy harvesting background since 2007  Ph.D. research at Cornell Nanoscale Science and Technology Facility on mechanical piezoelectric energy harvester (piezo-EH) from 2007 to 2012  Started MicroGen Systems, Inc. in 2010 – closed $8M Series A round and $4M grants  Transferred piezo-EH process on 100-mm substrates from Cornell to high volume, 200- mm Si substrate process at X-FAB MEMS Foundry in Germany  Powered TPMS in Class 8 truck tires with Bridgestone – MicroGen acquired July 2017 3
  • 5. December 9, 2021 What is energy harvesting?  Energy harvesting is energy generation from ambient sources in the environment: 4 Solar Thermal Mechanical
  • 6. December 9, 2021 EH bender designs for thin profile insoles “Flat Piezo-Elements for Wearables” – patent pending, July 10, 2020  Using PZT  operational thickness = 8.3-mm  Using AlN  operation thickness = 3.5-mm “Pre-shaped Piezo-Elements for Wearables” – patent pending, August 3, 2020  Using PZT  operational thickness = 6.3-mm  Using AlN  operation thickness = 2.5-mm 5 No plunger needed
  • 7. December 9, 2021 Aluminum nitride “AlN” -vs- Lead-based “PZT” Mechanical energy generation • Lead-based PZT produces energy U = 2-miliJoules (mJ) per step  U = 2-Joules per 1,000 steps • AlN produces U = 4X to 20X as compared to PZT depending upon scandium (Sc) doping level* – Two (2) AlN-based EH w/ Sc @ 0% doping  U = 4X  4 x (2-Joules) = 8-Joules in 1,000 steps – Two (2) AlN-based EH w/ Sc @ 26% doping  U = 20X  20 x (2-Joules) = 40-Joules in 1,000 steps 6 SEM cross-section of AlN film showing required highly orientated c-axis columnar grain structure X-ray diffraction (XRD) of highly orientated AlN film with (002) peak at 2Q = 36.2 degrees and FWHM < 3-degrees.
  • 8. December 9, 2021 Large area (LA) fabrication lowers production cost per energy harvester component using patent-pending EH/sensor/haptic designs and fabrication processes. IBC Coatings, Indianapolis, IN, USA • AB Advisor, Frank Papa Fraunhofer IST, Braunschweig, Germany, EU • AB Advisor, Dr. Ralf Bandorph, Head of Group 7  EH-bender prototypes in fall 2021  EH-bender prototypes in winter 2021 R&D and manufacturing partners
  • 9. December 9, 2021 What is sensor fusion and why is it important?  Sensor fusion is combining 2 or more sensor’s data to obtain a better result through software algorithms 8  foot swing + foot pressure  step count  accurate result low power + passive power  low energy usage!! • watch/ arm swing measured via 3-axis accelerometer  step count  inaccurate result • insole/ foot swing measured via 3-axis accelerometer  step count  inaccurate result Example  step count:
  • 10. December 9, 2021 Second example – SmartCalories™ • Top 7 smart watches on market are 27-93% inaccurate (Stanford University)  Uses only pulse-ox / heart rate to calculate burned calories 9 • INVIZA HEALTH is < 5% inaccurate (lower body burned calories only):  Pulse-ox / heart rate to calculate background burned calories (living calories) plus  Accelerometer A / motion in X, Y and Z to calculate mechanical power Pmechanical = force Fmechanical x speed s = (mass M x AX,Y, or Z) x (AX,Y, or Z x time t) Then, convert from Pmechanical to Phuman using known conversion factor to calories
  • 11. December 9, 2021 InvizaSole 1.0 insole alpha and pre-beta development Alpha-level InvizaSole 1.0 smart insole and Inviza®Life 1.0 app Pre-beta-level polyurethane (PU) Inviza®Sole 1.0 10 1st smart connected insole with all components shown in alpha-level insole in the picture to the left inserted inside during thermal PU process up to 163F (73C) CEO/CTO wore the SmartHealth PU-insoles for 1-week. I could not feel anything with insole, including the 5-mm thick battery in the arch area. Both insoles felt the same. Co-founder, CWO & EVP Fitness, Monica Restrepo Co-founder, President & CEO/CTO, Dr. Robert Andosca
  • 12. December 9, 2021 InvizaSole 1.0 beta-level insole development 11 Double click for video Semi rigid orthotic arch support foot cushion alignment shock absorber insole 3D CAD insole Insole designed for walking and comfort Materials 1. Fabric w/ anti-bacterial agent 2. Ethylene vinyl acetate (EVA) 3. Polypropylene (PP) 4. Polyurethane (PU) Using EVA as the footbed in an insole has now become common practice due to the supportive and comforting nature of the material. It is a foam-based material, lending itself naturally to supportive properties of an insole. EVA insoles are ideal as a shock- absorber, protecting the foot from impact with the ground and helping to protect the joints and ligaments in the foot. This rubber-like plastic has a high heat and cold resistance on top of being particularly durable.
  • 13. December 9, 2021 Inviza®Life 1.0 mobile app 12 Vital sign and fitness parameter globe carousel (patent pending) Your health at-a-glance! Double click for video https://vimeo.com/manage/videos/645072125
  • 14. December 9, 2021 Recommended sensor priority and sampling rates 1. 6-axis accelerometer/gyroscope  step count and motion-mass-based burned calorie calculations – every 3-seconds 2. IR temperature sensor  body temperature – 2X per day morning and evening, and on demand 3. pulse-ox (red/IR LED)  blood oxygen saturation – 1X per day, and on demand 4. pulse-ox (green LED)  heart rate  background “living” burned calorie calculations – every 6-minutes 5. piezo-force sensors  weight trends  overall health, e.g., rapidly increasing weight could indicate edema or pulmonary edema, which the latter is an early indicator of congestive heart failure (CHF) – every 1-hour (patent-pending design) 13 Vice Chair, Telehealth Group American Academy Family Physicians Dr. Laurie Montague, M.D. Chief Medical Officer and EVP Telehealth, INVIZA® HEALTH
  • 15. December 9, 2021 Inviza®Sole 1.0 smart insoles – Energy consumption and generation 14  3.0 x 6.0 cm2 Sc-AlN-based energy harvesters – energy generation in 1,000 steps = 40 Joules  Inviza®Sole 1.0 smart insole sensors – energy consumption per 10-hour day = 40.8 Joules* Inviza®Sole 1.0 components No. quantity Component/ description manufacturer part number voltage (V) Typical Idd (mA) Typical Power (mW) Transmission Sampling On time (sec) Energy/hr(mJ) Energy/10-hr(mJ) 1 6 capacitors any Samsung; CL21B105KBFVPNE n/a n/a n/a n/a n/a n/a n/a n/a 2 2 capacitors any Samsung; CL21B104KBFWPNE n/a n/a n/a n/a n/a n/a n/a n/a 3 2 capacitors any Samsung; CL21B475KBFVPNE n/a n/a n/a n/a n/a n/a n/a n/a 4 1 capacitors any Cal-Chip; GMC31X5R106K25NTLF n/a n/a n/a n/a n/a n/a n/a n/a 5 1 capacitors any Cal-Chip; GMC21CG682J50NTLF n/a n/a n/a n/a n/a n/a n/a n/a 6 3 Schottkey ON Semi or Equiv ON Semi; MBRM140T1G n/a n/a n/a n/a n/a n/a n/a n/a 7 1 inductor Coil Craft or similar Coilcraft;LPS6235-682ML n/a n/a n/a n/a n/a n/a n/a n/a 8 1 inductor TDK or similar TDK; NLCV32T-1R0M-PF n/a n/a n/a n/a n/a n/a n/a n/a 9 1 n-channel transistor Diodes Inc or similar Diodes Inc; DMN2041L-7 n/a n/a n/a n/a n/a n/a n/a n/a 10 15 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a 11 1 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a 12 1 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a 13 1 resistors any TBD n/a n/a n/a n/a n/a n/a n/a n/a 14 1 rechargeablecoin cell battery any 30-mA-Hr, 20-mm dia. n/a n/a n/a n/a n/a n/a n/a n/a 15 1 integratedcircuit Microchip MCP73871 n/a n/a n/a n/a n/a n/a n/a n/a 16 1 voltage regulator Linear Tech (ADI) LTC3528-2 n/a n/a n/a n/a n/a n/a n/a n/a 17 1 wireless charging coil any TBD n/a n/a n/a n/a n/a n/a n/a n/a 18 1 EH-converter Linear Tech (ADI) LTC3588EMSE-1#PBF 1.8-18.0 n/a n/a n/a n/a n/a n/a n/a 19 1 BLE radio / wireless communication Nordic NRF528040 3.0 5.7 17 every 10-mins --- 10 1020 10200 microcontroller 3.0 2.6 7.8 --- every 3-secs 0.3 2808 28080 20 1 6-axis IMU / burned calories ST Micro LIS2DTW12 3.6 5.6E-04 0.002 --- every 3-sec 0.3 0.72 7 21 1 pulse-ox (green) / heart rate Maxim (ADI) MAX30101 3.3 0.7 2.2 --- every 6-mins 10 220 2200 22 1 pulse-ox (red/IR) / blood oxygen saturation Maxim (ADI) MAX30100 3.3 0.7 2.2 --- 1X per day 10 0.9 9 23 1 IR temperature sensor / body temperature Melexis N.V. MLX90632 3.6 0.9 3.3 --- 2X per day 10 33 330 24 1 haptic motor / vibration feedback 产 品 规 格 书 1027 3.0 13.3 40 --- 6X per hour 1 240 2400 4323 43226 mJ w/ separate haptic motor 43.2 J w/o haptic motor, using INVIZA haptic devices 40.8 J
  • 16. December 9, 2021 Summary  Energy generated from harvesting must be greater than what is consumed – Choose low power sensors wisely – Choose low BLE transmission and sensor sampling rates and with reasonable duty-cycles – Choose AlN over PZT for piezoelectric mechanical energy harvesting to produce significantly greater energy per step  Use sensor fusion to reduce power consumption and obtain highly accurate results 15
  • 17. December 9, 2021 Thank you! Contact information Dr. Robert Andosca Co-founder, President and CEO/CTO INVIZA HEALTH – Powering Telemedicine Connectivity™ Headquarters – Virtual w/ distributed remote workforce Software Development – Primarily in New York w/ remote workers Mobile and WhatsApp | +1 (617) 447-1876 Email | randosca@inviza.com
  • 19. December 9, 2021 18 https://vimeo.com/manage/videos/645072125 mobile app demo password: 1nv1zahealth
  • 28. December 9, 2021 Thank you! Contact information Dr. Robert Andosca Co-founder, President and CEO/CTO INVIZA HEALTH – Powering Telemedicine Connectivity™ Headquarters – Virtual w/ distributed remote workforce Software Development – Primarily in New York w/ remote workers Mobile and WhatsApp | +1 (617) 447-1876 Email | randosca@inviza.com