Presentation by Roumen Sedefov (European Monitoring Center for Drug and Drug Addictions (EMCDDA)) on the occasion of the EESC hearing on New Psychoactive Substances (Brussels, 27 November 2013)
Presentation by Péter Sárosi (Civil Society Forum on Drugs) on the occasion of the EESC hearing on New Psychoactive Substances (Brussels, 27 November 2013)
Presentation by John Corkery (University of Hertfordshire, UK) on the occasion of the EESC hearing on New Psychoactive Substances (Brussels, 27 November 2013)
'Legal Highs or Legal Killers' Conference PresentationsMentor
Mentor lead the conference 'Legal Highs or Legal Killers? Tackling the spread of New Psychoactive Substances' on 18th September 2014.
Its aim was to bring together a wide range of professionals to:
raise awareness of the nature and potential harms of NPS
understand where to find useful resources
get up-to-date on government approach to NPS, and to the current status of substance misuse law, and laws and guidance affecting trading standards
look at options for prevention and for building resilience in young people
assess options for tackling the marketing and sale of NPS, and the most effective role for the criminal justice system
This slideshare gives presentations from nearly all the speakers who were present.
For more details, head to http://www.mentoruk.org/2014/10/legal-highs-conference/.
TRAINING 2 Unpacking Tennessee Adolescent Substance Misuse DataKarenChenoaSergent
An overview of state (Tennessee) and county-level adolescent substance use data to include a summary of TN Together adolescent survey results from 2018/2019.
Presentation by Péter Sárosi (Civil Society Forum on Drugs) on the occasion of the EESC hearing on New Psychoactive Substances (Brussels, 27 November 2013)
Presentation by John Corkery (University of Hertfordshire, UK) on the occasion of the EESC hearing on New Psychoactive Substances (Brussels, 27 November 2013)
'Legal Highs or Legal Killers' Conference PresentationsMentor
Mentor lead the conference 'Legal Highs or Legal Killers? Tackling the spread of New Psychoactive Substances' on 18th September 2014.
Its aim was to bring together a wide range of professionals to:
raise awareness of the nature and potential harms of NPS
understand where to find useful resources
get up-to-date on government approach to NPS, and to the current status of substance misuse law, and laws and guidance affecting trading standards
look at options for prevention and for building resilience in young people
assess options for tackling the marketing and sale of NPS, and the most effective role for the criminal justice system
This slideshare gives presentations from nearly all the speakers who were present.
For more details, head to http://www.mentoruk.org/2014/10/legal-highs-conference/.
TRAINING 2 Unpacking Tennessee Adolescent Substance Misuse DataKarenChenoaSergent
An overview of state (Tennessee) and county-level adolescent substance use data to include a summary of TN Together adolescent survey results from 2018/2019.
AIM Target Programs is the leader in out-patient counseling and assessment, providing services for substance abuse, drug testing, BIP/domestic violence, anger management, and anti-theft. Incorporated in 1994, AIM Target has been helping adult residents of Southwest Florida for over 22 years with over 67,000 people served.
Now that medical cannabis is available in Maryland as well as DC, patients are looking for guidance from clinicians – who have received little or no information about this substance in their formal training. Furthermore, much of the information being offered about the dangers and benefits of cannabis tends to be distorted positively or negatively according to the philosophical orientation of the source.
Enfermedad minoritaria, terapias nuevas. Una patología que afecta a menos de cinco personas por cada 10.000 habitantes es considerada una enfermedad rara o minoritaria. 35 millones de europeos se ven afectados por alguna de ellas. El 80% son de origen genético y conseguir un diagnóstico rápido es vital para asegurar la calidad de vida futura. La clave, una vez más, es apostar y potenciar la investigación biomédica. Se revisarán los resultados obtenidos los últimos 14 años, en el marco científico y regulador impulsado por la UE desde el año 2000. Sin embargo, se analizarán las dificultades y oportunidades para impulsar la investigación traslacional en estas enfermedades.
Sigue la presentación en Youtube: https://www.youtube.com/watch?v=d4U4a8xFCzA&
AIM Target Programs is the leader in out-patient counseling and assessment, providing services for substance abuse, drug testing, BIP/domestic violence, anger management, and anti-theft. Incorporated in 1994, AIM Target has been helping adult residents of Southwest Florida for over 22 years with over 67,000 people served.
Now that medical cannabis is available in Maryland as well as DC, patients are looking for guidance from clinicians – who have received little or no information about this substance in their formal training. Furthermore, much of the information being offered about the dangers and benefits of cannabis tends to be distorted positively or negatively according to the philosophical orientation of the source.
Enfermedad minoritaria, terapias nuevas. Una patología que afecta a menos de cinco personas por cada 10.000 habitantes es considerada una enfermedad rara o minoritaria. 35 millones de europeos se ven afectados por alguna de ellas. El 80% son de origen genético y conseguir un diagnóstico rápido es vital para asegurar la calidad de vida futura. La clave, una vez más, es apostar y potenciar la investigación biomédica. Se revisarán los resultados obtenidos los últimos 14 años, en el marco científico y regulador impulsado por la UE desde el año 2000. Sin embargo, se analizarán las dificultades y oportunidades para impulsar la investigación traslacional en estas enfermedades.
Sigue la presentación en Youtube: https://www.youtube.com/watch?v=d4U4a8xFCzA&
A 90 minute presentation to Addiction and Mental Health workers in Ontario, Canada.
Contains many links to useful resources and information.
To provide a background and overview of some of the newer substances we are seeing and people may be consuming.
A focus on:
- MDMA / Ecstasy / Molly
- Drug Checking
- Bath Salts / Cathinones
- Synthetic Cannabinoids
**Unfortunately the speaker notes are not uploading. Please contact us if you would like a copy of these: http://www.ohsutp.ca/contact
Workshop for the 5th Annual Addictions and Mental Health Ontario Conference, Canada
Weekly reports of opioid overdoses. Residential treatment providers refusing people on methadone. Supervised injection services. Confusion about naloxone. We will go back to basics, examine the situation we are in, explore misunderstandings, misconceptions and stigma, and discuss progressive programming, linkages and coordination.
Learning objectives:
- Be more informed about the range of opioid drugs, including substitute therapies
- Consider the negative impacts of misunderstanding and stigma on access to effective supports and treatment options
- Feel more comfortable developing inter-agency/program partnerships
- Discuss why the crisis continues to escalate and keeping things in check
OPIOIDSWHAT ARE OPIOIDS• Psychoactive substances.docxLacieKlineeb
OPIOIDS
WHAT ARE
OPIOIDS
• Psychoactive substances
derived from the poppy plant,
or their synthetic analogues
• Derived from the resin that
comes from the seed pod of
the plant
• Used in medications to treat
pain
EXAMPLES OF OPIOIDS
• Prescription Opioids
• Oxycodone (Oxycontin)
• Hydrocodone (Vicodin)
• Codeine
• Morphine
• Illicit Opioids
• Heroin
• Synthetic
• Fentanyl
• Carfentanil
ALIASES, FORMS, AND METHODS OF
ABUSE
• Street Names: Big H, Black Tar, Brown Sugar, Dover's Powder, Hillbilly Heroin,
Horse, Junk, Lean or Purple Drank, MPTP (New Heroin), Mud, OC, Ox, Oxy,
Oxycotton, Paregoric, Sippin Syrup, Smack
• Forms: Tablets, capsules, skin patches, powder, chunks in varying colors (from
white to shades of brown and black), liquid form for oral use and injection,
syrups, suppositories, and lollipops
• Methods of abuse: Can be swallowed, smoked, sniffed, or injected.
OPIOID EFFECTS
• Prescribed to treat pain, suppress cough, cure diarrhea, and put people to sleep
• Effect on body
• Depends heavily on the dose, how it’s taken, and previous exposure to the drug
• Negative effects include: slowed physical activity, constriction of the pupils, flushing of
the face and neck, constipation, nausea, vomiting, and slowed breathing
OPIOID EFFECTS
• Effect on mind - Produces a general sense of well-being
• Reduces tension, anxiety, and aggression
• Unwanted effects: Drowsiness, inability to concentrate, and apathy
• Can create dependence
• Long after the physical need for the drug has passed, a person may continue to
think and talk about using drugs and feel overwhelmed coping with daily activities
OPIOID EFFECTS
• As the dose increases, both pain relief and the harmful effects become more
pronounced
• Physical dependence is a consequence of chronic opioid use, and withdrawal takes
place when drug use is discontinued
• Early withdrawal symptoms: watery eyes, runny nose, yawning, and sweating
• As withdrawal worsens, symptoms can include: restlessness, irritability, loss of
appetite, nausea, tremors, drug craving, severe depression, vomiting, increased heart
rate and blood pressure, and chills alternating with flushing and excessive sweating
• Most withdrawal physical symptoms disappear within days or weeks, depending on
the particular drug
OPIOID EFFECTS
• Overdose effects – Can be fatal
• Respiratory failure – lack of sufficient oxygen in the blood
• Vital organs like the heart and brain start to fail
• Leads to unconsciousness, coma, death
• Physical signs of opioid overdose include: Constricted (pinpoint) pupils, cold
clammy skin, confusion, convulsions, extreme drowsiness, and slowed breathing
U.S. EPIDEMIC
• In the U.S., 5,480 people initiate nonmedical use of prescription opioids on a daily basis
• Amounts to 2 million persons/year
• Reasons for increase in misuse/abuse
• Ease of access
• Prescriptions for these medications have increased dramat.
Not for human consumption: new and emerging drugs in Australia - Stephen Brig...Australian Drug Foundation
By tweaking the molecular structure of banned chemicals, new drugs have been developed to circumvent the law. Despite little information about their toxicity, these new and emerging drugs have been sold online and in Australian adult stores. They are typically professionally packaged and labeled as ‘not for human consumption’. This presentation aims to provide participants with a brief overview of the context within which this phenomenon has developed and the types of products that have been available in Australia. This is a rapidly shifting market – each time one of these new drugs is banned, it seems like two more drugs emerge to replace it. As such, the limitations of legislative responses will be explored and alternative policy options considered. The presentation will also explore the need for better monitoring systems that are able to help us remain abreast of the rapid changes in the market.
What is the current Synthetic opioid situation in Europe? How can countries be better prepared and equipped for a continued rise in synthetic opioid prevalence, use, and incidents?
Similar to New psychoactive substances - analysing the problem (20)
Presentation by Vito Spinelli (Consultant in the ESCO secretariat, DG EMPL) on the occasion of the EESC Seminar on 'Delivering on Skills' organised in Brussels on 17 November 2014.
Presentation Michael HORGAN (Policy officer at DG EAC) on the occasion of the EESC Seminar on 'Delivering on Skills' organised in Brussels on 17 November 2014.
Presentation by Felix Rohn (Policy officer at DG EAC) on the occasion of the EESC Seminar on 'Delivering on Skills' organised in Brussels on 17 November 2014.
Presentation by Barbora Novotna (Policy co-ordinator at DG EMPL) on the occasion of the EESC Seminar on 'Delivering on Skills' organised in Brussels on 17 November 2014.
Presentation by Michael Guet, Council of Europe, on the occasion of the EESC conference on 'Better Roma inclusion through civil society initiatives: focus on education, employment, housing and antidiscrimination' (Brussels, 7 November 2014).
Presentation by Michael Guet, Council of Europe, on the occasion of the EESC conference on 'Better Roma inclusion through civil society initiatives: focus on education, employment, housing and antidiscrimination' (Brussels, 7 November 2014).
Presentation by Michael Guet, Council of Europe, on the occasion of the EESC conference on 'Better Roma inclusion through civil society initiatives: focus on education, employment, housing and antidiscrimination' (Brussels, 7 November 2014).
Presentation by Dan Pavel Doghi, Roma Education Fund, on the occasion of the EESC conference on 'Better Roma inclusion through civil society initiatives: focus on education, employment, housing and antidiscrimination' (Brussels, 7 November 2014).
Presentation by Szilvia Kalman, European Commission, DG EAC, on the occasion of the EESC conference on 'Better Roma inclusion through civil society initiatives: focus on education, employment, housing and antidiscrimination' (Brussels, 7 November 2014).
Presentation by Dominique Bé, European Commission, DG EMPL, on the occasion of the EESC conference on 'Better Roma inclusion through civil society initiatives: focus on education, employment, housing and antidiscrimination' (Brussels, 7 November 2014).
Presentation by Andor Urmos, DG REGIO, on the occasion of the EESC conference on 'Better Roma inclusion through civil society initiatives: focus on education, employment, housing and antidiscrimination' (Brussels, 7 November 2014).
Presentation by Wiet van Meel, volunteer sustainable development advisor to Coöperatieve Esbeek and professional occupation at Pontifax and Coopnet, on the occasion of the EESC conference on "Social economy and social innovation as drivers of competitiveness, growth and social well-being - Perspecitves and priorities for the new Commission and the European Parliament" (Brussels, 1 October 2014)
Presentation by Matthew Brown, Manager of The Wales Council for Voluntary Actions, Communities Investment Fund, on the occasion of the EESC conference on "Social economy and social innovation as drivers of competitiveness, growth and social well-being - Perspecitves and priorities for the new Commission and the European Parliament" (Brussels, 1 October 2014)
Presentation by Julie Savary, Head of Mission, Cabinet of the Presidency - Le mutual Groupe MGEN, France, on the occasion of the EESC conference on "Social economy and social innovation as drivers of competitiveness, growth and social well-being - Perspecitves and priorities for the new Commission and the European Parliament" (Brussels, 1 October 2014)
Presentation by Sarah Cook, Director, United Nations Research Institute for Social Development, United Nations, on the occasion of the EESC conference on "Social economy and social innovation as drivers of competitiveness, growth and social well-being - Perspecitves and priorities for the new Commission and the European Parliament" (Brussels, 1 October 2014)
Presentation by Antonella Noya, Senior Policy Analyst, OECD, on the occasion of the EESC conference on "Social economy and social innovation as drivers of competitiveness, growth and social well-being - Perspecitves and priorities for the new Commission and the European Parliament" (Brussels, 1 October 2014)
Presentation by Xavier Le Mounier, Policy Officer (Innovation Policy for Growth), DG Enterprise and Industry, European Commission, on the occasion of the EESC conference on "Social economy and social innovation as drivers of competitiveness, growth and social well-being - Perspecitves and priorities for the new Commission and the European Parliament" (Brussels, 1 October 2014)
Presentation by Apostolos Ioakimidis, Policy Officer (Entrepreunership 2020 Cooperatives, Mutuals, Social Enterprises, Family Businesses), DG Enterprise and Industry, European Commission, on the occasion of the EESC conference on "Social economy and social innovation as drivers of competitiveness, growth and social well-being - Perspecitves and priorities for the new Commission and the European Parliament" (Brussels, 1 October 2014)
Presentation by Peter Lambreghts, EDF Board member & European Network of Independent Living,on the occasion of the EESC SOC section conference on Civil society perspectives on the implementation of the UN Convention on the Rights of Persons with Disabilities (UNCRPD) in Brussels on 2 October 2014.
Presentation by Stefano Palmieri, EESC Europe 2020 Steering Committee, on the occasion of the EESC SOC section conference on Civil society perspectives on the implementation of the UN Convention on the Rights of Persons with Disabilities (UNCRPD) in Brussels on 2 October 2014.
More from European Economic and Social Committee - SOC Section (20)
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
New psychoactive substances - analysing the problem
1. New drugs
New psychoactive substances
Analysing the problem
Roumen Sedefov
European Economic and Social Committee, Public Hearing, 27 November 2013
2. I will ask and maybe answer…
• What are NPS and what do we know about them?
• Why should we be concerned about them?
• What information do we need in order to respond
effectively to them?
3. From designer drugs to legal highs
How did we get here? The role of globalisation and innovation
4. The new drug phenomenon in the EU today
Four broad and overlapping groups
• Designer drugs: produced in clandestine labs and
sold on illicit drug market as replacements for
‘ecstasy’ or ‘speed’ or heroin. Users mostly unaware
that they are taking them
• Legal highs: produced by chemical companies and
sold on open market, often as branded products in
sophisticated packaging. Sold on the Internet, in head
shops and by street-level drug dealers
• Dietary supplements: sold on open market aimed
at people going to the gym, looking to loose weight.
Sold on Amazon and eBay
Limited data on toxicity and harms
• Medicines: diverted within Europe or imported
5. Huge growth in number, type and availability
303 new drugs notified 2005–2013, 67 notified in 2013 so far…
More than 200 have
been notified since
2010
6. Types of products & users are also broadening
out…
• Traditionally most new drugs were marketed to ‘recreational’ users:
psychonauts, early adopters (dance music fans)
• Diffusion may have then spread to the broader population (e.g.
mephedrone)
• Now seeing both branded and unbranded products used by:
• lifestyle users: gym-goers (‘Craze’, DMAA), weight loss, other
enhancement reasons (phenibut)
• problematic users: IV opioid injectors using stimulants (mephedrone and
MDPV) or fentanyls (ocfentanyl, carfentanyl)
• self-medication (overlap with all user groups): e.g. importation of noncontrolled benzodiazepines from outside EU
7. Seizures of synthetic cannabinoids
Multi-kilogram quantities usually shipped from China
Amount
Cannabinoid
Date
54 kg
JWH-018 quinolinylcarboxylate derivative
Nov 2012
7 kg
JWH-018 carboxamide derivative
Jul 2012
5 kg
JWH-073
Aug 2012
21 kg
JWH-018 adamantyl carboxamide derivative
Jul 2012
10 kg
5F-UR-144
Jan 2013
20 kg
AM-2201
Jan 2013
8. Processing and packaging in Europe
Potent synthetic cannabinoids sold as 'herbal' smoking mixtures
9. Internet shops and bricks and mortar shops
The Internet plays a key role in shaping the market
693 online shops identified in
2012 selling to EU
10. Lifetime use of 'legal highs' in the EU
15–24 year olds, percentage by country, n > 12000
In certain countries some new substances that imitate the
effects of illicit drugs are being sold as legal substances in the
form of - for example - powders, tablets/pills or herbs. Have
you ever used such substances?
11. Mephedrone…
Last year use in the United Kingdom
2010/11:
Ages 16-24: 4.4% ~ cocaine, the second
most used drug
Ages 16-59: 1.4% ~ ecstasy, the third
most used drug
2011/12:
Ages 16-24: 3.3% ~ ecstasy, the third
most used drug
Ages 16-59: 1.1%
12. Do NPS have other uses?
Examples…
• Medicines: phenazepam, GHB, pregabalin, etizolam, carfentanil, ketamine
• Intermediates for synthesis of API: mCPP, 2-AI, other?
(both groups excluded from risk assessment and control at EU level)
• Industrial chemicals: GBL, 1,4 BD
• Scientific research & developmental, potential medicines?
13. Detecting and responding to harms
EWS is an event-based monitoring system allowing early detection of signals of harm
4-MA and 5-IT: risk assessed in 2013 and subject to
controls
25I-NBOMe: phenethylamine, often sold as LSD, large seizures of
blotters, seizures of bulk powders (China)
• Identified in 14 countries, 30+ non-fatal intoxications reported,
some very serious
AH-7921: synthetic opioid, sold as ‘research chemical’
• Identified in 6 countries, 10 deaths reported
MDPV: synthetic cathinone, sold as ‘legal high’, ‘research chemical’,
and on illicit drug market
• Identified in 17 countries, large seizures, 40 deaths reported
Methoxetamine: ketamine derivative, sold as ‘legal high’, ’research
chemical’ and on illicit market as ketamine
• Identified in 12 countries, 9 deaths reported
14. Knowledge gaps and areas that require
strengthening
• Toxicovigilance: acute emergencies, poisons centres, deaths
• Better epidemiological data across the board
• Better understanding of motives of use and models of diffusion potential
and interplay with illicit drug market
• Internet monitoring
• Better detail on major production sites and seizures
• Producer countries and trends in production
• Availability and trends at global level