This document summarizes key points from Jon's talk on cannabis legalization. It notes that national legalization following an alcohol model is likely. Long-run cannabis consumption may double. Prices and quantity consumed matter more than the number of consumers. There are many policy levers but it is unclear if they are being used effectively to learn what works. National legalization is not guaranteed and effects in states like Colorado are still uncertain due to many complicating factors. The fundamental tradeoff is that legalization may reduce average harm per dose while increasing total doses consumed, with the net public health effect unknown.